Systemic lupus erythematosus

Common Name(s)

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by {92:Oishi et al., 2008}). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; {614420}) is caused by mutation in the DNASE1L3 gene ({602244}) on chromosome 3p14.3. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic lupus erythematosus" returned 3907 free, full-text research articles on human participants. First 3 results:

Belimumab for the treatment of refractory systemic lupus erythematosus: real-life experience in the first year of use in 18 Italian patients.
 

Author(s): Laura Andreoli, Rossella Reggia, Lara Pea, Micol Frassi, Alessandra Zanola, Stefania Cartella, Franco Franceschini, Angela Tincani

Journal: Isr. Med. Assoc. J.. 2014 Oct;16(10):651-3.

 

Last Updated: 2 Dec 2014

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Mortality due to sepsis in patients with systemic lupus erythematosus and rheumatoid arthritis.
 

Author(s): Orit Barrett, Ella Abramovich, Jacob Dreiher, Victor Novack, Mahmoud Abu-Shakra

Journal: Isr. Med. Assoc. J.. 2014 Oct;16(10):634-5.

 

Last Updated: 2 Dec 2014

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BLyS levels in sera of patients with systemic lupus erythematosus: clinical and serological correlation.
 

Author(s): Daniel Elbirt, Ilan Asher, Keren Mahlab-Guri, Shira Bezalel-Rosenberg, Victor Edelstein, Zev Sthoeger

Journal: Isr. Med. Assoc. J.. 2014 Aug;16(8):491-6.

 

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by disturbance of the innate and adaptive immune systems with the production of autoantibodies by stimulated B lymphocytes. The BLyS protein (B lymphocyte stimulator) is secreted mainly by monocytes and activated ...

Last Updated: 1 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic lupus erythematosus" returned 403 free, full-text review articles on human participants. First 3 results:

Advances in mechanisms of systemic lupus erythematosus.
 

Author(s): Barbara Dema, Nicolas Charles

Journal: Discov Med. 2014 May;17(95):247-55.

 

Systemic lupus erythematosus (SLE) is a complex autoimmune disease associated with hormonal, environmental, and genetic factors and linked to the tolerance breakdown of B and T cells to self-antigens. SLE is characterized by the presence in patient serum of autoantibodies raised against ...

Last Updated: 2 Jun 2014

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An update on pathogenesis of systemic lupus erythematosus.
 

Author(s): Pedram Ahmadpoor, Nooshin Dalili, Mehrdad Rostami

Journal: Iran J Kidney Dis. 2014 May;8(3):171-84.

 

Systemic lupus erythematosus is a group of diseases that seem to become separate entities by etiology in the near future. Its pathogenesis remains elusive; however, multifactorial interactions among genetic and environmental factors may be involved. Systemic lupus erythematosus is ...

Last Updated: 2 Jun 2014

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The pathology of T cells in systemic lupus erythematosus.
 

Author(s): Anselm Mak, Nien Yee Kow

Journal: J Immunol Res. 2014 ;2014():419029.

 

Systemic lupus erythematosus (SLE) is characterized by the production of a wide array of autoantibodies. Thus, the condition was traditionally classified as a "B-cell disease". Compelling evidence has however shown that without the assistance of the helper T lymphocytes, it is indeed ...

Last Updated: 27 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 11 Nov 2014

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Cardiology Prevention in Systemic Lupus Erythematosus (SLE)
 

Status: Not yet recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 3 Oct 2008

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GENetic & Immunologic Abnomalies in Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus (SLE)

 

Last Updated: 18 Nov 2013

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