Systemic lupus erythematosus

Common Name(s)

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by {92:Oishi et al., 2008}). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; {614420}) is caused by mutation in the DNASE1L3 gene ({602244}) on chromosome 3p14.3. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic lupus erythematosus" returned 3919 free, full-text research articles on human participants. First 3 results:

Acute transverse myelitis as the first clinical manifestation of systemic lupus erythematosus.
 

Author(s): Aleksandra Loster-Niewinska, Justyna Chojdak-Lukasiewicz, Marek Sasiadek, Magdalena Szmyrka-Kaczmarek, Boguslaw Paradowski

Journal: Neurol India. ;62(6):712-3.

 

Last Updated: 16 Jan 2015

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Systemic lupus erythematosus and subarachnoid hemorrhage.
 

Author(s): Hasan Hüseyin Kozak, Muazzez Betigül Yürüten Çorbacıoğlu, Süleyman Ömer Anlıaçık

Journal: Neurol India. ;62(6):689-90.

 

Last Updated: 16 Jan 2015

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Belimumab for the treatment of refractory systemic lupus erythematosus: real-life experience in the first year of use in 18 Italian patients.
 

Author(s): Laura Andreoli, Rossella Reggia, Lara Pea, Micol Frassi, Alessandra Zanola, Stefania Cartella, Franco Franceschini, Angela Tincani

Journal: Isr. Med. Assoc. J.. 2014 Oct;16(10):651-3.

 

Last Updated: 2 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic lupus erythematosus" returned 403 free, full-text review articles on human participants. First 3 results:

Neuropsychiatric systemic lupus erythematosus and cognitive dysfunction: the MRL-lpr mouse strain as a model.
 

Author(s): Hélène Jeltsch-David, Sylviane Muller

Journal: Autoimmun Rev. 2014 Sep;13(9):963-73.

 

Mouse models of autoimmunity, such as (NZB×NZW)F1, MRL/MpJ-Fas(lpr) (MRL-lpr) and BXSB mice, spontaneously develop systemic lupus erythematosus (SLE)-like syndromes with heterogeneity and complexity that characterize human SLE. Despite their inherent limitations, such models have ...

Last Updated: 20 Sep 2014

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Advances in mechanisms of systemic lupus erythematosus.
 

Author(s): Barbara Dema, Nicolas Charles

Journal: Discov Med. 2014 May;17(95):247-55.

 

Systemic lupus erythematosus (SLE) is a complex autoimmune disease associated with hormonal, environmental, and genetic factors and linked to the tolerance breakdown of B and T cells to self-antigens. SLE is characterized by the presence in patient serum of autoantibodies raised against ...

Last Updated: 2 Jun 2014

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An update on pathogenesis of systemic lupus erythematosus.
 

Author(s): Pedram Ahmadpoor, Nooshin Dalili, Mehrdad Rostami

Journal: Iran J Kidney Dis. 2014 May;8(3):171-84.

 

Systemic lupus erythematosus is a group of diseases that seem to become separate entities by etiology in the near future. Its pathogenesis remains elusive; however, multifactorial interactions among genetic and environmental factors may be involved. Systemic lupus erythematosus is ...

Last Updated: 2 Jun 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 11 Nov 2014

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Cardiology Prevention in Systemic Lupus Erythematosus (SLE)
 

Status: Not yet recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 3 Oct 2008

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GENetic & Immunologic Abnomalies in Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus (SLE)

 

Last Updated: 11 Mar 2015

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