Systemic lupus erythematosus

Common Name(s)

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by {92:Oishi et al., 2008}). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; {614420}) is caused by mutation in the DNASE1L3 gene ({602244}) on chromosome 3p14.3. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic lupus erythematosus" returned 3979 free, full-text research articles on human participants. First 3 results:

Inflammatory cytokine kinetics to single bouts of acute moderate and intense aerobic exercise in women with active and inactive systemic lupus erythematosus.
 

Author(s): L A Perandini, D Sales-de-Oliveira, Sbv Mello, N O Camara, F B Benatti, F R Lima, E Borba, E Bonfa, H Roschel, A L Sá-Pinto, B Gualano

Journal: Exerc Immunol Rev. 2015 ;21():174-85.

 

The aim of this study was to evaluate changes in the cytokines INF-γ, IL-10, IL-6, TNF-α and soluble TNF receptors (sTNFR1 and sTNFR2) in response to single bouts of acute moderate and intense exercise in systemic lupus erythematosus women with active (SLE(ACTIVE)) and inactive ...

Last Updated: 1 Apr 2015

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Acute transverse myelitis as the first clinical manifestation of systemic lupus erythematosus.
 

Author(s): Aleksandra Loster-Niewinska, Justyna Chojdak-Lukasiewicz, Marek Sasiadek, Magdalena Szmyrka-Kaczmarek, Boguslaw Paradowski

Journal: Neurol India. ;62(6):712-3.

 

Last Updated: 16 Jan 2015

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Systemic lupus erythematosus and subarachnoid hemorrhage.
 

Author(s): Hasan Hüseyin Kozak, Muazzez Betigül Yürüten Çorbacıoğlu, Süleyman Ömer Anlıaçık

Journal: Neurol India. ;62(6):689-90.

 

Last Updated: 16 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic lupus erythematosus" returned 417 free, full-text review articles on human participants. First 3 results:

Neuropsychiatric manifestations associated with anti-endothelial cell antibodies in systemic lupus erythematosus.
 

Author(s): Carlo Perricone, Monica Pendolino, Marta Olivieri, Fabrizio Conti, Guido Valesini, Cristiano Alessandri

Journal: Isr. Med. Assoc. J.. 2015 Mar;17(3):171-8.

 

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem involvement due to immune dysregulation. Neuropsychiatric systemic lupus erythematosus (NPSLE) includes neurological syndromes involving the central, peripheral and autonomic nervous system, ...

Last Updated: 7 May 2015

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Neuropsychiatric systemic lupus erythematosus and cognitive dysfunction: the MRL-lpr mouse strain as a model.
 

Author(s): Hélène Jeltsch-David, Sylviane Muller

Journal: Autoimmun Rev. 2014 Sep;13(9):963-73.

 

Mouse models of autoimmunity, such as (NZB×NZW)F1, MRL/MpJ-Fas(lpr) (MRL-lpr) and BXSB mice, spontaneously develop systemic lupus erythematosus (SLE)-like syndromes with heterogeneity and complexity that characterize human SLE. Despite their inherent limitations, such models have ...

Last Updated: 20 Sep 2014

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Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus.
 

Author(s): Steve P Crampton, Peter A Morawski, Silvia Bolland

Journal: Dis Model Mech. 2014 Sep;7(9):1033-46.

 

Systemic lupus erythematosus (SLE) represents a challenging autoimmune disease from a clinical perspective because of its varied forms of presentation. Although broad-spectrum steroids remain the standard treatment for SLE, they have many side effects and only provide temporary relief ...

Last Updated: 22 Aug 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 11 Nov 2014

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Cardiology Prevention in Systemic Lupus Erythematosus (SLE)
 

Status: Not yet recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 3 Oct 2008

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GENetic & Immunologic Abnomalies in Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus (SLE)

 

Last Updated: 11 Mar 2015

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