Systemic lupus erythematosus

Common Name(s)

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by {93:Oishi et al., 2008}). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; {614420}) is caused by mutation in the DNASE1L3 gene ({602244}) on chromosome 3p14.3. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic lupus erythematosus" returned 4427 free, full-text research articles on human participants. First 3 results:

Voice disorder in systemic lupus erythematosus.
 

Author(s): Milena S F C de Macedo, KauĂȘ M Costa, Manoel da Silva Filho

Journal:

 

Systemic lupus erythematosus (SLE) is a chronic disease characterized by progressive tissue damage. In recent decades, novel treatments have greatly extended the life span of SLE patients. This creates a high demand for identifying the overarching symptoms associated with SLE and ...

Last Updated: 17 Apr 2017

Go To URL
Association between killer cell immunoglobulin-like receptor (KIR) polymorphisms and systemic lupus erythematosus (SLE) in populations: A PRISMA-compliant meta-analysis.
 

Author(s): Hui-Ling Liang, Shu-Juan Ma, Hong-Zhuan Tan

Journal: Medicine (Baltimore). 2017 Mar;96(10):e6166.

 

Recently, a growing number of studies show that the killer cell immunoglobulin-like receptor (KIR) gene polymorphisms may play a role in the systemic lupus erythematosus (SLE) susceptibility. Nonetheless, the results were inconsistent. Thus, a meta-analysis was carried out by integrating ...

Last Updated: 8 Mar 2017

Go To URL
Development of the Systemic Lupus Erythematosus Steroid Questionnaire (SSQ): a novel patient-reported outcome tool to assess the impact of oral steroid treatment.
 

Author(s): Susan D Mathias, Pamela Berry, Jane De Vries, Anca Askanase, Katie Pascoe, Hilary H Colwell, David J Chang

Journal:

 

Oral glucocorticoids (steroids) are the mainstay of treatment for systemic lupus erythematosus (SLE), but their use is often associated with short- and long-term side effects. Following a literature review and discussions with patients with SLE, clinicians, and payers, a need was ...

Last Updated: 1 Mar 2017

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic lupus erythematosus" returned 519 free, full-text review articles on human participants. First 3 results:

Extracellular Vesicles as Therapeutic Agents in Systemic Lupus Erythematosus.
 

Author(s): Javier Perez-Hernandez, Josep Redon, Raquel Cortes

Journal:

 

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that affects multiple organs. Currently, therapeutic molecules present adverse side effects and are only effective in some SLE patient subgroups. Extracellular vesicles (EV), including exosomes, microvesicles ...

Last Updated: 28 Mar 2017

Go To URL
Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?
 

Author(s): Francesco Di Virgilio, Anna Lisa Giuliani

Journal: Biomed J. 2016 Oct;39(5):326-338.

 

Purinergic signalling plays a crucial role in immunity and autoimmunity. Among purinergic receptors, the P2X7 receptor (P2X7R) has an undisputed role as it is expressed to high level by immune cells, triggers cytokine release and modulates immune cell differentiation. In this review, ...

Last Updated: 25 Nov 2016

Go To URL
Systemic Lupus Erythematosus Presenting as Refractory Thrombotic Thrombocytopenic Purpura: A Diagnostic and Management Challenge. A Case Report and Concise Review of the Literature.
 

Author(s): Mohammad Abu-Hishmeh, Alamgir Sattar, Fnu Zarlasht, Mohamed Ramadan, Aisha Abdel-Rahman, Shante Hinson, Caroline Hwang

Journal:

 

BACKGROUND Thrombotic thrombocytopenic purpura (TTP) is one of the thrombotic microangiopathic (TMA) syndromes, caused by severely reduced activity of the vWF-cleaving protease ADAMTS13. Systemic lupus erythematosus (SLE), on the other hand, is an autoimmune disease that affects various ...

Last Updated: 25 Oct 2016

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Walk With Ease Program For Patients With Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 26 May 2016

Go to URL
Efficacy and Safety of Anifrolumab Compared to Placebo in Adult Subjects With Active Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Active Systemic Lupus Erythematosus

 

Last Updated: 22 Nov 2016

Go to URL

Last Updated: 22 Nov 2016

Go to URL