Systemic lupus erythematosus

Common Name(s)

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by {92:Oishi et al., 2008}). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; {614420}) is caused by mutation in the DNASE1L3 gene ({602244}) on chromosome 3p14.3. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic lupus erythematosus" returned 4442 free, full-text research articles on human participants. First 3 results:

Association of novel polymorphisms in TMEM39A gene with systemic lupus erythematosus in a Chinese Han population.
 

Author(s): Xinze Cai, Wenyue Huang, Xudong Liu, Lining Wang, Yi Jiang

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This study aimed to assess the association between 14 single nucleotide polymorphisms (SNPs) in six genes (IRF8, TMEM39A, IKZF3, ORMDL3, GSDMB, and ZPBP2) and systemic lupus erythematosus (SLE) in a Chinese Han population sample.

Last Updated: 21 Apr 2017

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Voice disorder in systemic lupus erythematosus.
 

Author(s): Milena S F C de Macedo, Kauê M Costa, Manoel da Silva Filho

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Systemic lupus erythematosus (SLE) is a chronic disease characterized by progressive tissue damage. In recent decades, novel treatments have greatly extended the life span of SLE patients. This creates a high demand for identifying the overarching symptoms associated with SLE and ...

Last Updated: 17 Apr 2017

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Excess atherosclerosis in systemic lupus erythematosus,-A matter of renal involvement: Case control study of 281 SLE patients and 281 individually matched population controls.
 

Author(s): Johanna T Gustafsson, Marie Herlitz Lindberg, Iva Gunnarsson, Susanne Pettersson, Kerstin Elvin, John Öhrvik, Anders Larsson, Kerstin Jensen-Urstad, Elisabet Svenungsson

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Systemic lupus erythematosus (SLE), is a heterogeneous disease which predominantly affects young females (90%). SLE is associated with a shorter life expectancy than in the general population. Standardized mortality ratios (SMR) of 2.4 have been reported, which is comparable to diabetes. ...

Last Updated: 17 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic lupus erythematosus" returned 524 free, full-text review articles on human participants. First 3 results:

Extracellular Vesicles as Therapeutic Agents in Systemic Lupus Erythematosus.
 

Author(s): Javier Perez-Hernandez, Josep Redon, Raquel Cortes

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Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that affects multiple organs. Currently, therapeutic molecules present adverse side effects and are only effective in some SLE patient subgroups. Extracellular vesicles (EV), including exosomes, microvesicles ...

Last Updated: 28 Mar 2017

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Spotlight on blisibimod and its potential in the treatment of systemic lupus erythematosus: evidence to date.
 

Author(s): Aleksander Lenert, Timothy B Niewold, Petar Lenert

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B cells in general and BAFF (B cell activating factor of the tumor necrosis factor [TNF] family) in particular have been primary targets of recent clinical trials in systemic lupus erythematosus (SLE). In 2011, belimumab, a monoclonal antibody against BAFF, became the first biologic ...

Last Updated: 23 Mar 2017

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Regulation of T Cell Activation and Differentiation by Extracellular Vesicles and Their Pathogenic Role in Systemic Lupus Erythematosus and Multiple Sclerosis.
 

Author(s): Cristina Ulivieri, Cosima T Baldari

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How autoreactive tissue-infiltrated effector T cells are induced and sustained in autoimmune disease, usually dominated by the Th1 and Th17 subsets, is still largely unknown. In organ-specific autoimmunity, self-reactive T cells initially activated by dendritic cells (DCs) in the ...

Last Updated: 3 Feb 2017

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Walk With Ease Program For Patients With Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 28 Apr 2017

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Efficacy and Safety of Anifrolumab Compared to Placebo in Adult Subjects With Active Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Active Systemic Lupus Erythematosus

 

Last Updated: 22 May 2017

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Last Updated: 22 May 2017

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