Systemic lupus erythematosus

Common Name(s)

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by {93:Oishi et al., 2008}). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; {614420}) is caused by mutation in the DNASE1L3 gene ({602244}) on chromosome 3p14.3. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic lupus erythematosus" returned 4842 free, full-text research articles on human participants. First 3 results:

Aberrant Epigenetic Regulation in the Pathogenesis of Systemic Lupus Erythematosus and Its Implication in Precision Medicine.
 

Author(s): Yi Zhan, Yu Guo, Qianjin Lu

Journal: Cytogenet. Genome Res.. 2016 ;149(3):141-155.

 

Great progress has been made in the last decades in understanding the complex immune dysregulation in systemic lupus erythematosus (SLE), yet the efforts to pursue an effective treatment of SLE proved to be futile. The pathoetiology of SLE involves extremely complicated and multifactorial ...

Last Updated: 8 Sep 2016

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Evaluation of a novel autoinjector for subcutaneous self-administration of belimumab in systemic lupus erythematosus
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Author(s): Saira Z Sheikh, Anne E Hammer, Norma Lynn Fox, James Groark, Herbert Struemper, David Roth, David Gordon

Journal: Int J Clin Pharmacol Ther. 2016 Nov;54(11):914-922.

 

To study self-administration and pharmacokinetics (PK) of subcutaneous (SC) belimumab in patients with systemic lupus erythematosus (SLE).

Last Updated: 26 Sep 2016

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Guillain-Barré syndrome in a patient with neuropsychiatric systemic lupus erythematosus.
 

Author(s): G K Rajeshwari, C H Bangaru Rao, N V Sundarachary, S K Moula Ali, J S Kalyani, A Sridhar

Journal: Natl Med J India. ;29(1):14-7.

 

Guillain-Barré syndrome is a rare manifestation of neuropsychiatric systemic lupus erythematosus (SLE). Clinical and electrophysiological features of Guillain-Barré syndrome in patients with SLE are different from those in patients without SLE. There is considerable variation in ...

Last Updated: 5 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic lupus erythematosus" returned 557 free, full-text review articles on human participants. First 3 results:

Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?
 

Author(s): Francesco Di Virgilio, Anna Lisa Giuliani

Journal: Biomed J. 2016 Oct;39(5):326-338.

 

Purinergic signalling plays a crucial role in immunity and autoimmunity. Among purinergic receptors, the P2X7 receptor (P2X7R) has an undisputed role as it is expressed to high level by immune cells, triggers cytokine release and modulates immune cell differentiation. In this review, ...

Last Updated: 25 Nov 2016

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One year in review 2016: systemic lupus erythematosus.
 

Author(s): Antonella Adinolfi, Eleonora Valentini, Emanuele Calabresi, Giulia Tesei, Viola Signorini, Simone Barsotti, Chiara Tani

Journal: Clin. Exp. Rheumatol.. ;34(4):569-74.

 

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a highly variable course and prognosis. The management of the disease is still a clinical challenge for the treating physicians as many aspects regarding the disease pathogenesis, clinical picture and outcomes ...

Last Updated: 28 Jul 2016

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Vitamin D and Systemic Lupus Erythematosus: Myth or Reality?
 

Author(s): Abdulla Watad, Shana G Neumann, Alessandra Soriano, Howard Amital, Yehuda Shoenfeld

Journal: Isr. Med. Assoc. J.. ;18(3-4):177-82.

 

There is growing interest in the contribution of vitamin D deficiency to autoimmunity. Several studies have shown an association between low levels of vitamin D and autoimmune disorders, including multiple sclerosis, rheumatoid arthritis, type 1 diabetes, autoimmune thyroid diseases, ...

Last Updated: 27 May 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Exploratory Study of MT-1303 in Systemic Lupus Erythematosus Patients
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 15 Sep 2016

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Walk With Ease Program For Patients With Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 26 May 2016

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A Phase 2a, Efficacy and Safety Study of Ustekinumab in Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 6 Jan 2017

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