Systemic lupus erythematosus

Common Name(s)

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by {93:Oishi et al., 2008}). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; {614420}) is caused by mutation in the DNASE1L3 gene ({602244}) on chromosome 3p14.3. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic lupus erythematosus" returned 4408 free, full-text research articles on human participants. First 3 results:

Pulmonary Granulomatous Inflammation in Systemic Lupus Erythematosus.
 

Author(s): Lone Sølling Avnon, Alexander Smoliakov, Igor Sinelko, Mahmoud Abu-Shakra

Journal: Isr. Med. Assoc. J.. 2015 Oct;17(10):650-2.

 

Last Updated: 10 Dec 2015

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Successful Pregnancy Following Assisted Reproduction in Woman With Systemic Lupus Erythematosus and Hypertension: A Case Report.
 

Author(s): José Fernando de Macedo, Gustavo Capinzaiki de Macedo, Luciana Aparecida Campos, Ovidiu Constantin Baltatu

Journal: Medicine (Baltimore). 2015 Sep;94(37):e1531.

 

Patients with systemic lupus erythematosus have a poor prognosis of pregnancy, since it is associated with significant maternal and fetal morbidity, including spontaneous miscarriage, pre-eclampsia, intrauterine growth restriction, fetal death and pre-term delivery. We report a case ...

Last Updated: 17 Sep 2015

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Bilateral visual loss in patient with systemic lupus erythematosus.
 

Author(s): Ahmed Chebil, Nibrass Chaker, Belgacem Baroudi, Yosra Falfoul, Leila El Matri

Journal: Tunis Med. 2015 Feb;93(2):117-8.

 

Last Updated: 5 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic lupus erythematosus" returned 482 free, full-text review articles on human participants. First 3 results:

Is B Cell-Targeted Therapy Effective in Systemic Lupus Erythematosus?
 

Author(s): Daphna Paran, Yaakov Naparstek

Journal: Isr. Med. Assoc. J.. 2015 Feb;17(2):98-103.

 

In the past decade we have witnessed a dramatic change in the management of autoimmune diseases, such as rheumatoid arthritis, due to the development of new biologic drugs designed to target key mediators in the autoimmune process. However, the development of similar target-specific ...

Last Updated: 30 Jul 2015

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Anti-NR2A/B Antibodies and Other Major Molecular Mechanisms in the Pathogenesis of Cognitive Dysfunction in Systemic Lupus Erythematosus.
 

Author(s): Sen Hee Tay, Anselm Mak

Journal:

 

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects approximately 1-45.3 per 100,000 people worldwide. Although deaths as a result of active and renal diseases have been substantially declining amongst SLE patients, disease involving the central nervous system ...

Last Updated: 9 May 2015

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Neuropsychiatric manifestations associated with anti-endothelial cell antibodies in systemic lupus erythematosus.
 

Author(s): Carlo Perricone, Monica Pendolino, Marta Olivieri, Fabrizio Conti, Guido Valesini, Cristiano Alessandri

Journal: Isr. Med. Assoc. J.. 2015 Mar;17(3):171-8.

 

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem involvement due to immune dysregulation. Neuropsychiatric systemic lupus erythematosus (NPSLE) includes neurological syndromes involving the central, peripheral and autonomic nervous system, ...

Last Updated: 7 May 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 21 Jan 2016

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Walk With Ease Program For Patients With Systemic Lupus Erythematosus
 

Status: Not yet recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 11 Dec 2015

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GENetic & Immunologic Abnomalies in Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus (SLE)

 

Last Updated: 11 Mar 2015

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