Systemic lupus erythematosus

Common Name(s)

Systemic lupus erythematosus

Systemic lupus erythematosis (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of gentic components in SLE susceptibility (summary by {92:Oishi et al., 2008}). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; {614420}) is caused by mutation in the DNASE1L3 gene ({602244}) on chromosome 3p14.3. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic lupus erythematosus" returned 3884 free, full-text research articles on human participants. First 3 results:

BLyS levels in sera of patients with systemic lupus erythematosus: clinical and serological correlation.
 

Author(s): Daniel Elbirt, Ilan Asher, Keren Mahlab-Guri, Shira Bezalel-Rosenberg, Victor Edelstein, Zev Sthoeger

Journal: Isr. Med. Assoc. J.. 2014 Aug;16(8):491-6.

 

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by disturbance of the innate and adaptive immune systems with the production of autoantibodies by stimulated B lymphocytes. The BLyS protein (B lymphocyte stimulator) is secreted mainly by monocytes and activated ...

Last Updated: 1 Oct 2014

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The one-and-a-half syndrome as the presenting sign of systemic lupus erythematosus.
 

Author(s): Payam Sasannejad, Nahid Olfati, Mohsen Soltani Sabi, Ali Ghabeli Juibary

Journal: Neurol India. ;62(3):307-8.

 

Last Updated: 18 Jul 2014

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Educational and vocational outcomes of adults with childhood- and adult-onset systemic lupus erythematosus: nine years of followup.
 

Author(s): Erica F Lawson, Aimee O Hersh, Laura Trupin, Emily von Scheven, Megumi J Okumura, Jinoos Yazdany, Edward H Yelin

Journal: Arthritis Care Res (Hoboken). 2014 May;66(5):717-24.

 

To compare educational and vocational outcomes among adults with childhood-onset systemic lupus erythematosus (SLE) and adult-onset SLE.

Last Updated: 29 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic lupus erythematosus" returned 395 free, full-text review articles on human participants. First 3 results:

Type I interferon signature in systemic lupus erythematosus.
 

Author(s): Shira Bezalel, Keren Mahlab Guri, Daniel Elbirt, Ilan Asher, Zev Moshe Sthoeger

Journal: Isr. Med. Assoc. J.. 2014 Apr;16(4):246-9.

 

Type I interferons (IFN) are primarily regarded as an inhibitor of viral replication. However, type I IFN, mainly IFNalpha, plays a major role in activation of both the innate and adaptive immune systems. Systemic lupus erythematosus (SLE) is a chronic, multi-systemic, inflammatory ...

Last Updated: 19 May 2014

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Treat-to-target in systemic lupus erythematosus: recommendations from an international task force.
 

Author(s): Ronald F van Vollenhoven, Marta Mosca, George Bertsias, David Isenberg, Annegret Kuhn, Kirsten Lerstrøm, Martin Aringer, Hendrika Bootsma, Dimitrios Boumpas, Ian N Bruce, Ricard Cervera, Ann Clarke, Nathalie Costedoat-Chalumeau, László Czirják, Ronald Derksen, Thomas Dörner, Caroline Gordon, Winfried Graninger, Frédéric Houssiau, Murat Inanc, Søren Jacobsen, David Jayne, Anna Jedryka-Goral, Adrian Levitsky, Roger Levy, Xavier Mariette, Eric Morand, Sandra Navarra, Irmgard Neumann, Anisur Rahman, Jozef Rovensky, Josef Smolen, Carlos Vasconcelos, Alexandre Voskuyl, Anne Voss, Helena Zakharova, Asad Zoma, Matthias Schneider

Journal: Ann. Rheum. Dis.. 2014 Jun;73(6):958-67.

 

The principle of treating-to-target has been successfully applied to many diseases outside rheumatology and more recently to rheumatoid arthritis. Identifying appropriate therapeutic targets and pursuing these systematically has led to improved care for patients with these diseases ...

Last Updated: 5 May 2014

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Oxidative stress and its biomarkers in systemic lupus erythematosus.
 

Author(s): Dilip Shah, Nidhi Mahajan, Sangita Sah, Swapan K Nath, Bishnuhari Paudyal

Journal:

 

Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease whose etiology remains largely unknown. The uncontrolled oxidative stress in SLE contributes to functional oxidative modifications of cellular protein, lipid and DNA and consequences of oxidative modification ...

Last Updated: 25 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 6 Sep 2014

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Cardiology Prevention in Systemic Lupus Erythematosus (SLE)
 

Status: Not yet recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 3 Oct 2008

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GENetic & Immunologic Abnomalies in Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus (SLE)

 

Last Updated: 18 Nov 2013

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