Systemic lupus erythematosus

Common Name(s)

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by {93:Oishi et al., 2008}). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; {614420}) is caused by mutation in the DNASE1L3 gene ({602244}) on chromosome 3p14.3. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic lupus erythematosus" returned 3491 free, full-text research articles on human participants. First 3 results:

Systemic Lupus Erythematosus with Stage IV Nephritis in an African Girl.
 

Author(s): Sandy Mpho Mosenye, José Antonio Moulton Alvarez, Rafael E Cruz Abascal, Matthew N Tanko, Francesca Cainelli, Sandro Vento

Journal: Isr. Med. Assoc. J.. 2015 Jun;17(6):394-5.

 

Last Updated: 3 Aug 2015

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Taenia solium in a patient with systemic lupus erythematosus: do parasites protect against autoimmune diseases.
 

Author(s): Lior Zeller, Leonid Barski, Elena Shleyfer, Uri Netz, Vered Stavi, Mahmoud Abu-Shakra

Journal: Isr. Med. Assoc. J.. 2015 Apr;17(4):259-60.

 

Last Updated: 4 Jun 2015

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Inflammatory cytokine kinetics to single bouts of acute moderate and intense aerobic exercise in women with active and inactive systemic lupus erythematosus.
 

Author(s): L A Perandini, D Sales-de-Oliveira, Sbv Mello, N O Camara, F B Benatti, F R Lima, E Borba, E Bonfa, H Roschel, A L Sá-Pinto, B Gualano

Journal: Exerc Immunol Rev. 2015 ;21():174-85.

 

The aim of this study was to evaluate changes in the cytokines INF-γ, IL-10, IL-6, TNF-α and soluble TNF receptors (sTNFR1 and sTNFR2) in response to single bouts of acute moderate and intense exercise in systemic lupus erythematosus women with active (SLE(ACTIVE)) and inactive ...

Last Updated: 1 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic lupus erythematosus" returned 401 free, full-text review articles on human participants. First 3 results:

Is B Cell-Targeted Therapy Effective in Systemic Lupus Erythematosus?
 

Author(s): Daphna Paran, Yaakov Naparstek

Journal: Isr. Med. Assoc. J.. 2015 Feb;17(2):98-103.

 

In the past decade we have witnessed a dramatic change in the management of autoimmune diseases, such as rheumatoid arthritis, due to the development of new biologic drugs designed to target key mediators in the autoimmune process. However, the development of similar target-specific ...

Last Updated: 30 Jul 2015

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Neuropsychiatric manifestations associated with anti-endothelial cell antibodies in systemic lupus erythematosus.
 

Author(s): Carlo Perricone, Monica Pendolino, Marta Olivieri, Fabrizio Conti, Guido Valesini, Cristiano Alessandri

Journal: Isr. Med. Assoc. J.. 2015 Mar;17(3):171-8.

 

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem involvement due to immune dysregulation. Neuropsychiatric systemic lupus erythematosus (NPSLE) includes neurological syndromes involving the central, peripheral and autonomic nervous system, ...

Last Updated: 7 May 2015

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[Pattern of systemic lupus erythematosus in Benin and West African patients].
 

Author(s): Zavier Zomalheto, Michee Assogba, Anthelme Agbodande, Felix Atadokpede, Marcelle Gounongbe, Martin Avimadje

Journal: Tunis Med. 2014 Dec;92(12):707-10.

 

To describe the clinical features, laboratory characteristics and the treatment of systemic lupus erythematosus (SLE) among Benin people and West Africa people.

Last Updated: 17 Apr 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 6 Aug 2015

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Cardiology Prevention in Systemic Lupus Erythematosus (SLE)
 

Status: Not yet recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 3 Oct 2008

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GENetic & Immunologic Abnomalies in Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus (SLE)

 

Last Updated: 11 Mar 2015

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