Systemic lupus erythematosus

Common Name(s)

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by {93:Oishi et al., 2008}). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; {614420}) is caused by mutation in the DNASE1L3 gene ({602244}) on chromosome 3p14.3. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic lupus erythematosus" returned 4799 free, full-text research articles on human participants. First 3 results:

The feet in systemic lupus erythematosus; are we underestimating their involvement and functional impact?
 

Author(s): Rosario Morales-Lozano, Julia Martínez-Barrio, María Luz González-Fernández, Francisco Javier López-Longo, Juan Gabriel Ovalles-Bonilla, Lara Valor, Iustina Janta, Juan Carlos Nieto, Diana Hernández-Flórez, Carlos M González, Indalecio Monteagudo, Jesús Garrido, Luis Carreño, Esperanza Naredo

Journal: Clin. Exp. Rheumatol.. ;34(4):609-17.

 

To evaluate biomechanical and ultrasound (US) abnormalities in SLE patients as compared with controls and to assess the relationship between these abnormalities and SLE activity.

Last Updated: 28 Jul 2016

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The Importance of an Early Diagnosis in Systemic Lupus Erythematosus.
 

Author(s): Gian D Sebastiani, Immacolata Prevete, Annamaria Iuliano, Giovanni Minisola

Journal: Isr. Med. Assoc. J.. ;18(3-4):212-5.

 

Systemic lupus erythematosus (SLE) is an autoimmune disease with a high degree of variability at onset, making it difficult to reach a correct and prompt diagnosis.

Last Updated: 27 May 2016

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Quality of Life, Coping and Depression in Systemic Lupus Erythematosus.
 

Author(s): Mahmoud Abu-Shakra

Journal: Isr. Med. Assoc. J.. ;18(3-4):144-5.

 

Physical, mental and social well-being are important outcomes in patients with chronic rheumatic diseases, including systemic lupus erythematosus (SLE). The MOS SF-36 and the WHO QoL Bref are appropriate for assessing quality of life (QoL) in patients with SLE. The QoL of patients ...

Last Updated: 27 May 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic lupus erythematosus" returned 551 free, full-text review articles on human participants. First 3 results:

One year in review 2016: systemic lupus erythematosus.
 

Author(s): Antonella Adinolfi, Eleonora Valentini, Emanuele Calabresi, Giulia Tesei, Viola Signorini, Simone Barsotti, Chiara Tani

Journal: Clin. Exp. Rheumatol.. ;34(4):569-74.

 

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a highly variable course and prognosis. The management of the disease is still a clinical challenge for the treating physicians as many aspects regarding the disease pathogenesis, clinical picture and outcomes ...

Last Updated: 28 Jul 2016

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Vitamin D and Systemic Lupus Erythematosus: Myth or Reality?
 

Author(s): Abdulla Watad, Shana G Neumann, Alessandra Soriano, Howard Amital, Yehuda Shoenfeld

Journal: Isr. Med. Assoc. J.. ;18(3-4):177-82.

 

There is growing interest in the contribution of vitamin D deficiency to autoimmunity. Several studies have shown an association between low levels of vitamin D and autoimmune disorders, including multiple sclerosis, rheumatoid arthritis, type 1 diabetes, autoimmune thyroid diseases, ...

Last Updated: 27 May 2016

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Lupus Panniculitis as an Initial Manifestation of Systemic Lupus Erythematosus: A Case Report.
 

Author(s): Yu-Kun Zhao, Fang Wang, Wen-Na Chen, Rui Xu, Zhuo Wang, Yuan-Wen Jiang, Di-Qing Luo, Jian-De Han

Journal: Medicine (Baltimore). 2016 Apr;95(16):e3429.

 

Lupus erythematosus panniculitis (LEP) is a variant of chronic cutaneous lupus erythematosus (CCLE). Reported cases of LEP lesions before the diagnosis of systemic lupus erythematosus (SLE) were very rare; only 9 cases have been reported, to the best of our knowledge. We now describe ...

Last Updated: 22 Apr 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Exploratory Study of MT-1303 in Systemic Lupus Erythematosus Patients
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 15 Sep 2016

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Walk With Ease Program For Patients With Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 26 May 2016

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A Phase 2a, Efficacy and Safety Study of Ustekinumab in Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 11 Nov 2016

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