Systemic lupus erythematosus

Common Name(s)

Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by {93:Oishi et al., 2008}). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; {614420}) is caused by mutation in the DNASE1L3 gene ({602244}) on chromosome 3p14.3. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

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International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

Last Updated: 18 Sep 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Systemic lupus erythematosus" for support, advocacy or research.

Logo
International Foundation for Autoimmune Arthritis

We are committed to eliminating the adversity caused by autoimmune arthritis by uniting resources that will raise global awareness, providing wellness education and support, and conducting patient-centered research that will improve the quality of life for those affected by these diseases.

http://www.ifautoimmunearthritis.org

Last Updated: 18 Sep 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Systemic lupus erythematosus" returned 4805 free, full-text research articles on human participants. First 3 results:

[Multiple myeloma in systemic lupus erythematosus. Report of two cases].
 

Author(s): Irene Castro, Consuelo Arroyo S, Valentina Yáñez, Claudia Cabezas

Journal: Rev Med Chil. 2018 May;146(5):670-674.

 

There is an increased incidence of hematological malignancies, particularly non-Hodgkin lymphoma (NHL) in systemic lupus erythematosus (SLE). In contrast, the concurrence with Multiple Myeloma (MM) is very rare, and the possible pathogenetic mechanisms underlying this association ...

Last Updated: 31 Dec 1969

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Two case reports of pyoderma gangrenosum and systemic lupus erythematosus: A rare but nonfortuitous association?
 

Author(s): Delphine Lebrun, Ailsa Robbins, Maxime Hentzien, Ségolène Toquet, Julie Plee, Anne Durlach, Jean-David Bouaziz, Firouzé Bani-Sadr, Amélie Servettaz

Journal: Medicine (Baltimore). 2018 Aug;97(34):e11933.

 

Pyoderma gangrenosum (PG), like other neutrophilic dermatosis, may be associated with a variety of systemic disorders including inflammatory bowel diseases, rheumatoid arthritis, and hematologic disorders. Conversely, the association between PG and systemic lupus erythematosus (SLE) ...

Last Updated: 31 Dec 1969

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Self-Reported Physical Activity Is Associated with Lupus Nephritis in Systemic Lupus Erythematosus: Data from KORean Lupus Network (KORNET) Registry.
 

Author(s): Seong Kyu Kim, Jung Yoon Choe, Shin Seok Lee

Journal: Yonsei Med. J.. 2018 Sep;59(7):857-864.

 

The aim of this study was to identify the associations among physical activity, disease activity, and organ damage in patients with systemic lupus erythematosus (SLE).

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Systemic lupus erythematosus" returned 588 free, full-text review articles on human participants. First 3 results:

Protective Effects of Hydroxychloroquine against Accelerated Atherosclerosis in Systemic Lupus Erythematosus.
 

Author(s): Alberto Floris, Matteo Piga, Arduino Aleksander Mangoni, Alessandra Bortoluzzi, Gian Luca Erre, Alberto Cauli

Journal:

 

Cardiovascular (CV) morbidity and mortality are a challenge in management of patients with systemic lupus erythematosus (SLE). Higher risk of CV disease in SLE patients is mostly related to accelerated atherosclerosis. Nevertheless, high prevalence of traditional cardiovascular risk ...

Last Updated: 31 Dec 1969

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[Research advances in the role of neutrophil extracellular traps in childhood-onset systemic lupus erythematosus].
 

Author(s): Lu Li, Hai-Dong Fu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2018 Mar;20(3):251-254.

 

Neutrophil extracellular traps (NETs) represent a form of cell death distinct from apoptosis or necrosis. The imbalance between the formation and degradation of NETs has long been considered to be closely associated with the activity of autoimmune diseases such as systemic lupus erythematous ...

Last Updated: 31 Dec 1969

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Concomitant systemic lupus erythematosus and HIV infection: A rare case report and literature review.
 

Author(s): Hong-Yan Liao, Chuan-Min Tao, Jun Su

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9337.

 

Coexisting systemic lupus erythematosus (SLE) and human immunodeficiency virus (HIV) infection cases are rare worldwide. Great challenges are posed on the diagnosis and treatment of such concurrent cases.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Systemic Lupus Erythematosus (SLE) Prospective Observational Cohort Study (SPOCS)
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 12 Sep 2018

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Exploratory Study of DHA in Systemic Lupus Erythematosus Patients
 

Status: Not yet recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 18 Jan 2018

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Safety and Efficacy of AMG 592 in Subjects With Active Systemic Lupus Erythematosus
 

Status: Recruiting

Condition Summary: Systemic Lupus Erythematosus

 

Last Updated: 25 Jul 2018

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