Schizophrenia 4

Common Name(s)

Schizophrenia 4

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Schizophrenia 4" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Schizophrenia 4" returned 18 free, full-text research articles on human participants. First 3 results:

Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
 

Author(s): Uyen Le, Bruce J Melancon, Thomas M Bridges, Paige N Vinson, Thomas J Utley, Atin Lamsal, Alice L Rodriguez, Daryl Venable, Douglas J Sheffler, Carrie K Jones, Anna L Blobaum, Michael R Wood, J Scott Daniels, P Jeffrey Conn, Colleen M Niswender, Craig W Lindsley, Corey R Hopkins

Journal: Bioorg. Med. Chem. Lett.. 2013 Jan;23(1):346-50.

 

Herein we report a next generation muscarinic receptor 4 (M(4)) positive allosteric modulator (PAM), ML253 which exhibits nanomolar activity at both the human (EC(50)=56 nM) and rat (EC(50)=176 nM) receptors and excellent efficacy by the left-ward shift of the ACh concentration response ...

Last Updated: 18 Dec 2012

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Transcription factor 4 as an important determinant of gating function in schizophrenia.
 

Author(s): Panos Roussos

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2012 Apr;109(16):5915-6.

 

Last Updated: 18 Apr 2012

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Glutamate as a marker of cognitive function in schizophrenia: a proton spectroscopic imaging study at 4 Tesla.
 

Author(s): Juan R Bustillo, Hongji Chen, Charles Gasparovic, Paul Mullins, Arvind Caprihan, Clifford Qualls, William Apfeldorf, John Lauriello, Stefan Posse

Journal: Biol. Psychiatry. 2011 Jan;69(1):19-27.

 

Cognitive deficits in schizophrenia may be related to glutamatergic dysfunction, but in vivo measurement of glutamate metabolism has been challenging. We examined the relationship between glutamate metabolism and cognitive function in schizophrenia.

Last Updated: 14 Dec 2010

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Schizophrenia 4" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Investigation of the Drug Dimethoxbenzylidene Anabaseine in Treating Schizophrenia Patients
 

Status: Recruiting

Condition Summary: Schizophrenia; Psychotic Disorders

 

Last Updated: 13 Nov 2013

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Trial of DMXB-A in Schizophrenia
 

Status: Recruiting

Condition Summary: Schizophrenia

 

Last Updated: 23 Apr 2014

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Kuvan in People With Schizophrenia and Schizoaffective Disorder
 

Status: Recruiting

Condition Summary: Schizophrenia; Schizoaffective Disorder

 

Last Updated: 19 Dec 2013

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