Recurrent spontaneous abortion

Common Name(s)

Recurrent spontaneous abortion, Recurrent miscarriage

Miscarriage, the commonest complication of pregnancy, is the spontaneous loss of a pregnancy before the fetus has reached viability. The term therefore includes all pregnancy losses from the time of conception until 24 weeks of gestation. Recurrent miscarriage, defined as 3 or more consecutive pregnancy losses, affects about 1% of couples; when defined as 2 or more losses, the scale of the problem increases to 5% of all couples trying to conceive (summary by {10:Rai and Regan, 2006}). Pregnancy losses have traditionally been designated 'spontaneous abortions' if they occur before 20 weeks gestation and 'stillbirths' if they occur after 20 weeks. Subtypes of spontaneous abortions can be further distinguished on the basis of embryonic development and include anembryonic loss in the first 5 weeks after conception (so-called 'blighted ovum'), embryonic loss from 6 to 9 weeks' gestation, and fetal loss from 10 weeks' gestation through the remainder of the pregnancy. These distinctions are important because the causes of pregnancy loss vary over gestational ages, with anembryonic losses being more likely to be associated with chromosomal abnormalities, for example. Possible etiologies for RPRGL include uterine anatomic abnormalities, cytogenetic abnormalities in the parents or fetus, single gene disorders, thrombophilic conditions, and immunologic or endocrine factors as well as environmental or infectious agents (summary by {13:Warren and Silver, 2008}). Genetic Heterogeneity of Recurrent Pregnancy Loss Susceptibility to RPRGL2 ({614390}) is conferred by mutation in the coagulation factor II gene ({176930}) on chromosome 11p11; RPRGL3 ({614391}) by mutation in the ANXA5 gene ({131230}) on chromosome 4q27; and RPRGL4 (see {270960}) by mutation in the SYCP3 gene ({604759}) on chromosome 12q23. Genetic variation in the conceptus itself that results in decreased viability of the embryo or fetus is discussed in the respective gene and/or phenotype entry (see, e.g., MTHFR, {607093.0004}; NLRP7, {609661}; hydatidiform mole, {231090}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Recurrent spontaneous abortion" for support, advocacy or research.

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Mommies Enduring Neonatal Death

M.E.N.D. (Mommies Enduring Neonatal Death) is a Christian, non-profit organization that reaches out to families who have suffered the loss of a baby through miscarriage, stillbirth, or early infant death.

Last Updated: 15 Apr 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Recurrent spontaneous abortion" for support, advocacy or research.

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Mommies Enduring Neonatal Death

M.E.N.D. (Mommies Enduring Neonatal Death) is a Christian, non-profit organization that reaches out to families who have suffered the loss of a baby through miscarriage, stillbirth, or early infant death.

http://www.mend.org

Last Updated: 15 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Recurrent spontaneous abortion" returned 64 free, full-text research articles on human participants. First 3 results:

Evaluation of failed immunotherapy among patients with negative APLA recurrent spontaneous abortion by serum anticardiolipin antibodies and mononuclear cell of Tim-1.
 

Author(s): J Li, D Xu, H-L Li

Journal: Eur Rev Med Pharmacol Sci. 2017 Mar;21(5):908-912.

 

The present study is aimed to analyze the expression of serum anticardiolipin antibody (ACA) and mononuclear cells of Tim-1 among the patients with negative anti paternal lymphocyte antibody (APLA) recurrent spontaneous abortion conducted by lymphocyte immunotherapy resulting in failure.

Last Updated: 24 Mar 2017

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Genetic variation in leptin and leptin receptor genes is a risk factor for idiopathic recurrent spontaneous abortion.
 

Author(s): Andrijana Müller, Jasenka Wagner, Alenka Hodžić, Aleš Maver, Ivana Škrlec, Marija Heffer, Lada Zibar, Borut Peterlin

Journal: Croat. Med. J.. 2016 Dec;57(6):566-571.

 

To determine whether maternal leptin (LEP) and leptin receptor (LEPR) gene polymorphisms are associated with idiopathic recurrent spontaneous abortion (IRSA).

Last Updated: 4 Jan 2017

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Association of CD46 IVS1-1724 C>G Single Nucleotide Polymorphism in Iranian Women with Unexplained Recurrent Spontaneous Abortion (URSA).
 

Author(s): Shiva Abdi-Shayan, Amir Monfaredan, Zahra Moradi, Mehrangiz Rajaii Oskoui, Tohid Kazemi

Journal: Iran J Allergy Asthma Immunol. 2016 Aug;15(4):303-308.

 

There are several known and unknown factors for unexplained recurrent spontaneous abortion (URSA). Among them, complement regulatory protein CD46 plays a pivotal role in preventing uncontrolled activation of complement and successful continuation of pregnancy. We aimed in this study ...

Last Updated: 6 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Recurrent spontaneous abortion" returned 5 free, full-text review articles on human participants. First 3 results:

Systematic review and meta-analysis of genetic association studies in idiopathic recurrent spontaneous abortion.
 

Author(s): Nina Pereza, Saša Ostojić, Miljenko Kapović, Borut Peterlin

Journal: Fertil. Steril.. 2017 Jan;107(1):150-159.e2.

 

1) To perform the first comprehensive systematic review of genetic association studies (GASs) in idiopathic recurrent spontaneous abortion (IRSA); 2) to analyze studies according to recurrent spontaneous abortion (RSA) definition and selection criteria for patients and control subjects; ...

Last Updated: 15 Nov 2016

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Quality of reporting on randomized controlled trials on recurrent spontaneous abortion in China.
 

Author(s): Jie Gao, Gaopi Deng, Yunyun Hu, Yanxi Huang, Liming Lu, Dandan Huang, Yadi Li, Lin Zhu, Xiaojing Liu, Xin Jin, Songping Luo

Journal:

 

Despite increasing numbers of RCTs done in China, detailed information on the quality of Chinese RCTs is still missing. The aim of this study was to assess the reporting quality of RSA RCTs and to identify significant predictors of reporting quality.

Last Updated: 21 Apr 2015

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Association of VEGF genetic polymorphisms with recurrent spontaneous abortion risk: a systematic review and meta-analysis.
 

Author(s): Xinghua Xu, Chigang Du, Huihui Li, Jing Du, Xue Yan, Lina Peng, Guangyao Li, Zi-Jiang Chen

Journal:

 

Studies of the associations between the genetic polymorphisms of the vascular endothelial growth factor (VEGF) gene and recurrent spontaneous abortion (RSA) have revealed conflicting results. The present meta-analysis was performed to provide a more precise estimation of these relationships ...

Last Updated: 21 Apr 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Intralipid Related Effect on NKcells in Patients With Unexplained Recurrent Spontaneous Abortion
 

Status: Not yet recruiting

Condition Summary: Recurrent Miscarriage

 

Last Updated: 25 Apr 2017

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The Epidemiology of Recurrent Spontaneous Abortion Associated With Thrombophilla
 

Status: Recruiting

Condition Summary: Recurrent Pregnancy Loss

 

Last Updated: 13 Dec 2016

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