Pseudoexfoliation glaucoma

Common Name(s)

Pseudoexfoliation glaucoma

Exfoliation syndrome (XFS) is a common age-related disorder of the extracellular matrix that is frequently associated with severe chronic secondary open-angle glaucoma and cataract. XFS syndrome may affect up to 30% of people over 60 years of age worldwide and is biomicroscopically diagnosed by abnormal microfibrillar deposits on ocular structures that line the aqueous-bathed surfaces of the anterior segment (summary by {18:Schlotzer-Schrehardt and Naumann, 2006}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pseudoexfoliation glaucoma" for support, advocacy or research.

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The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

Last Updated: 19 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pseudoexfoliation glaucoma" for support, advocacy or research.

Logo
The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

http://www.glaucomafoundation.org

Last Updated: 19 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pseudoexfoliation glaucoma" returned 35 free, full-text research articles on human participants. First 3 results:

Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance.
 

Author(s): Nikitas Fountoulakis, Georgios Labiris, Antonios Aristeidou, Andreas Katsanos, Ioannis Tentes, Alexandros Kortsaris, Vassilios P Kozobolis

Journal:

 

To quantify the levels of tissue inhibitor of metalloproteinase 4 (TIMP4) and its ratios with free metalloproteinases (MMP) in the aqueous humor of patients with primary open angle glaucoma (POAG), pseudoexfoliation syndrome (PXS) and pseudoexfoliative glaucoma (PXG) and to evaluate ...

Last Updated: 6 Feb 2014

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The T allele of lysyl oxidase-like 1 rs41435250 is a novel risk factor for pseudoexfoliation syndrome and pseudoexfoliation glaucoma independently and through intragenic epistatic interaction.
 

Author(s): Dalia Guadarrama-Vallejo, Antonio Miranda-Duarte, Juan Carlos Zenteno

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Two coding single nucleotide polymorphisms (SNPs) in lysyl oxidase-like 1 (LOXL1) are major genetic risk factors for pseudoexfoliation syndrome (XFS) and pseudoexfoliation glaucoma (XFG) in diverse populations. However, recent conflicting results suggest that the currently known disease-associated ...

Last Updated: 26 Sep 2013

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Association of lysyl oxidase-like 1 gene common sequence variants in Greek patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
 

Author(s): Ioanna Metaxaki, Pantelis Constantoulakis, Miltiadis Papadimitropoulos, Eftihia Filiou, Gerasimos Georgopoulos, Aggeliki Chamchougia, Dimitrios Papakonstantinou, Nikos Markomichelakis, Chrysanthi Koutsandrea, Ioannis Halkiadakis

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Three common sequence variants in the lysyl oxidase-like 1 (LOXL1) gene were recently associated with pseudoexfoliation (PEX) and pseudoexfoliation glaucoma (PEXG) in populations from various parts of the world. In this study, the genetic association of these variants was investigated ...

Last Updated: 22 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pseudoexfoliation glaucoma" returned 1 free, full-text review articles on human participants. First 3 results:

The medical and surgical management of pseudoexfoliation glaucoma.
 

Author(s): Manishi A Desai, Richard K Lee

Journal: Int Ophthalmol Clin. 2008 ;48(4):95-113.

 

Last Updated: 21 Oct 2008

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Imaging Lens Deposits in Exfoliation Syndrome
 

Status: Recruiting

Condition Summary: Exfoliation Syndrome; Primary Open Angle Glaucoma; Cataracts

 

Last Updated: 12 Aug 2014

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LOXL1 Polymorphism in Pseudoexfoliation Syndrome
 

Status: Recruiting

Condition Summary: Pseudoexfoliation Syndrome

 

Last Updated: 23 Jan 2012

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Last Updated: 3 Sep 2013

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