Pseudoexfoliation glaucoma

Common Name(s)

Pseudoexfoliation glaucoma

Pseudoexfoliation glaucoma is a condition in which there is a blockage of fluid drainage from the eye. When fluid cannot drain properly from the eye, the pressure inside the eye may rise to a level that can damage the optic nerve. The optic nerve is the nerve that brings information from the back of the eye (retina), and damage to this nerve can result in vision loss and blindness. PseudoexfoIiation glaucoma is the most common form of secondary glaucoma and is caused by pseudoexfoliation syndrome. In pseudoexfoliation syndrome, there is an accumulation of small protein fibers in the eye. These fibers may obstruct normal fluid drainage between the colored part of the eye that controls light entry (iris) and the lens of the eye (cornea). Glaucoma results when this blockage results in fluid build up in the anterior chamber of the eye.

Glaucoma can be diagnosed with a comprehensive dilated eye exam and by measuring intraocular pressure (IOP). A diagnosis of pseudoexfoliation glaucoma can be made using a slit-lamp exam (biomicroscopy), in which a doctor uses a thin beam of light to examine structures of the eye. A gonioscopy may also be performed, in which a contact lens with a mirror is used to examine the angle between the cornea and iris.

Treatment options include medication, laser surgery to create holes in the meshwork and allow fluid to drain from the anterior chamber (laser trabeculoplasty), and surgery to alter the iris to allow fluid drainage. Medication may be less effective for pseudoexfoliation glaucoma. Frequent appointments with an eye doctor are needed to monitor the progression of glaucoma in order to best prevent vision loss. If you have been diagnosed with pseudoexfoliation glaucoma, talk to your doctor about the most current treatment options. Support groups are good sources of more information and can connect you with other people living with glaucoma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pseudoexfoliation glaucoma" for support, advocacy or research.

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The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

Last Updated: 19 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Pseudoexfoliation glaucoma" for support, advocacy or research.

Logo
The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

http://www.glaucomafoundation.org

Last Updated: 19 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Pseudoexfoliation glaucoma" returned 37 free, full-text research articles on human participants. First 3 results:

LOXL1 gene variants and their association with pseudoexfoliation glaucoma (XFG) in Spanish patients.
 

Author(s): Lydia Álvarez, Montserrat García, Héctor González-Iglesias, Julio Escribano, Pedro P Rodríguez-Calvo, Luis Fernández-Vega, Miguel Coca-Prados

Journal:

 

LOXL1 gene is the most important genetic risk factor known so far for pseudoexfoliation glaucoma (XFG). Our purpose was to evaluate the potential association of individual genetic variants of the lysyl oxidase-like 1 (LOXL1) gene and haplotypes with XFG in Spanish patients.

Last Updated: 31 Aug 2015

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Association of known common genetic variants with primary open angle, primary angle closure, and pseudoexfoliation glaucoma in Pakistani cohorts.
 

Author(s): Shazia Micheal, Humaira Ayub, Muhammad Imran Khan, Bjorn Bakker, Frederieke E Schoenmaker-Koller, Mahmood Ali, Farah Akhtar, Wajid Ali Khan, Raheel Qamar, Anneke I den Hollander

Journal:

 

Despite the different etiology of primary open angle glaucoma (POAG), primary angle closure glaucoma (PACG), and pseudoexfoliative glaucoma (PEXG), several studies have suggested that these forms of glaucoma have overlapping genetic risk factors. Therefore, the aim of this study was ...

Last Updated: 9 Dec 2014

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Last Updated: 30 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Pseudoexfoliation glaucoma" returned 4 free, full-text review articles on human participants. First 3 results:

The cellular and molecular biology of the iris, an overlooked tissue: the iris and pseudoexfoliation glaucoma.
 

Author(s): Terete Borrás

Journal: J. Glaucoma. ;23(8 Suppl 1):S39-42.

 

Located between the cornea and the lens, the Iris is fully immersed in aqueous humor. During exfoliation syndrome, a disorder of the elastic fibers, an abnormal fibrillar material (XFM) is deposited on the anterior lens capsule underneath the pigment epithelium of the Iris. Release ...

Last Updated: 3 Oct 2014

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Genomic and proteomic pathophysiology of pseudoexfoliation glaucoma.
 

Author(s): Luis E Vazquez, Richard K Lee

Journal: Int Ophthalmol Clin. 2014 ;54(4):1-13.

 

Last Updated: 30 Aug 2014

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The medical and surgical management of pseudoexfoliation glaucoma.
 

Author(s): Manishi A Desai, Richard K Lee

Journal: Int Ophthalmol Clin. 2008 ;48(4):95-113.

 

Last Updated: 21 Oct 2008

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

LOXL1 Polymorphism in Pseudoexfoliation Syndrome
 

Status: Recruiting

Condition Summary: Pseudoexfoliation Syndrome

 

Last Updated: 23 Jan 2012

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Changes in Ocular Rigidity After Trabeculectomy in Patients With POAG
 

Status: Recruiting

Condition Summary: Glaucoma; Primary Open Angle Glaucoma; Pseudoexfoliation Glaucoma

 

Last Updated: 4 Sep 2015

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Following Patients After Selective and Pascal Laser Trabeculoplasty for Treatment of Chronic Open-Angle Glaucoma
 

Status: Recruiting

Condition Summary: Glaucoma, Open-Angle; Glaucoma, Primary Open Angle; Exfoliation Glaucoma; Glaucoma, Pigmentary

 

Last Updated: 13 Feb 2016

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