Progesterone resistance

Common Name(s)

Progesterone resistance

Progesterone prepares the endometrium for blastocyst implantation and allows maintenance of pregnancy. The major sources of progesterone are the corpus luteum during the second half of the menstrual cycle and at the beginning of pregnancy, and the placenta. The main hormones responsible for stimulation of progesterone secretion are luteinizing hormone (LH) for the corpus luteum of the menstrual cycle and chorionic gonadotropin for the corpus luteum of pregnancy. Complete end-organ resistance to progesterone would be incompatible with reproductive competence in females. Males would not be expected to be affected since progesterone has no known function in men. Failure of the uterus to respond to progesterone would lead to the development of a 'constantly proliferative' endometrium incompatible with blastocyst implantation. Partial resistance to progesterone, on the other hand, would be expected to be associated with various degrees of incomplete maturation of the endometrium, perhaps expressed clinically as infertility or early abortions. The syndrome would present with the clinical and histologic picture of a luteal phase defect in which the life span of the corpus luteum and the plasma progesterone concentrations would be normal or elevated.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progesterone resistance" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progesterone resistance" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progesterone resistance" returned 10 free, full-text research articles on human participants. First 3 results:

Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis.
 

Author(s): Fatima Barragan, Juan C Irwin, Shaina Balayan, David W Erikson, Joseph C Chen, Sahar Houshdaran, Terhi T Piltonen, Trimble L B Spitzer, Ashley George, Joseph T Rabban, Camran Nezhat, Linda C Giudice

Journal: Biol. Reprod.. 2016 May;94(5):118.

 

Human endometrium undergoes cyclic regeneration involving stem/progenitor cells, but the role of resident endometrial mesenchymal stem cells (eMSC) as progenitors of endometrial stromal fibroblasts (eSF) has not been definitively demonstrated. In endometriosis, eSF display progesterone ...

Last Updated: 31 Dec 1969

Go To URL
Progesterone receptor downregulates breast cancer resistance protein expression via binding to the progesterone response element in breast cancer.
 

Author(s): Xiaojuan Wu, Xiaofang Zhang, Hui Zhang, Peng Su, Weiwei Li, Li Li, Yan Wang, Wenjun Liu, Peng Gao, Gengyin Zhou

Journal: Cancer Sci.. 2012 May;103(5):959-67.

 

Breast cancer resistance protein (BCRP) plays a major role in multidrug resistance (MDR). Sequence analysis reveals there is a novel progesterone response element (PRE) in the BCRP promoter, suggesting progesterone receptor (PR) may have a function in the regulation of BCRP expression. ...

Last Updated: 31 Dec 1969

Go To URL
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.
 

Author(s): Ricardo F Savaris, Jeremy M Groll, Steven L Young, Franco J DeMayo, Jae-Wook Jeong, Amy E Hamilton, Linda C Giudice, Bruce A Lessey

Journal: J. Clin. Endocrinol. Metab.. 2011 Jun;96(6):1737-46.

 

Polycystic ovary syndrome (PCOS), the most common endocrinopathy of reproductive-aged women, is characterized by ovulatory dysfunction and hyperandrogenism.

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Progesterone resistance" returned 5 free, full-text review articles on human participants. First 3 results:

Endometrial progesterone resistance and PCOS.
 

Author(s): Xin Li, Yi Feng, Jin-Fang Lin, HÃ¥kan Billig, Ruijin Shao

Journal:

 

Polycystic ovary syndrome (PCOS) is a state of altered steroid hormone production and activity. Chronic estrogen exposure or lack of progesterone due to ovarian dysfunction can result in endometrial hyperplasia and carcinoma. A key contributor to our understanding of progesterone ...

Last Updated: 31 Dec 1969

Go To URL
17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis.
 

Author(s): Serdar E Bulun, You-Hong Cheng, Mary Ellen Pavone, Ping Yin, Gonca Imir, Hiroki Utsunomiya, Stephen Thung, Qing Xue, Erica E Marsh, Hideki Tokunaga, Hiroshi Ishikawa, Takeshi Kurita, Emily J Su

Journal: Semin. Reprod. Med.. 2010 Jan;28(1):44-50.

 

Estradiol (E2) stimulates the growth and inflammation in the ectopic endometriotic tissue that commonly resides on the pelvic organs. Several clinical and laboratory-based observations are indicative of resistance to progesterone action in endometriosis. The molecular basis of progesterone ...

Last Updated: 31 Dec 1969

Go To URL
Molecular mechanisms of treatment resistance in endometriosis: the role of progesterone-hox gene interactions.
 

Author(s): Hakan Cakmak, Hugh S Taylor

Journal: Semin. Reprod. Med.. 2010 Jan;28(1):69-74.

 

HOX genes, encoding homeodomain transcription factors, are dynamically expressed in endometrium, where they are necessary for endometrial growth, differentiation, and implantation. In human endometrium, the expression of HOXA10 and HOXA11 is driven by sex steroids, with peak expression ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Step Down FSH Approach and Late Follicular Phase in Progesterone Level
 

Status: Not yet recruiting

Condition Summary: Progesterone Resistance

 

Last Updated: 23 Nov 2017

Go to URL