Progesterone resistance

Common Name(s)

Progesterone resistance

Progesterone prepares the endometrium for blastocyst implantation and allows maintenance of pregnancy. The major sources of progesterone are the corpus luteum during the second half of the menstrual cycle and at the beginning of pregnancy, and the placenta. The main hormones responsible for stimulation of progesterone secretion are luteinizing hormone (LH) for the corpus luteum of the menstrual cycle and chorionic gonadotropin for the corpus luteum of pregnancy. Complete end-organ resistance to progesterone would be incompatible with reproductive competence in females. Males would not be expected to be affected since progesterone has no known function in men. Failure of the uterus to respond to progesterone would lead to the development of a 'constantly proliferative' endometrium incompatible with blastocyst implantation. Partial resistance to progesterone, on the other hand, would be expected to be associated with various degrees of incomplete maturation of the endometrium, perhaps expressed clinically as infertility or early abortions. The syndrome would present with the clinical and histologic picture of a luteal phase defect in which the life span of the corpus luteum and the plasma progesterone concentrations would be normal or elevated.
 

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Condition Specific Organizations

Following organizations serve the condition "Progesterone resistance" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progesterone resistance" returned 11 free, full-text research articles on human participants. First 3 results:

Progesterone receptor downregulates breast cancer resistance protein expression via binding to the progesterone response element in breast cancer.
 

Author(s): Xiaojuan Wu, Xiaofang Zhang, Hui Zhang, Peng Su, Weiwei Li, Li Li, Yan Wang, Wenjun Liu, Peng Gao, Gengyin Zhou

Journal: Cancer Sci.. 2012 May;103(5):959-67.

 

Breast cancer resistance protein (BCRP) plays a major role in multidrug resistance (MDR). Sequence analysis reveals there is a novel progesterone response element (PRE) in the BCRP promoter, suggesting progesterone receptor (PR) may have a function in the regulation of BCRP expression. ...

Last Updated: 25 Apr 2012

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Potential role of estradiol and progesterone in insulin resistance through constitutive androstane receptor.
 

Author(s): Hisashi Masuyama, Yuji Hiramatsu

Journal:

 

Normal pregnancy is characterized by insulin resistance, which contributes to the development of gestational diabetes mellitus and preeclampsia by incompletely understood mechanisms. The constitutive androstane receptor (CAR) may participate in insulin resistance in pregnancy, and ...

Last Updated: 8 Sep 2011

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Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.
 

Author(s): Ricardo F Savaris, Jeremy M Groll, Steven L Young, Franco J DeMayo, Jae-Wook Jeong, Amy E Hamilton, Linda C Giudice, Bruce A Lessey

Journal: J. Clin. Endocrinol. Metab.. 2011 Jun;96(6):1737-46.

 

Polycystic ovary syndrome (PCOS), the most common endocrinopathy of reproductive-aged women, is characterized by ovulatory dysfunction and hyperandrogenism.

Last Updated: 23 May 2011

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Reviews from the PubMed Database

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The terms "Progesterone resistance" returned 5 free, full-text review articles on human participants. First 3 results:

Endometrial progesterone resistance and PCOS.
 

Author(s): Xin Li, Yi Feng, Jin-Fang Lin, HÃ¥kan Billig, Ruijin Shao

Journal:

 

Polycystic ovary syndrome (PCOS) is a state of altered steroid hormone production and activity. Chronic estrogen exposure or lack of progesterone due to ovarian dysfunction can result in endometrial hyperplasia and carcinoma. A key contributor to our understanding of progesterone ...

Last Updated: 10 Feb 2014

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17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis.
 

Author(s): Serdar E Bulun, You-Hong Cheng, Mary Ellen Pavone, Ping Yin, Gonca Imir, Hiroki Utsunomiya, Stephen Thung, Qing Xue, Erica E Marsh, Hideki Tokunaga, Hiroshi Ishikawa, Takeshi Kurita, Emily J Su

Journal: Semin. Reprod. Med.. 2010 Jan;28(1):44-50.

 

Estradiol (E2) stimulates the growth and inflammation in the ectopic endometriotic tissue that commonly resides on the pelvic organs. Several clinical and laboratory-based observations are indicative of resistance to progesterone action in endometriosis. The molecular basis of progesterone ...

Last Updated: 29 Jan 2010

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Molecular mechanisms of treatment resistance in endometriosis: the role of progesterone-hox gene interactions.
 

Author(s): Hakan Cakmak, Hugh S Taylor

Journal: Semin. Reprod. Med.. 2010 Jan;28(1):69-74.

 

HOX genes, encoding homeodomain transcription factors, are dynamically expressed in endometrium, where they are necessary for endometrial growth, differentiation, and implantation. In human endometrium, the expression of HOXA10 and HOXA11 is driven by sex steroids, with peak expression ...

Last Updated: 27 Jan 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be Removed by Surgery and Liver or Kidney Dysfunction
 

Status: Not yet recruiting

Condition Summary: Estrogen Receptor Negative; Head and Neck Squamous Cell Carcinoma; HER2/Neu Negative; Hormone-Resistant Prostate Cancer; Metastatic Pancreatic Adenocarcinoma; Progesterone Receptor Negative; Solid Neoplasm; Stage III Mesothelioma; Stage IIIA Gastric Cancer; Stage IIIA Non-Small Cell Lung Cancer; Stage IIIA Ovarian Cancer; Stage IIIA Small Cell Lung Carcinoma; Stage IIIB Gastric Cancer; Stage IIIB Non-Small Cell Lung Cancer; Stage IIIB Ovarian Cancer; Stage IIIB Small Cell Lung Carcinoma; Stage IIIC Gastric Cancer; Stage IIIC Ovarian Cancer; Stage IV Mesothelioma; Stage IV Non-Small Cell Lung Cancer; Stage IV Ovarian Cancer; Stage IV Small Cell Lung Carcinoma; Triple-Negative Breast Carcinoma

 

Last Updated: 22 Nov 2016

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