Progesterone resistance

Common Name(s)

Progesterone resistance

Progesterone prepares the endometrium for blastocyst implantation and allows maintenance of pregnancy. The major sources of progesterone are the corpus luteum during the second half of the menstrual cycle and at the beginning of pregnancy, and the placenta. The main hormones responsible for stimulation of progesterone secretion are luteinizing hormone (LH) for the corpus luteum of the menstrual cycle and chorionic gonadotropin for the corpus luteum of pregnancy. Complete end-organ resistance to progesterone would be incompatible with reproductive competence in females. Males would not be expected to be affected since progesterone has no known function in men. Failure of the uterus to respond to progesterone would lead to the development of a 'constantly proliferative' endometrium incompatible with blastocyst implantation. Partial resistance to progesterone, on the other hand, would be expected to be associated with various degrees of incomplete maturation of the endometrium, perhaps expressed clinically as infertility or early abortions. The syndrome would present with the clinical and histologic picture of a luteal phase defect in which the life span of the corpus luteum and the plasma progesterone concentrations would be normal or elevated.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Progesterone resistance" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Progesterone resistance" returned 10 free, full-text research articles on human participants. First 3 results:

Potential role of estradiol and progesterone in insulin resistance through constitutive androstane receptor.
 

Author(s): Hisashi Masuyama, Yuji Hiramatsu

Journal:

 

Normal pregnancy is characterized by insulin resistance, which contributes to the development of gestational diabetes mellitus and preeclampsia by incompletely understood mechanisms. The constitutive androstane receptor (CAR) may participate in insulin resistance in pregnancy, and ...

Last Updated: 8 Sep 2011

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Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.
 

Author(s): Ricardo F Savaris, Jeremy M Groll, Steven L Young, Franco J DeMayo, Jae-Wook Jeong, Amy E Hamilton, Linda C Giudice, Bruce A Lessey

Journal: J. Clin. Endocrinol. Metab.. 2011 Jun;96(6):1737-46.

 

Polycystic ovary syndrome (PCOS), the most common endocrinopathy of reproductive-aged women, is characterized by ovulatory dysfunction and hyperandrogenism.

Last Updated: 23 May 2011

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Subfertility linked to combined luteal insufficiency and uterine progesterone resistance.
 

Author(s): Toshihiro Konno, Amanda R Graham, Lea A Rempel, Jennifer K Ho-Chen, S M Khorshed Alam, Pengli Bu, M A Karim Rumi, Michael J Soares

Journal: Endocrinology. 2010 Sep;151(9):4537-50.

 

Early pregnancy loss is common and can be caused by a range of factors. The Brown Norway (BN) rat exhibits reproductive dysfunction characterized by small litter size and pregnancy failure and represents a model for investigating early pregnancy loss. In this study, we investigated ...

Last Updated: 25 Aug 2010

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Reviews from the PubMed Database

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The terms "Progesterone resistance" returned 4 free, full-text review articles on human participants. First 3 results:

Endometrial progesterone resistance and PCOS.
 

Author(s): Xin Li, Yi Feng, Jin-Fang Lin, HÃ¥kan Billig, Ruijin Shao

Journal:

 

Polycystic ovary syndrome (PCOS) is a state of altered steroid hormone production and activity. Chronic estrogen exposure or lack of progesterone due to ovarian dysfunction can result in endometrial hyperplasia and carcinoma. A key contributor to our understanding of progesterone ...

Last Updated: 10 Feb 2014

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Molecular mechanisms of treatment resistance in endometriosis: the role of progesterone-hox gene interactions.
 

Author(s): Hakan Cakmak, Hugh S Taylor

Journal: Semin. Reprod. Med.. 2010 Jan;28(1):69-74.

 

HOX genes, encoding homeodomain transcription factors, are dynamically expressed in endometrium, where they are necessary for endometrial growth, differentiation, and implantation. In human endometrium, the expression of HOXA10 and HOXA11 is driven by sex steroids, with peak expression ...

Last Updated: 27 Jan 2010

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Dioxin and endometrial progesterone resistance.
 

Author(s): Kaylon L Bruner-Tran, Tianbing Ding, Kevin G Osteen

Journal: Semin. Reprod. Med.. 2010 Jan;28(1):59-68.

 

Development of endometriosis likely requires multiple, interactive mechanisms involving both the endocrine and immune systems. Environmental toxicants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), are of particular interest as potential contributory agents in the development ...

Last Updated: 27 Jan 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Hormone Blockade in Combination With Targeted Agents
 

Status: Recruiting

Condition Summary: Solid Tumors; Advanced Cancer

 

Last Updated: 17 Sep 2014

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