Primary open angle glaucoma

Common Name(s)

Primary open angle glaucoma

{20:Quigley (1993)} reviewed adult-onset primary open angle glaucoma, which combines a particular abnormal appearance of the optic disc (optic nerve head) with a slowly progressive loss of visual sensitivity. Many patients with glaucoma have intraocular pressures above the normal range, although this cannot be considered part of the definition of the disease, since some patients have normal intraocular pressures. Changes in the optic disc, either inherited or acquired, contribute to the development of the disorder, which leads to visual loss from increasing nerve fiber layer atrophy. {21:Quigley et al. (1994)} stated that POAG should be reviewed as a multifactorial disorder. Genetic Heterogeneity of Primary Open Angle Glaucoma Other forms of primary open angle glaucoma include GLC1A ({137750}), caused by mutation in the MYOC gene ({601652}) on chromosome 1q24.3-q25.2; GLC1B ({606689}) on chromosome 2cen-q13; GLC1C ({601682}) on chromosome 3q21-q24; GLC1D ({602429}) on chromosome 8q23; GLC1F ({603383}), caused by mutation in the ASB10 gene on chromosome 7q36; GLC1G ({609887}), caused by mutation in the WDR36 gene ({609669}) on chromosome 5q22; GLC1H ({611276}) on chromosome 2p16-p15; GLC1I ({609745}) on chromosome 15q11-q13; GLC1J ({608695}) on chromosome 9q22; GLC1K ({608696}) on chromosome 20p12; GLC1L (see {137750}) on chromosome 3p22-p21; GLC1M ({610535}) on chromosome 5q22; GLC1N ({611274}) on chromosome 15q22-q24; GLC1O ({613100}), caused by mutation in the NTF4 gene ({162662}) on chromosome 19q13.3; GLC1P ({177700}), caused by an approximately 300-kb duplication on chromosome 12q24, most likely involving the TBK1 gene ({604834}). Nail-patella syndrome (NPS; {161200}), which is caused by mutation in the LMX1B gene ({602575}) on chromosome 9q34, has open angle glaucoma as a pleiotropic feature. Other Forms of Glaucoma For a general description and a discussion of genetic heterogeneity of congenital forms of glaucoma, see GLC3A ({231300}). See {606657} for a discussion of normal tension glaucoma (NTG) or normal pressure glaucoma (NPG), a subtype of POAG.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary open angle glaucoma" for support, advocacy or research.

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The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

Last Updated: 19 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary open angle glaucoma" for support, advocacy or research.

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The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

http://www.glaucomafoundation.org

Last Updated: 19 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary open angle glaucoma" returned 400 free, full-text research articles on human participants. First 3 results:

The ocular hypotensive effect of saffron extract in primary open angle glaucoma: a pilot study.
 

Author(s): Mohammad Hossein Jabbarpoor Bonyadi, Shahin Yazdani, Saeed Saadat

Journal:

 

The progressive nature of glaucoma and its growing incidence make its therapy an important target for research. The role of oxidative damage in the pathogenesis of glaucoma makes antioxidants such as saffron extract an attractive target for potential clinical use. Herein, we evaluate ...

Last Updated: 28 Oct 2014

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Proparacaine hydrochloride topical drop and intracameral 0.5% lignocaine for phacotrabeculectomy in patients with primary open angle glaucoma.
 

Author(s): Rajesh Subhash Joshi

Journal: Middle East Afr J Ophthalmol. ;21(3):210-5.

 

To compare the efficacy and safety of 0.5% intracameral lignocaine to 1% intracameral lignocaine prior to phacotrabeculectomy.

Last Updated: 7 Aug 2014

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An updated meta-analysis: apolipoprotein E genotypes and risk of primary open-angle glaucoma.
 

Author(s): Rongfeng Liao, Minjie Ye, Xiping Xu

Journal:

 

To study the association of apolipoprotein E (APOE) polymorphisms and primary open-angle glaucoma (POAG).

Last Updated: 23 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary open angle glaucoma" returned 15 free, full-text review articles on human participants. First 3 results:

[Hypotensive therapy in patients with primary open-angle glaucoma].
 

Author(s): Beata Krasińska, Jarosław Kocięcki, Zbigniew Krasiński, Andrzej Tykarski

Journal: Kardiol Pol. 2013 ;71(8):869-74.

 

Last Updated: 19 Sep 2013

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Myocilin polymorphisms and primary open-angle glaucoma: a systematic review and meta-analysis.
 

Author(s): Jin-Wei Cheng, Shi-Wei Cheng, Xiao-Ye Ma, Ji-Ping Cai, You Li, Guo-Cai Lu, Rui-Li Wei

Journal: PLoS ONE. 2012 ;7(9):e46632.

 

Glaucoma is the leading cause of irreversible blindness in the world. Recent evidence indicates a role for genetic susceptibility to primary open-angle glaucoma (POAG). The relation between myocilin polymorphisms and POAG susceptibility has been studied in different populations.

Last Updated: 2 Oct 2012

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Association of TP53 polymorphisms with primary open-angle glaucoma: a meta-analysis.
 

Author(s): Yatu Guo, Hongtuan Zhang, Xia Chen, Xiong Yang, Wenbo Cheng, Kanxing Zhao

Journal:

 

To offer a comprehensive evaluation of the potential associations of TP53 polymorphisms with primary open-angle glaucoma (POAG) through a systematic review and meta-analysis of candidate genetic association study.

Last Updated: 22 Jun 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effect of Travoprost 0.004% on Retinal Oximetry in Primary Open Angle Glaucoma
 

Status: Not yet recruiting

Condition Summary: Primary Open Angle Glaucoma

 

Last Updated: 19 Oct 2012

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Correlation of Orbital Cerebrospinal Fluid Pressure and Retinal Venous Outflow in Primary Open-angle Glaucoma
 

Status: Recruiting

Condition Summary: Primary Open Angle Glaucoma; Normal Tension Glaucoma

 

Last Updated: 15 Feb 2013

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