Primary open angle glaucoma

Common Name(s)

Primary open angle glaucoma

Primary open-angle glaucoma is a condition in which there is a blockage of fluid drainage from the eye. When fluid cannot drain properly from the eye, the pressure inside the eye may rise to a level that can damage the optic nerve. The optic nerve is the nerve that brings information from the back of the eye (retina), and damage to this nerve can result in vision loss and blindness.

Primary open-angle glaucoma is the most common form of glaucoma. It affects at least 3 million Americans. In primary open-angle glaucoma, fluid builds up in the anterior chamber of the eye because it cannot drain through a meshwork structure between the colored part of the eye that controls light entry (iris) and the lens of the eye (cornea). In primary open-angle glaucoma, the spacing between the iris and cornea is normal. The risk of developing primary open-angle glaucoma increases with age, especially above age 50, and is higher in those with a family history of this condition. Primary open-angle glaucoma can be asymptomatic or may have symptoms of decreased vision, particularly in the side or periphery, as well as pain, nausea, and headache.

Primary open-angle glaucoma can be diagnosed with a comprehensive dilated eye exam and by measuring intraocular pressure (IOP). Regular eye exams are important because this form of glaucoma is often asymptomatic prior to permanent vision loss. Treatment options include medication, laser surgery to create holes in the meshwork and allow fluid to drain from the anterior chamber (laser trabeculoplasty), and surgery to alter the iris to allow fluid drainage. If you have been diagnosed with primary open-angle glaucoma, talk to your doctor about the most current treatment options. Support groups are good sources of more information and can connect you with other people living with glaucoma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary open angle glaucoma" for support, advocacy or research.

Logo
The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

Last Updated: 19 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary open angle glaucoma" for support, advocacy or research.

Logo
The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

http://www.glaucomafoundation.org

Last Updated: 19 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary open angle glaucoma" returned 458 free, full-text research articles on human participants. First 3 results:

Association of primary open-angle glaucoma with mitochondrial variants and haplogroups common in African Americans.
 

Author(s): David W Collins, Harini V Gudiseva, Benjamin Trachtman, Anita S Bowman, Anna Sagaser, Prithvi Sankar, Eydie Miller-Ellis, Amanda Lehman, Victoria Addis, Joan M O'Brien

Journal:

 

To estimate the population frequencies of all common mitochondrial variants and ancestral haplogroups among 1,999 subjects recruited for the Primary Open-Angle African American Glaucoma Genetics (POAAGG) Study, including 1,217 primary open-angle glaucoma (POAG) cases and 782 controls, ...

Last Updated: 24 May 2016

Go To URL
Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma.
 

Author(s): Mansi Vishal, Anchal Sharma, Lalit Kaurani, Giovanna Alfano, Suddhasil Mookherjee, Kiran Narta, Jyoti Agrawal, Iman Bhattacharya, Susanta Roychoudhury, Jharna Ray, Naushin H Waseem, Shomi S Bhattacharya, Analabha Basu, Abhijit Sen, Kunal Ray, Arijit Mukhopadhyay

Journal:

 

Glaucoma is the largest cause of irreversible blindness affecting more than 60 million people globally. The disease is defined as a gradual loss of peripheral vision due to death of Retinal Ganglion Cells (RGC). The RGC death is largely influenced by the rate of aqueous humor production ...

Last Updated: 22 Mar 2016

Go To URL
Clinical Assessment of Lamina Cribrosa Curvature in Eyes with Primary Open-Angle Glaucoma.
 

Author(s): Yong Woo Kim, Jin Wook Jeoung, Dai Woo Kim, Michael J A Girard, Jean Martial Mari, Ki Ho Park, Dong Myung Kim

Journal:

 

Quantitative evaluation of lamina cribrosa (LC) posterior bowing in primary open-angle glaucoma (POAG) eyes using swept-source optical coherence tomography.

Last Updated: 11 Mar 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary open angle glaucoma" returned 20 free, full-text review articles on human participants. First 3 results:

An Updated Review on the Genetics of Primary Open Angle Glaucoma.
 

Author(s): Khaled Abu-Amero, Altaf A Kondkar, Kakarla V Chalam

Journal:

 

Epidemiological studies suggest that by 2020 the prevalence of primary open angle glaucoma (POAG) is estimated to increase to 76.0 million, and to 111.8 million by 2040 globally due to the population aging. The prevalence of POAG is the highest among those of African descent, followed ...

Last Updated: 22 Dec 2015

Go To URL
Association of single nucleotide polymorphisms in the CYP1B1 gene with the risk of primary open-angle glaucoma: a meta-analysis.
 

Author(s): Z Wang, M Li, L Li, H Sun, X Y Lin

Journal:

 

Mutations in the CYP1B1 gene were detected in primary open-angle glaucoma (POAG) patients. However, the association between these mutations and the incidence of POAG remains to be elucidated. Here, we have conducted a meta-analysis to analyze this correlation, using relevant studies ...

Last Updated: 18 Dec 2015

Go To URL
The Association between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension.
 

Author(s): Hye Jin Chung, Hyung Bin Hwang, Na Young Lee

Journal: Biomed Res Int. 2015 ;2015():827516.

 

Glaucoma is the second leading cause of blindness worldwide. Although the mechanism of the development of primary open-angle glaucoma (POAG) is not fully understood, elevated intraocular pressure (IOP) is considered the most important risk factor. Several vascular factors have also ...

Last Updated: 11 Nov 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Levobetaxolol Hydrochloride Eye Drops for Treatment of Primary Open-angle Glaucoma
 

Status: Recruiting

Condition Summary: Primary Open-angle Glaucoma; Ocular Hypertension

 

Last Updated: 30 Nov 2015

Go to URL

Last Updated: 8 Apr 2016

Go to URL
Study of Fixed-Dose Combinations of Trabodenoson and Latanoprost in Adults With Ocular Hypertension or Primary Open-Angle Glaucoma
 

Status: Recruiting

Condition Summary: Primary Open-Angle Glaucoma (POAG); Ocular Hypertension (OHT)

 

Last Updated: 25 Jul 2016

Go to URL