Primary open angle glaucoma

Common Name(s)

Primary open angle glaucoma

{20:Quigley (1993)} reviewed adult-onset primary open angle glaucoma, which combines a particular abnormal appearance of the optic disc (optic nerve head) with a slowly progressive loss of visual sensitivity. Many patients with glaucoma have intraocular pressures above the normal range, although this cannot be considered part of the definition of the disease, since some patients have normal intraocular pressures. Changes in the optic disc, either inherited or acquired, contribute to the development of the disorder, which leads to visual loss from increasing nerve fiber layer atrophy. {21:Quigley et al. (1994)} stated that POAG should be reviewed as a multifactorial disorder. Genetic Heterogeneity of Primary Open Angle Glaucoma Other forms of primary open angle glaucoma include GLC1A ({137750}), caused by mutation in the MYOC gene ({601652}) on chromosome 1q24.3-q25.2; GLC1B ({606689}) on chromosome 2cen-q13; GLC1C ({601682}) on chromosome 3q21-q24; GLC1D ({602429}) on chromosome 8q23; GLC1F ({603383}), caused by mutation in the ASB10 gene on chromosome 7q36; GLC1G ({609887}), caused by mutation in the WDR36 gene ({609669}) on chromosome 5q22; GLC1H ({611276}) on chromosome 2p16-p15; GLC1I ({609745}) on chromosome 15q11-q13; GLC1J ({608695}) on chromosome 9q22; GLC1K ({608696}) on chromosome 20p12; GLC1L (see {137750}) on chromosome 3p22-p21; GLC1M ({610535}) on chromosome 5q22; GLC1N ({611274}) on chromosome 15q22-q24; GLC1O ({613100}), caused by mutation in the NTF4 gene ({162662}) on chromosome 19q13.3; GLC1P ({177700}), caused by an approximately 300-kb duplication on chromosome 12q24, most likely involving the TBK1 gene ({604834}). Nail-patella syndrome (NPS; {161200}), which is caused by mutation in the LMX1B gene ({602575}) on chromosome 9q34, has open angle glaucoma as a pleiotropic feature. Other Forms of Glaucoma For a general description and a discussion of genetic heterogeneity of congenital forms of glaucoma, see GLC3A ({231300}). See {606657} for a discussion of normal tension glaucoma (NTG) or normal pressure glaucoma (NPG), a subtype of POAG.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary open angle glaucoma" for support, advocacy or research.

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The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

Last Updated: 19 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary open angle glaucoma" for support, advocacy or research.

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The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

http://www.glaucomafoundation.org

Last Updated: 19 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary open angle glaucoma" returned 331 free, full-text research articles on human participants. First 3 results:

Efficacy and tolerability of fixed-combination bimatoprost/timolol versus fixed-combination dorzolamide/brimonidine/timolol in patients with primary open-angle glaucoma or ocular hypertension: a multicenter, prospective, crossover study.
 

Author(s): Alfonso García-López, José A Paczka, Jesús Jiménez-Román, Curt Hartleben

Journal:

 

Fixed-combination ocular hypotensives have multiple advantages, but triple-therapy dorzolamide/brimonidine/timolol (dorz/brim/tim) is only available in Latin and South America, and information on its relative efficacy is limited. This study compares the efficacy and tolerability of ...

Last Updated: 15 Jan 2015

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Association of known common genetic variants with primary open angle, primary angle closure, and pseudoexfoliation glaucoma in Pakistani cohorts.
 

Author(s): Shazia Micheal, Humaira Ayub, Muhammad Imran Khan, Bjorn Bakker, Frederieke E Schoenmaker-Koller, Mahmood Ali, Farah Akhtar, Wajid Ali Khan, Raheel Qamar, Anneke I den Hollander

Journal:

 

Despite the different etiology of primary open angle glaucoma (POAG), primary angle closure glaucoma (PACG), and pseudoexfoliative glaucoma (PEXG), several studies have suggested that these forms of glaucoma have overlapping genetic risk factors. Therefore, the aim of this study was ...

Last Updated: 9 Dec 2014

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DNA copy number variants of known glaucoma genes in relation to primary open-angle glaucoma.
 

Author(s): Yutao Liu, Melanie E Garrett, Brian L Yaspan, Jessica Cooke Bailey, Stephanie J Loomis, Murray Brilliant, Donald L Budenz, William G Christen, John H Fingert, Douglas Gaasterland, Terry Gaasterland, Jae H Kang, Richard K Lee, Paul Lichter, Sayoko E Moroi, Anthony Realini, Julia E Richards, Joel S Schuman, William K Scott, Kuldev Singh, Arthur J Sit, Douglas Vollrath, Robert Weinreb, Gadi Wollstein, Donald J Zack, Kang Zhang, Margaret A Pericak-Vance, Jonathan L Haines, Louis R Pasquale, Janey L Wiggs, R Rand Allingham, Allison E Ashley-Koch, Michael A Hauser

Journal:

 

We examined the role of DNA copy number variants (CNVs) of known glaucoma genes in relation to primary open angle glaucoma (POAG).

Last Updated: 19 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary open angle glaucoma" returned 15 free, full-text review articles on human participants. First 3 results:

Efficacy and tolerability of mono-compound topical treatments for reduction of intraocular pressure in patients with primary open angle glaucoma or ocular hypertension: an overview of reviews.
 

Author(s): Qëndresë Daka, Vladimir Trkulja

Journal: Croat. Med. J.. 2014 Oct;55(5):468-80.

 

To evaluate the existing evidence on relative efficacy and tolerability of topical mono-compound intraocular pressure (IOP)-lowering drugs in treatment of primary open angle glaucoma (POAG) and ocular hypertension (OHT).

Last Updated: 31 Oct 2014

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[Hypotensive therapy in patients with primary open-angle glaucoma].
 

Author(s): Beata Krasińska, Jarosław Kocięcki, Zbigniew Krasiński, Andrzej Tykarski

Journal: Kardiol Pol. 2013 ;71(8):869-74.

 

Last Updated: 19 Sep 2013

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Myocilin polymorphisms and primary open-angle glaucoma: a systematic review and meta-analysis.
 

Author(s): Jin-Wei Cheng, Shi-Wei Cheng, Xiao-Ye Ma, Ji-Ping Cai, You Li, Guo-Cai Lu, Rui-Li Wei

Journal: PLoS ONE. 2012 ;7(9):e46632.

 

Glaucoma is the leading cause of irreversible blindness in the world. Recent evidence indicates a role for genetic susceptibility to primary open-angle glaucoma (POAG). The relation between myocilin polymorphisms and POAG susceptibility has been studied in different populations.

Last Updated: 2 Oct 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effect of Travoprost 0.004% on Retinal Oximetry in Primary Open Angle Glaucoma
 

Status: Not yet recruiting

Condition Summary: Primary Open Angle Glaucoma

 

Last Updated: 19 Oct 2012

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Safety and Performance Study of the ARGOS-IO (Intraocular) System in Patients With Primary Open Angle Glaucoma (POAG)
 

Status: Recruiting

Condition Summary: Primary Open Angle Glaucoma (POAG)

 

Last Updated: 30 Apr 2015

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Correlation of Orbital Cerebrospinal Fluid Pressure and Retinal Venous Outflow in Primary Open-angle Glaucoma
 

Status: Recruiting

Condition Summary: Primary Open Angle Glaucoma; Normal Tension Glaucoma

 

Last Updated: 15 Feb 2013

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