Primary open angle glaucoma

Common Name(s)

Primary open angle glaucoma

Primary open-angle glaucoma is a condition in which there is a blockage of fluid drainage from the eye. When fluid cannot drain properly from the eye, the pressure inside the eye may rise to a level that can damage the optic nerve. The optic nerve is the nerve that brings information from the back of the eye (retina), and damage to this nerve can result in vision loss and blindness.

Primary open-angle glaucoma is the most common form of glaucoma. It affects at least 3 million Americans. In primary open-angle glaucoma, fluid builds up in the anterior chamber of the eye because it cannot drain through a meshwork structure between the colored part of the eye that controls light entry (iris) and the lens of the eye (cornea). In primary open-angle glaucoma, the spacing between the iris and cornea is normal. The risk of developing primary open-angle glaucoma increases with age, especially above age 50, and is higher in those with a family history of this condition. Primary open-angle glaucoma can be asymptomatic or may have symptoms of decreased vision, particularly in the side or periphery, as well as pain, nausea, and headache.

Primary open-angle glaucoma can be diagnosed with a comprehensive dilated eye exam and by measuring intraocular pressure (IOP). Regular eye exams are important because this form of glaucoma is often asymptomatic prior to permanent vision loss. Treatment options include medication, laser surgery to create holes in the meshwork and allow fluid to drain from the anterior chamber (laser trabeculoplasty), and surgery to alter the iris to allow fluid drainage. If you have been diagnosed with primary open-angle glaucoma, talk to your doctor about the most current treatment options. Support groups are good sources of more information and can connect you with other people living with glaucoma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary open angle glaucoma" for support, advocacy or research.

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The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

Last Updated: 19 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary open angle glaucoma" for support, advocacy or research.

Logo
The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

http://www.glaucomafoundation.org

Last Updated: 19 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary open angle glaucoma" returned 499 free, full-text research articles on human participants. First 3 results:

Comparison of MicroRNA Expression in Aqueous Humor of Normal and Primary Open-Angle Glaucoma Patients Using PCR Arrays: A Pilot Study.
 

Author(s): Hari Jayaram, Jay I Phillips, Diana C Lozano, Tiffany E Choe, William O Cepurna, Elaine C Johnson, John C Morrison, Devin M Gattey, Julie A Saugstad, Kate E Keller

Journal: Invest. Ophthalmol. Vis. Sci.. 2017 Jun;58(7):2884-2890.

 

MicroRNAs (miRNAs) are small, endogenous noncoding RNAs that have been detected in human aqueous humor (AH). Prior studies have pooled samples to obtain sufficient quantities for analysis or used next-generation sequencing. Here, we used PCR arrays with preamplification to identify ...

Last Updated: 6 Jun 2017

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A comparison of the diagnostic ability of vessel density and structural measurements of optical coherence tomography in primary open angle glaucoma.
 

Author(s): Harsha L Rao, Zia S Pradhan, Robert N Weinreb, Mohammed Riyazuddin, Srilakshmi Dasari, Jayasree P Venugopal, Narendra K Puttaiah, Dhanaraj A S Rao, Sathi Devi, Kaweh Mansouri, Carroll A B Webers

Journal:

 

To compare the diagnostic abilities of vessel density measurements of the optic nerve head (ONH), peripapillary and macular regions on optical coherence tomography (OCT) angiography in eyes with primary open angle glaucoma (POAG) with that of the ONH rim area, peripapillary retinal ...

Last Updated: 13 Mar 2017

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Choroidal area assessment in various fundus sectors of patients at different stages of primary open-angle glaucoma by using enhanced depth imaging optical coherence tomography.
 

Author(s): Mu Li, Xiao-Qin Yan, Yin-Wei Song, Jing-Min Guo, Hong Zhang

Journal: Medicine (Baltimore). 2017 Mar;96(10):e6293.

 

To compare the choroidal area in different eye fundus sectors of subjects with normal eyes, early-stage primary open-angle glaucoma (POAG) eyes, and 10┬░ tubular visual field POAG eyes using enhanced depth imaging optical coherence tomography.Twenty-five normal, 25 early-stage POAG, ...

Last Updated: 8 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary open angle glaucoma" returned 26 free, full-text review articles on human participants. First 3 results:

Association of WDR36 polymorphisms with primary open angle glaucoma: A systematic review and meta-analysis.
 

Author(s): Ke Liu, Wenling He, Jun Zhao, Yingxia Zeng, Hongbo Cheng

Journal: Medicine (Baltimore). 2017 Jun;96(26):e7291.

 

The association of the WDR36 gene with glaucoma has been controversial in the literature. We therefore conducted a systematic review and meta-analysis to assess the association of all reported common polymorphisms in WDR36 with primary open angle glaucoma (POAG) and its subtypes: ...

Last Updated: 28 Jun 2017

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Association between the p53 codon 72 polymorphism and primary open-angle glaucoma risk: Meta-analysis based on 11 case-control studies.
 

Author(s): Mohsen Gohari, Hossein Neámatzadeh, Mohammad Ali Jafari, Mahta Mazaheri, Masoud Zare-Shehneh, Elahe Abbasi-Shavazi

Journal: Indian J Ophthalmol. 2016 Oct;64(10):756-761.

 

The TP53 is important in functions of cell cycle control, apoptosis, and maintenance of DNA integrity. Studies on the association between p53 codon 72 polymorphism and primary open-angle glaucoma (POAG) risk have yielded conflicting results. Published literature from PubMed and Web ...

Last Updated: 1 Dec 2016

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Lowering of Intraocular Pressure After Phacoemulsification in Primary Open-Angle and Angle-Closure Glaucoma: A Bayesian Analysis.
 

Author(s): Ravi Thomas, Mark Walland, Aleysha Thomas, Kerrie Mengersen

Journal: Asia Pac J Ophthalmol (Phila). ;5(1):79-84.

 

Phacoemulsification as treatment for primary open-angle glaucoma (POAG) remains more controversial than for primary angle-closure glaucoma (PACG). If the objective of glaucoma surgery is an additional greater than or equal to 5 to 6 mm Hg reduction of intraocular pressure (IOP), the ...

Last Updated: 18 Feb 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

PRO-122 Versus Concomitant Therapy in Subjects With Uncontrolled Primary Open-angle Glaucoma (PRO-122LATAM)
 

Status: Recruiting

Condition Summary: Primary Open-angle Glaucoma

 

Last Updated: 18 Aug 2017

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Study of SHP639 Eye Drops in Adults With High Eye Pressure or Primary Open-angle Glaucoma
 

Status: Recruiting

Condition Summary: Ocular Hypertension, Primary Open-angle Glaucoma (POAG)

 

Last Updated: 6 Jun 2017

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Levobetaxolol Hydrochloride Eye Drops for Treatment of Primary Open-angle Glaucoma
 

Status: Recruiting

Condition Summary: Primary Open-angle Glaucoma; Ocular Hypertension

 

Last Updated: 30 Nov 2015

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