Primary open angle glaucoma

Common Name(s)

Primary open angle glaucoma

Primary open-angle glaucoma is a condition in which there is a blockage of fluid drainage from the eye. When fluid cannot drain properly from the eye, the pressure inside the eye may rise to a level that can damage the optic nerve. The optic nerve is the nerve that brings information from the back of the eye (retina), and damage to this nerve can result in vision loss and blindness.

Primary open-angle glaucoma is the most common form of glaucoma. It affects at least 3 million Americans. In primary open-angle glaucoma, fluid builds up in the anterior chamber of the eye because it cannot drain through a meshwork structure between the colored part of the eye that controls light entry (iris) and the lens of the eye (cornea). In primary open-angle glaucoma, the spacing between the iris and cornea is normal. The risk of developing primary open-angle glaucoma increases with age, especially above age 50, and is higher in those with a family history of this condition. Primary open-angle glaucoma can be asymptomatic or may have symptoms of decreased vision, particularly in the side or periphery, as well as pain, nausea, and headache.

Primary open-angle glaucoma can be diagnosed with a comprehensive dilated eye exam and by measuring intraocular pressure (IOP). Regular eye exams are important because this form of glaucoma is often asymptomatic prior to permanent vision loss. Treatment options include medication, laser surgery to create holes in the meshwork and allow fluid to drain from the anterior chamber (laser trabeculoplasty), and surgery to alter the iris to allow fluid drainage. If you have been diagnosed with primary open-angle glaucoma, talk to your doctor about the most current treatment options. Support groups are good sources of more information and can connect you with other people living with glaucoma.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary open angle glaucoma" for support, advocacy or research.

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The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

Last Updated: 19 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary open angle glaucoma" for support, advocacy or research.

Logo
The Glaucoma Foundation

The mission of The Glaucoma Foundation (TGF) is to fund groundbreaking research and to educate the public about the disease and the importance of early detection to prevent blindness.

http://www.glaucomafoundation.org

Last Updated: 19 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary open angle glaucoma" returned 439 free, full-text research articles on human participants. First 3 results:

Impact of Socioeconomic Status on the Diagnosis of Primary Open-Angle Glaucoma and Primary Angle Closure Glaucoma: A Nationwide Population-Based Study in Taiwan.
 

Author(s): Yu-Chieh Ko, De-Kuang Hwang, Wei-Ta Chen, Ching-Chih Lee, Catherine J Liu

Journal:

 

To understand the impact of socioeconomic status (SES) on the diagnosis of primary open-angle glaucoma (POAG) and primary angle closure glaucoma (PACG) in Taiwan.

Last Updated: 24 Feb 2016

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Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.
 

Author(s): Jessica N Cooke Bailey, Stephanie J Loomis, Jae H Kang, R Rand Allingham, Puya Gharahkhani, Chiea Chuen Khor, Kathryn P Burdon, Hugues Aschard, Daniel I Chasman, Robert P Igo, Pirro G Hysi, Craig A Glastonbury, Allison Ashley-Koch, Murray Brilliant, Andrew A Brown, Donald L Budenz, Alfonso Buil, Ching-Yu Cheng, Hyon Choi, William G Christen, Gary Curhan, Immaculata De Vivo, John H Fingert, Paul J Foster, Charles Fuchs, Douglas Gaasterland, Terry Gaasterland, Alex W Hewitt, Frank Hu, David J Hunter, Anthony P Khawaja, Richard K Lee, Zheng Li, Paul R Lichter, David A Mackey, Peter McGuffin, Paul Mitchell, Sayoko E Moroi, Shamira A Perera, Keating W Pepper, Qibin Qi, Tony Realini, Julia E Richards, Paul M Ridker, Eric Rimm, Robert Ritch, Marylyn Ritchie, Joel S Schuman, William K Scott, Kuldev Singh, Arthur J Sit, Yeunjoo E Song, Rulla M Tamimi, Fotis Topouzis, Ananth C Viswanathan, Shefali Setia Verma, Douglas Vollrath, Jie Jin Wang, Nicole Weisschuh, Bernd Wissinger, Gadi Wollstein, Tien Y Wong, Brian L Yaspan, Donald J Zack, Kang Zhang, Epic-Norfolk Eye Study, , Robert N Weinreb, Margaret A Pericak-Vance, Kerrin Small, Christopher J Hammond, Tin Aung, Yutao Liu, Eranga N Vithana, Stuart MacGregor, Jamie E Craig, Peter Kraft, Gareth Howell, Michael A Hauser, Louis R Pasquale, Jonathan L Haines, Janey L Wiggs

Journal: Nat. Genet.. 2016 Feb;48(2):189-94.

 

Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. To identify new susceptibility loci, we performed meta-analysis on genome-wide association study (GWAS) results from eight independent studies from the United States (3,853 cases and 33,480 controls) and ...

Last Updated: 27 Jan 2016

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Schlemm's Canal and Trabecular Meshwork in Eyes with Primary Open Angle Glaucoma: A Comparative Study Using High-Frequency Ultrasound Biomicroscopy.
 

Author(s): Xiaoqin Yan, Mu Li, Zhiqi Chen, Ying Zhu, Yinwei Song, Hong Zhang

Journal:

 

We investigated in vivo changes in Schlemm's canal and the trabecular meshwork in eyes with primary open angle glaucoma (POAG). Relationships between Schlemm's canal diameter, trabecular meshwork thickness, and intraocular pressure (IOP) were examined. Forty POAG patients and 40 normal ...

Last Updated: 5 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary open angle glaucoma" returned 16 free, full-text review articles on human participants. First 3 results:

Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis.
 

Author(s): Venediktos V Kapetanakis, Michelle P Y Chan, Paul J Foster, Derek G Cook, Christopher G Owen, Alicja R Rudnicka

Journal: Br J Ophthalmol. 2016 Jan;100(1):86-93.

 

Systematic review of published population based surveys to examine the relationship between primary open angle glaucoma (POAG) prevalence and demographic factors. A literature search identified population-based studies with quantitative estimates of POAG prevalence (to October 2014). ...

Last Updated: 22 Dec 2015

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Efficacy and tolerability of mono-compound topical treatments for reduction of intraocular pressure in patients with primary open angle glaucoma or ocular hypertension: an overview of reviews.
 

Author(s): Qëndresë Daka, Vladimir Trkulja

Journal: Croat. Med. J.. 2014 Oct;55(5):468-80.

 

To evaluate the existing evidence on relative efficacy and tolerability of topical mono-compound intraocular pressure (IOP)-lowering drugs in treatment of primary open angle glaucoma (POAG) and ocular hypertension (OHT).

Last Updated: 31 Oct 2014

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[Hypotensive therapy in patients with primary open-angle glaucoma].
 

Author(s): Beata Krasińska, Jarosław Kocięcki, Zbigniew Krasiński, Andrzej Tykarski

Journal: Kardiol Pol. 2013 ;71(8):869-74.

 

Last Updated: 19 Sep 2013

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Symptoms, Diagnosis, and Treatment

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There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effect of Travoprost 0.004% on Retinal Oximetry in Primary Open Angle Glaucoma
 

Status: Not yet recruiting

Condition Summary: Primary Open Angle Glaucoma

 

Last Updated: 19 Oct 2012

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Study of Trabodenoson in Adults With Ocular Hypertension or Primary Open-angle Glaucoma
 

Status: Recruiting

Condition Summary: Primary Open-Angle Glaucoma (POAG); Ocular Hypertension (OHT)

 

Last Updated: 2 Jul 2016

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Safety and Performance Study of the ARGOS-IO (Intraocular) System in Patients With Primary Open Angle Glaucoma (POAG)
 

Status: Recruiting

Condition Summary: Primary Open Angle Glaucoma (POAG)

 

Last Updated: 30 Apr 2015

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