Parkinson disease 1

Common Name(s)

Parkinson disease 1

Parkinson disease is the second most common neurogenic disorder after Alzheimer disease (AD; {104300}), affecting approximately 1% of the population over age 50. Clinical manifestations include resting tremor, muscular rigidity, bradykinesia, and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia ({17:Polymeropoulos et al., 1996}). For a general phenotypic description and a discussion of genetic heterogeneity of Parkinson disease, see {168600}.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Parkinson disease 1" for support, advocacy or research.

National Parkinson Foundation

The National Parkinson Foundation is the only organization with a singular focus on improving the quality of Parkinson's care through research, education and outreach. We continue to bring help and hope to the estimated one million individuals in the US, four to six million worldwide, who are living with Parkinson's disease. NPF has funded more than $180 million in research and support services to improve the lives of people with PD. NPF programs touch more than one million people a year through our global network of Centers of Excellence, our US chapters, conferences, and online resources.

Last Updated: 23 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Parkinson disease 1" for support, advocacy or research.

National Parkinson Foundation

The National Parkinson Foundation is the only organization with a singular focus on improving the quality of Parkinson's care through research, education and outreach. We continue to bring help and hope to the estimated one million individuals in the US, four to six million worldwide, who are living with Parkinson's disease. NPF has funded more than $180 million in research and support services to improve the lives of people with PD. NPF programs touch more than one million people a year through our global network of Centers of Excellence, our US chapters, conferences, and online resources.

http://parkinson.org

Last Updated: 23 Apr 2014

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General Support Organizations

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General Resources

Aware in Care

Aware in Care aims to help people with Parkinson’s disease get the best care possible during a hospital stay.

Updated 8 Apr 2014

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What You and Your Family Should Know

This book offers a basic overview of Parkinson’s disease. Topics include symptoms, diagnosis, parkinsonism, treatment options, putting your health team together, accepting and adapting to PD, and staying well.

Updated 23 Apr 2014

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Caring and Coping

Written for care partners of people with Parkinson’s, this book profiles caregiver roles and activities. Topics include what to expect, care options, activities of daily living, legal and financial planning and taking care of yourself as caregiver.

Updated 23 Apr 2014

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Fitness Counts

Exercise is important at any stage of Parkinson’s. This book describes exercise methods that contribute to stability and includes photos to demonstrate proper form.

Updated 23 Apr 2014

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10 Early Warning Signs of Parkinson's Disease

This short brochure describes 10 symptoms that may be early signs of Parkinson’s disease. Each symptom of concern is listed along with what is "normal." If you have more than one symptom, you may want to visit your doctor.

Updated 23 Apr 2014

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Medications

This book describes both motor and non-motor symptoms of Parkinson’s and provides detailed information on common medications used to treat these symptoms.

Updated 23 Apr 2014

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Nutrition Matters

This book focuses on optimal nutrition for people with Parkinson’s and explains how PD affects the gastrointestinal system. It also offers tips and recipes to help manage non-motor symptoms and medication side effects.

Updated 23 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Parkinson disease 1" returned 21 free, full-text research articles on human participants. First 3 results:

Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease.
 

Author(s): Ju-Hee Kang, David J Irwin, Alice S Chen-Plotkin, Andrew Siderowf, Chelsea Caspell, Christopher S Coffey, Teresa Waligórska, Peggy Taylor, Sarah Pan, Mark Frasier, Kenneth Marek, Karl Kieburtz, Danna Jennings, Tanya Simuni, Caroline M Tanner, Andrew Singleton, Arthur W Toga, Sohini Chowdhury, Brit Mollenhauer, John Q Trojanowski, Leslie M Shaw,

Journal: JAMA Neurol. 2013 Oct;70(10):1277-87.

 

We observed a significant correlation between cerebrospinal fluid (CSF) levels of tau proteins and α-synuclein, but not β-amyloid 1-42 (Aβ1-42), and lower concentration of CSF biomarkers, as compared with healthy controls, in a cohort of entirely untreated patients with Parkinson ...

Last Updated: 3 Feb 2014

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Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity.
 

Author(s): Benny Björkblom, Altynai Adilbayeva, Jodi Maple-Grødem, Dominik Piston, Mats Ökvist, Xiang Ming Xu, Cato Brede, Jan Petter Larsen, Simon Geir Møller

Journal: J. Biol. Chem.. 2013 Aug;288(31):22809-20.

 

The progressive loss of motor control due to reduction of dopamine-producing neurons in the substantia nigra pars compacta and decreased striatal dopamine levels are the classically described features of Parkinson disease (PD). Neuronal damage also progresses to other regions of the ...

Last Updated: 5 Aug 2013

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The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering.
 

Author(s): Denis Ottolini, Tito Calì, Alessandro Negro, Marisa Brini

Journal: Hum. Mol. Genet.. 2013 Jun;22(11):2152-68.

 

DJ-1 was first identified as an oncogene. More recently, mutations in its gene have been found causative for autosomal recessive familial Parkinson disease. Numerous studies support the DJ-1 role in the protection against oxidative stress and maintenance of mitochondria structure; ...

Last Updated: 14 May 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Parkinson disease 1" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A STUDY TO EVALUATE THE EFFICACY OF CJH1 (CLR4001) IN PARKINSON'S DISEASE
 

Status: Recruiting

Condition Summary: Parkinson's Disease

 

Last Updated: 12 Sep 2012

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Trodat 1 SPECT and Dopamine Polymorphism
 

Status: Not yet recruiting

Condition Summary: Parkinson Disease

 

Last Updated: 22 Jun 2011

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A Longitudinal Study in 1st Degree Relatives of Parkinson's Disease (PD) Patients
 

Status: Not yet recruiting

Condition Summary: Parkinson's Disease

 

Last Updated: 29 Dec 2011

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