Panic disorder 1

Common Name(s)

Panic disorder 1

The DSM-IV ({1:American Psychiatric Association, 1994}) defines panic disorder as the spontaneous, unexpected occurrence of panic attacks followed by persistent concern, worry, and anxiety about having additional panic attacks. Panic attacks are defined as a discrete period of intense fear or discomfort in which at least 4 of 13 symptom criteria are met that develop abruptly and reach a peak within 10 minutes. Some of these criteria include cardiac palpitations, sweating, feelings of choking, fear of losing control, and fear of dying. Panic disorder is divided into panic disorder with or without accompanying agoraphobia. However, agoraphobia can also occur without panic disorder, and panic attacks can occur in the absence of panic disorder. Comorbidity with depressive and addictive disorders is frequent. {2:Barlow et al. (1994)} and {22:Smoller and Tsuang (1998)} noted that because the diagnostic criteria remain purely clinical, the nosology of anxiety disorders, such as panic disorder, is controversial and evolving. Therefore, it is difficult to do genetic studies because of the difficulty in delineating overlapping phenotypes within the broader context of anxiety disorders. For example, there may be overlap of panic with specific phobias, variable expressivity of panic and anxiety or depression, or phenocopies within a family. The terms 'anxiety neurosis' and 'phobic neurosis' were used in the past (before the DSM-III in 1980) to encompass all of these disorders. {22:Smoller and Tsuang (1998)} suggested that dimensional personality traits, such as shyness, behavioral inhibition, and neuroticism (see {607834}), could be used to define an anxiety phenotype. {19:Schumacher et al. (2011)} provided a review of the genetics of panic disorder. They noted that there is high (80%) comorbidity with other psychiatric disorders, including agoraphobia, mood disorders, substance abuse, and other anxiety disorders. Associated personality traits include anxiety sensitivity, behavioral inhibition, neuroticism, and harm avoidance. Women are more susceptible to development of the disorder, which has an average age of onset at 23.6 years. Genetic Heterogeneity of Susceptibility to Panic Disorder See also PAND2 ({607853}), which has been mapped to chromosome 9, and PAND3 ({609985}), which has been mapped to chromosome 4.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Panic disorder 1" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

Last Updated: 15 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Panic disorder 1" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

http://www.adaa.org

Last Updated: 15 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Panic disorder 1" returned 5 free, full-text research articles on human participants. First 3 results:

Gender differences in associations of glutamate decarboxylase 1 gene (GAD1) variants with panic disorder.
 

Author(s): Heike Weber, Claus Jürgen Scholz, Katharina Domschke, Christian Baumann, Benedikt Klauke, Christian P Jacob, Wolfgang Maier, Jürgen Fritze, Borwin Bandelow, Peter Michael Zwanzger, Thomas Lang, Lydia Fehm, Andreas Ströhle, Alfons Hamm, Alexander L Gerlach, Georg W Alpers, Tilo Kircher, Hans-Ulrich Wittchen, Volker Arolt, Paul Pauli, Jürgen Deckert, Andreas Reif

Journal: PLoS ONE. 2012 ;7(5):e37651.

 

Panic disorder is common (5% prevalence) and females are twice as likely to be affected as males. The heritable component of panic disorder is estimated at 48%. Glutamic acid dehydrogenase GAD1, the key enzyme for the synthesis of the inhibitory and anxiolytic neurotransmitter GABA, ...

Last Updated: 4 Jun 2012

Go To URL
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene.
 

Author(s): Noomi Gregersen, Hans A Dahl, Henriette N Buttenschøn, Mette Nyegaard, Anne Hedemand, Thomas D Als, August G Wang, Sofus Joensen, David Pd Woldbye, Pernille Koefoed, Ann S Kristensen, Torben A Kruse, Anders D Børglum, Ole Mors

Journal: Eur. J. Hum. Genet.. 2012 Jan;20(1):84-90.

 

Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as ...

Last Updated: 13 Dec 2011

Go To URL
Life events and social support in a 1-year preceding panic disorder.
 

Author(s): Borjanka Batinić, G Trajković, D Duisin, G Nikolić-Balkoski

Journal: Psychiatr Danub. 2009 Mar;21(1):33-40.

 

The aim of the study was to examine the frequency and class of life events, as well as social support, in patients with panic disorder (with/without agoraphobia) (PD/PDA) in a 1-year period preceding the onset of panic attacks.

Last Updated: 9 Mar 2009

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Panic disorder 1" returned 0 free, full-text review articles on human participants.

 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Mechanisms of Panic Disorders Treatment
 

Status: Recruiting

Condition Summary: Panic Disorder; Agoraphobia; Panic Attacks

 

Last Updated: 8 Apr 2011

Go to URL
Escitalopram Trial for Irritable Bowel Syndrome (IBS) Patients With Panic Disorder
 

Status: Recruiting

Condition Summary: Irritable Bowel Syndrome; Panic Disorder

 

Last Updated: 10 Apr 2014

Go to URL
Panic Disorder and Cardiac Risk
 

Status: Recruiting

Condition Summary: Panic Disorder

 

Last Updated: 4 Apr 2007

Go to URL