Bowen's disease

Common Name(s)

Bowen's disease, Squamous cell carcinoma in situ

Bowen’s disease is a curable abnormal tumor growth of the skin and is considered to be an early stage of squamous cell carcinoma (cancer affecting epithelial cells, the top layer of your skin). Symptoms include a growing red, scaly patch with an irregular border. The red patches may be itchy and occasionally may be sore and bleed. Sometimes the red area may be raised. While the patches can occur anywhere on the body, they most commonly show up on the lower leg and rarely arise on your palms or soles. Bowen’s disease may be caused by sun damage, arsenic exposure, chronic skin injuries, suppressed immune systems (such as AIDS or due to medications after an organ transplant), viral infections (HPV), and other skin disorders. Bowen's disease is more common in women than men, and usually affects older people in their 70s-80s. It tends to be seen on people who have had lots of sun exposure (one of the main causes), especially those with fair skin.

Diagnosis is usually made by a skin sample (biopsy) taken by a doctor. Treatment includes local chemotherapy, photodynamic treatment (using non-toxic light), and freezing the growth. Since these growths have not yet reached the deeper skin layers, Bowen's disease has a better prognosis and is more easily cured than more invasive forms of skin cancer. Please see your doctor or a dermatologist, if you are experiencing any of these symptoms for early diagnosis. If you or a family member has been diagnosed with Bowen’s disease, talk with your doctor or dermatologist about current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bowen's disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bowen's disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bowen's disease" returned 65 free, full-text research articles on human participants. First 3 results:

Human papillomavirus infection and p16 expression in the immunocompetent patients with extragenital/extraungual Bowen's disease.
 

Author(s): Marián Švajdler, Roman Mezencev, Jana Kašpírková, Denisa Kacerovská, Dmitry V Kazakov, Ondrej Ondič, Michal Michal

Journal:

 

The role of human papillomaviruses (HPV) in the development of squamous cell carcinoma (SCC) has been established for anogenital lesions but still remains controversial for carcinomas in other sites. The aim of this study was to determine the α-HPV and β-HPV prevalence and their ...

Last Updated: 25 Jun 2016

Go To URL
Perianal multiple Bowen's disease: a case report.
 

Author(s): Wei Zhan, Xin Liao, Tian Tian, Ru-Yi Zhang, Po Li, Xiao-Ping Wu, Qing-Hua Ji, Qin Yang

Journal:

 

Bowen's disease, also known as an intraepithelial squamous cell neoplasia, is a carcinoma in situ firstly reported in 1912 by a dermatologist named Bowen from the United States [1]. About 3%~5% of Bowen's disease might develop into invasive squamous cell carcinomas of mocusa and skin ...

Last Updated: 29 Jan 2016

Go To URL
Squamous Cell Carcinoma Following Photodynamic Therapy for Cutaneous Bowen's Disease in a Series of 105 Patients.
 

Author(s): Carole Ratour-Bigot, Mireille Chemidling, Claire Montlahuc, Georges Abirached, Nika Madjlessi, Chantal Bullier, Maxime Battistella, Martine Bagot, Céleste Lebbe, Nicole Basset-Seguin

Journal: Acta Derm. Venereol.. 2016 Jun;96(5):658-63.

 

Photodynamic therapy (PDT) is an alternative to surgery for Bowen's disease. This monocentric retrospective study included 105 patients with Bowen's disease, treated with PDT between 2007 and 2013, who received a total of 151 different PDT fields. Comparison of immunocompromised and ...

Last Updated: 15 Jun 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bowen's disease" returned 1 free, full-text review articles on human participants. First 3 results:

Bowen's disease.
 

Author(s): M M Lee, M M Wick

Journal: CA Cancer J Clin. ;40(4):237-42.

 

Last Updated: 14 Aug 1990

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Laser Assisted Drug Delivery in the Treatment of Superficial Non Melanoma Skin Cancer: a Randomized Controlled Trial
 

Status: Recruiting

Condition Summary: Bowen's Disease; Superficial Basal Cell Carcinoma

 

Last Updated: 3 Jan 2017

Go to URL