Osteoporosis

Common Name(s)

Osteoporosis

Osteoporosis is a condition that causes bones to become weak and brittle. Bone is living tissue that is constantly being broken down and replaced. When you are young, your body typically makes new bone faster than it breaks down old bone. This leads to dense bone mass (strong bones). When the creation of new bone is unable to keep up with the removal of old bone, they become weak and brittle. If osteoporosis is severe enough, a crack or break (fracture) within the bone can occur from something as minor as a fall or even from a normal action, like coughing. Symptoms of osteoporosis may include back pain, decrease in height, a hunched posture, and increased risk of bone fractures.

Most people reach their peak bone mass by their early 20s. Individuals with a high peak bone mass when they are young have a lower chance of developing osteoporosis as they age. Gender, age, and race are all risk factors for developing osteoporosis. Women, individuals who are white or of Asian descent, and the elderly have an increased risk of developing osteoporosis. Low calcium intake, eating disorders, and gastrointestinal surgery can also cause a greater risk for osteoporosis. Certain medications, especially steroids, as well as tobacco use, excessive alcohol consumption and a sedentary lifestyle all increase the risk for osteoporosis.

Specific types of X-ray images, called DXA scans, may be used to determine your bone density and diagnose osteoporosis. There are many forms of treatment, depending on the severity. It is important to talk to your doctor, if you or someone you know has been diagnosed with osteoporosis, to review the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteoporosis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteoporosis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteoporosis" returned 1712 free, full-text research articles on human participants. First 3 results:

Effects of therapies for regulating and reinforcing lung and kidney on osteoporosis in rats with chronic obstructive pulmonary disease.
 

Author(s): Tian Yange, Li Ya, Li Jiansheng, Li Suyun, Jiang Suli, Wang Ying, Lu Xiaofan, Li Weiwei

Journal: J Tradit Chin Med. 2015 Apr;35(2):175-83.

 

To evaluate the efficacy and long-term effects of the three therapies for regulating and reinforcing lung and kidney (reinforcing lung and invigorating spleen, reinforcing lung and replenishing kidney, and supplementing Qi and nourishing kidney) in Traditional Chinese Medicine (TCM) ...

Last Updated: 15 May 2015

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Effect of naringenin in Qianggu capsule on population pharmacokinetics in Chinese women with primary osteoporosis.
 

Author(s): Wang Jiannong, Jiang Junjie, Xie Yanming, Wei Xu, Li Jianpeng, Duan Jingli, Xiong Xin

Journal: J Tradit Chin Med. 2015 Apr;35(2):141-53.

 

To characterize naringenin (NAR) pop- ulation pharmacokinetics (PPK) in Chinese women with primary osteoporosis.

Last Updated: 15 May 2015

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Toll-Like Receptor 4 Gene Polymorphism C1196T in Polish Women with Postmenopausal Osteoporosis - Preliminary Investigation.
 

Author(s): Beata Kaleta, Magdalena Walicka, Ada Sawicka, Agata Bogołowska-Stieblich, Andrzej Górski, Jacek Łukaszkiewicz, Ewa Marcinowska-Suchowierska

Journal: Adv Clin Exp Med. ;24(2):239-43.

 

Postmenopausal osteoporosis is a systemic bone disease characterized by low bone mass after menopause. Bone remodeling is regulated by a number of factors, including the immune system. Toll-like receptors 4 (TLR4) are expressed on bone cells and modify the immune response. TLR4 gene ...

Last Updated: 1 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteoporosis" returned 524 free, full-text review articles on human participants. First 3 results:

Common polymorphism in the LRP5 gene may increase the risk of bone fracture and osteoporosis.
 

Author(s): Guang-Yue Xu, Yong Qiu, Hai-Jun Mao

Journal: Biomed Res Int. 2014 ;2014():290531.

 

The low-density lipoprotein receptor-related protein 5 gene (LRP5) was identified to be linked to the variation in bone mineral density and types of bone diseases. The present study was aimed at examining the association of LRP5 rs3736228 C>T gene with bone fracture and osteoporosis ...

Last Updated: 12 Jan 2015

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Osteoporosis management among chronic glucocorticoid users: a systematic review.
 

Author(s): Jordan M Albaum, Soyoung Youn, Linda E Levesque, Andrea S Gershon, Suzanne M Cadarette

Journal: J Popul Ther Clin Pharmacol. 2014 ;21(3):e486-504.

 

Clinical practice guidelines recommend that all patients starting chronic oral glucocorticoid (GC) therapy receive bone mineral density (BMD) testing and osteoporosis pharmacotherapy.

Last Updated: 21 Dec 2014

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Systematic review of raloxifene in postmenopausal Japanese women with osteoporosis or low bone mass (osteopenia).
 

Author(s): Saeko Fujiwara, Etsuro Hamaya, Masayo Sato, Peita Graham-Clarke, Jennifer A Flynn, Russel Burge

Journal:

 

To systematically review the literature describing the efficacy, effectiveness, and safety of raloxifene for postmenopausal Japanese women with osteoporosis or low bone mass (osteopenia).

Last Updated: 14 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Adherence to Osteoporosis Treatment and Physicians' Perception Regarding Osteoporosis Medication
 

Status: Recruiting

Condition Summary: Osteoporosis, Postmenopausal; Osteoporosis, Steroid Induced

 

Last Updated: 12 Jun 2015

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Texture Analysis for Postmenopausal Osteoporosis
 

Status: Recruiting

Condition Summary: Osteoporosis; Osteopenia

 

Last Updated: 16 Mar 2007

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Osteoporosis Coordinator for Low Volume Community Hospitals
 

Status: Recruiting

Condition Summary: Osteoporosis; Fragility Fractures

 

Last Updated: 6 Aug 2007

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