Osteoporosis

Common Name(s)

Osteoporosis

Osteoporosis is a condition that causes bones to become weak and brittle. Bone is living tissue that is constantly being broken down and replaced. When you are young, your body typically makes new bone faster than it breaks down old bone. This leads to dense bone mass (strong bones). When the creation of new bone is unable to keep up with the removal of old bone, they become weak and brittle. If osteoporosis is severe enough, a crack or break (fracture) within the bone can occur from something as minor as a fall or even from a normal action, like coughing. Symptoms of osteoporosis may include back pain, decrease in height, a hunched posture, and increased risk of bone fractures.

Most people reach their peak bone mass by their early 20s. Individuals with a high peak bone mass when they are young have a lower chance of developing osteoporosis as they age. Gender, age, and race are all risk factors for developing osteoporosis. Women, individuals who are white or of Asian descent, and the elderly have an increased risk of developing osteoporosis. Low calcium intake, eating disorders, and gastrointestinal surgery can also cause a greater risk for osteoporosis. Certain medications, especially steroids, as well as tobacco use, excessive alcohol consumption and a sedentary lifestyle all increase the risk for osteoporosis.

Specific types of X-ray images, called DXA scans, may be used to determine your bone density and diagnose osteoporosis. There are many forms of treatment, depending on the severity. It is important to talk to your doctor, if you or someone you know has been diagnosed with osteoporosis, to review the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteoporosis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteoporosis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteoporosis" returned 2148 free, full-text research articles on human participants. First 3 results:

A cross-sectional study for estimation of associations between education level and osteoporosis in a Chinese men sample.
 

Author(s): Cai-Xia Yu, Xiu-Zhen Zhang, Keqin Zhang, Zihui Tang

Journal:

 

The main aim of this study was to evaluate the association between education level and osteoporosis (OP) in general Chinese Men.

Last Updated: 9 Dec 2015

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Increased levels of interleukin 31 (IL-31) in osteoporosis.
 

Author(s): Lia Ginaldi, Massimo De Martinis, Fedra Ciccarelli, Salvatore Saitta, Selene Imbesi, Carmen Mannucci, Sebastiano Gangemi

Journal:

 

Several inflammatory cytokines play a key part in the induction of osteoporosis. Until now, involvement of the Th2 cytokine interleukin-31 (IL-31) in osteoporosis hadn't yet been studied. IL-31 is a proinflammatory cytokine mediating multiple immune functions, whose involvement in ...

Last Updated: 9 Oct 2015

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The Efficacy of Parathyroid Hormone Analogues in Combination With Bisphosphonates for the Treatment of Osteoporosis: A Meta-Analysis of Randomized Controlled Trials.
 

Author(s): Wan Li, Wenjian Chen, Yang Lin

Journal: Medicine (Baltimore). 2015 Sep;94(38):e1156.

 

Parathyroid hormone (PTH) analogues increase bone strength primarily by stimulating bone formation, whereas antiresorptive drugs (bisphosphonates) reduce bone resorption. Therefore, some studies have been designed to test the hypothesis that the concurrent administration of the 2 ...

Last Updated: 25 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteoporosis" returned 593 free, full-text review articles on human participants. First 3 results:

Bisphosphonates for the prevention and treatment of osteoporosis.
 

Author(s): Spyridoula Maraka, Kurt A Kennel

Journal:

 

Osteoporosis is a systemic skeletal disorder characterized by bone loss, which leads to impaired bone strength and an increased risk of fractures. Two million fractures are attributed to osteoporosis annually in the United States and they are associated with serious morbidity and ...

Last Updated: 3 Sep 2015

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Management of endocrine disease: Diabetes and osteoporosis: cause for concern?
 

Author(s): Jakob Starup-Linde, Peter Vestergaard

Journal: Eur. J. Endocrinol.. 2015 Sep;173(3):R93-9.

 

Diabetes and osteoporosis are both frequent conditions, and they may thus occur simultaneously by chance. However, a growing body of evidence suggests that hyperglycemia may impair bone matrix formation and biochemical competence. Decreased biomechanical competence may be present ...

Last Updated: 5 Aug 2015

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Dose-Effectiveness Relationships Determining the Efficacy of Ibandronate for Management of Osteoporosis: A Meta-Analysis.
 

Author(s): Yanjie Hou, Ke Gu, Chao Xu, Huiyong Ding, Changxin Liu, Yilihamu Tuoheti

Journal: Medicine (Baltimore). 2015 Jul;94(26):e1007.

 

The purpose of this study was to perform a meta-analysis on the efficacy of ibandronate by evaluating the effect sizes of different dosing regimens.Major electronic databases were searched from 1985 to February 2015. A random effects meta-analysis was performed in STATA.Data from ...

Last Updated: 3 Jul 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Adherence to Osteoporosis Treatment and Physicians' Perception Regarding Osteoporosis Medication
 

Status: Recruiting

Condition Summary: Osteoporosis, Postmenopausal; Osteoporosis, Steroid Induced

 

Last Updated: 7 Dec 2015

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Texture Analysis for Postmenopausal Osteoporosis
 

Status: Recruiting

Condition Summary: Osteoporosis; Osteopenia

 

Last Updated: 16 Mar 2007

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Osteoporosis Coordinator for Low Volume Community Hospitals
 

Status: Recruiting

Condition Summary: Osteoporosis; Fragility Fractures

 

Last Updated: 6 Aug 2007

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