Osteoporosis

Common Name(s)

Osteoporosis

Osteoporosis is a condition that causes bones to become weak and brittle. Bone is living tissue that is constantly being broken down and replaced. When you are young, your body typically makes new bone faster than it breaks down old bone. This leads to dense bone mass (strong bones). When the creation of new bone is unable to keep up with the removal of old bone, they become weak and brittle. If osteoporosis is severe enough, a crack or break (fracture) within the bone can occur from something as minor as a fall or even from a normal action, like coughing. Symptoms of osteoporosis may include back pain, decrease in height, a hunched posture, and increased risk of bone fractures.

Most people reach their peak bone mass by their early 20s. Individuals with a high peak bone mass when they are young have a lower chance of developing osteoporosis as they age. Gender, age, and race are all risk factors for developing osteoporosis. Women, individuals who are white or of Asian descent, and the elderly have an increased risk of developing osteoporosis. Low calcium intake, eating disorders, and gastrointestinal surgery can also cause a greater risk for osteoporosis. Certain medications, especially steroids, as well as tobacco use, excessive alcohol consumption and a sedentary lifestyle all increase the risk for osteoporosis.

Specific types of X-ray images, called DXA scans, may be used to determine your bone density and diagnose osteoporosis. There are many forms of treatment, depending on the severity. It is important to talk to your doctor, if you or someone you know has been diagnosed with osteoporosis, to review the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteoporosis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Osteoporosis" for support, advocacy or research.

HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Osteoporosis" returned 2481 free, full-text research articles on human participants. First 3 results:

Romosozumab versus Alendronate and Fracture Risk in Women with Osteoporosis.
 

Author(s):

Journal: N. Engl. J. Med.. 2018 01;378(2):194-196.

 

Last Updated: 31 Dec 1969

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Improvements in osteoporosis testing and care are found following the wide scale implementation of the Ontario Fracture Clinic Screening Program: An interrupted time series analysis.
 

Author(s): Dorcas E Beaton, Muhammad Mamdani, Hong Zheng, Susan Jaglal, Suzanne M Cadarette, Earl R Bogoch, Joanna E M Sale, Rebeka Sujic, Ravi Jain,

Journal: Medicine (Baltimore). 2017 Dec;96(48):e9012.

 

We evaluated a system-wide impact of a health intervention to improve treatment of osteoporosis after a fragility fracture. The intervention consisted of assigning a screening coordinator to selected fracture clinics to identify, educate, and follow up with fragility fracture patients ...

Last Updated: 31 Dec 1969

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Association between osteoprotegerin gene T950C polymorphism and osteoporosis risk in the Chinese population: Evidence via meta-analysis.
 

Author(s): Shouyi Li, Huiqiang Jiang, Ningke Du

Journal:

 

Osteoporosis has been reported to be at least partially developed in response to functional polymorphisms of the osteoprotegerin (OPG). However, conflicting results have been found. This meta-analysis aimed to provide an assessment of the relationship between the risk for developing ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Osteoporosis" returned 678 free, full-text review articles on human participants. First 3 results:

Efficacy and safety of bazedoxifene in postmenopausal women with osteoporosis: A systematic review and meta-analysis.
 

Author(s): Lihua Peng, Qian Luo, Hui Lu

Journal: Medicine (Baltimore). 2017 Dec;96(49):e8659.

 

Bazedoxifene may be promising to treat osteoporosis of postmenopausal women. We conducted a systematic review and meta-analysis to explore the efficacy and safety of bazedoxifene in postmenopausal women with osteoporosis.

Last Updated: 31 Dec 1969

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Approach to the patient with pregnancy and lactation-associated osteoporosis: A case report and a review of the literature.
 

Author(s): Min Zhang, Ping Chen, Bin Li, Juan Du, Ting Pan, Jingyan Chen

Journal: Medicine (Baltimore). 2017 Nov;96(46):e8671.

 

Pregnancy and lactation-associated osteoporosis (PLO) is very rare, but it can cause severe vertebral compression fractures with disabling back pain. Although it is a rare, PLO must be kept in mind in the differential diagnosis in patients presenting with low back pain during or after pregnancy.

Last Updated: 31 Dec 1969

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MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis.
 

Author(s): Ernesto Canalis

Journal: Eur. J. Endocrinol.. 2018 Feb;178(2):R33-R44.

 

Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Jogging in the Change of Osteoporosis
 

Status: Not yet recruiting

Condition Summary: Osteoporosis

 

Last Updated: 29 Nov 2017

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Multicenter Cohort Study on Osteoporosis
 

Status: Not yet recruiting

Condition Summary: Osteoporosis

 

Last Updated: 4 Nov 2016

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Last Updated: 15 Jun 2016

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