Botulism

Common Name(s)

Botulism

Botulism is a disease caused by the bacteria Clostridium botulinum. There are three main types: infant botulism, foodbourne botulism, and wound botulism. All types are very serious and can be fatal. Each type of botulism has different symptoms, but all include muscle weakness, paralysis, and drooping of the eyes. For all cases, direct contact or ingestion of the bacteria causes the disease. There is an antitoxin available for early prevention of botulism that stops further harm by the infection. For foodborne infections, doctors may induce vomiting and bowel movements to force the bacteria out of your system.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Botulism" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Botulism" returned 227 free, full-text research articles on human participants. First 3 results:

Outbreak of Foodborne Botulism Associated with Improperly Jarred Pesto--Ohio and California, 2014.
 

Author(s): Patrick Burke, Michael Needham, Brendan R Jackson, Rick Bokanyi, Eric St Germain, Steven J Englender

Journal:

 

On July 28, 2014, the Cincinnati Health Department was notified of suspected cases of foodborne botulism in two women admitted to the same hospital 12 days apart. Patient A had been treated for 12 days for suspected autoimmune disease. When patient B, the roommate of patient A, was ...

Last Updated: 26 Feb 2016

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Characterizing the fecal microbiota of infants with botulism.
 

Author(s): T Brian Shirey, Janet K Dykes, Carolina Lúquez, Susan E Maslanka, Brian H Raphael

Journal:

 

Infant botulism is the most prevalent form of botulism in the USA, representing 68.5 % of cases reported from 2001-2012. Infant botulism results when botulinum toxin-producing clostridia (BTPC) colonize the infant gut with concomitant in vivo production of the highly potent botulinum ...

Last Updated: 23 Nov 2015

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Laboratory Investigation of the First Case of Botulism Caused by Clostridium butyricum Type E Toxin in the United States.
 

Author(s): Janet K Dykes, Carolina Lúquez, Brian H Raphael, Loretta McCroskey, Susan E Maslanka

Journal: J. Clin. Microbiol.. 2015 Oct;53(10):3363-5.

 

We report here the laboratory investigation of the first known case of botulism in the United States caused by Clostridium butyricum type E. This investigation demonstrates the importance of extensive microbiological examination of specimens, which resulted in the isolation of this organism.

Last Updated: 17 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Botulism" returned 15 free, full-text review articles on human participants. First 3 results:

Cargo-delivery platforms for targeted delivery of inhibitor cargos against botulism.
 

Author(s): Brenda A Wilson, Mengfei Ho

Journal: Curr Top Med Chem. 2014 ;14(18):2081-93.

 

Delivering therapeutic cargos to specific cell types in vivo poses many technical challenges. There is currently a plethora of drug leads and therapies against numerous diseases, ranging from small molecule compounds to nucleic acids to peptides to proteins with varying binding or ...

Last Updated: 12 Nov 2014

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Botulinum neurotoxins and botulism: a novel therapeutic approach.
 

Author(s): Jeeraphong Thanongsaksrikul, Wanpen Chaicumpa

Journal: Toxins (Basel). 2011 May;3(5):469-88.

 

Specific treatment is not available for human botulism. Current remedial mainstay is the passive administration of polyclonal antibody to botulinum neurotoxin (BoNT) derived from heterologous species (immunized animal or mouse hybridoma) together with supportive and symptomatic management. ...

Last Updated: 9 Nov 2011

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Food-borne botulism in Argentina.
 

Author(s): Victoria Rebagliati, Romina Philippi, Mariela Tornese, Analia Paiva, Laura Rossi, Alcides Troncoso

Journal:

 

Botulism is a severe neuroparalytic disease caused by Clostridium botulinum toxins. Although the disease is uncommon it is a cause of great concern due to its high rate of mortality. Food-borne outbreaks of botulism occur worldwide and require immediate public health attention and ...

Last Updated: 17 Sep 2009

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 25 Aug 2016

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