Acanthosis Nigricans

Common Name(s)

Acanthosis Nigricans

Acanthosis nigricans (AN) is a skin disorder in which there is darker, thick, velvety skin in body folds and creases. This condition usually appears slowly and doesn't cause any symptoms other than skin changes. Eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes. Less commonly, the lips, palms, soles of the feet, or other areas may be affected. The exact cause of this condition is not well understood; but it can be inherited or related to medical problems such as obesity, diabetes mellitus (insulin- resistance), some prescription drugs, and cancer.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acanthosis Nigricans" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acanthosis Nigricans" returned 70 free, full-text research articles on human participants. First 3 results:

Acanthosis nigricans in obese Chinese children.
 

Author(s): H Y Ng, Jack H M Young, K F Huen, Louis T W Chan

Journal: Hong Kong Med J. 2014 Aug;20(4):290-6.

 

OBJECTIVES. To investigate the demographic characteristics and insulin resistance in local overweight/obese Chinese children with and without acanthosis nigricans, and the associations of acanthosis nigricans with insulin resistance and other cardiometabolic co-morbidities. DESIGN. ...

Last Updated: 8 Aug 2014

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[Malignant acanthosis nigricans: report of a case].
 

Author(s): Rosana Lazzarini, Karine Simone, Gabriela Queiroz, Isabela Courral, Maria Elisa Magliari, Cecilia Kauffman Rutemberg Feder, Rute Lellis

Journal:

 

The authors present a case of a 44-year-old patient with a disseminated dermatosis diagnosed as acanthosis nigricans. The patient was a smoker and investigation of the cause of her skin lesions resulted in discovery of an asymptomatic metastatic carcinoma in the laryngopharanx, probably ...

Last Updated: 21 Apr 2014

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Cutaneous amyloidosis and insulin with coexistence of acanthosis nigricans.
 

Author(s): Bevinahalli N Nandeesh, T Rajalakshmi, B Shubha

Journal: Indian J Pathol Microbiol. ;57(1):127-9.

 

Skin is one of the important organs affected by amyloidosis which is characterized by extracellular deposition of fibrillary proteins having homogenous, eosinophilic on routine staining with distinct tinctorial properties. Nodular cutaneous amyloidosis is rare and may affect dermis, ...

Last Updated: 17 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acanthosis Nigricans" returned 7 free, full-text review articles on human participants. First 3 results:

Tripe palms associated with malignant acanthosis nigricans in a patient with gastric adenocarcinoma: a case report and review of the literature.
 

Author(s): Caterina Fabroni, Antonia Gimma, Carla Cardinali, Giovanni Lo Scocco

Journal:

 

Tripe palms (TP) is a rare dermatologic condition. TP alone, or associated with malignant acanthosis nigricans (MAN), in most cases is a cutaneous paraneoplastic disorder and its recognition should prompt a full diagnostic work-up for an underlying malignancy. We report a case of ...

Last Updated: 10 Dec 2012

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Association of acanthosis nigricans and skin tags with insulin resistance.
 

Author(s): Mariana Tremel Barbato, Paulo Ricardo Criado, Ana Kris da Silva, Evelyne Averbeck, Marina Bensen Guerine, Naiana Bittencourt de Sá

Journal: An Bras Dermatol. ;87(1):97-104.

 

Insulin resistance is a metabolic disorder in which target cells fail to respond to normal levels of circulating insulin. Insulin resistance has been associated with presence of acanthosis nigricans and acrochordons. It is known that early diagnosis and early initial treatment are ...

Last Updated: 6 Apr 2012

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Acanthosis nigricans in the setting of niacin therapy.
 

Author(s): Rachael Hartman, Taylor Defelice, Julia Tzu, Shane Meehan, Miguel Sanchez

Journal:

 

We report the case of a 63-year-old obese man with a rapid-onset of widespread acanthosis nigricans (AN) in the setting of having recently initiated treatment with niacin for dyslipidemia. Although obesity and insulin-resistance are risk factors for AN, AN associated with endocrine ...

Last Updated: 27 Oct 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity
 

Status: Not yet recruiting

Condition Summary: Acanthosis Nigricans

 

Last Updated: 5 May 2015

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Prevalence of Carbohydrate Intolerance in Lean and Obese Children
 

Status: Recruiting

Condition Summary: Obesity; Glucose Intolerance; Diabetes; Acanthosis Nigricans

 

Last Updated: 23 Jun 2005

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