Neural tube defects

Common Name(s)

Neural tube defects

Neural tube defects (NTDs) refers to a group of abnormalities resulting from abnormal development of the brain, spine and/or spinal column. During the development of an affected embryo, a structure called the neural tube does not close completely as it should, resulting in a hole somewhere along the spinal column. Specific examples of types of NTDs include spina bifida, anencephaly, and encephalocele. Symptoms vary depending on the type of NTD present but often include various forms of physical and/or mental disabilities. Many affected individuals do not survive. The exact cause of NTDs is not known but is thought to involve both genetic and nongenetic factors. Getting enough folic acid before and during pregnancy can reduce the risk of some NTDs. Treatment depends on the severity and type of defect and may include surgery.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neural tube defects" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neural tube defects" returned 390 free, full-text research articles on human participants. First 3 results:

Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model.
 

Author(s): Krista S Crider, Owen Devine, Ling Hao, Nicole F Dowling, Song Li, Anne M Molloy, Zhu Li, Jianghui Zhu, Robert J Berry

Journal:

 

To determine an optimal population red blood cell (RBC) folate concentration for the prevention of neural tube birth defects.

Last Updated: 30 Jul 2014

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Association of neural tube defects in children of mothers with MTHFR 677TT genotype and abnormal carbohydrate metabolism risk: a case-control study.
 

Author(s): N M Cadenas-Benitez, F Yanes-Sosa, A Gonzalez-Meneses, L Cerrillos, D Acosta, J M Praena-Fernandez, O Neth, I Gomez de Terreros, P Ybot-González

Journal:

 

Abnormalities in maternal folate and carbohydrate metabolism have both been shown to induce neural tube defects (NTD) in humans and animal models. However, the relationship between these two factors in the development of NTDs remains unclear. Data from mothers of children with spina ...

Last Updated: 16 Apr 2014

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Prevention of neural tube defects: a cross-sectional study of the uptake of folic acid supplementation in nearly half a million women.
 

Author(s): Jonathan P Bestwick, Wayne J Huttly, Joan K Morris, Nicholas J Wald

Journal:

 

Taking folic acid supplements before pregnancy to reduce the risk of a neural tube defect (NTD) is especially important in countries without universal folic acid fortification. The extent of folic acid supplementation among women who had antenatal screening for Down's syndrome and ...

Last Updated: 3 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neural tube defects" returned 49 free, full-text review articles on human participants. First 3 results:

Folate deficiency and folic acid supplementation: the prevention of neural-tube defects and congenital heart defects.
 

Author(s): Andrew E Czeizel, Istvan Dudás, Attila Vereczkey, Ferenc Bánhidy

Journal:

 

Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of this review paper is to show the characteristics of common and severe neural-tube defects together with congenital heart defects (CHD) as vitamin deficiencies play a role in their origin. ...

Last Updated: 28 Nov 2013

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Modeling anterior development in mice: diet as modulator of risk for neural tube defects.
 

Author(s): Claudia Kappen

Journal: Am J Med Genet C Semin Med Genet. 2013 Nov;163C(4):333-56.

 

Head morphogenesis is a complex process that is controlled by multiple signaling centers. The most common defects of cranial development are craniofacial defects, such as cleft lip and cleft palate, and neural tube defects, such as anencephaly and encephalocoele in humans. More than ...

Last Updated: 29 Oct 2013

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Neural tube defects, folate, and immune modulation.
 

Author(s): Kerina J Denny, Angela Jeanes, Kristin Fathe, Richard H Finnell, Stephen M Taylor, Trent M Woodruff

Journal: Birth Defects Res. Part A Clin. Mol. Teratol.. 2013 Sep;97(9):602-9.

 

Periconceptional supplementation with folic acid has led to a significant worldwide reduction in the incidence of neural tube defects (NTDs). However, despite increasing awareness of the benefits of folic acid supplementation and the implementation of food fortification programs in ...

Last Updated: 30 Sep 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetics of Neural Tube Defects
 

Status: Recruiting

Condition Summary: Neural Tube Defects

 

Last Updated: 2 Dec 2010

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Prevention of Neural Tube Defects by Inositol in Conjunction With Folic Acid (PONTI Study)
 

Status: Recruiting

Condition Summary: Recurrent Neural Tube Defects

 

Last Updated: 27 Mar 2007

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Fetoscopic Meningomyelocele Repair Study
 

Status: Recruiting

Condition Summary: Neural Tube Defect Repair

 

Last Updated: 2 Sep 2014

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