Neural tube defects

Common Name(s)

Neural tube defects

Neural tube defects (NTDs) refers to a group of abnormalities resulting from abnormal development of the brain, spine and/or spinal column. During the development of an affected embryo, a structure called the neural tube does not close completely as it should, resulting in a hole somewhere along the spinal column. Specific examples of types of NTDs include spina bifida, anencephaly, and encephalocele. Symptoms vary depending on the type of NTD present but often include various forms of physical and/or mental disabilities. Many affected individuals do not survive. The exact cause of NTDs is not known but is thought to involve both genetic and nongenetic factors. Getting enough folic acid before and during pregnancy can reduce the risk of some NTDs. Treatment depends on the severity and type of defect and may include surgery.
 

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Condition Specific Organizations

Following organizations serve the condition "Neural tube defects" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neural tube defects" returned 448 free, full-text research articles on human participants. First 3 results:

Folic acid fortified milk increases blood folate to concentrations associated with a very low risk of neural tube defects in Singaporean women of childbearing age.
 

Author(s): Magdalin Cheong, Huang Ying Xiao, Vicky Tay, Crystal D Karakochuk, Yazheng Amy Liu, Sarah Harvey, Yvonne Lamers, Lisa A Houghton, David D Kitts, Tim J Green

Journal: Asia Pac J Clin Nutr. 2016 ;25(1):62-70.

 

Folic acid (400 μg/d) taken during the periconceptional period reduces neural tube defect (NTD) risk by >75%. Achieving red cell folate (RCF) or plasma folate (PF) >905 nmol/L and >35 nmol/L, respectively, has been associated with a low risk of NTDs. We determined whether daily consumption ...

Last Updated: 11 Mar 2016

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Long term trends in prevalence of neural tube defects in Europe: population based study.
 

Author(s): Babak Khoshnood, Maria Loane, Hermien de Walle, Larraitz Arriola, Marie-Claude Addor, Ingeborg Barisic, Judit Beres, Fabrizio Bianchi, Carlos Dias, Elizabeth Draper, Ester Garne, Miriam Gatt, Martin Haeusler, Kari Klungsoyr, Anna Latos-Bielenska, Catherine Lynch, Bob McDonnell, Vera Nelen, Amanda J Neville, Mary T O'Mahony, Annette Queisser-Luft, Judith Rankin, Anke Rissmann, Annukka Ritvanen, Catherine Rounding, Antonin Sipek, David Tucker, Christine Verellen-Dumoulin, Diana Wellesley, Helen Dolk

Journal:

 

What are the long term trends in the total (live births, fetal deaths, and terminations of pregnancy for fetal anomaly) and live birth prevalence of neural tube defects (NTD) in Europe, where many countries have issued recommendations for folic acid supplementation but a policy for ...

Last Updated: 25 Nov 2015

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Prevalence of congenital defects including selected neural tube defects in Nepal: results from a health survey.
 

Author(s): Shiva Bhandari, Jamuna Tamrakar Sayami, Ricky Raj K C, Megha Raj Banjara

Journal:

 

In resource-limited nations like Nepal, congenital defects, including neural tube defects (NTDs), have great public health impact. NTDs and a few other congenital defects can be prevented by micronutrient supplementation. Without proper research regarding such defects, it is difficult ...

Last Updated: 22 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neural tube defects" returned 70 free, full-text review articles on human participants. First 3 results:

Birth prevalence of neural tube defects and orofacial clefts in India: a systematic review and meta-analysis.
 

Author(s): Komal Preet Allagh, B R Shamanna, Gudlavalleti V S Murthy, Andy R Ness, Pat Doyle, Sutapa B Neogi, Hira B Pant,

Journal:

 

In the last two decades, India has witnessed a substantial decrease in infant mortality attributed to infectious disease and malnutrition. However, the mortality attributed to birth defects remains constant. Studies on the prevalence of birth defects such as neural tube defects and ...

Last Updated: 15 Mar 2015

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Uronephrological outcomes of patients with neural tube defects. Does a spina bifida clinic make a difference?
 

Author(s): Hamdan H Al-Hazmi, Mahmoud S Trbay, Abdulmonem B Gomha, Ahmad A Elderwy, Amenah J Khatab, Khalid F Neel

Journal: Saudi Med J. 2014 Dec;35 Suppl 1():S64-7.

 

To review the uronephrological outcomes of myelomeningocele (MMC) patients attending a Spina Bifida Clinic.

Last Updated: 31 Dec 2014

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Classification, clinical features, and genetics of neural tube defects.
 

Author(s): Mustafa A Salih, Waleed R Murshid, Mohammed Z Seidahmed

Journal: Saudi Med J. 2014 Dec;35 Suppl 1():S5-S14.

 

Neural tube defects (NTDs) constitute a major health burden (0.5-2/1000 pregnancies worldwide), and remain a preventable cause of still birth, neonatal, and infant death, or significant lifelong handicaps. The malformations result from failure of the neural folds to fuse in the midline, ...

Last Updated: 31 Dec 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetics of Neural Tube Defects
 

Status: Recruiting

Condition Summary: Neural Tube Defects

 

Last Updated: 2 Dec 2010

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Fetoscopic Meningomyelocele Repair Study
 

Status: Recruiting

Condition Summary: Neural Tube Defect

 

Last Updated: 24 May 2016

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Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
 

Status: Recruiting

Condition Summary: Spinal Cord Injuries; Cerebral Palsy; Spinal Dysraphism; Brain Injuries; Spina Bifida; Traumatic Brain Injury

 

Last Updated: 28 Oct 2015

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