Neural tube defects

Common Name(s)

Neural tube defects

Neural tube defects (NTDs) refers to a group of abnormalities resulting from abnormal development of the brain, spine and/or spinal column. During the development of an affected embryo, a structure called the neural tube does not close completely as it should, resulting in a hole somewhere along the spinal column. Specific examples of types of NTDs include spina bifida, anencephaly, and encephalocele. Symptoms vary depending on the type of NTD present but often include various forms of physical and/or mental disabilities. Many affected individuals do not survive. The exact cause of NTDs is not known but is thought to involve both genetic and nongenetic factors. Getting enough folic acid before and during pregnancy can reduce the risk of some NTDs. Treatment depends on the severity and type of defect and may include surgery.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neural tube defects" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neural tube defects" returned 395 free, full-text research articles on human participants. First 3 results:

Updated estimates of neural tube defects prevented by mandatory folic Acid fortification - United States, 1995-2011.
 

Author(s): Jennifer Williams, Cara T Mai, Joe Mulinare, Jennifer Isenburg, Timothy J Flood, Mary Ethen, Barbara Frohnert, Russell S Kirby,

Journal: MMWR Morb. Mortal. Wkly. Rep.. 2015 Jan;64(1):1-5.

 

In 1992, the U.S. Public Health Service recommended that all women capable of becoming pregnant consume 400 µg of folic acid daily to prevent neural tube defects (NTDs). NTDs are major birth defects of the brain and spine that occur early in pregnancy as a result of improper closure ...

Last Updated: 16 Jan 2015

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Junctional neurulation: a unique developmental program shaping a discrete region of the spinal cord highly susceptible to neural tube defects.
 

Author(s): Alwyn Dady, Emmanuelle Havis, Virginie Escriou, Martin Catala, Jean-Loup Duband

Journal: J. Neurosci.. 2014 Sep;34(39):13208-21.

 

In higher vertebrates, the primordium of the nervous system, the neural tube, is shaped along the rostrocaudal axis through two consecutive, radically different processes referred to as primary and secondary neurulation. Failures in neurulation lead to severe anomalies of the nervous ...

Last Updated: 25 Sep 2014

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Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model.
 

Author(s): Krista S Crider, Owen Devine, Ling Hao, Nicole F Dowling, Song Li, Anne M Molloy, Zhu Li, Jianghui Zhu, Robert J Berry

Journal:

 

To determine an optimal population red blood cell (RBC) folate concentration for the prevention of neural tube birth defects.

Last Updated: 30 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neural tube defects" returned 49 free, full-text review articles on human participants. First 3 results:

Folate deficiency and folic acid supplementation: the prevention of neural-tube defects and congenital heart defects.
 

Author(s): Andrew E Czeizel, Istvan Dudás, Attila Vereczkey, Ferenc Bánhidy

Journal:

 

Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of this review paper is to show the characteristics of common and severe neural-tube defects together with congenital heart defects (CHD) as vitamin deficiencies play a role in their origin. ...

Last Updated: 28 Nov 2013

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Modeling anterior development in mice: diet as modulator of risk for neural tube defects.
 

Author(s): Claudia Kappen

Journal: Am J Med Genet C Semin Med Genet. 2013 Nov;163C(4):333-56.

 

Head morphogenesis is a complex process that is controlled by multiple signaling centers. The most common defects of cranial development are craniofacial defects, such as cleft lip and cleft palate, and neural tube defects, such as anencephaly and encephalocoele in humans. More than ...

Last Updated: 29 Oct 2013

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Neural tube defects, folate, and immune modulation.
 

Author(s): Kerina J Denny, Angela Jeanes, Kristin Fathe, Richard H Finnell, Stephen M Taylor, Trent M Woodruff

Journal: Birth Defects Res. Part A Clin. Mol. Teratol.. 2013 Sep;97(9):602-9.

 

Periconceptional supplementation with folic acid has led to a significant worldwide reduction in the incidence of neural tube defects (NTDs). However, despite increasing awareness of the benefits of folic acid supplementation and the implementation of food fortification programs in ...

Last Updated: 30 Sep 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetics of Neural Tube Defects
 

Status: Recruiting

Condition Summary: Neural Tube Defects

 

Last Updated: 2 Dec 2010

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Prevention of Neural Tube Defects by Inositol in Conjunction With Folic Acid (PONTI Study)
 

Status: Recruiting

Condition Summary: Recurrent Neural Tube Defects

 

Last Updated: 27 Mar 2007

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Fetoscopic Meningomyelocele Repair Study
 

Status: Recruiting

Condition Summary: Neural Tube Defect

 

Last Updated: 22 Dec 2014

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