Neural tube defects

Common Name(s)

Neural tube defects

Neural tube defects (NTDs) refers to a group of abnormalities resulting from abnormal development of the brain, spine and/or spinal column. During the development of an affected embryo, a structure called the neural tube does not close completely as it should, resulting in a hole somewhere along the spinal column. Specific examples of types of NTDs include spina bifida, anencephaly, and encephalocele. Symptoms vary depending on the type of NTD present but often include various forms of physical and/or mental disabilities. Many affected individuals do not survive. The exact cause of NTDs is not known but is thought to involve both genetic and nongenetic factors. Getting enough folic acid before and during pregnancy can reduce the risk of some NTDs. Treatment depends on the severity and type of defect and may include surgery.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neural tube defects" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neural tube defects" returned 430 free, full-text research articles on human participants. First 3 results:

Time trends in the prevalence and epidemiological characteristics of neural tube defects in Liaoning Province, China, 2006-2015: A population-based study.
 

Author(s): Tie-Ning Zhang, Ting-Ting Gong, Yan-Ling Chen, Qi-Jun Wu, Yuan Zhang, Cheng-Zhi Jiang, Jing Li, Li-Li Li, Chen Zhou, Yan-Hong Huang

Journal: Oncotarget. 2017 Mar;8(10):17092-17104.

 

To evaluate the time trends in the prevalence of neural tube defects and all their subtypes as well as to identify the epidemiological characteristics of these malformations documented in the Liaoning Province of northeast China from 2006 to 2015. This was a population-based observational ...

Last Updated: 31 Dec 1969

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Using state and provincial surveillance programs to reduce risk of recurrence of neural tube defects in the United States and Canada: A missed opportunity?
 

Author(s): Timothy J Flood, Chelsea M Rienks, Alina L Flores, Cara T Mai, Barbara K Frohnert, Rachel E Rutkowski, Jane A Evans, Russell S Kirby

Journal: Birth Defects Res. Part A Clin. Mol. Teratol.. 2016 Nov;106(11):875-880.

 

Once a woman has had a fetus or infant affected with a neural tube defect (NTD), the risk of recurrence is approximately 3%. This risk can be significantly reduced by folic acid supplement consumption during the periconceptional period; however, this requires women at risk to be adequately ...

Last Updated: 31 Dec 1969

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Research: Prevalence of neural tube defects Khartoum, Sudan August 2014-July 2015.
 

Author(s): Ilham M Omer, Osman M Abdullah, Inaam N Mohammed, Lina A Abbasher

Journal:

 

Neural tube defects (NTDs) are birth defects that results from failure of the neural tube to develop properly during early pregnancy.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neural tube defects" returned 70 free, full-text review articles on human participants. First 3 results:

Nutrition, One-Carbon Metabolism and Neural Tube Defects: A Review.
 

Author(s): Kelei Li, Mark L Wahlqvist, Duo Li

Journal:

 

Neural tube defects (NTDs) are a group of severe congenital malformations, induced by the combined effects of genes and the environment. The most valuable finding so far has been the protective effect of folic acid supplementation against NTDs. However, many women do not take folic ...

Last Updated: 31 Dec 1969

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Neighborhood Deprivation and Risk of Congenital Heart Defects, Neural Tube Defects and Orofacial Clefts: A Systematic Review and Meta-Analysis.
 

Author(s): Séverine Deguen, Wahida Kihal, Maxime Jeanjean, Cindy Padilla, Denis Zmirou-Navier

Journal:

 

We conducted this systematic review and meta-analysis to address the open question of a possible association between the socioeconomic level of the neighborhoods in which pregnant women live and the risk of Congenital Heart Defects (CHDs), Neural Tube Defects (NTDs) and OroFacial Clefts (OFCs).

Last Updated: 31 Dec 1969

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Describing the Prevalence of Neural Tube Defects Worldwide: A Systematic Literature Review.
 

Author(s): Ibrahim Zaganjor, Ahlia Sekkarie, Becky L Tsang, Jennifer Williams, Hilda Razzaghi, Joseph Mulinare, Joseph E Sniezek, Michael J Cannon, Jorge Rosenthal

Journal:

 

Folate-sensitive neural tube defects (NTDs) are an important, preventable cause of morbidity and mortality worldwide. There is a need to describe the current global burden of NTDs and identify gaps in available NTD data.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fetoscopic Meningomyelocele Repair Study
 

Status: Recruiting

Condition Summary: Neural Tube Defect

 

Last Updated: 22 Jun 2017

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Open Myelomeningocele Repair With High Maternal BMI
 

Status: Recruiting

Condition Summary: Neural Tube Defect

 

Last Updated: 3 Feb 2017

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EVALUATION OF THE SAFETY AND EFFICACY OF ADJUSTABLE CONTINENT THERAPY IN CHILDREN WITH SPINAL DYSRAPHISM.
 

Status: Not yet recruiting

Condition Summary: Neurogenic Bladder Due to Spinal Dysraphism

 

Last Updated: 21 Nov 2017

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