Microcytic anemia

Common Name(s)

Microcytic anemia

{8:Finberg et al. (2008)} referred to this phenotype as iron-refractory iron deficiency anemia (IRIDA) and reviewed the key features: a congenital hypochromic, microcytic anemia; a very low mean corpuscular erythrocyte volume; a low transferrin saturation; abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron; and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron. The authors noted that although urinary levels of hepcidin ({606464}) are typically undetectable in individuals with iron deficiency, in 5 individuals with IRIDA urinary hepcidin/creatinine ratios were within or above the normal range.
 

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Condition Specific Organizations

Following organizations serve the condition "Microcytic anemia" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Microcytic anemia" returned 33 free, full-text research articles on human participants. First 3 results:

Discrimination index of microcytic anemia in young soldiers: a single institutional analysis.
 

Author(s): Tzu-Chuan Huang, Yi-Ying Wu, Yu-Guang Chen, Shiue-Wei Lai, Sheng-Cheng Wu, Ren-Hua Ye, Chieh-Sheng Lu, Jia-Hong Chen

Journal:

 

The common differential diagnosis of microcytic anemia in young Asian men includes iron deficiency anemia (IDA), α-thalassemia (αT) and β-thalassemia (βT). In this study, we aimed to distinguish between these diseases in a distinct population of young men using a specific index.

Last Updated: 14 Feb 2015

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Compound heterozygosity for KLF1 mutations is associated with microcytic hypochromic anemia and increased fetal hemoglobin.
 

Author(s): Jiwei Huang, Xinhua Zhang, Dun Liu, Xiaofeng Wei, Xuan Shang, Fu Xiong, Lihua Yu, Xiaolin Yin, Xiangmin Xu

Journal: Eur. J. Hum. Genet.. 2015 Oct;23(10):1341-8.

 

Krüppel-like factor 1 (KLF1) regulates erythroid lineage commitment, globin switching, and the terminal maturation of red blood cells. Variants in human KLF1 have been identified as an important causative factor in a wide spectrum of phenotypes. This study investigated two unrelated ...

Last Updated: 17 Sep 2015

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Microcytic anemia.
 

Author(s): Thomas G DeLoughery

Journal: N. Engl. J. Med.. 2014 Dec;371(26):2537.

 

Last Updated: 25 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Microcytic anemia" returned 3 free, full-text review articles on human participants. First 3 results:

Discriminant indices for distinguishing thalassemia and iron deficiency in patients with microcytic anemia: a meta-analysis.
 

Author(s): Johannes J M L Hoffmann, Eloísa Urrechaga, Urko Aguirre

Journal: Clin. Chem. Lab. Med.. 2015 Nov;53(12):1883-94.

 

More than 40 mathematical indices have been proposed in the hematological literature for discriminating between iron deficiency anemia and thalassemia trait in subjects with microcytic red blood cells (RBCs). None of these discriminant indices is 100% sensitive and specific and also ...

Last Updated: 5 Nov 2015

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Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis.
 

Author(s): Achille Iolascon, Luigia De Falco, Carole Beaumont

Journal: Haematologica. 2009 Mar;94(3):395-408.

 

Microcytic anemia is the most commonly encountered anemia in general medical practice. Nutritional iron deficiency and beta thalassemia trait are the primary causes in pediatrics, whereas bleeding disorders and anemia of chronic disease are common in adulthood. Microcytic hypochromic ...

Last Updated: 2 Mar 2009

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alpha-globin gene deletion and point mutation analysis among in Iranian patients with microcytic hypochromic anemia.
 

Author(s): Masoud Garshasbi, Christian Oberkanins, Hai Yang Law, Maryam Neishabury, Roxana Kariminejad, Hossein Najmabadi

Journal: Haematologica. 2003 Oct;88(10):1196-7.

 

We tested 67 Iranian individuals, presenting with low mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) levels, normal hemoglobin electrophoresis and iron status, for the presence of twelve common alpha-thalassemia gene deletions and point mutations. Five different ...

Last Updated: 13 Oct 2003

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Triferic IRIDA Protocol
 

Status: Not yet recruiting

Condition Summary: Iron-Refractory Iron-Deficiency Anemia

 

Last Updated: 14 Sep 2016

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