Mast syndrome

Common Name(s)

Mast syndrome

Mast syndrome is an autosomal recessive complicated form of hereditary spastic paraplegia in which progressive spastic paraparesis is associated in more advanced cases with cognitive decline, dementia, and other neurologic abnormalities. Symptom onset usually occurs in adulthood, and the disorder is progressive with variable severity. Brain imaging shows thinning of the corpus callosum. The disorder occurs with high frequency in the Old Order Amish (summary by {3:Simpson et al., 2003)}. For a discussion of genetic heterogeneity of autosomal recessive spastic paraplegia, see SPG5A ({270800}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mast syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mast syndrome" returned 24 free, full-text research articles on human participants. First 3 results:

Mast cell activation syndrome as a significant comorbidity in sickle cell disease.
 

Author(s): Lawrence B Afrin

Journal: Am. J. Med. Sci.. 2014 Dec;348(6):460-4.

 

Some sickle cell anemia (SCA) patients suffer significantly worse phenotypes than others. Causes of such disparities are incompletely understood. Comorbid chronic inflammation likely is a factor. Recently, mast cell (MC) activation (creating an inflammatory state) was found to be ...

Last Updated: 21 Nov 2014

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Improved metastatic uterine papillary serous cancer outcome with treatment of mast cell activation syndrome.
 

Author(s): Lawrence B Afrin, Laura S Spruill, Stephen I Schabel, Jennifer L Young-Pierce

Journal: Oncology (Williston Park, N.Y.). 2014 Feb;28(2):129-31, 134.

 

Last Updated: 7 Apr 2014

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A clinicopathologic study of 24 cases of systemic mastocytosis involving the gastrointestinal tract and assessment of mucosal mast cell density in irritable bowel syndrome and asymptomatic patients.
 

Author(s): Leona A Doyle, Golrokh J Sepehr, Matthew J Hamilton, Cem Akin, Mariana C Castells, Jason L Hornick

Journal: Am. J. Surg. Pathol.. 2014 Jun;38(6):832-43.

 

Counting mast cells in gastrointestinal (GI) mucosal biopsies is becoming an increasingly common practice. The primary reason for this exercise is to evaluate for possible involvement by systemic mastocytosis (SM). However, the features of mastocytosis in GI biopsies are not well ...

Last Updated: 13 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mast syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

Immunology and clinical manifestations of non-clonal mast cell activation syndrome.
 

Author(s): Juan-Carlos Cardet, Mariana C Castells, Matthew J Hamilton

Journal: Curr Allergy Asthma Rep. 2013 Feb;13(1):10-8.

 

There is a spectrum of disorders that clinically manifest as a result of mast cell activation. A non-clonal form has emerged in the literature where many of the clinical features of systemic mastocytosis are shared despite having a distinct mast cell biology. In this review, we summarize ...

Last Updated: 14 Jan 2013

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Mast cells and metabolic syndrome.
 

Author(s): Jie Zhang, Guo-Ping Shi

Journal: Biochim. Biophys. Acta. 2012 Jan;1822(1):14-20.

 

Mast cells are critical effectors in the development of allergic diseases and in many immunoglobulin E-mediated immune responses. These cells exert their physiological and pathological activities by releasing granules containing histamine, cytokines, chemokines, and proteases, including ...

Last Updated: 5 Dec 2011

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Irritable bowel syndrome immune hypothesis. Part one: the role of lymphocytes and mast cells.
 

Author(s): M Ortiz-Lucas, P Saz-Peiró, J J Sebastián-Domingo

Journal: Rev Esp Enferm Dig. 2010 Nov;102(11):637-47.

 

To review the available evidence on the role of T-lymphocytes and mast cells in the etiopathogenesis of Irritable Bowel Syndrome.

Last Updated: 14 Dec 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pathogenesis of Physical Induced Urticarial Syndromes
 

Status: Recruiting

Condition Summary: Autoinflammatory Syndromes; Physical Urticaria

 

Last Updated: 11 Jun 2015

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Registry of Older Patients With Cancer
 

Status: Recruiting

Condition Summary: Chronic Myeloproliferative Disorders; Cognitive/Functional Effects; Leukemia; Lymphoma; Lymphoproliferative Disorder; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms; Unspecified Adult Solid Tumor, Protocol Specific

 

Last Updated: 22 Jun 2015

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Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer
 

Status: Recruiting

Condition Summary: Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Lymphoproliferative Disorder; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms; Nonmalignant Neoplasm

 

Last Updated: 18 Nov 2013

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