Major depressive disorder

Common Name(s)

Major depressive disorder, Major depression

Major depressive disorder is a serious form of depression which involves some combination of the following symptoms: sadness, inability to concentrate, difficulty sleeping (insomnia) or sleeping too much, feeling very tired (fatigue), weight gain or loss, irritability, loss of interest or pleasure in activities, feelings of guilt, worthlessness or hopelessness, and thoughts of suicide. It affects a person’s thoughts, moods, behavior and physical health. A major depressive episode usually lasts more than 2 weeks and interferes with a person’s ability to perform daily functions. Some people may only experience one episode, but others may experience multiple episodes in their lifetime. The cause of major depressive disorder is unknown. It may affect anyone of any age, race, ethnicity, gender or socioeconomic level. Certain factors increase a person’s risk including experiencing traumatic or stressful event(s), having a serious or chronic illness or anxiety related disorder, or having a family history of depression. Those who abuse alcohol or drugs are also at an increased risk.

Major depressive disorder is a serious illness. Without treatment an episode may continue with symptoms becoming increasingly more serious. Major depressive episodes may lead a person to feel that life is not worth living and to commit suicide. If you or someone you know is having thoughts of suicide call a suicide hot line or go to an emergency medical center. It is important to realize that depression is treatable. Treatment may include support groups, medication, talk therapy, or other strategies. Talk to your doctor to decide on the best treatment options if you or a family member is affected by major depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. See also depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Major depressive disorder" returned 776 free, full-text research articles on human participants. First 3 results:

Zhiqiaochuanxiong decoction for major depressive disorder complicated by functional dyspepsia: a case report with fast-acting efficacy.
 

Author(s): Min Luo, Xi Huang, Yang Wang, Ping Ren

Journal: J Tradit Chin Med. 2015 Dec;35(6):697-702.

 

To introduce a clinical case from Professor Huang Xi from Xiangya Hospital in traditional Chinese medical (TCM) treatment for a major depressive disorder (MDD) complicated by functional dyspepsia (FD).

Last Updated: 8 Jan 2016

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Major depressive disorder in chronic heart failure patients: Does silent cerebral infarction cause major depressive disorder in this patient population?
 

Author(s): Güliz Kozdağ, İrem Yaluğ, Nagihan İnan, Gökhan Ertaş, Macit Selekler, Hüseyin Kutlu, Ayşe Kutlu, Ender Emre, Metin Çetin, Dilek Ural

Journal: Turk Kardiyol Dern Ars. 2015 Sep;43(6):505-12.

 

Depression frequently occurs in patients with heart failure as similar pathophysiological mechanisms present in both these diseases. Patients with dilated cardiomyopathy (DCM) have a high incidence of clinically asymptomatic silent cerebral infarction (SCI). This study aimed to evaluate ...

Last Updated: 14 Sep 2015

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Adjunctive brexpiprazole 1 and 3 mg for patients with major depressive disorder following inadequate response to antidepressants: a phase 3, randomized, double-blind study.
 

Author(s): Michael E Thase, James M Youakim, Aleksandar Skuban, Mary Hobart, Peter Zhang, Robert D McQuade, Margaretta Nyilas, William H Carson, Raymond Sanchez, Hans Eriksson

Journal: J Clin Psychiatry. 2015 Sep;76(9):1232-40.

 

To evaluate efficacy, safety, and tolerability of brexpiprazole adjunctive to antidepressant treatments (ADTs) in patients with major depressive disorder (as defined by DSM-IV-TR criteria) with inadequate response to ADTs.

Last Updated: 12 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Major depressive disorder" returned 99 free, full-text review articles on human participants. First 3 results:

Antidepressants and their effect on cognition in major depressive disorder.
 

Author(s): George I Papakostas

Journal: J Clin Psychiatry. 2015 Aug;76(8):e1046.

 

Cognitive functioning is a symptom of major depressive disorder (MDD) that deserves particular attention by clinicians and researchers. Despite the fact that cognitive dysfunction represents a symptom of MDD as well as a functional outcome measure, cognition has been insufficiently ...

Last Updated: 4 Sep 2015

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Impact of untreated major depressive disorder on cognition and daily function.
 

Author(s): Larry Culpepper

Journal: J Clin Psychiatry. 2015 Jul;76(7):e901.

 

Cognitive symptoms are an emerging clinical focus in patients with major depressive disorder. Deficits in executive function, memory, attention, and processing speed, as well as negative cognitive bias, can contribute to low mood symptoms and reduced occupational and social functioning. ...

Last Updated: 3 Aug 2015

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Using biomarkers to predict treatment response in major depressive disorder: evidence from past and present studies.
 

Author(s): Michael E Thase

Journal: Dialogues Clin Neurosci. 2014 Dec;16(4):539-44.

 

Major depressive disorder (MDD) is a heterogeneous condition with a variable response to a wide range of treatments. Despite intensive efforts, no biomarker has been identified to date that can reliably predict response or non-response to any form of treatment, nor has one been identified ...

Last Updated: 3 Mar 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial
 

Status: Recruiting

Condition Summary: Major Depressive Disorder; Major Depressive Disorder, Recurrent, Unspecified; Major Depressive Disorder, Single Episode, Unspecified

 

Last Updated: 30 Nov 2015

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Study to Treat Major Depressive Disorder (MDD) With a New Medication
 

Status: Recruiting

Condition Summary: Major Depressive Disorder; Depression

 

Last Updated: 15 Jul 2015

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Major Depressive Disorder - Understanding The Link Between The Brain And The Heart
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 16 Dec 2013

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