Major depressive disorder

Common Name(s)

Major depressive disorder, Major depression

Major depressive disorder is a serious form of depression which involves some combination of the following symptoms: sadness, inability to concentrate, difficulty sleeping (insomnia) or sleeping too much, feeling very tired (fatigue), weight gain or loss, irritability, loss of interest or pleasure in activities, feelings of guilt, worthlessness or hopelessness, and thoughts of suicide. It affects a person’s thoughts, moods, behavior and physical health. A major depressive episode usually lasts more than 2 weeks and interferes with a person’s ability to perform daily functions. Some people may only experience one episode, but others may experience multiple episodes in their lifetime. The cause of major depressive disorder is unknown. It may affect anyone of any age, race, ethnicity, gender or socioeconomic level. Certain factors increase a person’s risk including experiencing traumatic or stressful event(s), having a serious or chronic illness or anxiety related disorder, or having a family history of depression. Those who abuse alcohol or drugs are also at an increased risk.

Major depressive disorder is a serious illness. Without treatment an episode may continue with symptoms becoming increasingly more serious. Major depressive episodes may lead a person to feel that life is not worth living and to commit suicide. If you or someone you know is having thoughts of suicide call a suicide hot line or go to an emergency medical center. It is important to realize that depression is treatable. Treatment may include support groups, medication, talk therapy, or other strategies. Talk to your doctor to decide on the best treatment options if you or a family member is affected by major depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. See also depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Major depressive disorder" returned 561 free, full-text research articles on human participants. First 3 results:

Coding of adverse events of suicidality in clinical study reports of duloxetine for the treatment of major depressive disorder: descriptive study.
 

Author(s): Emma Maund, Britta Tendal, Asbjørn Hróbjartsson, Andreas Lundh, Peter C Gøtzsche

Journal:

 

To assess the effects of coding and coding conventions on summaries and tabulations of adverse events data on suicidality within clinical study reports.

Last Updated: 6 Jun 2014

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Disorder-specific cognitive profiles in major depressive disorder and generalized anxiety disorder.
 

Author(s): Sanne M Hendriks, Carmilla M M Licht, Jan Spijker, Aartjan T F Beekman, Florian Hardeveld, Ron de Graaf, Brenda W J H Penninx

Journal:

 

This investigation examines differences in cognitive profiles in subjects with major depressive disorder (MDD) and generalized anxiety disorder (GAD).

Last Updated: 8 Apr 2014

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Level of agreement between self-rated and clinician-rated instruments when measuring major depressive disorder in the Thai elderly: a 1-year assessment as part of the THAISAD study.
 

Author(s): Nahathai Wongpakaran, Tinakon Wongpakaran, Kamonporn Wannarit, Nattha Saisavoey, Manee Pinyopornpanish, Peeraphon Lueboonthavatchai, Nattaporn Apisiridej, Thawanrat Srichan, Ruk Ruktrakul, Sirina Satthapisit, Daochompu Nakawiro, Thanita Hiranyatheb, Anakevich Temboonkiat, Namtip Tubtimtong, Sukanya Rakkhajeekul, Boonsanong Wongtanoi, Sitthinant Tanchakvaranont, Putipong Bookkamana, Usaree Srisutasanavong, Raviwan Nivataphand, Donruedee Petchsuwan

Journal:

 

Whether self-reporting and clinician-rated depression scales correlate well with one another when applied to older adults has not been well studied, particularly among Asian samples. This study aimed to compare the level of agreement among measurements used in assessing major depressive ...

Last Updated: 5 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Major depressive disorder" returned 75 free, full-text review articles on human participants. First 3 results:

Cognitive effects of pharmacotherapy for major depressive disorder: a systematic review.
 

Author(s): Richard S E Keefe, Shawn M McClintock, Robert M Roth, P Murali Doraiswamy, Steven Tiger, Manisha Madhoo

Journal: J Clin Psychiatry. 2014 Aug;75(8):864-76.

 

Cognitive impairment frequently accompanies major depressive disorder (MDD) and can persist during remission. This review examined pharmacotherapy effects on cognitive function in MDD.

Last Updated: 6 Sep 2014

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Benefits and harms in clinical trials of duloxetine for treatment of major depressive disorder: comparison of clinical study reports, trial registries, and publications.
 

Author(s): Emma Maund, Britta Tendal, Asbjørn Hróbjartsson, Karsten Juhl Jørgensen, Andreas Lundh, Jeppe Schroll, Peter C Gøtzsche

Journal:

 

To determine, using research on duloxetine for major depressive disorder as an example, if there are inconsistencies between protocols, clinical study reports, and main publicly available sources (journal articles and trial registries), and within clinical study reports themselves, ...

Last Updated: 6 Jun 2014

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The mistreatment of major depressive disorder.
 

Author(s): Joel Paris

Journal: Can J Psychiatry. 2014 Mar;59(3):148-51.

 

To examine the effects of classification on treatment in major depressive disorder (MDD).

Last Updated: 2 Jun 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial
 

Status: Recruiting

Condition Summary: Major Depressive Disorder; Major Depressive Disorder, Recurrent, Unspecified; Major Depressive Disorder, Single Episode, Unspecified

 

Last Updated: 1 Nov 2014

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Study to Treat Major Depressive Disorder (MDD) With a New Medication
 

Status: Not yet recruiting

Condition Summary: Major Depressive Disorder; Depression

 

Last Updated: 23 May 2014

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Major Depressive Disorder - Understanding The Link Between The Brain And The Heart
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 16 Dec 2013

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