Major depressive disorder

Common Name(s)

Major depressive disorder, Major depression

Major depressive disorder is a serious form of depression which involves some combination of the following symptoms: sadness, inability to concentrate, difficulty sleeping (insomnia) or sleeping too much, feeling very tired (fatigue), weight gain or loss, irritability, loss of interest or pleasure in activities, feelings of guilt, worthlessness or hopelessness, and thoughts of suicide. It affects a person’s thoughts, moods, behavior and physical health. A major depressive episode usually lasts more than 2 weeks and interferes with a person’s ability to perform daily functions. Some people may only experience one episode, but others may experience multiple episodes in their lifetime. The cause of major depressive disorder is unknown. It may affect anyone of any age, race, ethnicity, gender or socioeconomic level. Certain factors increase a person’s risk including experiencing traumatic or stressful event(s), having a serious or chronic illness or anxiety related disorder, or having a family history of depression. Those who abuse alcohol or drugs are also at an increased risk.

Major depressive disorder is a serious illness. Without treatment an episode may continue with symptoms becoming increasingly more serious. Major depressive episodes may lead a person to feel that life is not worth living and to commit suicide. If you or someone you know is having thoughts of suicide call a suicide hot line or go to an emergency medical center. It is important to realize that depression is treatable. Treatment may include support groups, medication, talk therapy, or other strategies. Talk to your doctor to decide on the best treatment options if you or a family member is affected by major depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. See also depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Major depressive disorder" returned 1281 free, full-text research articles on human participants. First 3 results:

Cost-Effectiveness of a Pharmacogenetic Test to Guide Treatment for Major Depressive Disorder.
 

Author(s): Erik J Groessl, Steven R Tally, Naomi Hillery, Alejandra Maciel, Jorge A Garces

Journal: J Manag Care Spec Pharm. 2018 Aug;24(8):726-734.

 

Recent clinical trials indicate that pharmacogenetic-guided treatment of major depressive disorder (MDD) results in higher treatment response rates by genetically matching patients to medications and avoiding a trial-and-error process.

Last Updated: 31 Dec 1969

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Migraine and greater pain symptoms at 10-year follow-up among patients with major depressive disorder.
 

Author(s): Ching-I Hung, Chia-Yih Liu, Ching-Hui Yang, Shuu-Jiun Wang

Journal:

 

No study has investigated the associations of migraine with pain symptoms over a ten-year period among outpatients with major depressive disorder (MDD). This study aimed to investigate this issue.

Last Updated: 31 Dec 1969

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Optimising first- and second-line treatment strategies for untreated major depressive disorder - the SUN☺D study: a pragmatic, multi-centre, assessor-blinded randomised controlled trial.
 

Author(s): Tadashi Kato, Toshi A Furukawa, Akio Mantani, Ken'ichi Kurata, Hajime Kubouchi, Susumu Hirota, Hirotoshi Sato, Kazuyuki Sugishita, Bun Chino, Kahori Itoh, Yoshio Ikeda, Yoshihiro Shinagawa, Masaki Kondo, Yasumasa Okamoto, Hirokazu Fujita, Motomu Suga, Shingo Yasumoto, Naohisa Tsujino, Takeshi Inoue, Noboru Fujise, Tatsuo Akechi, Mitsuhiko Yamada, Shinji Shimodera, Norio Watanabe, Masatoshi Inagaki, Kazuhira Miki, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Aran Tajika, Kiyomi Shinohara, Naohiro Yonemoto, Shiro Tanaka, Qi Zhou, Gordon H Guyatt,

Journal:

 

For patients starting treatment for depression, current guidelines recommend titrating the antidepressant dosage to the maximum of the licenced range if tolerated. When patients do not achieve remission within several weeks, recommendations include adding or switching to another antidepressant. ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Major depressive disorder" returned 195 free, full-text review articles on human participants. First 3 results:

Does Physical Exercise Increase Brain-Derived Neurotrophic Factor in Major Depressive Disorder? A Meta-Analysis.
 

Author(s): Yusuke Kurebayashi, Junichi Otaki

Journal: Psychiatr Danub. 2018 Jun;30(2):129-135.

 

Major depressive disorder (MDD) is one of the most common disorders in the world, but is generally refractory to antidepressant treatment. However, physical exercise has been demonstrated to improve MDD symptoms, though the mechanism through which this is achieved is not clear. This ...

Last Updated: 31 Dec 1969

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Efficacy and moderators of psychological interventions in treating subclinical symptoms of depression and preventing major depressive disorder onsets: protocol for an individual patient data meta-analysis of randomised controlled trials.
 

Author(s): David D Ebert, Claudia Buntrock, Jo Annika Reins, Johannes Zimmermann, Pim Cuijpers

Journal:

 

The long-term effectiveness of psychological interventions for the treatment of subthreshold depression and the prevention of depression is unclear and effects vary among subgroups of patients, indicating that not all patients profit from such interventions. Randomised clinical trials ...

Last Updated: 31 Dec 1969

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Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis.
 

Author(s): Andrea Cipriani, Toshi A Furukawa, Georgia Salanti, Anna Chaimani, Lauren Z Atkinson, Yusuke Ogawa, Stefan Leucht, Henricus G Ruhe, Erick H Turner, Julian P T Higgins, Matthias Egger, Nozomi Takeshima, Yu Hayasaka, Hissei Imai, Kiyomi Shinohara, Aran Tajika, John P A Ioannidis, John R Geddes

Journal: Lancet. 2018 04;391(10128):1357-1366.

 

Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological treatments are available; however, because of inadequate resources, antidepressants are used more frequently than psychological ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fish Oil as Adjunct Treatment for Major Depressive Disorder
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 6 Oct 2017

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Open Label Ketamine Treatment for Major Depressive Disorder in Veterans
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 1 Jun 2018

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The Safety and Efficacy of Brexpiprazole as Adjunctive Therapy in the Treatment of Major Depressive Disorder
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 21 Aug 2018

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