Major depressive disorder

Common Name(s)

Major depressive disorder, Major depression

Major depressive disorder is a serious form of depression which involves some combination of the following symptoms: sadness, inability to concentrate, difficulty sleeping (insomnia) or sleeping too much, feeling very tired (fatigue), weight gain or loss, irritability, loss of interest or pleasure in activities, feelings of guilt, worthlessness or hopelessness, and thoughts of suicide. It affects a person’s thoughts, moods, behavior and physical health. A major depressive episode usually lasts more than 2 weeks and interferes with a person’s ability to perform daily functions. Some people may only experience one episode, but others may experience multiple episodes in their lifetime. The cause of major depressive disorder is unknown. It may affect anyone of any age, race, ethnicity, gender or socioeconomic level. Certain factors increase a person’s risk including experiencing traumatic or stressful event(s), having a serious or chronic illness or anxiety related disorder, or having a family history of depression. Those who abuse alcohol or drugs are also at an increased risk.

Major depressive disorder is a serious illness. Without treatment an episode may continue with symptoms becoming increasingly more serious. Major depressive episodes may lead a person to feel that life is not worth living and to commit suicide. If you or someone you know is having thoughts of suicide call a suicide hot line or go to an emergency medical center. It is important to realize that depression is treatable. Treatment may include support groups, medication, talk therapy, or other strategies. Talk to your doctor to decide on the best treatment options if you or a family member is affected by major depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. See also depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Major depressive disorder" returned 660 free, full-text research articles on human participants. First 3 results:

Urinary neopterine levels in patients with major depressive disorder: alterations after treatment with paroxetine and comparison with healthy controls.
 

Author(s): Ibrahim Taymur, Kadir Özdel, Nurper Erberk Özen, Buket Belkiz Güngör, Murad Atmaca

Journal: Psychiatr Danub. 2015 Mar;27(1):25-30.

 

A close relationship has been shown between mood disorders and pteridine levels. The aim of this study was to examine alterations in the urine neopterine levels of patients with major depressive disorder (MDD) who responded to paroxetine during the initial treatment and to compare ...

Last Updated: 10 Mar 2015

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MDDScore: confirmation of a blood test to aid in the diagnosis of major depressive disorder.
 

Author(s): John A Bilello, Linda M Thurmond, Katie M Smith, Bo Pi, Robert Rubin, Suzin M Wright, Floyd Taub, Michael E Henry, Richard C Shelton, George I Papakostas

Journal: J Clin Psychiatry. 2015 Feb;76(2):e199-206.

 

Previously, a biomarker panel was developed for use as an aid to major depressive disorder (MDD) diagnosis; it consisted of 9 biomarkers associated with the neurotrophic, metabolic, inflammatory, and hypothalamic-pituitary-adrenal axis pathways. This panel and associated algorithm ...

Last Updated: 6 Mar 2015

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The economic burden of adults with major depressive disorder in the United States (2005 and 2010).
 

Author(s): Paul E Greenberg, Andree-Anne Fournier, Tammy Sisitsky, Crystal T Pike, Ronald C Kessler

Journal: J Clin Psychiatry. 2015 Feb;76(2):155-62.

 

The economic burden of depression in the United States--including major depressive disorder (MDD), bipolar disorder, and dysthymia--was estimated at $83.1 billion in 2000. We update these findings using recent data, focusing on MDD alone and accounting for comorbid physical and psychiatric ...

Last Updated: 6 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Major depressive disorder" returned 86 free, full-text review articles on human participants. First 3 results:

Cognitive dysfunction in major depressive disorder: effects on psychosocial functioning and implications for treatment.
 

Author(s): Raymond W Lam, Sidney H Kennedy, Roger S Mclntyre, Atul Khullar

Journal: Can J Psychiatry. 2014 Dec;59(12):649-54.

 

Last Updated: 23 Feb 2015

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Identifying predictors, moderators, and mediators of antidepressant response in major depressive disorder: neuroimaging approaches.
 

Author(s): Mary L Phillips, Henry W Chase, Yvette I Sheline, Amit Etkin, Jorge R C Almeida, Thilo Deckersbach, Madhukar H Trivedi

Journal: Am J Psychiatry. 2015 Feb;172(2):124-38.

 

Despite significant advances in neuroscience and treatment development, no widely accepted biomarkers are available to inform diagnostics or identify preferred treatments for individuals with major depressive disorder.

Last Updated: 2 Feb 2015

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Differential diagnosis of bipolar disorder and major depressive disorder.
 

Author(s): R M Hirschfeld

Journal: J Affect Disord. 2014 Dec;169 Suppl 1():S12-6.

 

Patients with bipolar disorder spend approximately half of their lives symptomatic and the majority of that time suffering from symptoms of depression, which complicates the accurate diagnosis of bipolar disorder.

Last Updated: 23 Dec 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial
 

Status: Recruiting

Condition Summary: Major Depressive Disorder; Major Depressive Disorder, Recurrent, Unspecified; Major Depressive Disorder, Single Episode, Unspecified

 

Last Updated: 26 May 2015

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Study to Treat Major Depressive Disorder (MDD) With a New Medication
 

Status: Recruiting

Condition Summary: Major Depressive Disorder; Depression

 

Last Updated: 15 Jul 2015

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Major Depressive Disorder - Understanding The Link Between The Brain And The Heart
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 16 Dec 2013

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