Major depressive disorder

Common Name(s)

Major depressive disorder, Major depression

Major depressive disorder is a serious form of depression which involves some combination of the following symptoms: sadness, inability to concentrate, difficulty sleeping (insomnia) or sleeping too much, feeling very tired (fatigue), weight gain or loss, irritability, loss of interest or pleasure in activities, feelings of guilt, worthlessness or hopelessness, and thoughts of suicide. It affects a person’s thoughts, moods, behavior and physical health. A major depressive episode usually lasts more than 2 weeks and interferes with a person’s ability to perform daily functions. Some people may only experience one episode, but others may experience multiple episodes in their lifetime. The cause of major depressive disorder is unknown. It may affect anyone of any age, race, ethnicity, gender or socioeconomic level. Certain factors increase a person’s risk including experiencing traumatic or stressful event(s), having a serious or chronic illness or anxiety related disorder, or having a family history of depression. Those who abuse alcohol or drugs are also at an increased risk.

Major depressive disorder is a serious illness. Without treatment an episode may continue with symptoms becoming increasingly more serious. Major depressive episodes may lead a person to feel that life is not worth living and to commit suicide. If you or someone you know is having thoughts of suicide call a suicide hot line or go to an emergency medical center. It is important to realize that depression is treatable. Treatment may include support groups, medication, talk therapy, or other strategies. Talk to your doctor to decide on the best treatment options if you or a family member is affected by major depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. See also depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Major depressive disorder" returned 1041 free, full-text research articles on human participants. First 3 results:

Rumination mediates the relationship between overgeneral autobiographical memory and depression in patients with major depressive disorder.
 

Author(s): Yansong Liu, Xinnian Yu, Bixiu Yang, Fuquan Zhang, Wenhua Zou, Aiguo Na, Xudong Zhao, Guangzhong Yin

Journal:

 

Overgeneral autobiographical memory has been identified as a risk factor for the onset and maintenance of depression. However, little is known about the underlying mechanisms that might explain overgeneral autobiographical memory phenomenon in depression. The purpose of this study ...

Last Updated: 22 Mar 2017

Go To URL
Treatment of Major Depressive Disorder with Iyengar Yoga and Coherent Breathing: A Randomized Controlled Dosing Study.
 

Author(s): Chris C Streeter, Patricia L Gerbarg, Theodore H Whitfield, Liz Owen, Jennifer Johnston, Marisa M Silveri, Marysia Gensler, Carol L Faulkner, Cathy Mann, Mary Wixted, Anne Marie Hernon, Maren B Nyer, E Richard P Brown, John E Jensen

Journal: J Altern Complement Med. 2017 Mar;23(3):201-207.

 

The aims of this study were to assess the effects of an intervention of Iyengar yoga and coherent breathing at five breaths per minute on depressive symptoms and to determine optimal intervention yoga dosing for future studies in individuals with major depressive disorder (MDD).

Last Updated: 15 Mar 2017

Go To URL
The Major Depressive Disorder Hierarchy: Rasch Analysis of 6 items of the Hamilton Depression Scale Covering the Continuum of Depressive Syndrome.
 

Author(s): Lucas Primo de Carvalho Alves, Marcelo Pio de Almeida Fleck, Aline Boni, Neusa Sica da Rocha

Journal:

 

Melancholic features of depression (MFD) seem to be a unidimensional group of signs and symptoms. However, little importance has been given to the evaluation of what features are related to a more severe disorder. That is, what are the MFD that appear only in the most depressed patients. ...

Last Updated: 23 Jan 2017

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Major depressive disorder" returned 164 free, full-text review articles on human participants. First 3 results:

Florida Best Practice Psychotherapeutic Medication Guidelines for Adults With Major Depressive Disorder.
 

Author(s): Roger S McIntyre, Trisha Suppes, Rajiv Tandon, Michael Ostacher

Journal: J Clin Psychiatry. 2017 Jun;78(6):703-713.

 

Herein we provide the 2015 update for the Florida Best Practice Psychotherapeutic Medication Guidelines (FPG) for major depressive disorder (MDD). The FPG represent evidence-based decision support for practitioners providing care to adults with MDD.

Last Updated: 6 Jul 2017

Go To URL
Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis.
 

Author(s): Janus Christian Jakobsen, Kiran Kumar Katakam, Anne Schou, Signe Gade Hellmuth, Sandra Elkjær Stallknecht, Katja Leth-Møller, Maria Iversen, Marianne Bjørnø Banke, Iggiannguaq Juhl Petersen, Sarah Louise Klingenberg, Jesper Krogh, Sebastian Elgaard Ebert, Anne Timm, Jane Lindschou, Christian Gluud

Journal:

 

The evidence on selective serotonin reuptake inhibitors (SSRIs) for major depressive disorder is unclear.

Last Updated: 9 Feb 2017

Go To URL
Indicators of patients with major depressive disorder in need of highly specialized care: A systematic review.
 

Author(s): Frédérique C W van Krugten, Meriam Kaddouri, Maartje Goorden, Anton J L M van Balkom, Claudi L H Bockting, Frenk P M L Peeters, Leona Hakkaart-van Roijen,

Journal:

 

Early identification of patients with major depressive disorder (MDD) that cannot be managed by secondary mental health services and who require highly specialized mental healthcare could enhance need-based patient stratification. This, in turn, may reduce the number of treatment ...

Last Updated: 8 Feb 2017

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Open Label Ketamine Treatment for Major Depressive Disorder in Veterans
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 20 Jul 2017

Go to URL
Music Therapy for Major Depressive Disorder Residual Symptoms
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 4 Oct 2016

Go to URL

Last Updated: 28 Jul 2017

Go to URL