Major depressive disorder

Common Name(s)

Major depressive disorder, Major depression

Major depressive disorder is a serious form of depression which involves some combination of the following symptoms: sadness, inability to concentrate, difficulty sleeping (insomnia) or sleeping too much, feeling very tired (fatigue), weight gain or loss, irritability, loss of interest or pleasure in activities, feelings of guilt, worthlessness or hopelessness, and thoughts of suicide. It affects a person’s thoughts, moods, behavior and physical health. A major depressive episode usually lasts more than 2 weeks and interferes with a person’s ability to perform daily functions. Some people may only experience one episode, but others may experience multiple episodes in their lifetime. The cause of major depressive disorder is unknown. It may affect anyone of any age, race, ethnicity, gender or socioeconomic level. Certain factors increase a person’s risk including experiencing traumatic or stressful event(s), having a serious or chronic illness or anxiety related disorder, or having a family history of depression. Those who abuse alcohol or drugs are also at an increased risk.

Major depressive disorder is a serious illness. Without treatment an episode may continue with symptoms becoming increasingly more serious. Major depressive episodes may lead a person to feel that life is not worth living and to commit suicide. If you or someone you know is having thoughts of suicide call a suicide hot line or go to an emergency medical center. It is important to realize that depression is treatable. Treatment may include support groups, medication, talk therapy, or other strategies. Talk to your doctor to decide on the best treatment options if you or a family member is affected by major depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. See also depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Major depressive disorder" returned 671 free, full-text research articles on human participants. First 3 results:

A randomized, double-blind, placebo-controlled study of the efficacy and safety of 2 doses of vortioxetine in adults with major depressive disorder.
 

Author(s): Atul R Mahableshwarkar, Paula L Jacobsen, Michael Serenko, Yinzhong Chen, Madhukar H Trivedi

Journal: J Clin Psychiatry. 2015 May;76(5):583-91.

 

This 8-week, randomized, double-blind, placebo-controlled study, conducted August 2010-May 2012 in the United States, evaluated the safety and efficacy of vortioxetine 10 mg and 15 mg in patients with major depressive disorder (MDD). The mechanism of action of vortioxetine is thought ...

Last Updated: 3 Jun 2015

Go To URL
A randomized, double-blind, placebo-controlled study of the efficacy and safety of vortioxetine 10 mg and 20 mg in adults with major depressive disorder.
 

Author(s): Paula L Jacobsen, Atul R Mahableshwarkar, Michael Serenko, Serena Chan, Madhukar H Trivedi

Journal: J Clin Psychiatry. 2015 May;76(5):575-82.

 

Vortioxetine (Lu AA21004) is an antidepressant with a mechanism of action thought to be related to a combination of 2 pharmacologic actions: direct modulation of several receptors and inhibition of the serotonin transporter.

Last Updated: 3 Jun 2015

Go To URL
Descriptive epidemiology of major depressive disorder in Canada in 2012.
 

Author(s): Scott B Patten, Jeanne V A Williams, Dina H Lavorato, Jian Li Wang, Keltie McDonald, Andrew G M Bulloch

Journal: Can J Psychiatry. 2015 Jan;60(1):23-30.

 

The epidemiology of major depressive disorder (MDD) was first described in the Canadian national population in 2002. Updated information is now available from a 2012 survey: the Canadian Community Health Study-Mental Health (CCHS-MH).

Last Updated: 18 Apr 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Major depressive disorder" returned 87 free, full-text review articles on human participants. First 3 results:

Cognitive dysfunction in major depressive disorder: effects on psychosocial functioning and implications for treatment.
 

Author(s): Raymond W Lam, Sidney H Kennedy, Roger S Mclntyre, Atul Khullar

Journal: Can J Psychiatry. 2014 Dec;59(12):649-54.

 

Last Updated: 23 Feb 2015

Go To URL
Identifying predictors, moderators, and mediators of antidepressant response in major depressive disorder: neuroimaging approaches.
 

Author(s): Mary L Phillips, Henry W Chase, Yvette I Sheline, Amit Etkin, Jorge R C Almeida, Thilo Deckersbach, Madhukar H Trivedi

Journal: Am J Psychiatry. 2015 Feb;172(2):124-38.

 

Despite significant advances in neuroscience and treatment development, no widely accepted biomarkers are available to inform diagnostics or identify preferred treatments for individuals with major depressive disorder.

Last Updated: 2 Feb 2015

Go To URL
Differential diagnosis of bipolar disorder and major depressive disorder.
 

Author(s): R M Hirschfeld

Journal: J Affect Disord. 2014 Dec;169 Suppl 1():S12-6.

 

Patients with bipolar disorder spend approximately half of their lives symptomatic and the majority of that time suffering from symptoms of depression, which complicates the accurate diagnosis of bipolar disorder.

Last Updated: 23 Dec 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial
 

Status: Recruiting

Condition Summary: Major Depressive Disorder; Major Depressive Disorder, Recurrent, Unspecified; Major Depressive Disorder, Single Episode, Unspecified

 

Last Updated: 26 May 2015

Go to URL
Study to Treat Major Depressive Disorder (MDD) With a New Medication
 

Status: Recruiting

Condition Summary: Major Depressive Disorder; Depression

 

Last Updated: 15 Jul 2015

Go to URL
Major Depressive Disorder - Understanding The Link Between The Brain And The Heart
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 16 Dec 2013

Go to URL