Major depressive disorder

Common Name(s)

Major depressive disorder, Major depression

Major depressive disorder is a serious form of depression which involves some combination of the following symptoms: sadness, inability to concentrate, difficulty sleeping (insomnia) or sleeping too much, feeling very tired (fatigue), weight gain or loss, irritability, loss of interest or pleasure in activities, feelings of guilt, worthlessness or hopelessness, and thoughts of suicide. It affects a person’s thoughts, moods, behavior and physical health. A major depressive episode usually lasts more than 2 weeks and interferes with a person’s ability to perform daily functions. Some people may only experience one episode, but others may experience multiple episodes in their lifetime. The cause of major depressive disorder is unknown. It may affect anyone of any age, race, ethnicity, gender or socioeconomic level. Certain factors increase a person’s risk including experiencing traumatic or stressful event(s), having a serious or chronic illness or anxiety related disorder, or having a family history of depression. Those who abuse alcohol or drugs are also at an increased risk.

Major depressive disorder is a serious illness. Without treatment an episode may continue with symptoms becoming increasingly more serious. Major depressive episodes may lead a person to feel that life is not worth living and to commit suicide. If you or someone you know is having thoughts of suicide call a suicide hot line or go to an emergency medical center. It is important to realize that depression is treatable. Treatment may include support groups, medication, talk therapy, or other strategies. Talk to your doctor to decide on the best treatment options if you or a family member is affected by major depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. See also depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Major depressive disorder" returned 845 free, full-text research articles on human participants. First 3 results:

DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder.
 

Author(s): Rosie May Walker, Andrea Nikie Christoforou, Daniel L McCartney, Stewart W Morris, Nicholas A Kennedy, Peter Morten, Susan Maguire Anderson, Helen Scott Torrance, Alix Macdonald, Jessika Elizabeth Sussmann, Heather Clare Whalley, Douglas H R Blackwood, Andrew Mark McIntosh, David John Porteous, Kathryn Louise Evans

Journal:

 

Bipolar disorder (BD) is a severe, familial psychiatric condition. Progress in understanding the aetiology of BD has been hampered by substantial phenotypic and genetic heterogeneity. We sought to mitigate these confounders by studying a multi-generational family multiply affected ...

Last Updated: 22 Jan 2016

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Zhiqiaochuanxiong decoction for major depressive disorder complicated by functional dyspepsia: a case report with fast-acting efficacy.
 

Author(s): Min Luo, Xi Huang, Yang Wang, Ping Ren

Journal: J Tradit Chin Med. 2015 Dec;35(6):697-702.

 

To introduce a clinical case from Professor Huang Xi from Xiangya Hospital in traditional Chinese medical (TCM) treatment for a major depressive disorder (MDD) complicated by functional dyspepsia (FD).

Last Updated: 8 Jan 2016

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Acquainted with the night again and again: key factors associated with relapse in major depressive disorder.
 

Author(s): Antolin M Llorente

Journal: J Clin Psychiatry. 2015 Oct;76(10):e1315-7.

 

Last Updated: 4 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Major depressive disorder" returned 105 free, full-text review articles on human participants. First 3 results:

Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis.
 

Author(s): Halle R Amick, Gerald Gartlehner, Bradley N Gaynes, Catherine Forneris, Gary N Asher, Laura C Morgan, Emmanuel Coker-Schwimmer, Erin Boland, Linda J Lux, Susan Gaylord, Carla Bann, Christiane Barbara Pierl, Kathleen N Lohr

Journal:

 

What are the benefits and harms of second generation antidepressants and cognitive behavioral therapies (CBTs) in the initial treatment of a current episode of major depressive disorder in adults?

Last Updated: 9 Dec 2015

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Antidepressants and their effect on cognition in major depressive disorder.
 

Author(s): George I Papakostas

Journal: J Clin Psychiatry. 2015 Aug;76(8):e1046.

 

Cognitive functioning is a symptom of major depressive disorder (MDD) that deserves particular attention by clinicians and researchers. Despite the fact that cognitive dysfunction represents a symptom of MDD as well as a functional outcome measure, cognition has been insufficiently ...

Last Updated: 4 Sep 2015

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Comorbidity between post-traumatic stress disorder and major depressive disorder: alternative explanations and treatment considerations.
 

Author(s): Janine D Flory, Rachel Yehuda

Journal: Dialogues Clin Neurosci. 2015 Jun;17(2):141-50.

 

Approximately half of people with post-traumatic stress disorder (PTSD) also suffer from Major Depressive Disorder (MDD). The current paper examines evidence for two explanations of this comorbidity. First, that the comorbidity reflects overlapping symptoms in the two disorders. Second, ...

Last Updated: 6 Aug 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial
 

Status: Recruiting

Condition Summary: Major Depressive Disorder; Major Depressive Disorder, Recurrent, Unspecified; Major Depressive Disorder, Single Episode, Unspecified

 

Last Updated: 30 Nov 2015

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Study of NSI-189 for Major Depressive Disorder
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 28 Apr 2016

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A Longitudinal Observational Cohort Study of NSI-189, With Out-Patients With Major Depressive Disorder
 

Status: Not yet recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 25 Mar 2016

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