Major depressive disorder

Common Name(s)

Major depressive disorder, Major depression

Major depressive disorder is a serious form of depression which involves some combination of the following symptoms: sadness, inability to concentrate, difficulty sleeping (insomnia) or sleeping too much, feeling very tired (fatigue), weight gain or loss, irritability, loss of interest or pleasure in activities, feelings of guilt, worthlessness or hopelessness, and thoughts of suicide. It affects a person’s thoughts, moods, behavior and physical health. A major depressive episode usually lasts more than 2 weeks and interferes with a person’s ability to perform daily functions. Some people may only experience one episode, but others may experience multiple episodes in their lifetime. The cause of major depressive disorder is unknown. It may affect anyone of any age, race, ethnicity, gender or socioeconomic level. Certain factors increase a person’s risk including experiencing traumatic or stressful event(s), having a serious or chronic illness or anxiety related disorder, or having a family history of depression. Those who abuse alcohol or drugs are also at an increased risk.

Major depressive disorder is a serious illness. Without treatment an episode may continue with symptoms becoming increasingly more serious. Major depressive episodes may lead a person to feel that life is not worth living and to commit suicide. If you or someone you know is having thoughts of suicide call a suicide hot line or go to an emergency medical center. It is important to realize that depression is treatable. Treatment may include support groups, medication, talk therapy, or other strategies. Talk to your doctor to decide on the best treatment options if you or a family member is affected by major depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. See also depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Major depressive disorder" returned 890 free, full-text research articles on human participants. First 3 results:

The White Matter Microintegrity Alterations of Neocortical and Limbic Association Fibers in Major Depressive Disorder and Panic Disorder: The Comparison.
 

Author(s): Chien-Han Lai, Yu-Te Wu

Journal: Medicine (Baltimore). 2016 Mar;95(9):e2982.

 

The studies regarding to the comparisons between major depressive disorder (MDD) and panic disorder (PD) in the microintegrity of white matter (WM) are uncommon. Therefore, we tried to a way to classify the MDD and PD. Fifty-three patients with 1st-episode medication-naive PD, 54 ...

Last Updated: 6 Mar 2016

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Blood Transcriptomic Markers in Patients with Late-Onset Major Depressive Disorder.
 

Author(s): Shigeo Miyata, Masashi Kurachi, Yoshiko Okano, Noriko Sakurai, Ayumi Kobayashi, Kenichiro Harada, Hirotaka Yamagata, Koji Matsuo, Keisuke Takahashi, Kosuke Narita, Masato Fukuda, Yasuki Ishizaki, Masahiko Mikuni

Journal:

 

We investigated transcriptomic markers of late-onset major depressive disorder (LOD; onset age of first depressive episode ≥ 50 years) from the genes expressed in blood cells and identified state-dependent transcriptomic markers in these patients. We assessed the genes expressed ...

Last Updated: 1 Mar 2016

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DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder.
 

Author(s): Rosie May Walker, Andrea Nikie Christoforou, Daniel L McCartney, Stewart W Morris, Nicholas A Kennedy, Peter Morten, Susan Maguire Anderson, Helen Scott Torrance, Alix Macdonald, Jessika Elizabeth Sussmann, Heather Clare Whalley, Douglas H R Blackwood, Andrew Mark McIntosh, David John Porteous, Kathryn Louise Evans

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Bipolar disorder (BD) is a severe, familial psychiatric condition. Progress in understanding the aetiology of BD has been hampered by substantial phenotypic and genetic heterogeneity. We sought to mitigate these confounders by studying a multi-generational family multiply affected ...

Last Updated: 22 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Major depressive disorder" returned 137 free, full-text review articles on human participants. First 3 results:

Significantly Higher Peripheral Insulin-Like Growth Factor-1 Levels in Patients With Major Depressive Disorder or Bipolar Disorder Than in Healthy Controls: A Meta-Analysis and Review Under Guideline of PRISMA.
 

Author(s): Kun-Yu Tu, Ming-Kung Wu, Yen-Wen Chen, Pao-Yen Lin, Hung-Yu Wang, Ching-Kuan Wu, Ping-Tao Tseng

Journal: Medicine (Baltimore). 2016 Jan;95(4):e2411.

 

An increasing amount of research has focused on insulin-like growth factor-1 (IGF-1) because of multiple neurotrophic effects, including neurogenesis, remyelination, and synaptogenesis. In addition, IGF-1 can mediate an antidepressant effect in patients with major affective disorder, ...

Last Updated: 30 Jan 2016

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Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis.
 

Author(s): Halle R Amick, Gerald Gartlehner, Bradley N Gaynes, Catherine Forneris, Gary N Asher, Laura C Morgan, Emmanuel Coker-Schwimmer, Erin Boland, Linda J Lux, Susan Gaylord, Carla Bann, Christiane Barbara Pierl, Kathleen N Lohr

Journal:

 

What are the benefits and harms of second generation antidepressants and cognitive behavioral therapies (CBTs) in the initial treatment of a current episode of major depressive disorder in adults?

Last Updated: 9 Dec 2015

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Challenging Treatment-Resistant Major Depressive Disorder: A Roadmap for Improved Therapeutics.
 

Author(s): Rafael T de Sousa, Marcus V Zanetti, Andre R Brunoni, Rodrigo Machado-Vieira

Journal: Curr Neuropharmacol. 2015 ;13(5):616-35.

 

Major depressive disorder (MDD) is associated with a significant burden and costs to the society. As remission of depressive symptoms is achieved in only one-third of the MDD patients after the first antidepressant trial, unsuccessful treatments contribute largely to the observed ...

Last Updated: 15 Oct 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial
 

Status: Recruiting

Condition Summary: Major Depressive Disorder; Major Depressive Disorder, Recurrent, Unspecified; Major Depressive Disorder, Single Episode, Unspecified

 

Last Updated: 10 May 2016

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Study of NSI-189 for Major Depressive Disorder
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 12 Jul 2016

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A Longitudinal Observational Cohort Study of NSI-189, With Out-Patients With Major Depressive Disorder
 

Status: Not yet recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 7 Jul 2016

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