Major depressive disorder

Common Name(s)

Major depressive disorder, Major depression

Major depressive disorder is a serious form of depression which involves some combination of the following symptoms: sadness, inability to concentrate, difficulty sleeping (insomnia) or sleeping too much, feeling very tired (fatigue), weight gain or loss, irritability, loss of interest or pleasure in activities, feelings of guilt, worthlessness or hopelessness, and thoughts of suicide. It affects a person’s thoughts, moods, behavior and physical health. A major depressive episode usually lasts more than 2 weeks and interferes with a person’s ability to perform daily functions. Some people may only experience one episode, but others may experience multiple episodes in their lifetime. The cause of major depressive disorder is unknown. It may affect anyone of any age, race, ethnicity, gender or socioeconomic level. Certain factors increase a person’s risk including experiencing traumatic or stressful event(s), having a serious or chronic illness or anxiety related disorder, or having a family history of depression. Those who abuse alcohol or drugs are also at an increased risk.

Major depressive disorder is a serious illness. Without treatment an episode may continue with symptoms becoming increasingly more serious. Major depressive episodes may lead a person to feel that life is not worth living and to commit suicide. If you or someone you know is having thoughts of suicide call a suicide hot line or go to an emergency medical center. It is important to realize that depression is treatable. Treatment may include support groups, medication, talk therapy, or other strategies. Talk to your doctor to decide on the best treatment options if you or a family member is affected by major depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. See also depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Major depressive disorder" returned 973 free, full-text research articles on human participants. First 3 results:

Genetic and Environmental Contribution to Major Depressive Disorder and Self-declared Depression.
 

Author(s): Chiara Fabbri

Journal: EBioMedicine. 2016 Dec;14():7-8.

 

Last Updated: 5 Dec 2016

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Study of the Serum Copper Levels in Patients with Major Depressive Disorder.
 

Author(s): Krzysztof Styczeń, Magdalena Sowa-Kućma, Marcin Siwek, Dominika Dudek, Witold Reczyński, Paulina Misztak, Bernadeta Szewczyk, Roman Topór-Mądry, Włodzimierz Opoka, Gabriel Nowak

Journal: Biol Trace Elem Res. 2016 Dec;174(2):287-293.

 

Copper may be involved in the pathophysiology of depression. Clinical data on this issue are very limited and not conclusive. The purpose of the study was to determine the copper concentration in the serum of patients with major depressive disorder and to discuss its potential clinical ...

Last Updated: 5 May 2016

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Auricular Acupuncture Versus Progressive Muscle Relaxation in Patients with Anxiety Disorders or Major Depressive Disorder: A Prospective Parallel Group Clinical Trial.
 

Author(s): Lukas de Lorent, Agorastos Agorastos, Alexander Yassouridis, Michael Kellner, Christoph Muhtz

Journal: J Acupunct Meridian Stud. 2016 Aug;9(4):191-9.

 

Although acupuncture treatment is increasingly in demand among psychiatric patients, to date no studies have investigated the effectiveness of auricular acupuncture (AA) in treating anxiety disorders or major depressive disorder. Thus, this study aimed to compare the effectiveness ...

Last Updated: 24 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Major depressive disorder" returned 153 free, full-text review articles on human participants. First 3 results:

Randomized controlled trials of serotonin-norepinephrine reuptake inhibitor in treating major depressive disorder in children and adolescents: a meta-analysis of efficacy and acceptability.
 

Author(s): Y Xu, S J Bai, X H Lan, B Qin, T Huang, P Xie

Journal: Braz. J. Med. Biol. Res.. 2016 May;49(6):.

 

New generation antidepressant therapies, including serotonin-norepinephrine reuptake inhibitor (SNRIs), were introduced in the late 1980s; however, few comprehensive studies have compared the benefits and risks of various contemporary treatments for major depressive disorder (MDD) ...

Last Updated: 29 Jun 2016

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The Preclinical and Clinical Effects of Vilazodone for the Treatment of Major Depressive Disorder.
 

Author(s): Zeyad T Sahli, Pradeep Banerjee, Frank I Tarazi

Journal: Expert Opin Drug Discov. 2016 ;11(5):515-23.

 

Major depressive disorder (MDD) is the leading cause of disability worldwide, and according to the STAR*D trial, only 33% of patients with MDD responded to initial drug therapy. Augmentation of the leading class of antidepressant treatment, selective serotonin reuptake inhibitors ...

Last Updated: 12 Apr 2016

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ω-3 Fatty acids for major depressive disorder in adults: an abridged Cochrane review.
 

Author(s): Katherine M Appleton, Hannah M Sallis, Rachel Perry, Andrew R Ness, Rachel Churchill

Journal:

 

To assess the effects of n-3 polyunsaturated fatty acids (n-3PUFAs; also known as ω-3 fatty acids) compared with comparator for major depressive disorder (MDD) in adults.

Last Updated: 3 Mar 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Open Label Ketamine Treatment for Major Depressive Disorder in Veterans
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 10 Feb 2017

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Music Therapy for Major Depressive Disorder Residual Symptoms
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 4 Oct 2016

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Family Psychoeducation for Major Depressive Disorder
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 27 Apr 2016

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