Major depressive disorder

Common Name(s)

Major depressive disorder, Major depression

Major Depressive Disorder is a form of depression that causes a continued feeling of sadness and loss of interest, characterized by symptoms that interfere with a person’s daily life—his or her ability to work, sleep, study, eat, and enjoy activities is affected, preventing a person from functioning normally. Some people may only experience one episode, but others may experience multiple episodes in their lifetime. Symptoms include feelings of sadness or unhappiness, inability or frustration, loss of interest in normal activities, reduced sex drive, insomnia or excessive sleeping, changes in appetite, agitation or restlessness, irritability or angry outbursts, slowed thinking, fatigue, frequent thoughts of death, and trouble thinking and concentrating.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Major depressive disorder" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Major depressive disorder" returned 522 free, full-text research articles on human participants. First 3 results:

Coding of adverse events of suicidality in clinical study reports of duloxetine for the treatment of major depressive disorder: descriptive study.
 

Author(s): Emma Maund, Britta Tendal, Asbjørn Hróbjartsson, Andreas Lundh, Peter C Gøtzsche

Journal:

 

To assess the effects of coding and coding conventions on summaries and tabulations of adverse events data on suicidality within clinical study reports.

Last Updated: 6 Jun 2014

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Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population.
 

Author(s): Ping Hua, Weiguo Liu, Donghui Chen, Yanyan Zhao, Ling Chen, Ning Zhang, Chun Wang, Suwan Guo, Li Wang, Hong Xiao, Sheng-Han Kuo

Journal: J Affect Disord. 2014 Mar;157():100-3.

 

Accumulating evidences indicate that circadian abnormalities lead to sleep disorder, neurodegenerative diseases and depression. We have reported that the polymorphisms of a clock-related gene, Tef, contributed to the risk of sleep disturbances and depression in the Parkinson disease. ...

Last Updated: 3 Mar 2014

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Discriminating risk and resilience endophenotypes from lifetime illness effects in familial major depressive disorder.
 

Author(s): Bradley S Peterson, Zhishun Wang, Guillermo Horga, Virginia Warner, Bret Rutherford, Kristin W Klahr, Barbara Graniello, Priya Wickramaratne, Felix Garcia, Shan Yu, Xuejun Hao, Phillip B Adams, Ming Qian, Jun Liu, Andrew Gerber, Myrna M Weissman

Journal: JAMA Psychiatry. 2014 Feb;71(2):136-48.

 

The neural systems that confer risk or vulnerability for developing familial depression, and those that protect against or confer resilience to becoming ill, can be disentangled from the effects of prior illness by comparing brain imaging measures in previously ill and never ill persons ...

Last Updated: 6 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Major depressive disorder" returned 74 free, full-text review articles on human participants. First 3 results:

Benefits and harms in clinical trials of duloxetine for treatment of major depressive disorder: comparison of clinical study reports, trial registries, and publications.
 

Author(s): Emma Maund, Britta Tendal, Asbjørn Hróbjartsson, Karsten Juhl Jørgensen, Andreas Lundh, Jeppe Schroll, Peter C Gøtzsche

Journal:

 

To determine, using research on duloxetine for major depressive disorder as an example, if there are inconsistencies between protocols, clinical study reports, and main publicly available sources (journal articles and trial registries), and within clinical study reports themselves, ...

Last Updated: 6 Jun 2014

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The mistreatment of major depressive disorder.
 

Author(s): Joel Paris

Journal: Can J Psychiatry. 2014 Mar;59(3):148-51.

 

To examine the effects of classification on treatment in major depressive disorder (MDD).

Last Updated: 2 Jun 2014

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Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence.
 

Author(s): Souhel Najjar, Daniel M Pearlman, Orrin Devinsky, Amanda Najjar, David Zagzag

Journal:

 

About one-third of people with major depressive disorder (MDD) fail at least two antidepressant drug trials at 1 year. Together with clinical and experimental evidence indicating that the pathophysiology of MDD is multifactorial, this observation underscores the importance of elucidating ...

Last Updated: 9 Dec 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Escitalopram, Placebo and tDCS in Depression: a Non-inferiority Trial
 

Status: Recruiting

Condition Summary: Major Depressive Disorder; Major Depressive Disorder, Recurrent, Unspecified; Major Depressive Disorder, Single Episode, Unspecified

 

Last Updated: 13 Aug 2014

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Algorithm Guided Treatment Strategies for Major Depressive Disorder
 

Status: Recruiting

Condition Summary: Major Depressive Disorder

 

Last Updated: 8 Jan 2013

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Using Neuroimaging to Investigate Major Depressive Disorder
 

Status: Recruiting

Condition Summary: Major Depressive Disorder; Depression; Anxiety

 

Last Updated: 11 Jan 2010

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