Ischemic stroke

Common Name(s)

Ischemic stroke

A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. It is said to be the third leading cause of death in the United States. {15:Gunel and Lifton (1996)} noted that about 20% of strokes are hemorrhagic, resulting in bleeding into the brain. Ischemic strokes, resulting from vascular occlusion, account for the majority of strokes. {4:Bersano et al. (2008)} reviewed genetic polymorphisms that have been implicated in the development of stroke. Candidate genes include those involved in hemostasis (see, e.g., F5; {612309}), the renin-angiotensin-aldosterone system (see, e.g., ACE; {106180}), homocysteine (see, e.g., MTHFR; {607093}), and lipoprotein metabolism (see, e.g., APOE; {107741}). See also hemorrhagic stroke, or intracerebral hemorrhage (ICH; {614519}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ischemic stroke" for support, advocacy or research.

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National Stroke Association

National Stroke Association’s mission is to reduce the incidence and impact of stroke by developing compelling education and programs focused on prevention, treatment, rehabilitation and support for all impacted by stroke.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ischemic stroke" for support, advocacy or research.

Logo
National Stroke Association

National Stroke Association’s mission is to reduce the incidence and impact of stroke by developing compelling education and programs focused on prevention, treatment, rehabilitation and support for all impacted by stroke.

https://www.stroke.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ischemic stroke" returned 2515 free, full-text research articles on human participants. First 3 results:

Association between genetic polymorphisms of cytochrome P450 2C19 and the risk of cerebral ischemic stroke in Chinese.
 

Author(s): Shuzhen Gu, Yan Sun, Ruifa Han, Lin Wang, Dongliang Wang, Jizuo Wang, Xin Li

Journal:

 

Cytochrome P450 (CYP) 2C19 is a very important drug metabolizing enzyme. Although the single nucleotide polymorphisms (SNPs) of CYP2C19 G681A and G636A have been suggested that they may increase the incidence of cardiovascular events, the relationship between SNPs in CYP2C19 and cerebral ...

Last Updated: 7 Aug 2014

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Impact of perioperative acute ischemic stroke on the outcomes of noncardiac and nonvascular surgery: a single centre prospective study.
 

Author(s): Murat Biteker, Kadir Kayatas, Funda M Türkmen, Cemile H Mısırlı

Journal: Can J Surg. 2014 Jun;57(3):E55-61.

 

Although ischemic stroke is a well-known complication of cardiovascular surgery it has not been extensively studied in patients undergoing noncardiac surgery. The aim of this study was to assess the predictors and outcomes of perioperative acute ischemic stroke (PAIS) in patients ...

Last Updated: 29 May 2014

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Clinical efficacy and safety of traditional Chinese medicine combined with Western Medicine in patients with diabetic acute ischemic stroke.
 

Author(s): Huan Zhao, Dongdong Yang, Min Shi, Jingtao Liang, Xuhong Yang, Shuoguo Jin

Journal: J Tradit Chin Med. 2014 Apr;34(2):145-9.

 

To observe the clinical efficacy and safety of Traditional Chinese Medicine (TCM) combined with Western Medicine (WM) in patients with diabetic acute ischemic stroke.

Last Updated: 2 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ischemic stroke" returned 290 free, full-text review articles on human participants. First 3 results:

Medium- and long-term efficacy of ligustrazine plus conventional medication on ischemic stroke: a systematic review and meta-analysis.
 

Author(s): Xiaojia Ni, Xiaojia Ni, Shaonan Liu, Xinfeng Guo

Journal: J Tradit Chin Med. 2013 Dec;33(6):715-20.

 

To evaluate the medium- to long-term efficacy of ligustrazine plus conventional medicine treating ischemic stroke.

Last Updated: 25 Mar 2014

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Current perspectives on the use of intravenous recombinant tissue plasminogen activator (tPA) for treatment of acute ischemic stroke.
 

Author(s): Sherita N Chapman, Prachi Mehndiratta, Michelle C Johansen, Timothy L McMurry, Karen C Johnston, Andrew M Southerland

Journal:

 

In 1995, the NINDS (National Institute of Neurological Disorders and Stroke) tPA (tissue plasminogen activator) Stroke Study Group published the results of a large multicenter clinical trial demonstrating efficacy of intravenous tPA by revealing a 30% relative risk reduction (absolute ...

Last Updated: 4 Mar 2014

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The paradox role of regulatory T cells in ischemic stroke.
 

Author(s): Xiaomeng Xu, Min Li, Yongjun Jiang

Journal:

 

The underlying mechanism of ischemic stroke is not completely known. Regulatory T cells (Tregs), a subset of T cells, play a pivotal role in the pathophysiological process of ischemic stroke. However, there is also controversy over the role of Tregs in stroke. Hence, the function ...

Last Updated: 29 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

DLBS1033 for Acute Ischemic Stroke Patients
 

Status: Not yet recruiting

Condition Summary: Ischemic Stroke; Partial Anterior Circulation Infarction; Lacunar Infarction by Bamford Criteria

 

Last Updated: 7 May 2014

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Tongxinluo Capsule in Ischemic Stroke Patients(TISS)
 

Status: Not yet recruiting

Condition Summary: Ischemic Stroke

 

Last Updated: 7 Aug 2013

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Occult Paroxysmal Atrial Fibrillation in Non-Cryptogenic Ischemic Stroke
 

Status: Recruiting

Condition Summary: Ischemic Stroke

 

Last Updated: 2 Sep 2014

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