Inflammatory bowel disease

Common Name(s)

Inflammatory bowel disease, IBD

Inflammatory bowel disease (IBD) is the chronic redness and swelling (inflammation) of all or part of the digestive tract, which includes the esophagus, stomach, small intestine, and large intestine. The exact cause of the inflammation in IBD is not known, but a person’s immune system and genetic makeup are both thought to play a role. Risk factors for developing IBD includes older age, Caucasian (white) ethnic background, cigarette smoking, and using certain medications.

The two main types of IBD are ulcerative colitis and Crohn’s disease. Ulcerative colitis is a condition that causes inflammation and sores (ulcers) on the inside lining of the large intestine. Crohn’s disease causes inflammation that spreads deep into the affected tissue and usually affects the large intestine, the small intestine, or both. Symptoms of IBD vary and depend on the location and severity of the inflammation. Symptoms may include diarrhea, fever and fatigue, abdominal pain and cramping, blood in the stool, reduced appetite, and unintended weight loss.

To diagnose IBD, a physician will first rule out other possible causes of the symptoms. To confirm a diagnosis of IBD, your doctor may order a blood test to look for low red blood cells (anemia), a procedure that uses a small camera to examines your digestive tract for signs of IBD (endoscopy or colonoscopy), and imaging tests (X-rays, CT, or MRI) to look for evidence of IBD. Treatment includes the use of medications that reduces the immune system’s response and decreases the inflammation in the digestive tract. In severe cases, surgery may be needed. Although this condition is serious, affected individuals can live a normal life with proper treatment and care. If you or your child has been diagnosed with IBD, talk with your doctor about the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory bowel disease" returned 1777 free, full-text research articles on human participants. First 3 results:

Cancers Complicating Inflammatory Bowel Disease.
 

Author(s): Laurent Beaugerie, Steven H Itzkowitz

Journal: N. Engl. J. Med.. 2015 Jul;373(2):195.

 

Last Updated: 9 Jul 2015

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Inflammatory bowel disease education: I can hear the extension for community healthcare outcomes.
 

Author(s): Kathleen Boynton, Ann Flynn, Terry Box, Anthony Dalpiaz, Leah Willis, Tyson Kay, John F Valentine

Journal: Inflamm. Bowel Dis.. 2015 Jun;21(6):1407-8.

 

Last Updated: 19 May 2015

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Risk factors of psychological disorders in inflammatory bowel disease in a tunisian survey. Results of a cross-sectional study.
 

Author(s): Rym Ennaifer, Nour Elleuch, Myriam Cheikh, Rania Hefaiedh, Hayfa Romdhane, Houda Ben Nejma, Najet Belhadj

Journal: Tunis Med. 2014 Dec;92(12):723-6.

 

Little is known in inflammatory bowel disease (IBD) regarding risk factors for psychological distress. The aims of our work were to evaluate the frequency of anxiety and depression among patients with IBD and to determine the factors associated with these psychological disorders in ...

Last Updated: 17 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory bowel disease" returned 590 free, full-text review articles on human participants. First 3 results:

Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials.
 

Author(s): Richard Conway, Candice Low, Robert J Coughlan, Martin J O'Donnell, John J Carey

Journal:

 

To evaluate the relative risk of pulmonary disease among patients with psoriasis, psoriatic arthritis, and inflammatory bowel disease treated with methotrexate.

Last Updated: 15 Mar 2015

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Inflammatory bowel disease in Hispanic communities: a concerted South American approach could identify the aetiology of Crohn's disease and ulcerative colitis.
 

Author(s): Affifa Farrukh, John Francis Mayberry

Journal: Arq Gastroenterol. ;51(4):271-5.

 

Despite intensive research we remain ignorant of the cause of both Crohn's disease and ulcerative colitis. The dramatic rise in incidence, particularly of Crohn's disease, points towards environmental factors as playing a significant role. A major purpose of this review is to stimulate ...

Last Updated: 16 Jan 2015

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The multifaceted mast cell in inflammatory bowel disease.
 

Author(s): Matthew J Hamilton, Sandra M Frei, Richard L Stevens

Journal: Inflamm. Bowel Dis.. 2014 Dec;20(12):2364-78.

 

Mast cells (MCs) are tissue-resident immune cells that carry out protective roles against pathogens. In disease states, such as inflammatory bowel disease, these granulocytes release a diverse array of mediators that contribute to inflammatory processes. They also participate in wound ...

Last Updated: 18 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gene Expression in Inflammatory Bowel Disease
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease

 

Last Updated: 6 Jul 2011

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Multi-Center African-American Inflammatory Bowel Disease Study (MAAIS): The Search for New Genes
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease

 

Last Updated: 6 Jul 2011

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Telemedicine in Patients With Inflammatory Bowel Disease (TELE-IBD)
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease; Crohn's Disease; Ulcerative Colitis; Indeterminate Colitis

 

Last Updated: 3 Dec 2014

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