Inflammatory bowel disease

Common Name(s)

Inflammatory bowel disease, IBD

Inflammatory bowel disease (IBD) is the chronic redness and swelling (inflammation) of all or part of the digestive tract, which includes the esophagus, stomach, small intestine, and large intestine. The exact cause of the inflammation in IBD is not known, but a person’s immune system and genetic makeup are both thought to play a role. Risk factors for developing IBD includes older age, Caucasian (white) ethnic background, cigarette smoking, and using certain medications.

The two main types of IBD are ulcerative colitis and Crohn’s disease. Ulcerative colitis is a condition that causes inflammation and sores (ulcers) on the inside lining of the large intestine. Crohn’s disease causes inflammation that spreads deep into the affected tissue and usually affects the large intestine, the small intestine, or both. Symptoms of IBD vary and depend on the location and severity of the inflammation. Symptoms may include diarrhea, fever and fatigue, abdominal pain and cramping, blood in the stool, reduced appetite, and unintended weight loss.

To diagnose IBD, a physician will first rule out other possible causes of the symptoms. To confirm a diagnosis of IBD, your doctor may order a blood test to look for low red blood cells (anemia), a procedure that uses a small camera to examines your digestive tract for signs of IBD (endoscopy or colonoscopy), and imaging tests (X-rays, CT, or MRI) to look for evidence of IBD. Treatment includes the use of medications that reduces the immune system’s response and decreases the inflammation in the digestive tract. In severe cases, surgery may be needed. Although this condition is serious, affected individuals can live a normal life with proper treatment and care. If you or your child has been diagnosed with IBD, talk with your doctor about the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory bowel disease" returned 2129 free, full-text research articles on human participants. First 3 results:

DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin.
 

Author(s): Małgorzata Zielińska-Przyjemska, Anna Olejnik, Agnieszka Dobrowolska-Zachwieja, Michał Łuczak, Wanda Baer-Dubowska

Journal:

 

Inflammatory bowel diseases (IBD) are chronic, relapsing, inflammatory disorders of the gastrointestinal tract, and continuing colonic inflammation is considered an important risk factor in the development of colorectal cancer. Our previous studies showed that beetroot (Beta vulgaris ...

Last Updated: 27 Apr 2016

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The Association of Mycobacterium avium subsp. paratuberculosis with Inflammatory Bowel Disease.
 

Author(s): Verlaine J Timms, George Daskalopoulos, Hazel M Mitchell, Brett A Neilan

Journal:

 

The association of Mycobacterium avium subspecies paratuberculosis (M. paratuberculosis) with Crohn's disease is a controversial issue. M. paratuberculosis is detected by amplifying the IS900 gene, as microbial culture is unreliable from humans. We determined the presence of M. paratuberculosis ...

Last Updated: 6 Feb 2016

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Circulating MicroRNA223 is a New Biomarker for Inflammatory Bowel Disease.
 

Author(s): Huiling Wang, Shenghong Zhang, Qiao Yu, Guang Yang, Jing Guo, Manying Li, Zhirong Zeng, Yao He, Baili Chen, Minhu Chen

Journal: Medicine (Baltimore). 2016 Feb;95(5):e2703.

 

Endoscopy is an important tool in screening and monitoring inflammatory bowel disease (IBD); however, it is invasive, costly, and associated with risks to the patients. Recently, circulating microRNAs (miRNAs) have emerged as promising noninvasive biomarkers. We proposed that the ...

Last Updated: 5 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory bowel disease" returned 772 free, full-text review articles on human participants. First 3 results:

Intravenous Versus Oral Iron for the Treatment of Anemia in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
 

Author(s): Stefanos Bonovas, Gionata Fiorino, Mariangela Allocca, Theodore Lytras, Argirios Tsantes, Laurent Peyrin-Biroulet, Silvio Danese

Journal: Medicine (Baltimore). 2016 Jan;95(2):e2308.

 

Anemia is the most prevalent extraintestinal complication of inflammatory bowel disease (IBD). Our aim was to evaluate the comparative efficacy and harm of intravenous (IV) versus oral iron supplementation for correcting anemia in adult IBD patients.We conducted a systematic review ...

Last Updated: 15 Jan 2016

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Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
 

Author(s): Jie Dong, Yi Chen, Yuchen Tang, Fei Xu, Chaohui Yu, Youming Li, Prasoon Pankaj, Ning Dai

Journal:

 

Prior work suggested that patients with inflammatory bowel diseases (IBD) have lower body mass index (BMI) than controls and patients with lower BMI have more serious complications.

Last Updated: 15 Dec 2015

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Endoscopic Disease Activity in Inflammatory Bowel Disease.
 

Author(s): Shara Nguyen Ket, Rebecca Palmer, Simon Travis

Journal: Curr Gastroenterol Rep. 2015 Dec;17(12):50.

 

Endoscopic scoring systems in Crohn's disease and ulcerative colitis aim to translate the assessment of mucosal disease activity into a quantified value. This value seeks to provide a clear, objective record of the endoscopic mucosal severity, which can then be used to guide medical ...

Last Updated: 24 Dec 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gene Expression in Inflammatory Bowel Disease
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease

 

Last Updated: 6 Jul 2011

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Multi-Center African-American Inflammatory Bowel Disease Study (MAAIS): The Search for New Genes
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease

 

Last Updated: 6 Jul 2011

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Standardized Fecal Microbiota Transplantation for Inflammatory Bowel Disease
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease; Ulcerative Colitis; Crohn's Disease

 

Last Updated: 8 Jan 2015

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