Idiopathic generalized epilepsy

Common Name(s)

Idiopathic generalized epilepsy

Idiopathic generalized epilepsy is a broad term that encompasses several common seizure phenotypes, classically including childhood absence epilepsy (CAE, ECA; see {600131}), juvenile absence epilepsy (JAE, EJA; see {607631}), juvenile myoclonic epilepsy (JME, EJM; see {254770}), and epilepsy with grand mal seizures on awakening ({4:Commission on Classification and Terminology of the International League Against Epilepsy, 1989}). These recurrent seizures occur in the absence of detectable brain lesions and/or metabolic abnormalities. Seizures are initially generalized with a bilateral, synchronous, generalized, symmetrical EEG discharge ({20:Zara et al., 1995}; {8:Lu and Wang, 2009}). See also childhood absence epilepsy (ECA1; {600131}), which has also been mapped to 8q24. Of note, benign neonatal epilepsy 2 (EBN2; {121201}) is caused by mutation in the KCNQ3 gene ({602232}) on 8q24. Genetic Heterogeneity of Idiopathic Generalized Epilepsy EIG1 has been mapped to chromosome 8q24. Other loci or genes associated with EIG include EIG2 ({606972}) on 14q23; EIG3 ({608762}) on 9q32; EIG4 ({609750}) on 10q25; EIG5 ({611934}) on 10p11; EIG6 ({611942}), caused by mutation in the CACNA1H gene ({607904}) on 16p; EIG7 ({604827}) on 15q14; EIG8 ({612899}), caused by mutation in the CASR gene ({601199}) on 3q13.3-q21; EIG9 ({607682}), caused by mutation in the CACNB4 gene ({601949}) on 2q22-q23; EIG10 ({613060}), caused by mutation in the GABRD gene ({137163}) on 1p36.3; EIG11 ({607628}), caused by variation in the CLCN2 gene ({600570}) on 3q36; and EIG12 ({614847}), caused by mutation in the SLC2A1 gene ({138140}) on 1p34.
 

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Condition Specific Organizations

Following organizations serve the condition "Idiopathic generalized epilepsy" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Idiopathic generalized epilepsy" returned 33 free, full-text research articles on human participants. First 3 results:

[Advance in genetic study for idiopathic generalized epilepsy].
 

Author(s): Yu-wu Jiang, Han Xie

Journal: Beijing Da Xue Xue Bao. 2013 Apr;45(2):186-91.

 

Epilepsy is a kind of common neurological diseases in the world. Over 50% of epilepsies have genetic basis. We define "idiopathic epilepsy" as a kind of epilepsy or epilepsy syndrome only with genetic factors, and idiopathic generalized epilepsies (IGEs) is a major type of idiopathic ...

Last Updated: 17 Apr 2013

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Relationship between large-scale functional and structural covariance networks in idiopathic generalized epilepsy.
 

Author(s): Wei Liao, Zhiqiang Zhang, Dante Mantini, Qiang Xu, Zhengge Wang, Guanghui Chen, Qing Jiao, Yu-Feng Zang, Guangming Lu

Journal: Brain Connect. 2013 ;3(3):240-54.

 

The human brain can be modeled as a network, whose structure can be revealed by either anatomical or functional connectivity analyses. Little is known, so far, about the topological features of the large-scale interregional functional covariance network (FCN) in the brain. Further, ...

Last Updated: 18 Jun 2013

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Reduced default mode network connectivity in treatment-resistant idiopathic generalized epilepsy.
 

Author(s): Benjamin P Kay, Mark W DiFrancesco, Michael D Privitera, Jean Gotman, Scott K Holland, Jerzy P Szaflarski

Journal: Epilepsia. 2013 Mar;54(3):461-70.

 

Idiopathic generalized epilepsy (IGE) resistant to treatment is common, but its neuronal correlates are not entirely understood. Therefore, the aim of this study was to examine resting-state default mode network (DMN) functional connectivity in patients with treatment-resistant IGE.

Last Updated: 5 Mar 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Idiopathic generalized epilepsy" returned 1 free, full-text review articles on human participants. First 3 results:

Genetics of idiopathic generalized epilepsy: an overview.
 

Author(s): D K V Prasad, U Satyanarayana, Anjana Munshi

Journal: Neurol India. ;61(6):572-7.

 

Idiopathic generalized epilepsy (IGE) is a common type of epilepsy. Strong support for a genetic role in IGE comes from twin and family studies. Several subtypes of IGE have been reported but families often have members affected with different subtypes. Major advances have been made ...

Last Updated: 20 Jan 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Blinking and Yawning in Epilepsy: The Role of Dopamine
 

Status: Recruiting

Condition Summary: Idiopathic Generalized Epilepsy

 

Last Updated: 20 Sep 2012

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