Idiopathic generalized epilepsy

Common Name(s)

Idiopathic generalized epilepsy

Idiopathic generalized epilepsy is a broad term that encompasses several common seizure phenotypes, classically including childhood absence epilepsy (CAE, ECA; see {600131}), juvenile absence epilepsy (JAE, EJA; see {607631}), juvenile myoclonic epilepsy (JME, EJM; see {254770}), and epilepsy with grand mal seizures on awakening ({4:Commission on Classification and Terminology of the International League Against Epilepsy, 1989}). These recurrent seizures occur in the absence of detectable brain lesions and/or metabolic abnormalities. Seizures are initially generalized with a bilateral, synchronous, generalized, symmetrical EEG discharge ({19:Zara et al., 1995}; {8:Lu and Wang, 2009}). See also childhood absence epilepsy (ECA1; {600131}), which has also been mapped to 8q24. Of note, benign neonatal epilepsy 2 (EBN2; {121201}) is caused by mutation in the KCNQ3 gene ({602232}) on 8q24. Genetic Heterogeneity of Idiopathic Generalized Epilepsy EIG1 has been mapped to chromosome 8q24. Other loci or genes associated with EIG include EIG2 ({606972}) on 14q23; EIG3 ({608762}) on 9q32; EIG4 ({609750}) on 10q25; EIG5 ({611934}) on 10p11; EIG6 ({611942}), caused by mutation in the CACNA1H gene ({607904}) on 16p; EIG7 ({604827}) on 15q14; EIG8 ({612899}), caused by mutation in the CASR gene ({601199}) on 3q13.3-q21; EIG9 ({607682}), caused by mutation in the CACNB4 gene ({601949}) on 2q22-q23; EIG10 ({613060}), caused by mutation in the GABRD gene ({137163}) on 1p36.3; EIG11 ({607628}), caused by variation in the CLCN2 gene ({600570}) on 3q36; EIG12 ({614847}), caused by mutation in the SLC2A1 gene ({138140}) on 1p34; EIG13 ({611136}), caused by mutation in the GABRA1 gene ({137160}) on 5q34; and EIG14 ({616685}), caused by mutation in the SLC12A5 gene ({606726}) on 20q12.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Idiopathic generalized epilepsy" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Idiopathic generalized epilepsy" returned 106 free, full-text research articles on human participants. First 3 results:

Patterns of Gray Matter Abnormalities in Idiopathic Generalized Epilepsy: A Meta-Analysis of Voxel-Based Morphology Studies.
 

Author(s): Guo Bin, Tianfu Wang, Hongwu Zeng, Xiaoming He, Feng Li, Jian Zhang, Bingsheng Huang

Journal:

 

We aimed to identify the consistent regions of gray matter volume (GMV) abnormalities in idiopathic generalized epilepsy (IGE), and to study the difference of GMV abnormalities among IGE subsyndromes by applying activation likelihood estimation (ALE) meta-analysis.

Last Updated: 6 Jan 2017

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Moral judgment in patients with idiopathic generalized epilepsy.
 

Author(s): YuBao Jiang, YiMing Zhu, JiaoNan Wu, Nong Zhou, PanPan Hu, Kai Wang

Journal: Seizure. 2016 Oct;41():154-9.

 

The aim of the current study was to investigate morality while also investigating frontal lobe function with the goal of studying the relationship between frontal lobe and morality in patients with idiopathic generalized epilepsy.

Last Updated: 25 Sep 2016

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A computational biomarker of idiopathic generalized epilepsy from resting state EEG.
 

Author(s): Helmut Schmidt, Wessel Woldman, Marc Goodfellow, Fahmida A Chowdhury, Michalis Koutroumanidis, Sharon Jewell, Mark P Richardson, John R Terry

Journal: Epilepsia. 2016 Oct;57(10):e200-e204.

 

Epilepsy is one of the most common serious neurologic conditions. It is characterized by the tendency to have recurrent seizures, which arise against a backdrop of apparently normal brain activity. At present, clinical diagnosis relies on the following: (1) case history, which can ...

Last Updated: 8 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Idiopathic generalized epilepsy" returned 14 free, full-text review articles on human participants. First 3 results:

Focal abnormalities in idiopathic generalized epilepsy: a critical review of the literature.
 

Author(s): Udaya Seneviratne, Mark Cook, Wendyl D'Souza

Journal: Epilepsia. 2014 Aug;55(8):1157-69.

 

Conventionally, epilepsy is dichotomized into distinct "focal" and "generalized" categories. However, many studies have reported so-called focal features among patients with idiopathic generalized epilepsy (IGE) in the domains of semiology, electroencephalography, neuropsychology, ...

Last Updated: 7 Aug 2014

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Genetics of idiopathic generalized epilepsy: an overview.
 

Author(s): D K V Prasad, U Satyanarayana, Anjana Munshi

Journal: Neurol India. ;61(6):572-7.

 

Idiopathic generalized epilepsy (IGE) is a common type of epilepsy. Strong support for a genetic role in IGE comes from twin and family studies. Several subtypes of IGE have been reported but families often have members affected with different subtypes. Major advances have been made ...

Last Updated: 20 Jan 2014

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The prognosis of idiopathic generalized epilepsy.
 

Author(s): Udaya Seneviratne, Mark Cook, Wendyl D'Souza

Journal: Epilepsia. 2012 Dec;53(12):2079-90.

 

Prognosis describes the trajectory and long-term outcome of a condition. Most studies indicate a better prognosis in idiopathic generalized epilepsy (IGE) in comparison with other epilepsy syndromes. Studies looking at the long-term outcome of different IGE syndromes are relatively ...

Last Updated: 4 Dec 2012

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Symptoms, Diagnosis, and Treatment

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