Idiopathic generalized epilepsy

Common Name(s)

Idiopathic generalized epilepsy

Idiopathic generalized epilepsy is a broad term that encompasses several common seizure phenotypes, classically including childhood absence epilepsy (CAE, ECA; see {600131}), juvenile absence epilepsy (JAE, EJA; see {607631}), juvenile myoclonic epilepsy (JME, EJM; see {254770}), and epilepsy with grand mal seizures on awakening ({4:Commission on Classification and Terminology of the International League Against Epilepsy, 1989}). These recurrent seizures occur in the absence of detectable brain lesions and/or metabolic abnormalities. Seizures are initially generalized with a bilateral, synchronous, generalized, symmetrical EEG discharge ({19:Zara et al., 1995}; {8:Lu and Wang, 2009}). See also childhood absence epilepsy (ECA1; {600131}), which has also been mapped to 8q24. Of note, benign neonatal epilepsy 2 (EBN2; {121201}) is caused by mutation in the KCNQ3 gene ({602232}) on 8q24. Genetic Heterogeneity of Idiopathic Generalized Epilepsy EIG1 has been mapped to chromosome 8q24. Other loci or genes associated with EIG include EIG2 ({606972}) on 14q23; EIG3 ({608762}) on 9q32; EIG4 ({609750}) on 10q25; EIG5 ({611934}) on 10p11; EIG6 ({611942}), caused by mutation in the CACNA1H gene ({607904}) on 16p; EIG7 ({604827}) on 15q14; EIG8 ({612899}), caused by mutation in the CASR gene ({601199}) on 3q13.3-q21; EIG9 ({607682}), caused by mutation in the CACNB4 gene ({601949}) on 2q22-q23; EIG10 ({613060}), caused by mutation in the GABRD gene ({137163}) on 1p36.3; EIG11 ({607628}), caused by variation in the CLCN2 gene ({600570}) on 3q36; EIG12 ({614847}), caused by mutation in the SLC2A1 gene ({138140}) on 1p34; EIG13 ({611136}), caused by mutation in the GABRA1 gene ({137160}) on 5q34; and EIG14 ({616685}), caused by mutation in the SLC12A5 gene ({606726}) on 20q12.
 

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Condition Specific Organizations

Following organizations serve the condition "Idiopathic generalized epilepsy" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Idiopathic generalized epilepsy" returned 96 free, full-text research articles on human participants. First 3 results:

Magnetoencephalography Reveals a Widespread Increase in Network Connectivity in Idiopathic/Genetic Generalized Epilepsy.
 

Author(s): Adham Elshahabi, Silke Klamer, Ashish Kaul Sahib, Holger Lerche, Christoph Braun, Niels K Focke

Journal:

 

Idiopathic/genetic generalized epilepsy (IGE/GGE) is characterized by seizures, which start and rapidly engage widely distributed networks, and result in symptoms such as absences, generalized myoclonic and primary generalized tonic-clonic seizures. Although routine magnetic resonance ...

Last Updated: 15 Sep 2015

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Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy A randomized trial.
 

Author(s): Jacqueline A French, Gregory L Krauss, Robert T Wechsler, Xue-Feng Wang, Bree DiVentura, Christian Brandt, Eugen Trinka, Terence J O'Brien, Antonio Laurenza, Anna Patten, Francesco Bibbiani

Journal: Neurology. 2015 Sep;85(11):950-7.

 

To assess efficacy and safety of adjunctive perampanel in patients with drug-resistant, primary generalized tonic-clonic (PGTC) seizures in idiopathic generalized epilepsy (IGE).

Last Updated: 30 Nov 2015

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Frequency-Specific Alterations of Local Synchronization in Idiopathic Generalized Epilepsy.
 

Author(s): Jue Wang, Zhiqiang Zhang, Gong-Jun Ji, Qiang Xu, Yubin Huang, Zhengge Wang, Qing Jiao, Fang Yang, Yu-Feng Zang, Wei Liao, Guangming Lu

Journal: Medicine (Baltimore). 2015 Aug;94(32):e1374.

 

Recurrently and abnormally hypersynchronous discharge is a striking feature of idiopathic generalized epilepsy (IGE). Resting-state functional magnetic resonance imaging has revealed aberrant spontaneous brain synchronization, predominately in low-frequency range (<0.1 Hz), in individuals ...

Last Updated: 13 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Idiopathic generalized epilepsy" returned 14 free, full-text review articles on human participants. First 3 results:

Focal abnormalities in idiopathic generalized epilepsy: a critical review of the literature.
 

Author(s): Udaya Seneviratne, Mark Cook, Wendyl D'Souza

Journal: Epilepsia. 2014 Aug;55(8):1157-69.

 

Conventionally, epilepsy is dichotomized into distinct "focal" and "generalized" categories. However, many studies have reported so-called focal features among patients with idiopathic generalized epilepsy (IGE) in the domains of semiology, electroencephalography, neuropsychology, ...

Last Updated: 7 Aug 2014

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Genetics of idiopathic generalized epilepsy: an overview.
 

Author(s): D K V Prasad, U Satyanarayana, Anjana Munshi

Journal: Neurol India. ;61(6):572-7.

 

Idiopathic generalized epilepsy (IGE) is a common type of epilepsy. Strong support for a genetic role in IGE comes from twin and family studies. Several subtypes of IGE have been reported but families often have members affected with different subtypes. Major advances have been made ...

Last Updated: 20 Jan 2014

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The prognosis of idiopathic generalized epilepsy.
 

Author(s): Udaya Seneviratne, Mark Cook, Wendyl D'Souza

Journal: Epilepsia. 2012 Dec;53(12):2079-90.

 

Prognosis describes the trajectory and long-term outcome of a condition. Most studies indicate a better prognosis in idiopathic generalized epilepsy (IGE) in comparison with other epilepsy syndromes. Studies looking at the long-term outcome of different IGE syndromes are relatively ...

Last Updated: 4 Dec 2012

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Symptoms, Diagnosis, and Treatment

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