Idiopathic generalized epilepsy

Common Name(s)

Idiopathic generalized epilepsy

Idiopathic generalized epilepsy is a broad term that encompasses several common seizure phenotypes, classically including childhood absence epilepsy (CAE, ECA; see {600131}), juvenile absence epilepsy (JAE, EJA; see {607631}), juvenile myoclonic epilepsy (JME, EJM; see {254770}), and epilepsy with grand mal seizures on awakening ({4:Commission on Classification and Terminology of the International League Against Epilepsy, 1989}). These recurrent seizures occur in the absence of detectable brain lesions and/or metabolic abnormalities. Seizures are initially generalized with a bilateral, synchronous, generalized, symmetrical EEG discharge ({19:Zara et al., 1995}; {8:Lu and Wang, 2009}). See also childhood absence epilepsy (ECA1; {600131}), which has also been mapped to 8q24. Of note, benign neonatal epilepsy 2 (EBN2; {121201}) is caused by mutation in the KCNQ3 gene ({602232}) on 8q24. Genetic Heterogeneity of Idiopathic Generalized Epilepsy EIG1 has been mapped to chromosome 8q24. Other loci or genes associated with EIG include EIG2 ({606972}) on 14q23; EIG3 ({608762}) on 9q32; EIG4 ({609750}) on 10q25; EIG5 ({611934}) on 10p11; EIG6 ({611942}), caused by mutation in the CACNA1H gene ({607904}) on 16p; EIG7 ({604827}) on 15q14; EIG8 ({612899}), caused by mutation in the CASR gene ({601199}) on 3q13.3-q21; EIG9 ({607682}), caused by mutation in the CACNB4 gene ({601949}) on 2q22-q23; EIG10 ({613060}), caused by mutation in the GABRD gene ({137163}) on 1p36.3; EIG11 ({607628}), caused by variation in the CLCN2 gene ({600570}) on 3q36; EIG12 ({614847}), caused by mutation in the SLC2A1 gene ({138140}) on 1p34; EIG13 ({611136}), caused by mutation in the GABRA1 gene ({137160}) on 5q34; and EIG14 ({616685}), caused by mutation in the SLC12A5 gene ({606726}) on 20q12.
 

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Condition Specific Organizations

Following organizations serve the condition "Idiopathic generalized epilepsy" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Idiopathic generalized epilepsy" returned 101 free, full-text research articles on human participants. First 3 results:

No relation between EFHC2 gene polymorphism and Idiopathic generalized epilepsy.
 

Author(s): Tuğrul Berrin, Yılmaz Hikmet, Vatandaş Gülşen, Bozyiğit Ferda, Balcan Erdal, Onur Ece

Journal: Afr Health Sci. 2015 Dec;15(4):1204-10.

 

Idiopathic generalized epilepsy (IGE) is an epilepsy form without an underlying brain lesion or neurological indication or symptom. Recent investigations on the genetic origins of IGE and its subtypes report that certain mutations of various ion and non-ion channels genes in the central ...

Last Updated: 9 Mar 2016

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Benign adult familial myoclonus epilepsy is a progressive disorder: no longer idiopathic generalized epilepsy.
 

Author(s): Takefumi Hitomi, Katsuya Kobayashi, Takeyo Sakurai, Sakiho Ueda, Naoto Jingami, Kyoko Kanazawa, Riki Matsumoto, Ryosuke Takahashi, Akio Ikeda

Journal: Epileptic Disord. 2016 Mar;18(1):67-72.

 

Brain dysfunction in Japanese benign adult familial myoclonus epilepsy (BAFME) has not been elucidated. To clarify diffuse brain dysfunction as indicated by posterior dominant rhythm (PDR) slowing in patients with BAFME. The frequency of PDR on EEG was studied in 19 BAFME patients ...

Last Updated: 8 Mar 2016

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Understanding the burden of idiopathic generalized epilepsy in the United States, Europe, and Brazil: An analysis from the National Health and Wellness Survey.
 

Author(s): Shaloo Gupta, Patrick Kwan, Edward Faught, Wan Tsong, Anna Forsythe, Phillipe Ryvlin

Journal: Epilepsy Behav. 2016 Feb;55():146-56.

 

The aim of this study was to understand the current burden of primary generalized tonic-clonic seizures (PGTCS) associated with idiopathic generalized epilepsy (IGE) as a function of seizure frequency. We analyzed data for (IGE) as a proxy measure of PGTCS. Little is known about the ...

Last Updated: 8 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Idiopathic generalized epilepsy" returned 14 free, full-text review articles on human participants. First 3 results:

Focal abnormalities in idiopathic generalized epilepsy: a critical review of the literature.
 

Author(s): Udaya Seneviratne, Mark Cook, Wendyl D'Souza

Journal: Epilepsia. 2014 Aug;55(8):1157-69.

 

Conventionally, epilepsy is dichotomized into distinct "focal" and "generalized" categories. However, many studies have reported so-called focal features among patients with idiopathic generalized epilepsy (IGE) in the domains of semiology, electroencephalography, neuropsychology, ...

Last Updated: 7 Aug 2014

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Genetics of idiopathic generalized epilepsy: an overview.
 

Author(s): D K V Prasad, U Satyanarayana, Anjana Munshi

Journal: Neurol India. ;61(6):572-7.

 

Idiopathic generalized epilepsy (IGE) is a common type of epilepsy. Strong support for a genetic role in IGE comes from twin and family studies. Several subtypes of IGE have been reported but families often have members affected with different subtypes. Major advances have been made ...

Last Updated: 20 Jan 2014

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The prognosis of idiopathic generalized epilepsy.
 

Author(s): Udaya Seneviratne, Mark Cook, Wendyl D'Souza

Journal: Epilepsia. 2012 Dec;53(12):2079-90.

 

Prognosis describes the trajectory and long-term outcome of a condition. Most studies indicate a better prognosis in idiopathic generalized epilepsy (IGE) in comparison with other epilepsy syndromes. Studies looking at the long-term outcome of different IGE syndromes are relatively ...

Last Updated: 4 Dec 2012

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Symptoms, Diagnosis, and Treatment

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