Idiopathic generalized epilepsy

Common Name(s)

Idiopathic generalized epilepsy

Idiopathic generalized epilepsy is a broad term that encompasses several common seizure phenotypes, classically including childhood absence epilepsy (CAE, ECA; see {600131}), juvenile absence epilepsy (JAE, EJA; see {607631}), juvenile myoclonic epilepsy (JME, EJM; see {254770}), and epilepsy with grand mal seizures on awakening ({4:Commission on Classification and Terminology of the International League Against Epilepsy, 1989}). These recurrent seizures occur in the absence of detectable brain lesions and/or metabolic abnormalities. Seizures are initially generalized with a bilateral, synchronous, generalized, symmetrical EEG discharge ({20:Zara et al., 1995}; {8:Lu and Wang, 2009}). See also childhood absence epilepsy (ECA1; {600131}), which has also been mapped to 8q24. Of note, benign neonatal epilepsy 2 (EBN2; {121201}) is caused by mutation in the KCNQ3 gene ({602232}) on 8q24. Genetic Heterogeneity of Idiopathic Generalized Epilepsy EIG1 has been mapped to chromosome 8q24. Other loci or genes associated with EIG include EIG2 ({606972}) on 14q23; EIG3 ({608762}) on 9q32; EIG4 ({609750}) on 10q25; EIG5 ({611934}) on 10p11; EIG6 ({611942}), caused by mutation in the CACNA1H gene ({607904}) on 16p; EIG7 ({604827}) on 15q14; EIG8 ({612899}), caused by mutation in the CASR gene ({601199}) on 3q13.3-q21; EIG9 ({607682}), caused by mutation in the CACNB4 gene ({601949}) on 2q22-q23; EIG10 ({613060}), caused by mutation in the GABRD gene ({137163}) on 1p36.3; EIG11 ({607628}), caused by variation in the CLCN2 gene ({600570}) on 3q36; and EIG12 ({614847}), caused by mutation in the SLC2A1 gene ({138140}) on 1p34.
 

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Condition Specific Organizations

Following organizations serve the condition "Idiopathic generalized epilepsy" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Idiopathic generalized epilepsy" returned 38 free, full-text research articles on human participants. First 3 results:

MRI segmentation analysis in temporal lobe and idiopathic generalized epilepsy.
 

Author(s): Hila Goldberg, Arie Weinstock, Niels Bergsland, Michael G Dwyer, Osman Farooq, Mona Sazgar, Guy Poloni, Cierra Treu, Bianca Weinstock-Guttman, Murali Ramanathan, Robert Zivadinov

Journal:

 

Temporal lobe epilepsy (TLE) and idiopathic generalized epilepsy (IGE) patients have each been associated with extensive brain atrophy findings, yet to date there are no reports of head to head comparison of both patient groups. Our aim was to assess and compare between tissue-specific ...

Last Updated: 26 Jun 2014

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Carbamazepine treatment of generalized tonic-clonic seizures in idiopathic generalized epilepsy.
 

Author(s): Katharine Kenyon, Scott Mintzer, Maromi Nei

Journal: Seizure. 2014 Mar;23(3):234-6.

 

Evaluate the efficacy of carbamazepine in the treatment of idiopathic generalized epilepsy (IGE).

Last Updated: 26 Feb 2014

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Association study of the 2-bp deletion polymorphism in exon 6 of the CHRFAM7A gene with idiopathic generalized epilepsy.
 

Author(s): Agata Rozycka, Jolanta Dorszewska, Barbara Steinborn, Margarita Lianeri, Anna Winczewska-Wiktor, Aleksandra Sniezawska, Kamila Wisniewska, Pawel P Jagodzinski

Journal: DNA Cell Biol.. 2013 Nov;32(11):640-7.

 

There is evidence of linkage between the 15q13-q14 locus, containing the gene encoding the α7 subunit (CHRNA7) of the neuronal nicotinic acetylcholine receptor (nAChR) and its partially duplicated isoform (CHRFAM7A), and epilepsy. Additionally, a 2-bp deletion polymorphism (c.497-498delTG; ...

Last Updated: 21 Oct 2013

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Reviews from the PubMed Database

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The terms "Idiopathic generalized epilepsy" returned 1 free, full-text review articles on human participants. First 3 results:

Genetics of idiopathic generalized epilepsy: an overview.
 

Author(s): D K V Prasad, U Satyanarayana, Anjana Munshi

Journal: Neurol India. ;61(6):572-7.

 

Idiopathic generalized epilepsy (IGE) is a common type of epilepsy. Strong support for a genetic role in IGE comes from twin and family studies. Several subtypes of IGE have been reported but families often have members affected with different subtypes. Major advances have been made ...

Last Updated: 20 Jan 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 30 Apr 2015

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