Blastoma

Common Name(s)

Blastoma

Blastoma is abnormal cell growth of precursor or immature cells. These cells have yet to develop into cells with specific organ function. As a result, the symptoms that arise from these tumors vary greatly, since they are determined by their location in the body. Blastomas can occur in every part of the body, such as the brain, liver, kidneys, nervous system, bones and even the retina. Blastomas are usually found in children and are harder to diagnose due to their variability. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. If blastomas are found, doctors may suggest chemotherapy to combat the tumor problems.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Blastoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Blastoma" returned 78 free, full-text research articles on human participants. First 3 results:

Biphasic Pulmonary Blastoma Associated with Cerebral Metastasis.
 

Author(s): Dalokay Kilic, Cem Yilmaz, Merih Tepeoglu, Cigdem Vural, Hakan Caner

Journal: Turk Neurosurg. 2016 ;26(1):169-72.

 

Pulmonary blastoma is a very rare malignant tumor of the lungs. A biphasic pulmonary blastoma was histologically diagnosed by a characteristic finding as it was mainly constituted of immature tumor tissue that had both epithelial and mesenchymal components. We present a case of a ...

Last Updated: 15 Jan 2016

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Can congenital pulmonary airway malformation be distinguished from Type I pleuropulmonary blastoma based on clinical and radiological features?
 

Author(s): Adina Feinberg, Nigel J Hall, Gretchen M Williams, Kris Ann P Schultz, Doug Miniati, D Ashley Hill, Louis P Dehner, Yoav H Messinger, Jacob C Langer

Journal: J. Pediatr. Surg.. 2016 Jan;51(1):33-7.

 

The management of congenital cystic lung lesions is controversial. Arguments for routine resection during infancy include the possibility of the lesion being Type I pleuropulmonary blastoma (PPB) rather than a cystic congenital pulmonary airway malformation (CPAM). We aimed to identify ...

Last Updated: 15 Jan 2016

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Insulin-like Growth Factor 2 Gene Expression Molecularly Differentiates Pleuropulmonary Blastoma and Embryonal Rhabdomyosarcoma.
 

Author(s): Rajkumar Venkatramani, Timothy J Triche, Larry Wang, Hiroyuki Shimada, Leo Mascarenhas

Journal: J. Pediatr. Hematol. Oncol.. 2015 Aug;37(6):e356-60.

 

The sarcomatous element in pleuropulmonary blastoma (PPB) is often histologically indistinguishable from embryonal rhabdomyosarcoma (ERMS). A diagnosis of PPB is often made after definitive surgical resection based on pathologic features, most notably the presence of hamartomatous ...

Last Updated: 18 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Blastoma" returned 5 free, full-text review articles on human participants. First 3 results:

Classic biphasic pulmonary blastoma with brain and axillary metastases: a case report with molecular analysis and review of literature.
 

Author(s): Yingjie Xiu, Lili Jiang, Weiping Liu

Journal:

 

Pulmonary blastoma is a rare series of malignant lung tumor, which contains three categories: classic biphasic pulmonary blastoma, pluropulmonary blastoma, and well-differentiated fetal adenocarcinoma. In this study, a 19-year old female suffering with classic biphasic pulmonary blastoma ...

Last Updated: 10 Mar 2015

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Pulmonary blastoma: a case report and review of the literature.
 

Author(s): Robert J Smyth, Aurelie Fabre, Johnathan D Dodd, Waldemar Bartosik, Charles G Gallagher, Edward F McKone

Journal:

 

Pulmonary blastomas are a rare aggressive neoplasm comprising 0.25-0.5% of all primary lung tumors and portend a poor prognosis. They display a biphasic histology with mesenchymal and epithelial components. Historically, the term pulmonary blastoma had included both pure fetal adenocarcinomas, ...

Last Updated: 4 Jun 2014

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Pleuropulmonary blastoma. The so-called pulmonary blastoma of childhood.
 

Author(s): J C Manivel, J R Priest, J Watterson, M Steiner, W G Woods, M R Wick, L P Dehner

Journal: Cancer. 1988 Oct;62(8):1516-26.

 

The authors studied 11 pediatric intrathoracic neoplasms that share clinicopathologic features and constitute a specific tumor in children. These neoplasms were intrapulmonary, mediastinal, or pleural-based masses. A common histologic feature was the presence of small, primitive cells ...

Last Updated: 8 Nov 1988

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

International Pleuropulmonary Blastoma (PPB) Treatment and Biology Registry
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma

 

Last Updated: 1 Feb 2016

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DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma; Cystic Nephroma; Ovarian Sertoli-Leydig Cell Tumors; Ocular Medulloepithelioma; Nasal Chondromesenchymal Hamartoma

 

Last Updated: 28 Sep 2016

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Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma; Cystic Nephroma; Sertoli-Leydig Cell Tumor of Ovary; Medulloepithelioma; Embryonal Rhabdomyosarcoma of Cervix; Goiter; Sarcoma; Pineoblastoma; Pituitary Tumors; Wilms Tumor

 

Last Updated: 28 Jul 2016

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