Blastoma

Common Name(s)

Blastoma

Blastoma is abnormal cell growth of precursor or immature cells. These cells have yet to develop into cells with specific organ function. As a result, the symptoms that arise from these tumors vary greatly, since they are determined by their location in the body. Blastomas can occur in every part of the body, such as the brain, liver, kidneys, nervous system, bones and even the retina. Blastomas are usually found in children and are harder to diagnose due to their variability. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. If blastomas are found, doctors may suggest chemotherapy to combat the tumor problems.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Blastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Blastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Blastoma" returned 75 free, full-text research articles on human participants. First 3 results:

Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma.
 

Author(s): Yongjun Yin, Angela M Castro, Marrit Hoekstra, Thomas J Yan, Ajay C Kanakamedala, Louis P Dehner, D Ashley Hill, David M Ornitz

Journal:

 

Pleuropulmonary Blastoma (PPB) is the primary neoplastic manifestation of a pediatric cancer predisposition syndrome that is associated with several diseases including cystic nephroma, Wilms tumor, neuroblastoma, rhabdomyosarcoma, medulloblastoma, and ovarian Sertoli-Leydig cell tumor. ...

Last Updated: 18 May 2015

Go To URL
Pleuropulmonary blastoma: a case report.
 

Author(s): Sümeyye Ekmekci, Anıl Aysal, Nur Olgun, Mustafa Olguner, Handan Çakmakci, Erdener Özer

Journal: Turk Patoloji Derg. 2015 ;31(1):68-71.

 

Pleuropulmonary blastoma is rare embryonal tumor of infancy and early childhood and it often arises from lung and more rarely from the parietal pleura. We present this entity which has no systematic data associated with its incidence in order to discuss clinical, histopathological, ...

Last Updated: 6 Jan 2015

Go To URL
Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma.
 

Author(s): Purnima K Wagh, Margaret A Gardner, Xiaolan Ma, Melissa Callahan, John M Shannon, Susan E Wert, Yoav H Messinger, Louis P Dehner, D Ashley Hill, Kathryn A Wikenheiser-Brokamp

Journal: J. Pathol.. 2015 May;236(1):41-52.

 

Inherited syndromes provide unique opportunities to identify key regulatory mechanisms governing human disease. We previously identified germline loss-of-function DICER1 mutations in a human syndrome defined by the childhood lung neoplasm pleuropulmonary blastoma (PPB), which arises ...

Last Updated: 15 Apr 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Blastoma" returned 5 free, full-text review articles on human participants. First 3 results:

Classic biphasic pulmonary blastoma with brain and axillary metastases: a case report with molecular analysis and review of literature.
 

Author(s): Yingjie Xiu, Lili Jiang, Weiping Liu

Journal:

 

Pulmonary blastoma is a rare series of malignant lung tumor, which contains three categories: classic biphasic pulmonary blastoma, pluropulmonary blastoma, and well-differentiated fetal adenocarcinoma. In this study, a 19-year old female suffering with classic biphasic pulmonary blastoma ...

Last Updated: 10 Mar 2015

Go To URL
Pulmonary blastoma: a case report and review of the literature.
 

Author(s): Robert J Smyth, Aurelie Fabre, Johnathan D Dodd, Waldemar Bartosik, Charles G Gallagher, Edward F McKone

Journal:

 

Pulmonary blastomas are a rare aggressive neoplasm comprising 0.25-0.5% of all primary lung tumors and portend a poor prognosis. They display a biphasic histology with mesenchymal and epithelial components. Historically, the term pulmonary blastoma had included both pure fetal adenocarcinomas, ...

Last Updated: 4 Jun 2014

Go To URL
Pleuropulmonary blastoma. The so-called pulmonary blastoma of childhood.
 

Author(s): J C Manivel, J R Priest, J Watterson, M Steiner, W G Woods, M R Wick, L P Dehner

Journal: Cancer. 1988 Oct;62(8):1516-26.

 

The authors studied 11 pediatric intrathoracic neoplasms that share clinicopathologic features and constitute a specific tumor in children. These neoplasms were intrapulmonary, mediastinal, or pleural-based masses. A common histologic feature was the presence of small, primitive cells ...

Last Updated: 8 Nov 1988

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

International Pleuropulmonary Blastoma (PPB) Treatment and Biology Registry
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma

 

Last Updated: 1 Feb 2016

Go to URL
DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma; Cystic Nephroma; Ovarian Sertoli-Leydig Cell Tumors; Ocular Medulloepithelioma; Nasal Chondromesenchymal Hamartoma

 

Last Updated: 4 Jun 2016

Go to URL
Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
 

Status: Recruiting

Condition Summary: Pleuropulmonary Blastoma; Cystic Nephroma; Sertoli-Leydig Cell Tumor of Ovary; Medulloepithelioma; Embryonal Rhabdomyosarcoma of Cervix; Goiter; Sarcoma; Pineoblastoma; Pituitary Tumors; Wilms Tumor

 

Last Updated: 28 Jul 2016

Go to URL