Hereditary diffuse gastric cancer

Common Name(s)

Hereditary diffuse gastric cancer, HDGC

Hereditary diffuse gastric cancer (HDGC) is a type of stomach (gastric) cancer that runs through families. HDGC is different from other types of stomach cancer because the cancer cells do not form into a solid tumor. Instead, HDGC cancer cells disperse or scatter throughout the stomach tissue. Because of this, this type of cancer spreads (metastasizes) more easily to other parts of the body.

Symptoms of this condition are often not recognized until the cancer is in later stages. These symptoms may include stomach pain, vomiting, and weight loss. Unfortunately, this type of cancer is difficult to catch in early stages. Therefore, if you have a history of HDGC in your family, it is important to get regular and frequent stomach (endoscopy) exams to detect for any cancer cell formation.

HDGC is caused by a genetic mutation in the CDH1 gene which is located on chromosome 16. When a mutation is present in the gene, the gene is unable to pass along the correct instructions to the rest of the cells of the body. As a result, a person with a mutation in the CDH1 gene has a higher risk of developing HDGC, lobular breast cancer, and some forms of colon cancer.

Inheriting a CDH1 mutation does not mean that you will definitely develop these forms of cancer. Rather, the mutation increases your risk of developing HDGC, lobular breast cancer and colon cancer. If you have a family member diagnosed with HDGC or a mutation in the CDH1 gene, talk with a genetic counselor to see if genetic testing is right for you. If you or a family member has been diagnosed with HDGC, talk with your doctor and specialists about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary diffuse gastric cancer" for support, advocacy or research.

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No Stomach For Cancer

Our mission is to support research and united the caring power of people worldwide affected by stomach cancer. We advance awareness and education about stomach cancer, including Hereditary Diffuse Gastric Cancer (HDGC), provide a support network for affected families, and support research for screening, early detection, treatment, and prevention of stomach cancer.

Last Updated: 12 May 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary diffuse gastric cancer" for support, advocacy or research.

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No Stomach For Cancer

Our mission is to support research and united the caring power of people worldwide affected by stomach cancer. We advance awareness and education about stomach cancer, including Hereditary Diffuse Gastric Cancer (HDGC), provide a support network for affected families, and support research for screening, early detection, treatment, and prevention of stomach cancer.

http://www.nostomachforcancer.org

Last Updated: 12 May 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary diffuse gastric cancer" returned 23 free, full-text research articles on human participants. First 3 results:

Clinical utility gene card for: Hereditary diffuse gastric cancer (HDGC).
 

Author(s): Carla Oliveira, Raquel Seruca, Nicoline Hoogerbrugge, Marjolijn Ligtenberg, Fátima Carneiro

Journal: Eur. J. Hum. Genet.. 2013 Aug;21(8):.

 

Last Updated: 18 Jul 2013

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Catenin family genes are not commonly mutated in hereditary diffuse gastric cancer.
 

Author(s): Johanna M Schuetz, Stephen Leach, Pardeep Kaurah, Jennifer Jeyes, Yaron Butterfield, David Huntsman, Angela R Brooks-Wilson

Journal: Cancer Epidemiol. Biomarkers Prev.. 2012 Dec;21(12):2272-4.

 

Approximately one third of the hereditary diffuse gastric cancer (HDGC) families carry germline mutations in the E-cadherin gene (CDH1). Risk prediction in members of families with this rare but deadly cancer could be improved by the identification of additional HDGC genes in non-CDH1 families.

Last Updated: 10 Dec 2012

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Hereditary diffuse gastric cancer: strategies to reduce tumoral risk.
 

Author(s): Maite Herráiz, Víctor Valentí, Jesús Sola, Pilar Pérez-Rojo, Fernando Rotellar, Javier A Cienfuegos

Journal: Rev Esp Enferm Dig. 2012 Jun;104(6):326-9.

 

The main goal at a High-Risk Gastrointestinal Cancer Clinic is to identify individuals at increased risk of developing tumors for diagnosis them in presymptomatic stages, when they are potentially curable. We report an asymptomatic patient belonging to a family with hereditary diffuse ...

Last Updated: 28 Jun 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary diffuse gastric cancer" returned 4 free, full-text review articles on human participants. First 3 results:

Hereditary diffuse gastric cancer: a family diagnosis and treatment.
 

Author(s): Adedayo A Onitilo, Govinda Aryal, Jessica M Engel

Journal: Clin Med Res. 2013 Feb;11(1):36-41.

 

Hereditary diffuse gastric cancer (HDGC) is a rare cancer representing approximately 2% of all gastric cancers. It is caused by CDHI gene mutations, inherited in an autosomal dominant fashion, that affect the function of E-cadherin. Approximately 38% of HDGC families have a CDHI gene ...

Last Updated: 15 Feb 2013

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Hereditary diffuse gastric cancer: prophylactic surgical oncology implications.
 

Author(s): Henry T Lynch, Edibaldo Silva, Debrah Wirtzfeld, Pamela Hebbard, Jane Lynch, David G Huntsman

Journal: Surg. Clin. North Am.. 2008 Aug;88(4):759-78, vi-vii.

 

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominantly inherited syndrome attributed to mutations of the E-cadherin gene, CDH1. There is no proven effective screening for early HDGC, and symptomatic disease is almost universally fatal. The only available effective option ...

Last Updated: 1 Aug 2008

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Hereditary diffuse gastric cancer: association with lobular breast cancer.
 

Author(s): Kasmintan A Schrader, Serena Masciari, Niki Boyd, Sara Wiyrick, Pardeep Kaurah, Janine Senz, Wylie Burke, Henry T Lynch, Judy E Garber, David G Huntsman

Journal: Fam. Cancer. 2008 ;7(1):73-82.

 

Hereditary diffuse gastric cancer (HDGC) has been shown to be caused by germline mutations in the gene CDH1 located at 16q22.1, which encodes the cell-cell adhesion molecule, E-cadherin. Not only does loss of expression of E-cadherin account for the morphologic differences between ...

Last Updated: 25 Feb 2008

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Screening for Familial Gastric Cancer in First Degree Relatives
 

Status: Recruiting

Condition Summary: Malignant Neoplasm of Stomach; Carcinoma, Diffuse Type; Intestinal Type Adenocarcinoma of Stomach; Relative (Related Person)

 

Last Updated: 16 Nov 2012

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Early Onset and Familial Gastric Cancer Registry
 

Status: Recruiting

Condition Summary: Gastric Cancer

 

Last Updated: 17 Mar 2015

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