Heparin cofactor II deficiency

Common Name(s)

Heparin cofactor II deficiency

Heparin cofactor II (HCF2; {142360}) rapidly inhibits thrombin in plasma in the presence of dermatan sulfate or heparin. Congenital HCF2 deficiency is associated with thromboembolism and is classified into type I (quantitative) or type II (qualitative) deficiency ({5:Kondo et al., 1996}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heparin cofactor II deficiency" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Heparin cofactor II deficiency" returned 2 free, full-text research articles on human participants. First 3 results:

Homozygous deficiency of heparin cofactor II: relevance of P17 glutamate residue in serpins, relationship with conformational diseases, and role in thrombosis.
 

Author(s): Javier Corral, Justo Aznar, Rocio Gonzalez-Conejero, Piedad Villa, Antonia Miñano, Amparo Vayá, Robin W Carrell, James A Huntington, Vicente Vicente

Journal: Circulation. 2004 Sep;110(10):1303-7.

 

Heparin cofactor II (HCII) is a hepatic serpin with significant antithrombin activity that has been implicated in coagulation, inflammation, atherosclerosis, and wound repair. Recent data obtained in mice lacking HCII suggest that this serpin might inhibit thrombosis in the arterial ...

Last Updated: 8 Sep 2004

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Molecular and cellular basis for type I heparin cofactor II deficiency (heparin cofactor II Awaji).
 

Author(s): S Kondo, F Tokunaga, K Kario, T Matsuo, T Koide

Journal: Blood. 1996 Feb;87(3):1006-12.

 

Heparin cofactor II (HCII) is a serine proteinase inhibitor in human plasma that rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. To understand the molecular mechanism for HCII deficiency in a patient with reduced circulating HCII antigen, we studied a Japanese ...

Last Updated: 1 Mar 1996

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Reviews from the PubMed Database

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The terms "Heparin cofactor II deficiency" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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