Bipolar disorder

Common Name(s)

Bipolar disorder, Manic depression

Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. Signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). Mood episodes may also include symptoms of both mania and depression (a mixed state). Bipolar disorder often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. Bipolar disorder can run in families, although no single gene is thought to cause the condition. Many factors acting together may increase a person's risk to develop the disorder. Treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms.

Bipolar disorder differs significantly from clinical depression, although the symptoms for the depressive phase of the illness are similar (please also see: depression). The mood swings from high to low can be severe, ranging from extreme energy to deep despair. The severity of the mood swings and the way they disrupt normal life activities distinguish bipolar mood episodes from ordinary mood changes. It is important to tell your doctor if you experience both highs and lows because the treatment for bipolar disorder is different than for depression. Talk with your doctor to decide on the best treatment plan. Support groups are also a good source of up to date information and can help connect you with others affected by depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar disorder" for support, advocacy or research.

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Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

Last Updated: 24 Jun 2015

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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

Last Updated: 15 Apr 2014

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everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

Last Updated: 25 Mar 2013

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 6 Apr 2015

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Simons VIP Connect

The Simons Variation in Individuals Project (Simons VIP) is an online community and research initiative. We provide a platform to partner families and researchers to better understand over 40 genetic changes (genomic variants) associated with features related to autism and developmental delay.

Last Updated: 20 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar disorder" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

http://www.adaa.org

Last Updated: 24 Jun 2015

View Details
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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

http://www.ndmda.org

Last Updated: 15 Apr 2014

View Details
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everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

http://www.everyminute.org

Last Updated: 25 Mar 2013

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 6 Apr 2015

View Details
Logo
Simons VIP Connect

The Simons Variation in Individuals Project (Simons VIP) is an online community and research initiative. We provide a platform to partner families and researchers to better understand over 40 genetic changes (genomic variants) associated with features related to autism and developmental delay.

http://www.simonsvipconnect.org

Last Updated: 20 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
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General Resources

Bipolar Disorder

A brochure for individuals and families outlining symptoms, causes, treatment and recovery supports.

Updated 29 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bipolar disorder" returned 2120 free, full-text research articles on human participants. First 3 results:

Depression and Anxiety in the Postpartum Period and Risk of Bipolar Disorder: A Danish Nationwide Register-Based Cohort Study.
 

Author(s): Xiaoqin Liu, Esben Agerbo, Jiong Li, Samantha Meltzer-Brody, Veerle Bergink, Trine Munk-Olsen

Journal: J Clin Psychiatry. 2017 May;78(5):e469-e476.

 

The first-onset affective episode requiring inpatient treatment in the postpartum period can be a marker of bipolar disorder, but it is unknown whether milder postpartum affective episodes are also indicators of underlying bipolarity. Therefore, we aimed to study whether women with ...

Last Updated: 1 Jun 2017

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GeneAnalytics Pathway Analysis and Genetic Overlap among Autism Spectrum Disorder, Bipolar Disorder and Schizophrenia.
 

Author(s): Naveen S Khanzada, Merlin G Butler, Ann M Manzardo

Journal:

 

Bipolar disorder (BPD) and schizophrenia (SCH) show similar neuropsychiatric behavioral disturbances, including impaired social interaction and communication, seen in autism spectrum disorder (ASD) with multiple overlapping genetic and environmental influences implicated in risk and ...

Last Updated: 7 Mar 2017

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Comparison of associated features and drug treatment between co-occurring unipolar and bipolar disorders in depressed eating disorder patients.
 

Author(s): Mei-Chih Meg Tseng, Chin-Hao Chang, Shih-Cheng Liao, Hsi-Chung Chen

Journal:

 

To examine the differences of associated characteristics and prescription drug use between co-occurring unipolar and bipolar disorders in patients with eating disorders (EDs).

Last Updated: 28 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bipolar disorder" returned 401 free, full-text review articles on human participants. First 3 results:

The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment.
 

Author(s): A H Ashok, T R Marques, S Jauhar, M M Nour, G M Goodwin, A H Young, O D Howes

Journal: Mol. Psychiatry. 2017 May;22(5):666-679.

 

Bipolar affective disorder is a common neuropsychiatric disorder. Although its neurobiological underpinnings are incompletely understood, the dopamine hypothesis has been a key theory of the pathophysiology of both manic and depressive phases of the illness for over four decades. ...

Last Updated: 14 Mar 2017

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Negative experiences in childhood and the development and course of bipolar disorder.
 

Author(s): Paulina Jaworska-Andryszewska, Janusz Rybakowski

Journal: Psychiatr. Pol.. 2016 Oct;50(5):989-1000.

 

The aim of this paper is to review the effects of negative childhood experiences on the development and course of bipolar disorder (BD) and to discuss the involved mechanisms. The negative childhood experiences that may play a role in BD are critical or traumatic events including ...

Last Updated: 19 Dec 2016

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Gsk3 Signalling and Redox Status in Bipolar Disorder: Evidence from Lithium Efficacy.
 

Author(s): Antonina Luca, Carmela Calandra, Maria Luca

Journal: Oxid Med Cell Longev. 2016 ;2016():3030547.

 

Objective. To discuss the link between glycogen synthase kinase-3 (GSK3) and the main biological alterations demonstrated in bipolar disorder (BD), with special attention to the redox status and the evidence supporting the efficacy of lithium (a GSK3 inhibitor) in the treatment of ...

Last Updated: 16 Sep 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Occupational Stress and Bipolar Disorder
 

Status: Recruiting

Condition Summary: Bipolar Disorder

 

Last Updated: 19 May 2017

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Targeting Cognition in Bipolar Disorder With Pramipexole
 

Status: Recruiting

Condition Summary: Bipolar Disorder

 

Last Updated: 26 Apr 2017

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Interval Training in Bipolar Disorder
 

Status: Recruiting

Condition Summary: Bipolar Disorder

 

Last Updated: 10 Aug 2015

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