Bipolar disorder

Common Name(s)

Bipolar disorder, Manic depression

Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. Signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). Mood episodes may also include symptoms of both mania and depression (a mixed state). Bipolar disorder often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. Bipolar disorder can run in families, although no single gene is thought to cause the condition. Many factors acting together may increase a person's risk to develop the disorder. Treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms.

Bipolar disorder differs significantly from clinical depression, although the symptoms for the depressive phase of the illness are similar (please also see: depression). The mood swings from high to low can be severe, ranging from extreme energy to deep despair. The severity of the mood swings and the way they disrupt normal life activities distinguish bipolar mood episodes from ordinary mood changes. It is important to tell your doctor if you experience both highs and lows because the treatment for bipolar disorder is different than for depression. Talk with your doctor to decide on the best treatment plan. Support groups are also a good source of up to date information and can help connect you with others affected by depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar disorder" for support, advocacy or research.

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Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

Last Updated: 24 Jun 2015

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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

Last Updated: 15 Apr 2014

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everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

Last Updated: 25 Mar 2013

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 6 Apr 2015

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Simons VIP Connect

The Simons Variation in Individuals Project (Simons VIP) is an online community and research initiative. We provide a platform to partner families and researchers to better understand over 40 genetic changes (genomic variants) associated with features related to autism and developmental delay.

Last Updated: 20 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar disorder" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

http://www.adaa.org

Last Updated: 24 Jun 2015

View Details
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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

http://www.ndmda.org

Last Updated: 15 Apr 2014

View Details
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everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

http://www.everyminute.org

Last Updated: 25 Mar 2013

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 6 Apr 2015

View Details
Logo
Simons VIP Connect

The Simons Variation in Individuals Project (Simons VIP) is an online community and research initiative. We provide a platform to partner families and researchers to better understand over 40 genetic changes (genomic variants) associated with features related to autism and developmental delay.

http://www.simonsvipconnect.org

Last Updated: 20 Jul 2015

View Details

 

General Support Organizations

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General Resources

Bipolar Disorder

A brochure for individuals and families outlining symptoms, causes, treatment and recovery supports.

Updated 29 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bipolar disorder" returned 1807 free, full-text research articles on human participants. First 3 results:

Test-retest study of the six-minute walk test in people with bipolar disorder.
 

Author(s): Davy Vancampfort, Sabine Wyckaert, Pascal Sienaert, Marc De Hert, Andrew Soundy, Simon Rosenbaum, Justin Richards, Michel Probst

Journal: Psychiatr Danub. 2016 Mar;28(1):39-44.

 

The multidisciplinary care for bipolar disorder is highly fragmented with limited opportunities for prevention and treatment of medical co-morbidities. We examined the reliability of the 6-minute walk test (6MWT). Secondary aims were to assess minimal detectable changes (MDC(95)), ...

Last Updated: 4 Mar 2016

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DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder.
 

Author(s): Rosie May Walker, Andrea Nikie Christoforou, Daniel L McCartney, Stewart W Morris, Nicholas A Kennedy, Peter Morten, Susan Maguire Anderson, Helen Scott Torrance, Alix Macdonald, Jessika Elizabeth Sussmann, Heather Clare Whalley, Douglas H R Blackwood, Andrew Mark McIntosh, David John Porteous, Kathryn Louise Evans

Journal:

 

Bipolar disorder (BD) is a severe, familial psychiatric condition. Progress in understanding the aetiology of BD has been hampered by substantial phenotypic and genetic heterogeneity. We sought to mitigate these confounders by studying a multi-generational family multiply affected ...

Last Updated: 22 Jan 2016

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Clinical characteristics and influence of childhood trauma on the prodrome of bipolar disorder.
 

Author(s): Mariane N Noto, Cristiano Noto, André C Caribé, Ângela Miranda-Scippa, Sandra O Nunes, Ana C Chaves, Denise Amino, Rodrigo Grassi-Oliveira, Christoph U Correll, Elisa Brietzke

Journal: Rev Bras Psiquiatr. ;37(4):280-8.

 

To describe the onset pattern, frequency, and severity of the signs and symptoms of the prodrome of the first hypomanic/manic episode and first depressive episode of bipolar disorder (BD) and to investigate the influence of a history of childhood maltreatment on the expression of prodromal symptoms.

Last Updated: 22 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bipolar disorder" returned 271 free, full-text review articles on human participants. First 3 results:

Early stages of bipolar disorder: characterization and strategies for early intervention.
 

Author(s): Adiel C Rios, Mariane N Noto, Lucas B Rizzo, Rodrigo Mansur, Flávio E Martins, Rodrigo Grassi-Oliveira, Christoph U Correll, Elisa Brietzke

Journal: Rev Bras Psiquiatr. ;37(4):343-9.

 

To characterize the early stages of bipolar disorder (BD), defined as the clinical prodrome/subsyndromal stage and first-episode phase, and strategies for their respective treatment.

Last Updated: 22 Dec 2015

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Consequences of misdiagnosis: inaccurate treatment and poor patient outcomes in bipolar disorder.
 

Author(s): Henry A Nasrallah

Journal: J Clin Psychiatry. 2015 Oct;76(10):e1328.

 

Bipolar depression is difficult to diagnose and is often mistaken for unipolar depression. Unfortunately, this misdiagnosis creates a cascade of negative outcomes. Patients will probably receive inadequate or inappropriate treatment that will not alleviate the symptoms or impairment ...

Last Updated: 4 Nov 2015

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Mobile Apps for Bipolar Disorder: A Systematic Review of Features and Content Quality.
 

Author(s): Jennifer Nicholas, Mark Erik Larsen, Judith Proudfoot, Helen Christensen

Journal:

 

With continued increases in smartphone ownership, researchers and clinicians are investigating the use of this technology to enhance the management of chronic illnesses such as bipolar disorder (BD). Smartphones can be used to deliver interventions and psychoeducation, supplement ...

Last Updated: 18 Aug 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Retrain Your Brain in Children/Adolescents With Bipolar Disorder: A Pilot Study
 

Status: Recruiting

Condition Summary: Bipolar Disorder; Pediatric Bipolar Disorder; Childhood-onset Bipolar Disorder

 

Last Updated: 11 Jan 2016

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Inositol Hexaphosphate: A Novel Treatment Strategy for Bipolar Disorder?
 

Status: Recruiting

Condition Summary: Bipolar Disorder; Manic Depression

 

Last Updated: 19 Nov 2015

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Ondansetron for Bipolar Disorder and Alcohol Use Disorders
 

Status: Recruiting

Condition Summary: Bipolar Disorder; Alcohol Use Disorder; Dual Diagnosis

 

Last Updated: 3 May 2016

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