Bipolar disorder

Common Name(s)

Bipolar disorder, Manic depression

Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. Signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). Mood episodes may also include symptoms of both mania and depression (a mixed state). Bipolar disorder often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. Bipolar disorder can run in families, although no single gene is thought to cause the condition. Many factors acting together may increase a person's risk to develop the disorder. Treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms.

Bipolar disorder differs significantly from clinical depression, although the symptoms for the depressive phase of the illness are similar (please also see: depression). The mood swings from high to low can be severe, ranging from extreme energy to deep despair. The severity of the mood swings and the way they disrupt normal life activities distinguish bipolar mood episodes from ordinary mood changes. It is important to tell your doctor if you experience both highs and lows because the treatment for bipolar disorder is different than for depression. Talk with your doctor to decide on the best treatment plan. Support groups are also a good source of up to date information and can help connect you with others affected by depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar disorder" for support, advocacy or research.

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Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

Last Updated: 24 Jun 2015

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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

Last Updated: 15 Apr 2014

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everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

Last Updated: 25 Mar 2013

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 6 Apr 2015

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Simons VIP Connect

The Simons Variation in Individuals Project (Simons VIP) is an online community and research initiative. We provide a platform to partner families and researchers to better understand over 40 genetic changes (genomic variants) associated with features related to autism and developmental delay.

Last Updated: 20 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar disorder" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

http://www.adaa.org

Last Updated: 24 Jun 2015

View Details
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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

http://www.ndmda.org

Last Updated: 15 Apr 2014

View Details
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everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

http://www.everyminute.org

Last Updated: 25 Mar 2013

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 6 Apr 2015

View Details
Logo
Simons VIP Connect

The Simons Variation in Individuals Project (Simons VIP) is an online community and research initiative. We provide a platform to partner families and researchers to better understand over 40 genetic changes (genomic variants) associated with features related to autism and developmental delay.

http://www.simonsvipconnect.org

Last Updated: 20 Jul 2015

View Details

 

General Support Organizations

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General Resources

Bipolar Disorder

A brochure for individuals and families outlining symptoms, causes, treatment and recovery supports.

Updated 29 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bipolar disorder" returned 2304 free, full-text research articles on human participants. First 3 results:

Elevated heat shock proteins in bipolar disorder patients with hypothalamic pituitary adrenal axis dysfunction.
 

Author(s): Yuhang Cheng, Zhili Li, San He, Yujie Tian, Fan He, Wenbiao Li

Journal: Medicine (Baltimore). 2018 Jul;97(27):e11089.

 

Heat shock proteins (HSP) might be useful as biomarkers for bipolar disorder (BD) which would be clinically valuable since no reliable biomarker for BD has so far been identified. The purpose of this study was to assess the heat shock proteins CPN10, CPN60, and CPN70 as potential biomarkers of BD.

Last Updated: 31 Dec 1969

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The aldehyde dehydrogenase 2 polymorphisms on neuropsychological performance in bipolar II disorder with or without comorbid anxiety disorder.
 

Author(s): Ru-Band Lu, Yun-Hsuan Chang, Tzu-Yun Wang, Sheng-Yu Lee, Po See Chen, Yen Kuang Yang

Journal:

 

Anxiety disorders (ADs), the most common comorbid illnesses with bipolar disorder (BP) has been reported to associate with dopamine system. Dopamine, metabolized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase 2 (ALDH2), and the distribution of the ALDH2*1/*1, ...

Last Updated: 31 Dec 1969

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Reasons for lithium discontinuation in men and women with bipolar disorder: a retrospective cohort study.
 

Author(s): Louise Öhlund, Michael Ott, Sofia Oja, Malin Bergqvist, Robert Lundqvist, Mikael Sandlund, Ellinor Salander Renberg, Ursula Werneke

Journal:

 

Lithium remains first choice as maintenance treatment for bipolar affective disorder. Yet, about half of all individuals may stop their treatment at some point, despite lithium's proven benefits concerning the prevention of severe affective episodes and suicide.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bipolar disorder" returned 437 free, full-text review articles on human participants. First 3 results:

An Oldie but Goodie: Lithium in the Treatment of Bipolar Disorder through Neuroprotective and Neurotrophic Mechanisms.
 

Author(s): Eunsoo Won, Yong-Ku Kim

Journal:

 

Lithium has been used for the treatment of bipolar disorder (BD) for the last sixty or more years, and recent studies with more reliable designs and updated guidelines have recommended lithium to be the treatment of choice for acute manic, mixed and depressive episodes of BD, along ...

Last Updated: 31 Dec 1969

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Obstructive Sleep Apnea as a Complication of Bipolar Disorder and Its Treatment: A Review and Approach to Management.
 

Author(s): Surinder S Moonga, David Mischoulon, John W Winkelman, Theodore A Stern

Journal:

 

Last Updated: 31 Dec 1969

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Asenapine Treatment in Pediatric Patients with Bipolar I Disorder or Schizophrenia: A Review.
 

Author(s): Ekaterina Stepanova, Bradley Grant, Robert L Findling

Journal: Paediatr Drugs. 2018 Apr;20(2):121-134.

 

Asenapine, administered as a twice-daily (BID) sublingual tablet, is approved in the US as monotherapy for the acute treatment of manic and mixed episodes of bipolar I disorder in children and adolescents aged 10-17 years based on the positive results of one 3-week, double-blind, ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Occupational Stress and Bipolar Disorder
 

Status: Recruiting

Condition Summary: Bipolar Disorder

 

Last Updated: 4 May 2018

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Imaging 5HT7 Antagonist Effects in Bipolar Disorder
 

Status: Recruiting

Condition Summary: Bipolar Disorder

 

Last Updated: 13 Aug 2018

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Targeting Cognition in Bipolar Disorder With Pramipexole
 

Status: Recruiting

Condition Summary: Bipolar Disorder

 

Last Updated: 15 Jun 2018

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