Bipolar Disorder

Common Name(s)

Bipolar Disorder

Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. Signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). Mood episodes may also include symptoms of both mania and depression (a mixed state). Bipolar disorder often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. Bipolar disorder can run in families, although no single gene is thought to cause the condition. Many factors acting together may increase a person's risk to develop the disorder. Treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms.

Bipolar disorder differs significantly from clinical depression, although the symptoms for the depressive phase of the illness are similar (please also see: depression). The mood swings from high to low can be severe, ranging from extreme energy to deep despair. The severity of the mood swings and the way they disrupt normal life activities distinguish bipolar mood episodes from ordinary mood changes. It is important to tell your doctor if you experience both highs and lows because the treatment for bipolar disorder is different than for depression. Talk with your doctor to decide on the best treatment plan. Support groups are also a good source of up to date information and can help connect you with others affected by depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar Disorder" for support, advocacy or research.

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Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

Last Updated: 15 Feb 2013

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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

Last Updated: 15 Apr 2014

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everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

Last Updated: 25 Mar 2013

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 6 Apr 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar Disorder" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

http://www.adaa.org

Last Updated: 15 Feb 2013

View Details
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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

http://www.ndmda.org

Last Updated: 15 Apr 2014

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everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

http://www.everyminute.org

Last Updated: 25 Mar 2013

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 6 Apr 2015

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General Support Organizations

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General Resources

Bipolar Disorder

A brochure for individuals and families outlining symptoms, causes, treatment and recovery supports.

Updated 29 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bipolar Disorder" returned 1427 free, full-text research articles on human participants. First 3 results:

Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder.
 

Author(s): Robert Maier, Gerhard Moser, Guo-Bo Chen, Stephan Ripke, , William Coryell, James B Potash, William A Scheftner, Jianxin Shi, Myrna M Weissman, Christina M Hultman, Mikael Landén, Douglas F Levinson, Kenneth S Kendler, Jordan W Smoller, Naomi R Wray, S Hong Lee

Journal: Am. J. Hum. Genet.. 2015 Feb;96(2):283-94.

 

Genetic risk prediction has several potential applications in medical research and clinical practice and could be used, for example, to stratify a heterogeneous population of patients by their predicted genetic risk. However, for polygenic traits, such as psychiatric disorders, the ...

Last Updated: 9 Feb 2015

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The effect of electroconvulsive therapy on neurocognitive function in treatment-resistant bipolar disorder depression.
 

Author(s): Ute Kessler, Helle K Schoeyen, Ole A Andreassen, Geir E Eide, Ulrik F Malt, Ketil J Oedegaard, Gunnar Morken, Kjetil Sundet, Arne E Vaaler

Journal: J Clin Psychiatry. 2014 Nov;75(11):e1306-13.

 

To compare the effects of right unilateral (RUL) electroconvulsive therapy (ECT) and algorithm-based pharmacologic treatment (APT) on neurocognitive function in treatment-resistant bipolar disorder depression.

Last Updated: 4 Dec 2014

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The use of the Clock Drawing Test in bipolar disorder with or without dementia of Alzheimer's type.
 

Author(s): Ivan Aprahamian, Marcia Radanovic, Paula Villela Nunes, Rodolfo Braga Ladeira, Orestes Vicente Forlenza

Journal: Arq Neuropsiquiatr. 2014 Dec;72(12):913-8.

 

There is limited data regarding the cognitive profile from screening tests of older adults with bipolar disorder (BD) with dementia. Objective To investigate the Clock Drawing Test (CDT) among older adults with BD with and without Alzheimer's disease (AD). Method 209 older adults ...

Last Updated: 18 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bipolar Disorder" returned 218 free, full-text review articles on human participants. First 3 results:

Differential diagnosis of bipolar disorder and major depressive disorder.
 

Author(s): R M Hirschfeld

Journal: J Affect Disord. 2014 Dec;169 Suppl 1():S12-6.

 

Patients with bipolar disorder spend approximately half of their lives symptomatic and the majority of that time suffering from symptoms of depression, which complicates the accurate diagnosis of bipolar disorder.

Last Updated: 23 Dec 2014

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[New insights into ways of determining cortisol exposure in patients with bipolar disorder].
 

Author(s): A T Spijker, S M Staufenbiel, E F C van Rossum

Journal: Tijdschr Psychiatr. 2014 ;56(12):788-97.

 

Previous research has shown a relationship between the stress hormone cortisol and bipolar disorder. The level of cortisol exposure is usually examined by means of measurements that provide a snapshot of cortisol exposure or by means of dynamic testing. Recently, a new technique has ...

Last Updated: 16 Dec 2014

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Controversies in the psychopharmacology of bipolar disorder.
 

Author(s): Robert M Post, Michael J Ostacher, Vivek Singh

Journal: J Clin Psychiatry. 2014 Nov;75(11):e30.

 

Few studies have examined the decision-making process for selecting a mood stabilizer or antipsychotic for patients with bipolar disorder. Despite a lack of evidence regarding their efficacy, conventional unimodal antidepressants continue to be used in bipolar treatment regimens. ...

Last Updated: 4 Dec 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Retrain Your Brain in Children/Adolescents With Bipolar Disorder: A Pilot Study
 

Status: Recruiting

Condition Summary: Bipolar Disorder; Pediatric Bipolar Disorder; Childhood-onset Bipolar Disorder

 

Last Updated: 19 Aug 2014

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Mindfulness Based Cognitive Therapy for Youth With Anxiety at Risk for Bipolar Disorder
 

Status: Recruiting

Condition Summary: Childhood Anxiety; Parents With Bipolar Disorder; Children at Risk for Bipolar Disorder

 

Last Updated: 15 Jan 2015

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Inositol Hexaphosphate: A Novel Treatment Strategy for Bipolar Disorder?
 

Status: Not yet recruiting

Condition Summary: Bipolar Disorder; Manic Depression

 

Last Updated: 6 Mar 2014

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