Bipolar Disorder

Common Name(s)

Bipolar Disorder

Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. Signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). Mood episodes may also include symptoms of both mania and depression (a mixed state). It often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. Bipolar disorder can run in families, although no single gene is thought to cause the condition. Many factors acting together likely increase a person's risk to develop the disorder. Treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar Disorder" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

Last Updated: 15 Feb 2013

View Details
Logo
Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

Last Updated: 15 Apr 2014

View Details
Logo
everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

Last Updated: 25 Mar 2013

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 29 Jan 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar Disorder" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

http://www.adaa.org

Last Updated: 15 Feb 2013

View Details
Logo
Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

http://www.ndmda.org

Last Updated: 15 Apr 2014

View Details
Logo
everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

http://www.everyminute.org

Last Updated: 25 Mar 2013

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 29 Jan 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

Bipolar Disorder

A brochure for individuals and families outlining symptoms, causes, treatment and recovery supports.

Updated 29 Jan 2013

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bipolar Disorder" returned 1279 free, full-text research articles on human participants. First 3 results:

Variant GADL1 and response to lithium in bipolar I disorder.
 

Author(s): Chau-Shoun Lee, Andrew Tai-Ann Cheng

Journal: N. Engl. J. Med.. 2014 May;370(19):1859-60.

 

Last Updated: 8 May 2014

Go To URL
Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia.
 

Author(s): Shashwath A Meda, Gualberto Ruaño, Andreas Windemuth, Kasey O'Neil, Clifton Berwise, Sabra M Dunn, Leah E Boccaccio, Balaji Narayanan, Mohan Kocherla, Emma Sprooten, Matcheri S Keshavan, Carol A Tamminga, John A Sweeney, Brett A Clementz, Vince D Calhoun, Godfrey D Pearlson

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 May;111(19):E2066-75.

 

The brain's default mode network (DMN) is highly heritable and is compromised in a variety of psychiatric disorders. However, genetic control over the DMN in schizophrenia (SZ) and psychotic bipolar disorder (PBP) is largely unknown. Study subjects (n = 1,305) underwent a resting-state ...

Last Updated: 14 May 2014

Go To URL
GRIN2B gene and associated brain cortical white matter changes in bipolar disorder: a preliminary combined platform investigation.
 

Author(s): Carissa Nadia Kuswanto, Min Yi Sum, Christopher Ren Zhi Thng, Yi Bin Zhang, Guo Liang Yang, Wieslaw Lucjan Nowinski, Yih Yian Sitoh, Chian Ming Low, Kang Sim

Journal: Biomed Res Int. 2013 ;2013():635131.

 

Abnormalities in glutamate signaling and glutamate toxicity are thought to be important in the pathophysiology of bipolar disorder (BD). Whilst previous studies have found brain white matter changes in BD, there is paucity of data about how glutamatergic genes affect brain white matter ...

Last Updated: 3 Feb 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bipolar Disorder" returned 204 free, full-text review articles on human participants. First 3 results:

Pharmacotherapy of bipolar disorder in children and adolescents: an update.
 

Author(s): Tatiana Lauxen Peruzzolo, Silzá Tramontina, Luis Augusto Rohde, Cristian Patrick Zeni

Journal: Rev Bras Psiquiatr. ;35(4):393-405.

 

To review the options for acute and maintenance pharmacological treatment of bipolar disorder in children and adolescents, including the treatment of bipolar depression and comorbid attention deficit/hyperactivity disorder (ADHD).

Last Updated: 9 Jan 2014

Go To URL
The relationship between borderline personality disorder and bipolar disorder.
 

Author(s): Mark Zimmerman, Theresa A Morgan

Journal: Dialogues Clin Neurosci. 2013 Jun;15(2):155-69.

 

It is clinically important to recognize both bipolar disorder and borderline personality disorder (BPD) in patients seeking treatment for depression, and it is important to distinguish between the two. Research considering whether BPD should be considered part of a bipolar spectrum ...

Last Updated: 31 Oct 2013

Go To URL
Systematic review of genome-wide gene expression studies of bipolar disorder.
 

Author(s): Fayaz Seifuddin, Mehdi Pirooznia, Jennifer T Judy, Fernando S Goes, James B Potash, Peter P Zandi

Journal:

 

Numerous genome-wide gene expression studies of bipolar disorder (BP) have been carried out. These studies are heterogeneous, underpowered and use overlapping samples. We conducted a systematic review of these studies to synthesize the current findings.

Last Updated: 15 Nov 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Retrain Your Brain in Children/Adolescents With Bipolar Disorder: A Pilot Study
 

Status: Recruiting

Condition Summary: Bipolar Disorder; Pediatric Bipolar Disorder; Childhood-onset Bipolar Disorder

 

Last Updated: 19 Aug 2014

Go to URL
Mindfulness Based Cognitive Therapy for Youth With Anxiety at Risk for Bipolar Disorder
 

Status: Recruiting

Condition Summary: Childhood Anxiety; Parents With Bipolar Disorder; Children at Risk for Bipolar Disorder

 

Last Updated: 14 Mar 2014

Go to URL
Inositol Hexaphosphate: A Novel Treatment Strategy for Bipolar Disorder?
 

Status: Not yet recruiting

Condition Summary: Bipolar Disorder; Manic Depression

 

Last Updated: 6 Mar 2014

Go to URL