Bipolar disorder

Common Name(s)

Bipolar disorder, Manic depression

Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. Signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). Mood episodes may also include symptoms of both mania and depression (a mixed state). Bipolar disorder often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. Bipolar disorder can run in families, although no single gene is thought to cause the condition. Many factors acting together may increase a person's risk to develop the disorder. Treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms.

Bipolar disorder differs significantly from clinical depression, although the symptoms for the depressive phase of the illness are similar (please also see: depression). The mood swings from high to low can be severe, ranging from extreme energy to deep despair. The severity of the mood swings and the way they disrupt normal life activities distinguish bipolar mood episodes from ordinary mood changes. It is important to tell your doctor if you experience both highs and lows because the treatment for bipolar disorder is different than for depression. Talk with your doctor to decide on the best treatment plan. Support groups are also a good source of up to date information and can help connect you with others affected by depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar disorder" for support, advocacy or research.

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Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

Last Updated: 24 Jun 2015

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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

Last Updated: 15 Apr 2014

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everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

Last Updated: 25 Mar 2013

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 6 Apr 2015

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Simons VIP Connect

The Simons Variation in Individuals Project (Simons VIP) is an online community and research initiative. We provide a platform to partner families and researchers to better understand over 40 genetic changes (genomic variants) associated with features related to autism and developmental delay.

Last Updated: 20 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar disorder" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

http://www.adaa.org

Last Updated: 24 Jun 2015

View Details
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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

http://www.ndmda.org

Last Updated: 15 Apr 2014

View Details
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everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

http://www.everyminute.org

Last Updated: 25 Mar 2013

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 6 Apr 2015

View Details
Logo
Simons VIP Connect

The Simons Variation in Individuals Project (Simons VIP) is an online community and research initiative. We provide a platform to partner families and researchers to better understand over 40 genetic changes (genomic variants) associated with features related to autism and developmental delay.

http://www.simonsvipconnect.org

Last Updated: 20 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
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General Resources

Bipolar Disorder

A brochure for individuals and families outlining symptoms, causes, treatment and recovery supports.

Updated 29 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bipolar disorder" returned 1665 free, full-text research articles on human participants. First 3 results:

[Hypomania following the use of varenicline in two patients with bipolar disorder].
 

Author(s): M L Sluys, A Remmers, R J Beerthuis

Journal: Tijdschr Psychiatr. 2015 ;57(11):835-8.

 

Varenicline is a drug that has been developed to help people stop smoking . Results regarding its efficacy are promising. The safety of the drug, however, is controversial when used for patients with mental illnesses because it can have neuropsychiatric side-effects. Although Dutch ...

Last Updated: 10 Nov 2015

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Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder.
 

Author(s): Jerome Mertens, Qiu-Wen Wang, Yongsung Kim, Diana X Yu, Son Pham, Bo Yang, Yi Zheng, Kenneth E Diffenderfer, Jian Zhang, Sheila Soltani, Tameji Eames, Simon T Schafer, Leah Boyer, Maria C Marchetto, John I Nurnberger, Joseph R Calabrese, Ketil J Ødegaard, Michael J McCarthy, Peter P Zandi, Martin Alba, Caroline M Nievergelt, , Shuangli Mi, Kristen J Brennand, John R Kelsoe, Fred H Gage, Jun Yao

Journal: Nature. 2015 Nov;527(7576):95-9.

 

Bipolar disorder is a complex neuropsychiatric disorder that is characterized by intermittent episodes of mania and depression; without treatment, 15% of patients commit suicide. Hence, it has been ranked by the World Health Organization as a top disorder of morbidity and lost productivity. ...

Last Updated: 5 Nov 2015

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[Cushing's syndrome in a manic patient with a long-standing bipolar disorder: cause or coincidence?].
 

Author(s): L D de Witte, R B Smits, M Bartel, M Kleijweg, G D Valk, C H Vinkers, M Vergeer

Journal: Tijdschr Psychiatr. 2015 ;57(10):757-61.

 

Hypercortisolism is associated with mood disorders such as depression and bipolar disorder. A 75-year-old female patient who had been diagnosed with bipolar disorder forty years ago was admitted to our hospital with a severe, therapy-resistant mania. Careful diagnostic considerations, ...

Last Updated: 20 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bipolar disorder" returned 255 free, full-text review articles on human participants. First 3 results:

Risk factors for suicide among children and youths with bipolar spectrum and early bipolar disorder.
 

Author(s): Aleksandra Rajewska-Rager, Piotr Sibilski, Natalia Lepczyńska

Journal: Psychiatr. Pol.. ;49(3):477-88.

 

In recent years much attention has been given to determine risk factors for suicide among adults with bipolar disorder. Such studies concerning children and youths, which would also take into account the specificity of the developmental age, are still too few. The ability to identify ...

Last Updated: 16 Aug 2015

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[Social cognition in bipolar disorder].
 

Author(s): A Temmerman, B Sabbe, M Morrens

Journal: Tijdschr Psychiatr. 2015 ;57(6):405-14.

 

Bipolar disorder is characterised by disturbed mood regulation. Recently, research has focused on cognitive deficits, including social-cognitive deficits, which have a major impact on daily functioning.

Last Updated: 15 Jun 2015

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Bipolar disorder prevalence: a systematic review and meta-analysis of the literature.
 

Author(s): Adauto S Clemente, Breno S Diniz, Rodrigo Nicolato, Flavio P Kapczinski, Jair C Soares, Josélia O Firmo, Érico Castro-Costa

Journal: Rev Bras Psiquiatr. ;37(2):155-61.

 

Bipolar disorder (BD) is common in clinical psychiatric practice, and several studies have estimated its prevalence to range from 0.5 to 5% in community-based samples. However, no systematic review and meta-analysis of the prevalence of BD type 1 and type 2 has been published in the ...

Last Updated: 18 Jun 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Retrain Your Brain in Children/Adolescents With Bipolar Disorder: A Pilot Study
 

Status: Recruiting

Condition Summary: Bipolar Disorder; Pediatric Bipolar Disorder; Childhood-onset Bipolar Disorder

 

Last Updated: 11 Jan 2016

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Mindfulness Based Cognitive Therapy for Youth With Anxiety at Risk for Bipolar Disorder
 

Status: Recruiting

Condition Summary: Childhood Anxiety; Parents With Bipolar Disorder; Children at Risk for Bipolar Disorder

 

Last Updated: 26 May 2015

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Inositol Hexaphosphate: A Novel Treatment Strategy for Bipolar Disorder?
 

Status: Recruiting

Condition Summary: Bipolar Disorder; Manic Depression

 

Last Updated: 19 Nov 2015

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