Bipolar Disorder

Common Name(s)

Bipolar Disorder

Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. Signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). Mood episodes may also include symptoms of both mania and depression (a mixed state). Bipolar disorder often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. Bipolar disorder can run in families, although no single gene is thought to cause the condition. Many factors acting together may increase a person's risk to develop the disorder. Treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms.

Bipolar disorder differs significantly from clinical depression, although the symptoms for the depressive phase of the illness are similar. The mood swings from high to low can be severe, ranging from extreme energy to deep despair. The severity of the mood swings and the way they disrupt normal life activities distinguish bipolar mood episodes from ordinary mood changes. It is important to tell your doctor if you experience both highs and lows because the treatment for bipolar disorder is different than for depression. Talk with your doctor to decide on the best treatment plan. Support groups are also a good source of up to date information and can help connect you with others affected by depression. See also depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar Disorder" for support, advocacy or research.

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Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

Last Updated: 15 Feb 2013

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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

Last Updated: 15 Apr 2014

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everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

Last Updated: 25 Mar 2013

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 29 Jan 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bipolar Disorder" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

http://www.adaa.org

Last Updated: 15 Feb 2013

View Details
Logo
Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

http://www.ndmda.org

Last Updated: 15 Apr 2014

View Details
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everyminute.org

everyminute.org is a grassroots campaign uniting advocates, mental health professionals and organizations into a single coalition creating a public forum advancing the need and benefit of increased mental health research.

http://www.everyminute.org

Last Updated: 25 Mar 2013

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 29 Jan 2013

View Details

 

General Support Organizations

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General Resources

Bipolar Disorder

A brochure for individuals and families outlining symptoms, causes, treatment and recovery supports.

Updated 29 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bipolar Disorder" returned 1349 free, full-text research articles on human participants. First 3 results:

Suicide, hospital-presenting suicide attempts, and criminality in bipolar disorder: examination of risk for multiple adverse outcomes.
 

Author(s): Roger T Webb, Paul Lichtenstein, Henrik Larsson, John R Geddes, Seena Fazel

Journal: J Clin Psychiatry. 2014 Aug;75(8):e809-16.

 

To compare risks for suicidality and criminality in a national cohort of people diagnosed with bipolar disorder, and to assess how risk factor profiles differ between these outcomes.

Last Updated: 6 Sep 2014

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Decision-making and trait impulsivity in bipolar disorder are associated with reduced prefrontal regulation of striatal reward valuation.
 

Author(s): Liam Mason, Noreen O'Sullivan, Daniela Montaldi, Richard P Bentall, Wael El-Deredy

Journal: Brain. 2014 Aug;137(Pt 8):2346-55.

 

Bipolar disorder is characterized by impaired decision-making captured in impulsivity and risk-taking. We sought to determine whether this is driven by a failure to effectively weight the lower-order goal of obtaining a strongly desired reward in relation to higher-order goals, and ...

Last Updated: 24 Jul 2014

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Metabolic syndrome and cortisol/DHEAS ratio in patients with bipolar disorder and schizophrenia.
 

Author(s): Bjanka Vuksan-Ćusa, Marina Sagud, Alma Mihaljević-Peleš, Nenad Jakšić, Miro Jakovljević

Journal: Psychiatr Danub. 2014 Jun;26(2):187-9.

 

The cortisol/DHEAS ratio has been found to predict different health outcomes. We examined the association between cortisol/DHEAS ratio and metabolic syndrome (MetS) in patients suffering from bipolar disorder and schizophrenia. The only subcomponent of MetS positively associated with ...

Last Updated: 9 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bipolar Disorder" returned 212 free, full-text review articles on human participants. First 3 results:

Suicide in bipolar disorder: a review.
 

Author(s): Klara Latalova, Dana Kamaradova, Jan Prasko

Journal: Psychiatr Danub. 2014 Jun;26(2):108-14.

 

Suicide is a leading cause of death in patients with bipolar disorder. Risk factors and prevention of suicide in this illness are the focus of considerable current research.

Last Updated: 9 Jun 2014

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Pharmacotherapy of bipolar disorder in children and adolescents: an update.
 

Author(s): Tatiana Lauxen Peruzzolo, Silzá Tramontina, Luis Augusto Rohde, Cristian Patrick Zeni

Journal: Rev Bras Psiquiatr. ;35(4):393-405.

 

To review the options for acute and maintenance pharmacological treatment of bipolar disorder in children and adolescents, including the treatment of bipolar depression and comorbid attention deficit/hyperactivity disorder (ADHD).

Last Updated: 9 Jan 2014

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Overdiagnosis of bipolar disorder: a critical analysis of the literature.
 

Author(s): Amna A Ghouse, Marsal Sanches, Giovana Zunta-Soares, Alan C Swann, Jair C Soares

Journal:

 

Bipolar disorder (BD) is considered one of the most disabling mental conditions, with high rates of morbidity, disability, and premature death from suicide. Although BD is often misdiagnosed as major depressive disorder, some attention has recently been drawn to the possibility that ...

Last Updated: 18 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Retrain Your Brain in Children/Adolescents With Bipolar Disorder: A Pilot Study
 

Status: Recruiting

Condition Summary: Bipolar Disorder; Pediatric Bipolar Disorder; Childhood-onset Bipolar Disorder

 

Last Updated: 19 Aug 2014

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Inositol Hexaphosphate: A Novel Treatment Strategy for Bipolar Disorder?
 

Status: Not yet recruiting

Condition Summary: Bipolar Disorder; Manic Depression

 

Last Updated: 6 Mar 2014

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Mindfulness Based Cognitive Therapy for Youth With Anxiety at Risk for Bipolar Disorder
 

Status: Recruiting

Condition Summary: Childhood Anxiety; Parents With Bipolar Disorder; Children at Risk for Bipolar Disorder

 

Last Updated: 1 Oct 2014

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