Biotinidase Deficiency

Common Name(s)

Biotinidase Deficiency, Late-onset multiple carboxylase deficiency

Biotindase deficiency (BIOT) is a rare genetic condition. BIOT results from a mutation (error) in the BTD gene. People with BIOT cannot reuse and recycle the vitamin, biotin. Biotin is needed to break down the fats, proteins, and carbohydrates we get from eating food. Typically, enzymes (special proteins) break down the food we eat into substances our body can use. If our body does not make enough of a working enzyme, then the substances we need from our food may not be available. In this case, there is not enough functioning or working biotinidase to free the vitamin biotin from our food. As a result, other enzymes which need biotin to work correctly cannot function.

There are two forms of BIOT. If there is less than 10% working biotindase, profound BIOT occurs and the symptoms and damage are more severe. If there is 10-30% working biotindase then partial BIOT occurs with symptoms are less severe. Signs of this condition often begin to show a few months after birth. However, in some cases they do not appear until childhood. A few symptoms include seizures, weak muscle tone, trouble breathing, skin rash, hair loss, trouble balancing, or a fungal infection called candidiasis. Treatment for this condition includes biotin supplements to help break down the fats, proteins, and carbohydrates. Lifelong treatment is needed.

BIOT is autosomal recessive. Early diagnosis has shown to be effective in improving the health of individuals with BIOT. Many babies are screened at birth so that treatment may begin early, however the conditions included in newborn screening vary state by state. For more information, visit Baby’s First Test. Talk with your doctor to determine which treatment options are best for your child. Support groups are a good source of information. A genetic counselor will help you understand the genetics.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biotinidase Deficiency" for support, advocacy or research.

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Biotinidase Deficiency Family Support Group

Our mission is to establish a forum to exchange information about biotinidase deficiency among affected individuals and with medical professionals and to advocate for the inclusion of biotinidase testing in all newborn screening programs.

Last Updated: 24 Nov 2009

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CLIMB - Children Living with Inherited Metabolic Diseases

Climb is committed to fighting metabolic diseases through research, awareness and support. We are the UK's only dedicated organisation to provide advice, information and support on all metabolic diseases to children, young adults, families, carers and professionals.

Last Updated: 28 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biotinidase Deficiency" for support, advocacy or research.

Logo
Biotinidase Deficiency Family Support Group

Our mission is to establish a forum to exchange information about biotinidase deficiency among affected individuals and with medical professionals and to advocate for the inclusion of biotinidase testing in all newborn screening programs.

http://biotinidasedeficiency.20m.com

Last Updated: 24 Nov 2009

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CLIMB - Children Living with Inherited Metabolic Diseases

Climb is committed to fighting metabolic diseases through research, awareness and support. We are the UK's only dedicated organisation to provide advice, information and support on all metabolic diseases to children, young adults, families, carers and professionals.

http://www.climb.org.uk/

Last Updated: 28 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Biotinidase Deficiency" returned 33 free, full-text research articles on human participants. First 3 results:

Biotinidase deficiency: Genotype-biochemical phenotype association in Brazilian patients.
 

Author(s): Taciane Borsatto, Fernanda Sperb-Ludwig, Samyra E Lima, Maria R S Carvalho, Pablo A S Fonseca, José S Camelo, Erlane M Ribeiro, Paula F V de Medeiros, Charles M Lourenço, Carolina F M de Souza, Raquel Boy, Têmis M Félix, Camila M Bittar, Louise L C Pinto, Eurico C Neto, Henk J Blom, Ida V D Schwartz

Journal:

 

The association between the BTD genotype and biochemical phenotype [profound biotinidase deficiency (BD), partial BD or heterozygous activity] is not always consistent. This study aimed to investigate the genotype-biochemical phenotype association in patients with low biotinidase activity.

Last Updated: 12 May 2017

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Clinical, Biochemical and Genetic Analysis of Biotinidase Deficiency in Iranian Population.
 

Author(s): Arezou Asgari, Soghra Rouhi Dehnabeh, Mehryar Zargari, Soghra Khani, Hadi Mozafari, Abdolreza Varasteh, Fatemeh Keyfi, Mina Barzegari, Rayhaneh Hasanzaeh, Shohreh Khatami

Journal: Arch Iran Med. 2016 Nov;19(11):774-778.

 

Biotinidase deficiency (BTD) is an autosomal recessive disorder of biotin metabolism. Biotin is a coenzyme that enhances the action of the four enzymes that play an important role in carbohydrates, amino acid, and fatty acid metabolism. Defects in these pathways cause severe metabolic ...

Last Updated: 15 Nov 2016

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Comment on: Childhood optic atrophy in biotinidase deficiency.
 

Author(s): N Venugopal, Sherin Kummararaj

Journal: Indian J Ophthalmol. 2016 08;64(8):614.

 

Last Updated: 30 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Biotinidase Deficiency" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

BIOtinidase Test In Optic-Neuropathy
 

Status: Recruiting

Condition Summary: Biotin Deficiency; Optic Neuropathy

 

Last Updated: 5 Sep 2017

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