Biliary Tract Cancer

Common Name(s)

Biliary Tract Cancer

Bile Tract Cancer is a rare digestive cancer characterized by abnormal cell growth in the bile ducts and gallbladder. Individuals with this disorder may grow harmful tumors that can spread to the rest of the body if not diagnosed early. The bile duct system is responsible for storing and transporting bile from the liver, where it is made, to the intestines, where it helps to digest food. Incomplete development of the ducts inhibits the flow of bile. Individuals with this defect have digestion problems as well as a yellow discoloration of the eye and skin (jaundice). Doctors are usually able to diagnose this defect early in the abnormal growth process, as the resulting symptoms are quickly apparent. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. For prevention measures, digestion specialists may suggest individuals eat a lower-fat diet, or undergo surgery to relieve the blockage or create a tube to allow bile to reach the digestive system. If an individual's cancer has progressed, doctors may suggest chemotherapy to combat cancer symptoms.

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Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Tract Cancer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Biliary Tract Cancer" returned 140 free, full-text research articles on human participants. First 3 results:

Successful immune checkpoint blockade in a patient with advanced stage microsatellite-unstable biliary tract cancer.
 

Author(s): Elena Czink, Matthias Kloor, Benjamin Goeppert, Stefan Fröhling, Sebastian Uhrig, Tim F Weber, Jörn Meinel, Christian Sutter, Karl Heinz Weiss, Peter Schirmacher, Magnus von Knebel Doeberitz, Dirk Jäger, Christoph Springfeld

Journal:

 

Cancers acquire multiple somatic mutations that can lead to the generation of immunogenic mutation-induced neoantigens. These neoantigens can be recognized by the host's immune system. However, continuous stimulation of immune cells against tumor antigens can lead to immune cell exhaustion, ...

Last Updated: 16 Jun 2017

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Diet and biliary tract cancer risk in Shanghai, China.
 

Author(s): Shakira M Nelson, Yu-Tang Gao, Leticia M Nogueira, Ming-Chang Shen, Bingsheng Wang, Asif Rashid, Ann W Hsing, Jill Koshiol

Journal:

 

Trends in biliary tract cancer incidence rates have increased in Shanghai, China. These trends have coincided with economic and developmental growth, as well as a shift in dietary patterns to a more Westernized diet. To examine the effect of dietary changes on incident disease, we ...

Last Updated: 13 Mar 2017

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A randomized phase II trial of personalized peptide vaccine with low dose cyclophosphamide in biliary tract cancer.
 

Author(s): Takahisa Shirahama, Daisuke Muroya, Satoko Matsueda, Akira Yamada, Shigeki Shichijo, Masayasu Naito, Takuto Yamashita, Shinjiro Sakamoto, Koji Okuda, Kyogo Itoh, Tetsuro Sasada, Shigeru Yutani

Journal: Cancer Sci.. 2017 May;108(5):838-845.

 

Since the prognosis of advanced biliary tract cancer (aBTC) still remains very poor, new therapeutic approaches, including immunotherapies, need to be developed. In the current study, we conducted an open-label randomized phase II study to test whether low dose cyclophosphamide (CPA) ...

Last Updated: 11 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Biliary Tract Cancer" returned 14 free, full-text review articles on human participants. First 3 results:

[Chemotherapy for Biliary Tract Cancer].
 

Author(s): Sang Myung Woo

Journal: Korean J Gastroenterol. 2017 Mar;69(3):172-176.

 

The term of biliary tract cancer (BTC) refers to all tumors that arise from the biliary tract or the biliary drainage system, including the intra- and extra-hepatic bile ducts as well as the gallbladder. BTCs are aggressive tumors with limited treatment options and poor overall survival. ...

Last Updated: 22 Mar 2017

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Deregulated MicroRNAs in Biliary Tract Cancer: Functional Targets and Potential Biomarkers.
 

Author(s): Christian Mayr, Marlena Beyreis, Andrej Wagner, Martin Pichler, Daniel Neureiter, Tobias Kiesslich

Journal: Biomed Res Int. 2016 ;2016():4805270.

 

Biliary tract cancer (BTC) is still a fatal disease with very poor prognosis. The lack of reliable biomarkers for early diagnosis and of effective therapeutic targets is a major demanding problem in diagnosis and management of BTC. Due to the clinically silent and asymptomatic characteristics ...

Last Updated: 13 Dec 2016

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Adjuvant therapy for resected biliary tract cancer: a review.
 

Author(s): Mark K Doherty, Jennifer J Knox

Journal: Chin Clin Oncol. 2016 Oct;5(5):64.

 

Surgical resection remains the most important treatment for patients with biliary tract cancer (BTC), but despite radical surgical techniques many patients ultimately develop recurrent disease. BTC encompasses several distinct disease entities-intrahepatic, perihilar and distal bile ...

Last Updated: 5 Oct 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Apatinib as Second Line Therapy in Patients With Advanced Refractory Biliary Tract Cancers
 

Status: Recruiting

Condition Summary: Biliary Tract Cancer

 

Last Updated: 8 May 2017

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MEK162 in Combination With Capecitabine in Advanced Biliary Tract Cancer
 

Status: Recruiting

Condition Summary: Biliary Tract Cancer

 

Last Updated: 15 May 2016

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Last Updated: 1 Feb 2017

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