Biliary Tract Cancer

Common Name(s)

Biliary Tract Cancer

Bile Tract Cancer is a rare digestive cancer characterized by abnormal cell growth in the bile ducts and gallbladder. Individuals with this disorder may grow harmful tumors that can spread to the rest of the body if not diagnosed early. The bile duct system is responsible for storing and transporting bile from the liver, where it is made, to the intestines, where it helps to digest food. Incomplete development of the ducts inhibits the flow of bile. Individuals with this defect have digestion problems as well as a yellow discoloration of the eye and skin (jaundice). Doctors are usually able to diagnose this defect early in the abnormal growth process, as the resulting symptoms are quickly apparent. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. For prevention measures, digestion specialists may suggest individuals eat a lower-fat diet, or undergo surgery to relieve the blockage or create a tube to allow bile to reach the digestive system. If an individual's cancer has progressed, doctors may suggest chemotherapy to combat cancer symptoms.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Tract Cancer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Biliary Tract Cancer" returned 132 free, full-text research articles on human participants. First 3 results:

Relevance of MicroRNA200 Family and MicroRNA205 for Epithelial to Mesenchymal Transition and Clinical Outcome in Biliary Tract Cancer Patients.
 

Author(s): Romana Urbas, Christian Mayr, Eckhard Klieser, Julia Fuereder, Doris Bach, Stefan Stättner, Florian Primavesi, Tarkan Jaeger, Stefanie Stanzer, Anna Lena Ress, Magdalena Löffelberger, Andrej Wagner, Frieder Berr, Markus Ritter, Martin Pichler, Daniel Neureiter, Tobias Kiesslich

Journal:

 

Extensive stromal interaction is one reason for the dismal outcome of biliary tract cancer (BTC) patients. Epithelial to mesenchymal transition (EMT) is involved in tumor invasion and metastasis and is partly regulated by microRNAs (miRs). This study explores the expression of anti-EMT ...

Last Updated: 12 Dec 2016

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Src as a Therapeutic Target in Biliary Tract Cancer.
 

Author(s): Ah-Rong Nam, Ji-Won Kim, Ji Eun Park, Ju-Hee Bang, Mei Hua Jin, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Do-Youn Oh, Yung-Jue Bang

Journal: Mol. Cancer Ther.. 2016 Jul;15(7):1515-24.

 

Src, a nonreceptor tyrosine kinase, is involved in a number of cancer-related signaling pathways and aberrantly activated in biliary tract cancer (BTC). This study aimed to elucidate the potential role of Src as a therapeutic target in BTC. We tested bosutinib, an orally active c-Src/Abl ...

Last Updated: 7 Jul 2016

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Predictive Factors of Biliary Tract Cancer in Anomalous Union of the Pancreaticobiliary Duct.
 

Author(s): Jin-Seok Park, Tae Jun Song, Tae Young Park, Dongwook Oh, Hyun Kyo Lee, Do Hyun Park, Sang Soo Lee, Dong Wan Seo, Sung Koo Lee, Myung-Hwan Kim

Journal: Medicine (Baltimore). 2016 May;95(20):e3526.

 

The assessment of malignancies associated with anomalous union of the pancreaticobiliary duct (AUPBD) is essential for the design of appropriate treatment strategies. The aim of the present study is to measure the incidence of AUPBD-related pancreaticobiliary malignancy and to identify ...

Last Updated: 20 May 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Biliary Tract Cancer" returned 13 free, full-text review articles on human participants. First 3 results:

[Chemotherapy for Biliary Tract Cancer].
 

Author(s): Sang Myung Woo

Journal: Korean J Gastroenterol. 2017 Mar;69(3):172-176.

 

The term of biliary tract cancer (BTC) refers to all tumors that arise from the biliary tract or the biliary drainage system, including the intra- and extra-hepatic bile ducts as well as the gallbladder. BTCs are aggressive tumors with limited treatment options and poor overall survival. ...

Last Updated: 22 Mar 2017

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Deregulated MicroRNAs in Biliary Tract Cancer: Functional Targets and Potential Biomarkers.
 

Author(s): Christian Mayr, Marlena Beyreis, Andrej Wagner, Martin Pichler, Daniel Neureiter, Tobias Kiesslich

Journal: Biomed Res Int. 2016 ;2016():4805270.

 

Biliary tract cancer (BTC) is still a fatal disease with very poor prognosis. The lack of reliable biomarkers for early diagnosis and of effective therapeutic targets is a major demanding problem in diagnosis and management of BTC. Due to the clinically silent and asymptomatic characteristics ...

Last Updated: 13 Dec 2016

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Adjuvant therapy for resected biliary tract cancer: a review.
 

Author(s): Mark K Doherty, Jennifer J Knox

Journal: Chin Clin Oncol. 2016 Oct;5(5):64.

 

Surgical resection remains the most important treatment for patients with biliary tract cancer (BTC), but despite radical surgical techniques many patients ultimately develop recurrent disease. BTC encompasses several distinct disease entities-intrahepatic, perihilar and distal bile ...

Last Updated: 5 Oct 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Apatinib as Second Line Therapy in Patients With Advanced Refractory Biliary Tract Cancers
 

Status: Recruiting

Condition Summary: Biliary Tract Cancer

 

Last Updated: 8 May 2017

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MEK162 in Combination With Capecitabine in Advanced Biliary Tract Cancer
 

Status: Recruiting

Condition Summary: Biliary Tract Cancer

 

Last Updated: 15 May 2016

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Last Updated: 1 Feb 2017

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