Essential hypertension

Common Name(s)

Essential hypertension

The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple environmental factors determine the level of one's blood pressure just as the determination of stature and intelligence is multifactorial, and that 'essential hypertension' is merely the upper end of the distribution ({66:Pickering, 1978}). In this view the person with essential hypertension is one who happens to inherit an aggregate of genes determining hypertension (and also is exposed to exogenous factors that favor hypertension). The Platt school took the view that essential hypertension is a simple mendelian dominant trait ({69:Platt, 1963}). {57:McDonough et al. (1964)} defended the monogenic idea. See {58:McKusick (1960)} and {52:Kurtz and Spence (1993)} for reviews. {78:Swales (1985)} reviewed the Platt-Pickering controversy as an 'episode in recent medical history.' The Pickering point of view appears to be more consistent with the observations.
 

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Condition Specific Organizations

Following organizations serve the condition "Essential hypertension" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Essential hypertension" returned 1409 free, full-text research articles on human participants. First 3 results:

Effects of slow breathing rate on heart rate variability and arterial baroreflex sensitivity in essential hypertension.
 

Author(s): Changjun Li, Qinghua Chang, Jia Zhang, Wenshu Chai

Journal: Medicine (Baltimore). 2018 May;97(18):e0639.

 

This study is to investigate the effects of slow breathing on heart rate variability (HRV) and arterial baroreflex sensitivity in essential hypertension.We studied 60 patients with essential hypertension and 60 healthy controls. All subjects underwent controlled breathing at 8 and ...

Last Updated: 31 Dec 1969

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A Randomized, Multicenter, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and the Tolerability of a Triple Combination of Amlodipine/Losartan/Rosuvastatin in Patients With Comorbid Essential Hypertension and Hyperlipidemia.
 

Author(s): Hae-Young Lee, Seok-Yeon Kim, Kee-Joon Choi, Byung-Su Yoo, Dong-Hun Cha, Hae Ok Jung, Dong-Ryeol Ryu, Joon Hyouk Choi, Kwang Je Lee, Tae Ho Park, Ju Hyeon Oh, Sang Min Kim, Ji-Yong Choi, Kye Hun Kim, Jaemin Shim, Woo-Shik Kim, Si-Wan Choi, Dae-Gyun Park, Pil-Sang Song, Taek-Jong Hong, Moo-Yong Rhee, Seung-Woon Rha, Seung Woo Park

Journal: Clin Ther. 2017 Dec;39(12):2366-2379.

 

The objective of this study was to evaluate the efficacy and tolerability of a triple combination of amlodipine/losartan/rosuvastatin in patients with hypertension and hypercholesterolemia.

Last Updated: 31 Dec 1969

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Association of NOS3 gene polymorphisms with essential hypertension in Sudanese patients: a case control study.
 

Author(s): Sahar Gamil, Jeanette Erdmann, Ihab B Abdalrahman, Abdelrahim O Mohamed

Journal:

 

Essential hypertension (EH) is influenced by various environmental and genetic factors. Nitric oxide is important for the functional integrity of the vascular endothelium and is produced in endothelial cells by the enzyme endothelial nitric oxide synthase (eNOS). EH has a strong genetic ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Essential hypertension" returned 111 free, full-text review articles on human participants. First 3 results:

Tianma Gouteng decoction for essential hypertension: Protocol for a systematic review and meta-analysis.
 

Author(s): Benjian Chen, Yuanping Wang, Zhuogen He, Dawei Wang, Xia Yan, Pingchang Xie

Journal: Medicine (Baltimore). 2018 Feb;97(8):e9972.

 

Essential hypertension is one of the most common chronic diseases, as well as one of the leading risk factors for cardio-cerebrovascular diseases. Tianma Gouteng decoction has been commonly used in clinical practice for patients with essential hypertension. It is important to update ...

Last Updated: 31 Dec 1969

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Inflammation, Autoimmunity, and Hypertension: The Essential Role of Tissue Transglutaminase.
 

Author(s): Chen Liu, Rodney E Kellems, Yang Xia

Journal: Am. J. Hypertens.. 2017 Aug;30(8):756-764.

 

Inflammatory cytokines cause hypertension when introduced into animals. Additional evidence indicates that cytokines induce the production of autoantibodies that activate the AT1 angiotensin receptor (AT1R). Extensive evidence shows that these autoantibodies, termed AT1-AA, contribute ...

Last Updated: 31 Dec 1969

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The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures.
 

Author(s): Alan Alper Sag, Oguzhan Sal, Yagmur Kilic, Emine Meltem Onal, Mehmet Kanbay

Journal: J Clin Hypertens (Greenwich). 2017 May;19(5):530-533.

 

This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Renal Sympathetic Modification in Patients With Essential Hypertension
 

Status: Recruiting

Condition Summary: Essential Hypertension

 

Last Updated: 13 Jul 2017

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Last Updated: 18 Jan 2018

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Efficacy and Safety of Arotinolol Hydrochloride on Morning Blood Pressure and Heart Rate
 

Status: Recruiting

Condition Summary: Essential Hypertension

 

Last Updated: 13 Oct 2016

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