Essential hypertension

Common Name(s)

Essential hypertension

The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple environmental factors determine the level of one's blood pressure just as the determination of stature and intelligence is multifactorial, and that 'essential hypertension' is merely the upper end of the distribution ({66:Pickering, 1978}). In this view the person with essential hypertension is one who happens to inherit an aggregate of genes determining hypertension (and also is exposed to exogenous factors that favor hypertension). The Platt school took the view that essential hypertension is a simple mendelian dominant trait ({69:Platt, 1963}). {57:McDonough et al. (1964)} defended the monogenic idea. See {58:McKusick (1960)} and {52:Kurtz and Spence (1993)} for reviews. {78:Swales (1985)} reviewed the Platt-Pickering controversy as an 'episode in recent medical history.' The Pickering point of view appears to be more consistent with the observations.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Essential hypertension" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Essential hypertension" returned 1377 free, full-text research articles on human participants. First 3 results:

Comparison of Efficacy and Safety of Azilsartan and Olmesartan in Patients With Essential Hypertension.
 

Author(s): Yuhei Shiga, Shin-Ichiro Miura, Kota Motozato, Kenji Norimatsu, Masaya Yano, Yuka Hitaka, Sen Adachi, Takashi Kuwano, Ken Inoue, Asao Inoue, Kazuaki Fujisawa, Tetsuro Shirotani, Takaaki Kusumoto, Munehito Ideishi, Keijiro Saku

Journal: Int Heart J. 2017 May;58(3):416-421.

 

Many patients still have high blood pressure (BP) after treatment with angiotensin II type 1 (AT1) receptor blockers (ARBs). We compared the efficacy and safety of azilsartan to those of olmesartan in a prospective randomized clinical trial. Sixty-four hypertensive patients who were ...

Last Updated: 12 May 2017

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Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis.
 

Author(s): Yinyin Wu, Juntao Ni, Xiao Cai, Fuzhi Lian, Haiyan Ma, Liangwen Xu, Lei Yang

Journal:

 

Several studies have been conducted to examine the association between aldehyde dehydrogenase 2 family (ALDH2) rs671 polymorphism and essential hypertension (EH). However, the results remain inconsistent. This study aimed to clarify the association between ALDH2 rs671 polymorphism ...

Last Updated: 4 May 2017

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micro-RNA screening and prediction model construction for diagnosis of salt-sensitive essential hypertension.
 

Author(s): Han Qi, Zheng Liu, Bin Liu, Han Cao, Weiping Sun, Yuxiang Yan, Ling Zhang

Journal: Medicine (Baltimore). 2017 Apr;96(17):e6417.

 

Commonly used tests for diagnosis of salt-sensitive hypertension (SSH) are complex and time-consuming, so new methods are required. Many studies have demonstrated roles for miRNAs in hypertension; however, the diagnostic value of miRNAs has yet to be determined for human SSH. In this ...

Last Updated: 26 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Essential hypertension" returned 106 free, full-text review articles on human participants. First 3 results:

Free versus Fixed Combination Antihypertensive Therapy for Essential Arterial Hypertension: A Systematic Review and Meta-Analysis.
 

Author(s): Samir G Mallat, Bassem Y Tanios, Houssam S Itani, Tamara Lotfi, Elie A Akl

Journal:

 

In a free drug combination, each Blood pressure (BP)-lowering drug is administered as a separate pill, while in a fixed drug combination several BP-lowering agents are combined in a single pill. Using a single pill may enhance compliance and simplify treatment, which would translate ...

Last Updated: 23 Aug 2016

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Association of Polymorphisms in the Atrial Natriuretic Factor Gene with the Risk of Essential Hypertension: A Systematic Review and Meta-Analysis.
 

Author(s): Jinyao Wang, Zhenkun Wang, Chuanhua Yu

Journal:

 

Studies evaluating the association between the atrial natriuretic peptide (ANP) genetic polymorphism and the risk of essential hypertension (EH) have reported inconsistent results. The aim of this meta-analysis was to provide a more reliable estimation of the possible relationship ...

Last Updated: 4 May 2016

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Epigenetic Modifications in Essential Hypertension.
 

Author(s): Ingrid A Wise, Fadi J Charchar

Journal:

 

Essential hypertension (EH) is a complex, polygenic condition with no single causative agent. Despite advances in our understanding of the pathophysiology of EH, hypertension remains one of the world's leading public health problems. Furthermore, there is increasing evidence that ...

Last Updated: 30 Mar 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Renal Sympathetic Modification in Patients With Essential Hypertension
 

Status: Recruiting

Condition Summary: Essential Hypertension

 

Last Updated: 13 Jul 2017

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Study of Personalized Dietary Intervention for the Control of Essential Hypertension
 

Status: Recruiting

Condition Summary: Essential Hypertension

 

Last Updated: 10 Nov 2015

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Efficacy and Safety of Arotinolol Hydrochloride on Morning Blood Pressure and Heart Rate
 

Status: Recruiting

Condition Summary: Essential Hypertension

 

Last Updated: 13 Oct 2016

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