Essential hypertension

Common Name(s)

Essential hypertension

The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple environmental factors determine the level of one's blood pressure just as the determination of stature and intelligence is multifactorial, and that 'essential hypertension' is merely the upper end of the distribution ({66:Pickering, 1978}). In this view the person with essential hypertension is one who happens to inherit an aggregate of genes determining hypertension (and also is exposed to exogenous factors that favor hypertension). The Platt school took the view that essential hypertension is a simple mendelian dominant trait ({69:Platt, 1963}). {57:McDonough et al. (1964)} defended the monogenic idea. See {58:McKusick (1960)} and {52:Kurtz and Spence (1993)} for reviews. {78:Swales (1985)} reviewed the Platt-Pickering controversy as an 'episode in recent medical history.' The Pickering point of view appears to be more consistent with the observations.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Essential hypertension" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Essential hypertension" returned 1385 free, full-text research articles on human participants. First 3 results:

Association of NOS3 gene polymorphisms with essential hypertension in Sudanese patients: a case control study.
 

Author(s): Sahar Gamil, Jeanette Erdmann, Ihab B Abdalrahman, Abdelrahim O Mohamed

Journal:

 

Essential hypertension (EH) is influenced by various environmental and genetic factors. Nitric oxide is important for the functional integrity of the vascular endothelium and is produced in endothelial cells by the enzyme endothelial nitric oxide synthase (eNOS). EH has a strong genetic ...

Last Updated: 31 Dec 1969

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Effects of four different antihypertensive drugs on plasma metabolomic profiles in patients with essential hypertension.
 

Author(s): Timo P Hiltunen, Jenni M Rimpelä, Robert P Mohney, Steven M Stirdivant, Kimmo K Kontula

Journal:

 

In order to search for metabolic biomarkers of antihypertensive drug responsiveness, we measured >600 biochemicals in plasma samples of subjects participating in the GENRES Study. Hypertensive men received in a double-blind rotational fashion amlodipine, bisoprolol, hydrochlorothiazide ...

Last Updated: 31 Dec 1969

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Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island.
 

Author(s): Ana Célia Sousa, Roberto Palma Dos Reis, Andreia Pereira, Sofia Borges, Ana Isabel Freitas, Graça Guerra, Teresa Góis, Mariana Rodrigues, Eva Henriques, Sónia Freitas, Ilídio Ornelas, Décio Pereira, António Brehm, Maria Isabel Mendonça

Journal: Medicine (Baltimore). 2017 Oct;96(42):e7861.

 

Essential hypertension (EH) is a complex disease in which physiological, environmental, and genetic factors are involved in its genesis. The genetic variant of the alpha-adducin gene (ADD1) has been described as a risk factor for EH, but with controversial results.The objective of ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Essential hypertension" returned 106 free, full-text review articles on human participants. First 3 results:

Free versus Fixed Combination Antihypertensive Therapy for Essential Arterial Hypertension: A Systematic Review and Meta-Analysis.
 

Author(s): Samir G Mallat, Bassem Y Tanios, Houssam S Itani, Tamara Lotfi, Elie A Akl

Journal:

 

In a free drug combination, each Blood pressure (BP)-lowering drug is administered as a separate pill, while in a fixed drug combination several BP-lowering agents are combined in a single pill. Using a single pill may enhance compliance and simplify treatment, which would translate ...

Last Updated: 31 Dec 1969

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Association of Polymorphisms in the Atrial Natriuretic Factor Gene with the Risk of Essential Hypertension: A Systematic Review and Meta-Analysis.
 

Author(s): Jinyao Wang, Zhenkun Wang, Chuanhua Yu

Journal:

 

Studies evaluating the association between the atrial natriuretic peptide (ANP) genetic polymorphism and the risk of essential hypertension (EH) have reported inconsistent results. The aim of this meta-analysis was to provide a more reliable estimation of the possible relationship ...

Last Updated: 31 Dec 1969

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Epigenetic Modifications in Essential Hypertension.
 

Author(s): Ingrid A Wise, Fadi J Charchar

Journal:

 

Essential hypertension (EH) is a complex, polygenic condition with no single causative agent. Despite advances in our understanding of the pathophysiology of EH, hypertension remains one of the world's leading public health problems. Furthermore, there is increasing evidence that ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Renal Sympathetic Modification in Patients With Essential Hypertension
 

Status: Recruiting

Condition Summary: Essential Hypertension

 

Last Updated: 13 Jul 2017

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Study of Personalized Dietary Intervention for the Control of Essential Hypertension
 

Status: Recruiting

Condition Summary: Essential Hypertension

 

Last Updated: 10 Nov 2015

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Last Updated: 6 Nov 2017

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