Essential hypertension

Common Name(s)

Essential hypertension

The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple environmental factors determine the level of one's blood pressure just as the determination of stature and intelligence is multifactorial, and that 'essential hypertension' is merely the upper end of the distribution ({66:Pickering, 1978}). In this view the person with essential hypertension is one who happens to inherit an aggregate of genes determining hypertension (and also is exposed to exogenous factors that favor hypertension). The Platt school took the view that essential hypertension is a simple mendelian dominant trait ({69:Platt, 1963}). {57:McDonough et al. (1964)} defended the monogenic idea. See {58:McKusick (1960)} and {52:Kurtz and Spence (1993)} for reviews. {78:Swales (1985)} reviewed the Platt-Pickering controversy as an 'episode in recent medical history.' The Pickering point of view appears to be more consistent with the observations.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Essential hypertension" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Essential hypertension" returned 1381 free, full-text research articles on human participants. First 3 results:

Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island.
 

Author(s): Ana Célia Sousa, Roberto Palma Dos Reis, Andreia Pereira, Sofia Borges, Ana Isabel Freitas, Graça Guerra, Teresa Góis, Mariana Rodrigues, Eva Henriques, Sónia Freitas, Ilídio Ornelas, Décio Pereira, António Brehm, Maria Isabel Mendonça

Journal: Medicine (Baltimore). 2017 Oct;96(42):e7861.

 

Essential hypertension (EH) is a complex disease in which physiological, environmental, and genetic factors are involved in its genesis. The genetic variant of the alpha-adducin gene (ADD1) has been described as a risk factor for EH, but with controversial results.The objective of ...

Last Updated: 19 Oct 2017

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A novel haplotype of low-frequency variants in the aldosterone synthase gene among northern Han Chinese with essential hypertension.
 

Author(s): Hao Zhang, Xueyan Li, Li Zhou, Keyong Zhang, Qi Zhang, Jingping Li, Ningning Wang, Ming Jin, Nan Wu, Mingyu Cong, Changchun Qiu

Journal: Medicine (Baltimore). 2017 Sep;96(39):e8150.

 

Low-frequency variants showed that there is more power to detect risk variants than to detect protective variants in complex diseases. Aldosterone plays an important role in the renin-angiotensin-aldosterone system, and aldosterone synthase catalyzes the speed-controlled steps of ...

Last Updated: 27 Sep 2017

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Up-regulation of gap junction in peripheral blood T lymphocytes contributes to the inflammatory response in essential hypertension.
 

Author(s): Xin Ni, Ai Wang, Liang Zhang, Li-Ya Shan, Hai-Chao Zhang, Li Li, Jun-Qiang Si, Jian Luo, Xin-Zhi Li, Ke-Tao Ma

Journal:

 

Inflammation has been shown to play an important role in the mechanisms involved in the pathogenesis of hypertension. Connexins (Cxs)-based gap junction channels (GJCs) or hemichannels (HCs) are involved in the maintenance of homeostasis in the immune system. However, the role of ...

Last Updated: 14 Sep 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Essential hypertension" returned 106 free, full-text review articles on human participants. First 3 results:

Free versus Fixed Combination Antihypertensive Therapy for Essential Arterial Hypertension: A Systematic Review and Meta-Analysis.
 

Author(s): Samir G Mallat, Bassem Y Tanios, Houssam S Itani, Tamara Lotfi, Elie A Akl

Journal:

 

In a free drug combination, each Blood pressure (BP)-lowering drug is administered as a separate pill, while in a fixed drug combination several BP-lowering agents are combined in a single pill. Using a single pill may enhance compliance and simplify treatment, which would translate ...

Last Updated: 23 Aug 2016

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Association of Polymorphisms in the Atrial Natriuretic Factor Gene with the Risk of Essential Hypertension: A Systematic Review and Meta-Analysis.
 

Author(s): Jinyao Wang, Zhenkun Wang, Chuanhua Yu

Journal:

 

Studies evaluating the association between the atrial natriuretic peptide (ANP) genetic polymorphism and the risk of essential hypertension (EH) have reported inconsistent results. The aim of this meta-analysis was to provide a more reliable estimation of the possible relationship ...

Last Updated: 4 May 2016

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Epigenetic Modifications in Essential Hypertension.
 

Author(s): Ingrid A Wise, Fadi J Charchar

Journal:

 

Essential hypertension (EH) is a complex, polygenic condition with no single causative agent. Despite advances in our understanding of the pathophysiology of EH, hypertension remains one of the world's leading public health problems. Furthermore, there is increasing evidence that ...

Last Updated: 30 Mar 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Renal Sympathetic Modification in Patients With Essential Hypertension
 

Status: Recruiting

Condition Summary: Essential Hypertension

 

Last Updated: 13 Jul 2017

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Study of Personalized Dietary Intervention for the Control of Essential Hypertension
 

Status: Recruiting

Condition Summary: Essential Hypertension

 

Last Updated: 10 Nov 2015

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Last Updated: 6 Nov 2017

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