Essential hypertension

Common Name(s)

Essential hypertension

The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple environmental factors determine the level of one's blood pressure just as the determination of stature and intelligence is multifactorial, and that 'essential hypertension' is merely the upper end of the distribution ({66:Pickering, 1978}). In this view the person with essential hypertension is one who happens to inherit an aggregate of genes determining hypertension (and also is exposed to exogenous factors that favor hypertension). The Platt school took the view that essential hypertension is a simple mendelian dominant trait ({69:Platt, 1963}). {57:McDonough et al. (1964)} defended the monogenic idea. See {58:McKusick (1960)} and {52:Kurtz and Spence (1993)} for reviews. {78:Swales (1985)} reviewed the Platt-Pickering controversy as an 'episode in recent medical history.' The Pickering point of view appears to be more consistent with the observations.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Essential hypertension" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Essential hypertension" returned 1383 free, full-text research articles on human participants. First 3 results:

Interactions between CYP11B2 Promoter Methylation and Smoking Increase Risk of Essential Hypertension.
 

Author(s): Tianlun Gu, Shuqi Mao, Rui Fan, Fade Zhong, Fubao Zhu, Lingmei Hao, Lina Zhang, Fengying Yin

Journal: Biomed Res Int. 2016 ;2016():1454186.

 

Aldosterone synthase (CYP11B2) is closely linked to essential hypertension (EH). However, it remains unclear whether the methylation of the CYP11B2 promoter is involved in the development of EH in humans. Our study is aimed at evaluating the contribution of CYP11B2 promoter methylation ...

Last Updated: 12 Jan 2017

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Longitudinal genome-wide methylation study of Roux-en-Y gastric bypass patients reveals novel CpG sites associated with essential hypertension.
 

Author(s): Adrian E Boström, Jessica Mwinyi, Sarah Voisin, Wenting Wu, Bernd Schultes, Kang Zhang, Helgi B Schiöth

Journal:

 

Essential hypertension is a significant risk factor for cardiovascular diseases. Emerging research suggests a role of DNA methylation in blood pressure physiology. We aimed to investigate epigenetic associations of promoter related CpG sites to essential hypertension in a genome-wide ...

Last Updated: 23 Apr 2016

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Association between the MTHFR C677T gene polymorphism and essential hypertension in South West Cameroon.
 

Author(s): S M Ghogomu, N E Ngolle, R N Mouliom, B F Asa

Journal:

 

The association of the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and essential hypertension has been reported but with controversial results in diverse populations in Asia and Europe, thereby suggesting a dependency on ethnicity. The aim of this study was ...

Last Updated: 7 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Essential hypertension" returned 110 free, full-text review articles on human participants. First 3 results:

Epigenetic Modifications in Essential Hypertension.
 

Author(s): Ingrid A Wise, Fadi J Charchar

Journal:

 

Essential hypertension (EH) is a complex, polygenic condition with no single causative agent. Despite advances in our understanding of the pathophysiology of EH, hypertension remains one of the world's leading public health problems. Furthermore, there is increasing evidence that ...

Last Updated: 30 Mar 2016

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Vitamin D deficiency and essential hypertension.
 

Author(s): Songcang Chen, Yingxian Sun, Devendra K Agrawal

Journal: J Am Soc Hypertens. 2015 Nov;9(11):885-901.

 

Essential hypertension (EH) results when the balance between vasoconstriction and vasodilation is shifted in favor of vasoconstriction. This balance is controlled by the interaction of genetic and epigenetic factors. When there is an unstable balance, vitamin D deficiency as an epigenetic ...

Last Updated: 10 Nov 2015

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Associations of pregnancy-associated plasma protein-A level with essential hypertension and hypertensive disorders in pregnancy in Chinese population: a meta-analysis of 20 research studies involving 3332 individuals.
 

Author(s): Gaojun Cai, Bifeng Zhang, Weijin Weng, Liping Yang, Ganwei Shi, Sheliang Xue, Xingli Fu

Journal:

 

To explore the associations between serum pregnancy-associated plasma protein-A (PAPP-A) level, and essential hypertension (EH) and hypertensive disorders in pregnancy (HDP) in Chinese population.

Last Updated: 29 Sep 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of CS-3150 Compared to Olmesartan in Patients With Essential Hypertension
 

Status: Recruiting

Condition Summary: Essential Hypertension

 

Last Updated: 22 Aug 2016

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Study of CS-3150 in Patients With Essential Hypertension
 

Status: Recruiting

Condition Summary: Essential Hypertension

 

Last Updated: 26 Sep 2016

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