Biliary Atresia Extrahepatic

Common Name(s)

Biliary Atresia Extrahepatic

Biliary atresia is a disorder of infants in which there is progressive obliteration or discontinuity of the extrahepatic biliary system, resulting in obstruction of bile flow. Untreated, the resulting cholestasis leads to progressive conjugated hyperbilirubinemia, cirrhosis, and hepatic failure ({1:Bates et al., 1998}). Most patients require liver transplantation within the first year of life ({9:Leyva-Vega et al., 2010}). See also Alagille syndrome ({118450}), which includes biliary atresia as a feature.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Atresia Extrahepatic" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Biliary Atresia Extrahepatic" returned 23 free, full-text research articles on human participants. First 3 results:

Extrahepatic anomalies in infants with biliary atresia: results of a large prospective North American multicenter study.
 

Author(s): Kathleen B Schwarz, Barbara H Haber, Philip Rosenthal, Cara L Mack, Jeffrey Moore, Kevin Bove, Jorge A Bezerra, Saul J Karpen, Nanda Kerkar, Benjamin L Shneider, Yumirle P Turmelle, Peter F Whitington, Jean P Molleston, Karen F Murray, Vicky L Ng, René Romero, Kasper S Wang, Ronald J Sokol, John C Magee,

Journal: Hepatology. 2013 Nov;58(5):1724-31.

 

The etiology of biliary atresia (BA) is unknown. Given that patterns of anomalies might provide etiopathogenetic clues, we used data from the North American Childhood Liver Disease Research and Education Network to analyze patterns of anomalies in infants with BA. In all, 289 infants ...

Last Updated: 20 Jan 2014

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Extrahepatic cholangiocyte cilia are abnormal in biliary atresia.
 

Author(s): Sara Karjoo, Nicholas J Hand, Lorena Loarca, Pierre A Russo, Joshua R Friedman, Rebecca G Wells

Journal: J. Pediatr. Gastroenterol. Nutr.. 2013 Jul;57(1):96-101.

 

Biliary atresia (BA) is a rapidly progressive form of biliary fibrosis affecting neonates. We previously reported that primary cilia on the intrahepatic cholangiocytes of patients with both syndromic and nonsyndromic BA were structurally abnormal. Our objective was to determine whether ...

Last Updated: 26 Jun 2013

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Early diagnosis of extrahepatic biliary atresia in an open-access medical system.
 

Author(s): Justin Hollon, Matilda Eide, Gregory Gorman

Journal: PLoS ONE. 2012 ;7(11):e49643.

 

Biliary atresia (BA) is the most common cause of cholestatic jaundice in infancy. Early diagnosis and surgical management, ideally before 60 days of age, result in improved outcomes. We aimed to determine the age at diagnosis of BA in the Military Health System (MHS) and to compare ...

Last Updated: 27 Nov 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Biliary Atresia Extrahepatic" returned 3 free, full-text review articles on human participants. First 3 results:

Extrahepatic biliary atresia: current concepts and future directions.
 

Author(s): Elisa de Carvalho, Cláudia Alexandra Pontes Ivantes, Jorge A Bezerra

Journal: J Pediatr (Rio J). ;83(2):105-20.

 

To provide an updated review on extrahepatic biliary atresia, focusing mainly on its etiopathogenesis, diagnosis, treatment and prognosis.

Last Updated: 11 Apr 2007

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[Extrahepatic biliary atresia: diagnostic methods].
 

Author(s): Sydney M Cauduro

Journal: J Pediatr (Rio J). ;79(2):107-14.

 

To emphasize the importance of precocious diagnosis of extrahepatic biliary atresia and its direct relationship with the surgical re-establishment of the biliary flow before the second month of life. To discuss several complementary methods with the aim of selecting the ones that ...

Last Updated: 22 Sep 2003

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Extrahepatic biliary atresia. Recent developments in management.
 

Author(s): E R Howard, A P Mowat

Journal: Arch. Dis. Child.. 1977 Nov;52(11):825-7.

 

Last Updated: 23 Feb 1978

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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