Biliary Atresia

Common Name(s)

Biliary Atresia

Biliary Atresia is a digestive disorder characterized by the incomplete development of the bile duct system. The bile duct system is responsible for storing and transporting bile from the liver, where it is made, to the intestines, where it helps to digest food. Incomplete development of the ducts inhibits the flow of bile. Individuals with this defect have digestion problems as well as a yellow discoloration of the eye and skin (jaundice). Doctors diagnose this defect early in life, as the resulting symptoms are quickly apparent. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. Digestion specialists may suggest individuals eat a lower-fat diet, or undergo surgery to relieve the blockage or create a tube to allow bile to reach the digestive system.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Atresia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Atresia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Biliary Atresia" returned 271 free, full-text research articles on human participants. First 3 results:

A New Era of Laparoscopic Revision of Kasai Portoenterostomy for the Treatment of Biliary Atresia.
 

Author(s): Naruhiko Murase, Hiroo Uchida, Yasuyuki Ono, Takahisa Tainaka, Kazuki Yokota, Akihide Tanano, Chiyoe Shirota, Ryo Shirotsuki

Journal: Biomed Res Int. 2015 ;2015():173014.

 

Kasai portoenterostomy is the standard therapy for biliary atresia (BA). If Kasai is unsuccessful, there is controversy over whether revision of Kasai restores adequate biliary drainage. Although there are several reports of laparoscopic Kasai (Lap-Kasai), none has described laparoscopic ...

Last Updated: 12 Aug 2015

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Inguinal Hernias Represent the Most Frequent Surgical Complication after Kasai in Biliary Atresia Infants.
 

Author(s): Omid Madadi-Sanjani, Nathalie Carl, Thomas Longerich, Claus Petersen, Julia H K Andruszkow

Journal: Biomed Res Int. 2015 ;2015():383791.

 

Biliary atresia (BA) is an orphan medical condition of the newborn, resulting in end-stage liver cirrhosis due to obliterative cholangiopathy of the extrahepatic bile duct. Although Kasai's hepatoportoenterostomy (KPE) is the well-established first-line therapy, little is known about ...

Last Updated: 4 Aug 2015

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Telomere Length in Peripheral Blood Leukocytes Is Associated with Severity of Biliary Atresia.
 

Author(s): Wanvisa Udomsinprasert, Yong Poovorawan, Voranush Chongsrisawat, Paisarn Vejchapipat, Dong Zhan, Sittisak Honsawek

Journal:

 

The purpose of this study was to investigate the association of telomere length in peripheral blood leukocytes with the severity of biliary atresia (BA).

Last Updated: 3 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Biliary Atresia" returned 30 free, full-text review articles on human participants. First 3 results:

The Sea Lamprey as an Etiological Model for Biliary Atresia.
 

Author(s): Yu-Wen Chung-Davidson, Chu-Yin Yeh, Weiming Li

Journal: Biomed Res Int. 2015 ;2015():832943.

 

Biliary atresia (BA) is a progressive, inflammatory, and fibrosclerosing cholangiopathy in infants that results in obstruction of both extrahepatic and intrahepatic bile ducts. It is the most common cause for pediatric liver transplantation. In contrast, the sea lamprey undergoes ...

Last Updated: 23 Jun 2015

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Beyond the Pediatric end-stage liver disease system: solutions for infants with biliary atresia requiring liver transplant.
 

Author(s): Mary Elizabeth M Tessier, Sanjiv Harpavat, Ross W Shepherd, Girish S Hiremath, Mary L Brandt, Amy Fisher, John A Goss

Journal: World J. Gastroenterol.. 2014 Aug;20(32):11062-8.

 

Biliary atresia (BA), a chronic progressive cholestatic disease of infants, is the leading cause for liver transplant in children, especially in patients under two years of age. BA can be successfully treated with the Kasai portoenterostomy; however most patients still require a liver ...

Last Updated: 29 Aug 2014

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Maternal microchimerism in biliary atresia: are maternal cells effector cells, targets, or just bystanders?
 

Author(s): Toshihiro Muraji

Journal: Chimerism. ;5(1):1-5.

 

The etiology of biliary atresia (BA) is unknown; however, the liver histology is similar to that observed in immune-mediated hepatic disorders. Liver fibrosis in BA progresses even after bile drainage has been achieved by the Kasai operation. Maternal microchimerism has been purported ...

Last Updated: 18 Apr 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biliary Atresia Study in Infants and Children
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 27 Aug 2015

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Pentoxifylline Therapy in Biliary Atresia
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 11 Jan 2016

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Ultrasound Shear Wave Elastography Evaluation of Suspected and Known Biliary Atresia
 

Status: Not yet recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 8 Jan 2016

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