Biliary Atresia

Common Name(s)

Biliary Atresia

Biliary Atresia is a digestive disorder characterized by the incomplete development of the bile duct system. The bile duct system is responsible for storing and transporting bile from the liver, where it is made, to the intestines, where it helps to digest food. Incomplete development of the ducts inhibits the flow of bile. Individuals with this defect have digestion problems as well as a yellow discoloration of the eye and skin (jaundice). Doctors diagnose this defect early in life, as the resulting symptoms are quickly apparent. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. Digestion specialists may suggest individuals eat a lower-fat diet, or undergo surgery to relieve the blockage or create a tube to allow bile to reach the digestive system.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Atresia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Atresia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Biliary Atresia" returned 287 free, full-text research articles on human participants. First 3 results:

Surgical outcome and etiologic heterogeneity of infants with biliary atresia who received Kasai operation less than 60 days after birth: A retrospective study.
 

Author(s): Zai Song, Rui Dong, Zhen Shen, Gong Chen, Yifan Yang, Shan Zheng

Journal: Medicine (Baltimore). 2017 Jun;96(26):e7267.

 

This study aimed to analyze the impact of etiologic heterogeneity and operation age on prognosis of infants with biliary atresia (BA) who received Kasai operation prior to 60 days of age.From 2004 to 2010, 158 infants received Kasai operation before turning 60 days old. According ...

Last Updated: 28 Jun 2017

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Initial assessment of the infant with neonatal cholestasis-Is this biliary atresia?
 

Author(s): Benjamin L Shneider, Jeff Moore, Nanda Kerkar, John C Magee, Wen Ye, Saul J Karpen, Binita M Kamath, Jean P Molleston, Jorge A Bezerra, Karen F Murray, Kathleen M Loomes, Peter F Whitington, Philip Rosenthal, Robert H Squires, Stephen L Guthery, Ronen Arnon, Kathleen B Schwarz, Yumirle P Turmelle, Averell H Sherker, Ronald J Sokol,

Journal:

 

Optimizing outcome in biliary atresia (BA) requires timely diagnosis. Cholestasis is a presenting feature of BA, as well as other diagnoses (Non-BA). Identification of clinical features of neonatal cholestasis that would expedite decisions to pursue subsequent invasive testing to ...

Last Updated: 11 May 2017

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Patient complexity and genotype-phenotype correlations in biliary atresia: a cross-sectional analysis.
 

Author(s): Guo Cheng, Patrick Ho-Yu Chung, Edwin Kin-Wai Chan, Man-Ting So, Pak-Chung Sham, Stacey S Cherny, Paul Kwong-Hang Tam, Maria-Mercè Garcia-Barceló

Journal:

 

Biliary Atresia (BA) is rare and genetically complex, and the pathogenesis is elusive. The disease course is variable and can represent heterogeneity, which hinders effective disease management. Deciphering the BA phenotypic variance is a priority in clinics and can be achieved by ...

Last Updated: 18 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Biliary Atresia" returned 36 free, full-text review articles on human participants. First 3 results:

Steroids after the Kasai procedure for biliary atresia: the effect of age at Kasai portoenterostomy.
 

Author(s): Athanasios Tyraskis, Mark Davenport

Journal: Pediatr. Surg. Int.. 2016 Mar;32(3):193-200.

 

The use of adjuvant steroids following Kasai porteoenterostomy (KPE) for biliary atresia is controversial. The aim of this study was twofold: a systematic review of published literature and an update of the clinical Kings College Hospital series to look for evidence of an effect of ...

Last Updated: 17 Feb 2016

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Recent Trends in the Diagnosis and Management of Biliary Atresia in Developing Countries.
 

Author(s): Priya Ramachandran, Mohamed Safwan, Mettu Srinivas Reddy, Mohamed Rela

Journal: Indian Pediatr. 2015 Oct;52(10):871-9.

 

Biliary atresia is a progressive obstructive cholangiopathy and is fatal if left untreated within 2 years of life. Delay in referral is because of difficulties in differentiating it from physiologic jaundice and identifying an abnormal stool color. This paper presents an overview ...

Last Updated: 27 Oct 2015

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The Sea Lamprey as an Etiological Model for Biliary Atresia.
 

Author(s): Yu-Wen Chung-Davidson, Chu-Yin Yeh, Weiming Li

Journal: Biomed Res Int. 2015 ;2015():832943.

 

Biliary atresia (BA) is a progressive, inflammatory, and fibrosclerosing cholangiopathy in infants that results in obstruction of both extrahepatic and intrahepatic bile ducts. It is the most common cause for pediatric liver transplantation. In contrast, the sea lamprey undergoes ...

Last Updated: 23 Jun 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biliary Atresia Study in Infants and Children
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 6 Sep 2017

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Pentoxifylline Therapy in Biliary Atresia
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 12 Sep 2017

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Mapping Disease Pathways for Biliary Atresia
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 1 Sep 2017

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