Biliary Atresia

Common Name(s)

Biliary Atresia

Biliary Atresia is a digestive disorder characterized by the incomplete development of the bile duct system. The bile duct system is responsible for storing and transporting bile from the liver, where it is made, to the intestines, where it helps to digest food. Incomplete development of the ducts inhibits the flow of bile. Individuals with this defect have digestion problems as well as a yellow discoloration of the eye and skin (jaundice). Doctors diagnose this defect early in life, as the resulting symptoms are quickly apparent. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. Digestion specialists may suggest individuals eat a lower-fat diet, or undergo surgery to relieve the blockage or create a tube to allow bile to reach the digestive system.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Atresia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Atresia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Biliary Atresia" returned 231 free, full-text research articles on human participants. First 3 results:

Three-dimensional magnetic resonance cholangiopancreatography for the diagnosis of biliary atresia in infants and neonates.
 

Author(s): Bo Liu, Jinhua Cai, Ye Xu, Xuehua Peng, Helin Zheng, Kaiping Huang, Jing Yang

Journal:

 

Magnetic resonance cholangiopancreatography (MRCP) is widely accepted for visualization of the biliary system. However, the sensitivity and specificity of MRCP for the diagnosis of biliary atresia (BA) are still not fully elucidated. This study aimed to investigate the diagnostic ...

Last Updated: 7 Feb 2014

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Identification of the plasma metabolomics as early diagnostic markers between biliary atresia and neonatal hepatitis syndrome.
 

Author(s): Dongying Zhao, Lianshu Han, Zhengjuan He, Jun Zhang, Yongjun Zhang

Journal:

 

Early detection is the most effective way to improve the clinical outcome of biliary atresia (BA). Emerging metabolomics provides a powerful platform for discovering novel biomarkers and biochemical pathways to improve early diagnosis. The aim of this study is to find the potential ...

Last Updated: 13 Jan 2014

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Clinical benefit of liver stiffness measurement at 3 months after Kasai hepatoportoenterostomy to predict the liver related events in biliary atresia.
 

Author(s): Seung Min Hahn, Seung Kim, Kook In Park, Seok Joo Han, Hong Koh

Journal:

 

The progression of hepatic fibrosis may result in decompensated hepatic failure with cirrhosis, liver related events (LRE) such as ascites, variceal bleeding, and death after successful and timely Kasai hepatoportoenterostomy (HPE) in biliary atresia. The aim of this study is to suggest ...

Last Updated: 22 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Biliary Atresia" returned 25 free, full-text review articles on human participants. First 3 results:

Aetiology of biliary atresia: what is actually known?
 

Author(s): Claus Petersen, Mark Davenport

Journal:

 

Biliary atresia (BA) is a rare disease of unknown etiology and unpredictable outcome, even when there has been timely diagnosis and exemplary surgery. It has been the commonest indication for liver transplantation during childhood for the past 20 years. Hence much clinical and basic ...

Last Updated: 15 Nov 2013

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The long-term outcome of the Kasai operation in patients with biliary atresia: a systematic review.
 

Author(s): E J Bijl, K D Bharwani, R H J Houwen, R A de Man

Journal: Neth J Med. 2013 May;71(4):170-3.

 

Biliary atresia (BA) is a progressive inflammatory destructive process of the bile ducts occurring in about one of every 20,000 live births. If left untreated, biliary atresia can lead to liver failure. The only effective treatments for BA at the moment are the Kasai operation and ...

Last Updated: 31 May 2013

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Clues to the etiology of bile duct injury in biliary atresia.
 

Author(s): Cara L Mack, Amy G Feldman, Ronald J Sokol

Journal: Semin. Liver Dis.. 2012 Nov;32(4):307-16.

 

Biliary atresia (BA) is an infantile obstructive cholangiopathy of unknown etiology with suboptimal therapy, which is responsible for 40 to 50% of all pediatric liver transplants. Although the etiology of bile duct injury in BA in unknown, it is postulated that a pre- or perinatal ...

Last Updated: 11 Feb 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biliary Atresia Study in Infants and Children
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 15 Sep 2014

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Pentoxifylline Therapy in Biliary Atresia
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 23 Jan 2013

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Evaluation of Immune Function in Biliary Atresia Children With Prolonged Jaundice
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 9 Sep 2005

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