Biliary Atresia

Common Name(s)

Biliary Atresia

Biliary Atresia is a digestive disorder characterized by the incomplete development of the bile duct system. The bile duct system is responsible for storing and transporting bile from the liver, where it is made, to the intestines, where it helps to digest food. Incomplete development of the ducts inhibits the flow of bile. Individuals with this defect have digestion problems as well as a yellow discoloration of the eye and skin (jaundice). Doctors diagnose this defect early in life, as the resulting symptoms are quickly apparent. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. Digestion specialists may suggest individuals eat a lower-fat diet, or undergo surgery to relieve the blockage or create a tube to allow bile to reach the digestive system.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Atresia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Atresia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Biliary Atresia" returned 235 free, full-text research articles on human participants. First 3 results:

Biliary atresia: evaluation on two distinct periods at a reference pediatric service.
 

Author(s): Thais Costa Nascentes Queiroz, Alexandre Rodrigues Ferreira, Eleonora Druve Tavares Fagundes, Mariza Leitão Valadares Roquete, Francisco José Penna

Journal: Arq Gastroenterol. ;51(1):53-8.

 

Biliary atresia is a progressive, idiopathic, fibro-obliterative disease of the extrahepatic biliary tree that presents with biliary obstruction exclusively in the neonatal period.

Last Updated: 24 Apr 2014

Go To URL
Improved severe hepatopulmonary syndrome after liver transplantation in an adolescent with end-stage liver disease secondary to biliary atresia.
 

Author(s): Tae Jun Park, Keun Soo Ahn, Yong Hoon Kim, Hyungseop Kim, Ui Jun Park, Hyoung Tae Kim, Won Hyun Cho, Woo-Hyun Park, Koo Jeong Kang

Journal: Clin Mol Hepatol. 2014 Mar;20(1):76-80.

 

Hepatopulmonary syndrome (HPS) is a serious complication of end-stage liver disease, which is characterized by hypoxia, intrapulmonary vascular dilatation, and liver cirrhosis. Liver transplantation (LT) is the only curative treatment modality for patients with HPS. However, morbidity ...

Last Updated: 23 Apr 2014

Go To URL
HMGB1-promoted and TLR2/4-dependent NK cell maturation and activation take part in rotavirus-induced murine biliary atresia.
 

Author(s): Yinrong Qiu, Jixin Yang, Wenmei Wang, Wentao Zhao, Fei Peng, Ying Xiang, Gang Chen, Tao Chen, Chengwei Chai, Shuaiyu Zheng, Daniel J Watkins, Jiexiong Feng

Journal:

 

Recent studies show that NK cells play important roles in murine biliary atresia (BA), and a temporary immunological gap exists in this disease. In this study, we found high-mobility group box-1 (HMGB1) and TLRs were overexpressed in human and rotavirus-induced murine BA. The overexpressed ...

Last Updated: 21 Mar 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Biliary Atresia" returned 25 free, full-text review articles on human participants. First 3 results:

Aetiology of biliary atresia: what is actually known?
 

Author(s): Claus Petersen, Mark Davenport

Journal:

 

Biliary atresia (BA) is a rare disease of unknown etiology and unpredictable outcome, even when there has been timely diagnosis and exemplary surgery. It has been the commonest indication for liver transplantation during childhood for the past 20 years. Hence much clinical and basic ...

Last Updated: 15 Nov 2013

Go To URL
The long-term outcome of the Kasai operation in patients with biliary atresia: a systematic review.
 

Author(s): E J Bijl, K D Bharwani, R H J Houwen, R A de Man

Journal: Neth J Med. 2013 May;71(4):170-3.

 

Biliary atresia (BA) is a progressive inflammatory destructive process of the bile ducts occurring in about one of every 20,000 live births. If left untreated, biliary atresia can lead to liver failure. The only effective treatments for BA at the moment are the Kasai operation and ...

Last Updated: 31 May 2013

Go To URL
Clues to the etiology of bile duct injury in biliary atresia.
 

Author(s): Cara L Mack, Amy G Feldman, Ronald J Sokol

Journal: Semin. Liver Dis.. 2012 Nov;32(4):307-16.

 

Biliary atresia (BA) is an infantile obstructive cholangiopathy of unknown etiology with suboptimal therapy, which is responsible for 40 to 50% of all pediatric liver transplants. Although the etiology of bile duct injury in BA in unknown, it is postulated that a pre- or perinatal ...

Last Updated: 11 Feb 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Biliary Atresia Study in Infants and Children
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 15 Sep 2014

Go to URL
Pentoxifylline Therapy in Biliary Atresia
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 23 Jan 2013

Go to URL
Evaluation of Immune Function in Biliary Atresia Children With Prolonged Jaundice
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 9 Sep 2005

Go to URL