Biliary Atresia

Common Name(s)

Biliary Atresia

Biliary Atresia is a digestive disorder characterized by the incomplete development of the bile duct system. The bile duct system is responsible for storing and transporting bile from the liver, where it is made, to the intestines, where it helps to digest food. Incomplete development of the ducts inhibits the flow of bile. Individuals with this defect have digestion problems as well as a yellow discoloration of the eye and skin (jaundice). Doctors diagnose this defect early in life, as the resulting symptoms are quickly apparent. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. Digestion specialists may suggest individuals eat a lower-fat diet, or undergo surgery to relieve the blockage or create a tube to allow bile to reach the digestive system.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Atresia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Atresia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Biliary Atresia" returned 243 free, full-text research articles on human participants. First 3 results:

A histopathological study of liver and biliary remnants in the long-term survivors (>10 years) of cases of biliary atresia.
 

Author(s): Sabuj Ghana Mukhopadhyay, Paromita Roy, Uttara Chatterjee, Chhanda Datta, Mala Banerjee, Sugato Banerjee, Ashoke Kumar Basu, Manojit Ganguli

Journal: Indian J Pathol Microbiol. ;57(3):380-5.

 

Biliary atresia (BA) is a destructive process affecting both extra- and intra-hepatic bile ducts leading to fibrosis and obliteration of the biliary tree and cirrhosis usually within 2 years. Factors influencing the outcome of portoenterostomy (PE) have not been clearly defined.

Last Updated: 14 Aug 2014

Go To URL
Predictive value of hepatic ultrasound, liver biopsy, and duodenal tube test in the diagnosis of extrahepatic biliary atresia in Serbian infants.
 

Author(s): Aleksandra Boskovic, Ivana Kitic, Dragan Prokic, Ivica Stankovic, Blagoje Grujic

Journal: Turk J Gastroenterol. 2014 Apr;25(2):170-4.

 

Extrahepatic biliary atresia (EHBA) is the most important cause of neonatal cholestasis. The validity of different diagnostic methods in the diagnosis of EHBA in developed countries has been presented elsewhere, but data from developing countries with low national incomes are scarce. ...

Last Updated: 9 Jul 2014

Go To URL
Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial.
 

Author(s): Jorge A Bezerra, Cathie Spino, John C Magee, Benjamin L Shneider, Philip Rosenthal, Kasper S Wang, Jessi Erlichman, Barbara Haber, Paula M Hertel, Saul J Karpen, Nanda Kerkar, Kathleen M Loomes, Jean P Molleston, Karen F Murray, Rene Romero, Kathleen B Schwarz, Ross Shepherd, Frederick J Suchy, Yumirle P Turmelle, Peter F Whitington, Jeffrey Moore, Averell H Sherker, Patricia R Robuck, Ronald J Sokol,

Journal: JAMA. 2014 May;311(17):1750-9.

 

Biliary atresia is the most common cause of end-stage liver disease in children. Controversy exists as to whether use of steroids after hepatoportoenterostomy improves clinical outcome.

Last Updated: 5 May 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Biliary Atresia" returned 26 free, full-text review articles on human participants. First 3 results:

Maternal microchimerism in biliary atresia: are maternal cells effector cells, targets, or just bystanders?
 

Author(s): Toshihiro Muraji

Journal: Chimerism. ;5(1):1-5.

 

The etiology of biliary atresia (BA) is unknown; however, the liver histology is similar to that observed in immune-mediated hepatic disorders. Liver fibrosis in BA progresses even after bile drainage has been achieved by the Kasai operation. Maternal microchimerism has been purported ...

Last Updated: 18 Apr 2014

Go To URL
Aetiology of biliary atresia: what is actually known?
 

Author(s): Claus Petersen, Mark Davenport

Journal:

 

Biliary atresia (BA) is a rare disease of unknown etiology and unpredictable outcome, even when there has been timely diagnosis and exemplary surgery. It has been the commonest indication for liver transplantation during childhood for the past 20 years. Hence much clinical and basic ...

Last Updated: 15 Nov 2013

Go To URL
The long-term outcome of the Kasai operation in patients with biliary atresia: a systematic review.
 

Author(s): E J Bijl, K D Bharwani, R H J Houwen, R A de Man

Journal: Neth J Med. 2013 May;71(4):170-3.

 

Biliary atresia (BA) is a progressive inflammatory destructive process of the bile ducts occurring in about one of every 20,000 live births. If left untreated, biliary atresia can lead to liver failure. The only effective treatments for BA at the moment are the Kasai operation and ...

Last Updated: 31 May 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Biliary Atresia Study in Infants and Children
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 15 Sep 2014

Go to URL
Pentoxifylline Therapy in Biliary Atresia
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 5 Feb 2015

Go to URL
Evaluation of Immune Function in Biliary Atresia Children With Prolonged Jaundice
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 9 Sep 2005

Go to URL