Biliary Atresia

Common Name(s)

Biliary Atresia

Biliary Atresia is a digestive disorder characterized by the incomplete development of the bile duct system. The bile duct system is responsible for storing and transporting bile from the liver, where it is made, to the intestines, where it helps to digest food. Incomplete development of the ducts inhibits the flow of bile. Individuals with this defect have digestion problems as well as a yellow discoloration of the eye and skin (jaundice). Doctors diagnose this defect early in life, as the resulting symptoms are quickly apparent. Treatment is developed on a case-by-case basis and depends on the specific needs of the patient. Digestion specialists may suggest individuals eat a lower-fat diet, or undergo surgery to relieve the blockage or create a tube to allow bile to reach the digestive system.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Atresia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Biliary Atresia" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Biliary Atresia" returned 279 free, full-text research articles on human participants. First 3 results:

[Biliary atresia and polysplenia syndrome].
 

Author(s): Yosra Kerkeni, Amine Ksia, Hayet Zitouni, Mohsen Belghith, Sahnoun Lassad, Imed Krichene, Mongi Mekki, Abdellatif Nouri

Journal: Tunis Med. ;93(8-9):494-6.

 

Polysplenia syndrome is a rare malformation characterized by the association of multiple rates and other congenital anomalies dominated by cardiac, vascular, intestinal and bile malformations. We report the observation of a patient operated in the neonatal period (3 days) for an upper ...

Last Updated: 28 Jan 2016

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Newborn Screening for Biliary Atresia.
 

Author(s): Kasper S Wang, , ,

Journal: Pediatrics. 2015 Dec;136(6):e1663-9.

 

Biliary atresia is the most common cause of pediatric end-stage liver disease and the leading indication for pediatric liver transplantation. Affected infants exhibit evidence of biliary obstruction within the first few weeks after birth. Early diagnosis and successful surgical drainage ...

Last Updated: 2 Dec 2015

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Alagille Syndrome Mimicking Biliary Atresia in Early Infancy.
 

Author(s): Tomáš Dědič, Milan Jirsa, Radan Keil, Michal Rygl, Jiri Šnajdauf, Radana Kotalová

Journal:

 

Alagille syndrome may mimic biliary atresia in early infancy. Since mutations in JAG1 typical for Alagille syndrome type 1 have also been found in biliary atresia, we aimed to identify JAG1 mutations in newborns with proven biliary atresia (n = 72). Five biliary atresia patients with ...

Last Updated: 1 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Biliary Atresia" returned 33 free, full-text review articles on human participants. First 3 results:

Recent Trends in the Diagnosis and Management of Biliary Atresia in Developing Countries.
 

Author(s): Priya Ramachandran, Mohamed Safwan, Mettu Srinivas Reddy, Mohamed Rela

Journal: Indian Pediatr. 2015 Oct;52(10):871-9.

 

Biliary atresia is a progressive obstructive cholangiopathy and is fatal if left untreated within 2 years of life. Delay in referral is because of difficulties in differentiating it from physiologic jaundice and identifying an abnormal stool color. This paper presents an overview ...

Last Updated: 27 Oct 2015

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The Sea Lamprey as an Etiological Model for Biliary Atresia.
 

Author(s): Yu-Wen Chung-Davidson, Chu-Yin Yeh, Weiming Li

Journal: Biomed Res Int. 2015 ;2015():832943.

 

Biliary atresia (BA) is a progressive, inflammatory, and fibrosclerosing cholangiopathy in infants that results in obstruction of both extrahepatic and intrahepatic bile ducts. It is the most common cause for pediatric liver transplantation. In contrast, the sea lamprey undergoes ...

Last Updated: 23 Jun 2015

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Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes.
 

Author(s): Akihiro Asai, Alexander Miethke, Jorge A Bezerra

Journal: Nat Rev Gastroenterol Hepatol. 2015 Jun;12(6):342-52.

 

Biliary atresia is a severe cholangiopathy of early infancy that destroys extrahepatic bile ducts and disrupts bile flow. With a poorly defined disease pathogenesis, treatment consists of the surgical removal of duct remnants followed by hepatoportoenterostomy. Although this approach ...

Last Updated: 4 Jun 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biliary Atresia Study in Infants and Children
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 27 Aug 2015

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Pentoxifylline Therapy in Biliary Atresia
 

Status: Recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 18 Jul 2016

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Ultrasound Shear Wave Elastography Evaluation of Suspected and Known Biliary Atresia
 

Status: Not yet recruiting

Condition Summary: Biliary Atresia

 

Last Updated: 8 Jan 2016

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