Epidermal nevus

Common Name(s)

Epidermal nevus

Epidermal nevi are congenital lesions that affect about 1 in 1,000 people. They appear at or shortly after birth as localized epidermal thickening with hyperpigmentation that frequently follow the lines of Blaschko, suggesting that they result from postzygotic somatic mutation in the skin ({11:Paller et al., 1994}). A rare subgroup of epidermal nevi is clinically indistinguishable from other epidermal nevi, but displays histopathologic features typical of epidermolytic hyperkeratosis (see EHK, {113800}), and patients with this type of epidermal nevi sometimes have offspring with generalized EHK ({11:Paller et al., 1994}). See giant pigmented hairy nevus ({137550}) and malignant melanoma ({155600}). Nevus sebaceous is a benign congenital skin lesion that preferentially affects the scalp and face. It occurs in about 1 in 1,000 live births and is characterized by hairless, yellow-orange plaques of various size and shape. Histology shows that nevus sebaceous is a hamartoma consisting of epidermal, sebaceous, and apocrine elements. About 24% of nevi develop secondary tumors, some of which may be malignant (summary by {5:Groesser et al., 2012}).
 

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Condition Specific Organizations

Following organizations serve the condition "Epidermal nevus" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Epidermal nevus" returned 34 free, full-text research articles on human participants. First 3 results:

Verrucous epidermal nevus.
 

Author(s): Randie Kim, Shoshana Marmon, Jennifer Kaplan, Hideko Kamino, Miriam Keltz Pomeranz

Journal:

 

A 64-year-old man presented with a three-year history of an enlarging, pruritic, linear, verrucous plaque on his left lower extremity. Histopathologic examination was consistent with a verrucous epidermal nevus, which is a benign epidermal hamartoma, most commonly observed in the ...

Last Updated: 24 Dec 2013

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Analysis of mutations in the PIK3CA and FGFR3 genes in verrucous epidermal nevus.
 

Author(s): Ludmilla Queirós Miranda, Tainá Scalfoni Fracaroli, João Carlos Macedo Fonseca, Elisa Fontenelle, Raphael Pedro Machado Curvo, Luís Cristóvão Porto, Roberto Souto

Journal: An Bras Dermatol. ;88(6 Suppl 1):36-8.

 

Verrucous epidermal nevi are congenital hamartomas composed of keratinocytes and may occur alone or in association with developmental abnormalities. A close relationship between variations in the PIK3CA and FGFR3 genes and the appearance of nevi has been recently reported. Based on ...

Last Updated: 18 Dec 2013

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Involucrin in the differential diagnosis between linear psoriasis and inflammatory linear verrucous epidermal nevus: a report of one case.
 

Author(s): Flávia Regina Ferreira, Nilton Gioia Di Chiacchio, Márcia Lanzoni de Alvarenga, Samuel Henrique Mandelbaum

Journal: An Bras Dermatol. ;88(4):604-7.

 

Inflammatory linear verrucous epidermal nevus is a variant of verrucous epidermal nevus, characterized by recurrent inflammatory phenomena. Despite well-established clinical manifestations, the differential diagnosis between inflammatory linear verrucous epidermal nevus and linear ...

Last Updated: 26 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Epidermal nevus" returned 1 free, full-text review articles on human participants. First 3 results:

Oral linear epidermal nevus: a review of the literature and report of two new cases.
 

Author(s): Domenico Tesi, Giuseppe Ficarra

Journal: Head Neck Pathol. 2010 Jun;4(2):139-43.

 

Linear epidermal nevus (LEN) is a sporadic hamartomatous lesion of the skin due to the proliferation of clones of embryonic ectodermal cells, which are arranged according to a typical linear configuration known as Blaschko's lines. Oral involvement of LEN is very rare and few cases ...

Last Updated: 31 May 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase I Study for Autologous Dermal Substitutes and Dermo-epidermal Skin Substitutes for Treatment of Skin Defects
 

Status: Recruiting

Condition Summary: Burn Injury; Soft Tissue Injury; Skin Necrosis; Scars; Congenital Giant Nevus; Skin Tumors

 

Last Updated: 30 Jun 2014

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