Endometrial cancer

Common Name(s)

Endometrial cancer

Endometrial cancer is a type of cancer that begins in cells of the endometrium or lining of the uterus in women. Endometrial cancer is the 6th most common cancer in women worldwide, but is more common in high income countries. Risk increases with age, with most diagnosed after menopause.

Symptoms of endometrial cancer include abnormal vaginal bleeding or discharge, pelvic pain, and weight-loss. In general, symptoms occur in early stages of the cancer so it is usually diagnosed early. The overall 5 year survival rate is relatively high and is increasing due to medical research.

Most risk factors for endometrial cancer affect a woman’s estrogen (hormone) level. These include estrogen-only hormone replacement therapy and certain hormone therapies for breast cancer (tamoxifen). Conditions affecting ovulation (polycystic ovarian syndrome, diabetes and obesity) may increase a woman’s risk. Other risk factors include beginning your period before age 12, late menopause, never having been pregnant, and a personal history of breast or ovarian cancer. Lynch syndrome, a genetic condition, also increases a woman’s risk.

Diagnosis may include a pelvic exam, a transvaginal ultrasound (uses sound waves to picture the uterus), an exam using a hysteroscope (thin tube to see inside the uterus), and a uterine biopsy (testing a small piece of tissue). To confirm the diagnosis and stage of cancer, a D&C (special procedure in which cells are scraped from the uterine wall) may be performed.

Treatments may include surgery, hormonal therapy, chemotherapy, and radiation therapy. Prevention includes birth control pills containing both progesterone and estrogen, exercise, maintaining a healthy weight and stopping smoking. If you have been diagnosed with endometrial cancer, talk to your doctor about the most current treatment options. Support groups are good sources of information and can connect you living with endometrial cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Endometrial cancer" returned 1387 free, full-text research articles on human participants. First 3 results:

Hypoxia-inducible factor-1α, adrenomedullin and Bcl-2 although expected are not related to increased uptake of fluorine-18-fluorodeoxyglucose in endometrial cancer.
 

Author(s): Sevim Sureyya Cerci, Yakup Yalcin, Kemal Kursat Bozkurt, Ebru Erdemoglu, Burak Tatar, Evrim Erdemoglu

Journal: Hell J Nucl Med. ;18(3):228-32.

 

To study the relation between SUVmax, hypoxia inducible factor 1α (HIF-1α), angiogenetic factor adrenomedullin (AM) and antiapoptotic factor Bcl-2 in endometrial cancer.

Last Updated: 5 Dec 2015

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LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment.
 

Author(s): Christopher G Peña, Yuji Nakada, Hatice D Saatcioglu, Gina M Aloisio, Ileana Cuevas, Song Zhang, David S Miller, Jayanthi S Lea, Kwok-Kin Wong, Ralph J DeBerardinis, Antonio L Amelio, Rolf A Brekken, Diego H Castrillon

Journal: J. Clin. Invest.. 2015 Nov;125(11):4063-76.

 

Endometrial cancer is the most common gynecologic malignancy and the fourth most common malignancy in women. For most patients in whom the disease is confined to the uterus, treatment results in successful remission; however, there are no curative treatments for tumors that have progressed ...

Last Updated: 6 Nov 2015

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Project for the National Program of Early Diagnosis of Endometrial Cancer Part I.
 

Author(s): R E Bohîlțea, V Ancăr, M M Cirstoiu, V Rădoi, L C Bohîlțea, F Furtunescu

Journal: J Med Life. ;8(3):305-14.

 

Endometrial cancer recorded a peak incidence in ages 60-64 years in Romania, reaching in 2013 the average value of 8.06/ 100,000 women, and 15.97/ 100,000 women within the highest risk age range, having in recent years an increasing trend, being higher in urban than in rural population. ...

Last Updated: 9 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Endometrial cancer" returned 137 free, full-text review articles on human participants. First 3 results:

Soy Intake Is Associated With Lower Endometrial Cancer Risk: A Systematic Review and Meta-Analysis of Observational Studies.
 

Author(s): Guo-Qiang Zhang, Jin-Liang Chen, Qin Liu, Yong Zhang, Huan Zeng, Yong Zhao

Journal: Medicine (Baltimore). 2015 Dec;94(50):e2281.

 

Epidemiologic studies reporting the effect of soy intake on endometrial cancer risk conveyed conflicting results. We systematically reviewed the literature to investigate whether there was an inverse relation between dietary soy intake and endometrial cancer risk. PubMed, EMBASE, ...

Last Updated: 19 Dec 2015

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Improving survival after endometrial cancer: the big picture.
 

Author(s): Janice S Kwon

Journal: J Gynecol Oncol. 2015 Jul;26(3):227-31.

 

To improve survival in women with endometrial cancer, we need to look at the "big picture" beyond initial treatment. Although the majority of women will be diagnosed with early stage disease and are cured with surgery alone, there is a subgroup of women with advanced and high-risk ...

Last Updated: 22 Jul 2015

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Association between Breastfeeding and Endometrial Cancer Risk: Evidence from a Systematic Review and Meta-Analysis.
 

Author(s): Lianlian Wang, Jingxi Li, Zhan Shi

Journal:

 

Quantification of the association between breastfeeding and risk of endometrial cancer is still conflicting. We therefore conducted a meta-analysis to assess the association between breastfeeding and endometrial cancer risk. Pertinent studies were identified by a search of PubMed ...

Last Updated: 18 Jul 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of LY3023414 for the Treatment of Recurrent or Persistent Endometrial Cancer
 

Status: Recruiting

Condition Summary: Endometrial Cancer; Recurrent Endometrial Cancer

 

Last Updated: 10 Mar 2016

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Enzalutamide in Combination With Carboplatin and Paclitaxel in Endometrial Cancer
 

Status: Not yet recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 7 Apr 2016

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Endometrial Cancer Testing With Vaginal and Endometrial Cell Samples
 

Status: Recruiting

Condition Summary: Endometrial Cancer; Gynecological Cancers

 

Last Updated: 5 Nov 2015

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