Endometrial cancer

Common Name(s)

Endometrial cancer

Endometrial cancer is a type of cancer that begins in cells of the endometrium or lining of the uterus in women. Endometrial cancer is the 6th most common cancer in women worldwide, but is more common in high income countries. Risk increases with age, with most diagnosed after menopause.

Symptoms of endometrial cancer include abnormal vaginal bleeding or discharge, pelvic pain, and weight-loss. In general, symptoms occur in early stages of the cancer so it is usually diagnosed early. The overall 5 year survival rate is relatively high and is increasing due to medical research.

Most risk factors for endometrial cancer affect a woman’s estrogen (hormone) level. These include estrogen-only hormone replacement therapy and certain hormone therapies for breast cancer (tamoxifen). Conditions affecting ovulation (polycystic ovarian syndrome, diabetes and obesity) may increase a woman’s risk. Other risk factors include beginning your period before age 12, late menopause, never having been pregnant, and a personal history of breast or ovarian cancer. Lynch syndrome, a genetic condition, also increases a woman’s risk.

Diagnosis may include a pelvic exam, a transvaginal ultrasound (uses sound waves to picture the uterus), an exam using a hysteroscope (thin tube to see inside the uterus), and a uterine biopsy (testing a small piece of tissue). To confirm the diagnosis and stage of cancer, a D&C (special procedure in which cells are scraped from the uterine wall) may be performed.

Treatments may include surgery, hormonal therapy, chemotherapy, and radiation therapy. Prevention includes birth control pills containing both progesterone and estrogen, exercise, maintaining a healthy weight and stopping smoking. If you have been diagnosed with endometrial cancer, talk to your doctor about the most current treatment options. Support groups are good sources of information and can connect you living with endometrial cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Endometrial cancer" returned 1490 free, full-text research articles on human participants. First 3 results:

Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma.
 

Author(s): Chenglin Liu, Yu-Hang Zhang, Qinfang Deng, Yixue Li, Tao Huang, Songwen Zhou, Yu-Dong Cai

Journal: Biomed Res Int. 2017 ;2017():3859582.

 

The regulation of transcriptome expression level is a complex process involving multiple-level interactions among molecules such as protein coding RNA (mRNA), long noncoding RNA (lncRNA), and microRNA (miRNA), which are essential for the transcriptome stability and maintenance and ...

Last Updated: 10 Mar 2017

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Pattern of care in operable endometrial cancer treated at a rural-based tertiary care cancer center.
 

Author(s): S B Dessai, D Adrash, M Geetha, S Arvind, J Bipin, S Nayanar, K Sachin, M S Biji, S Balasubramanian

Journal: Indian J Cancer. ;53(3):416-419.

 

An audit was planned to study the demographics, staging, treatment details, and outcomes of operable endometrial cancers.

Last Updated: 28 Feb 2017

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Genomic Analysis of Uterine Lavage Fluid Detects Early Endometrial Cancers and Reveals a Prevalent Landscape of Driver Mutations in Women without Histopathologic Evidence of Cancer: A Prospective Cross-Sectional Study.
 

Author(s): Navya Nair, Olga Camacho-Vanegas, Dmitry Rykunov, Matthew Dashkoff, Sandra Catalina Camacho, Cassie A Schumacher, Jonathan C Irish, Timothy T Harkins, Elijah Freeman, Isaac Garcia, Elena Pereira, Sviatoslav Kendall, Rachel Belfer, Tamara Kalir, Robert Sebra, Boris Reva, Peter Dottino, John A Martignetti

Journal:

 

Endometrial cancer is the most common gynecologic malignancy, and its incidence and associated mortality are increasing. Despite the immediate need to detect these cancers at an earlier stage, there is no effective screening methodology or protocol for endometrial cancer. The comprehensive, ...

Last Updated: 27 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Endometrial cancer" returned 162 free, full-text review articles on human participants. First 3 results:

Metformin Use Is Associated with Reduced Incidence and Improved Survival of Endometrial Cancer: A Meta-Analysis.
 

Author(s): Yun-Liang Tang, Ling-Yan Zhu, Yu Li, Jiao Yu, Jiao Wang, Xiang-Xia Zeng, Kai-Xiang Hu, Jian-Ying Liu, Ji-Xiong Xu

Journal: Biomed Res Int. 2017 ;2017():5905384.

 

Studies have suggested that metformin can potentially decrease the incidence of cancer and improve survival outcomes. However, the association between metformin use and the incidence and survival of endometrial cancer (EC) remains controversial. So, a meta-analysis was performed. ...

Last Updated: 14 Apr 2017

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Robot-assisted versus conventional laparoscopic surgery for endometrial cancer staging: A meta-analysis.
 

Author(s): Shao-Hui Chen, Zhao-Ai Li, Rui Huang, Hui-Qin Xue

Journal: Taiwan J Obstet Gynecol. 2016 Aug;55(4):488-94.

 

This meta-analysis broadly compared the safety and efficacy of robot-assisted laparoscopy (RAL) with that of conventional laparoscopy (CL) for endometrial cancer staging. The advantages of RAL were evaluated through the outcomes in terms of conversion rates, complications, length ...

Last Updated: 3 Sep 2016

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Treatment of Older Women With Endometrial Cancer: Improving Outcomes With Personalized Care.
 

Author(s): Linda Duska, Armin Shahrokni, Melanie Powell

Journal: Am Soc Clin Oncol Educ Book. 2016 ;35():164-74.

 

Endometrial cancer is the most common gynecologic cancer, and with a median age of 62 at diagnosis, it affects a significant number of older women. With increasing age and obesity rates in the world's population, there is an anticipated concomitant increase in older women with endometrial ...

Last Updated: 2 Jun 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Avelumab in Patients With MSS, MSI-H and POLE-mutated Recurrent or Persistent Endometrial Cancer
 

Status: Recruiting

Condition Summary: Metastatic Endometrial Cancer

 

Last Updated: 27 Feb 2017

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Sentinel Lymph Node Dissection (SLND) in Patients With Apparent Early Stage Endometrial Cancer
 

Status: Recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 2 May 2017

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Last Updated: 28 Apr 2017

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