Endometrial cancer

Common Name(s)

Endometrial cancer

Endometrial cancer is a type of cancer that begins in cells of the endometrium or lining of the uterus in women. Endometrial cancer is the 6th most common cancer in women worldwide, but is more common in high income countries. Risk increases with age, with most diagnosed after menopause.

Symptoms of endometrial cancer include abnormal vaginal bleeding or discharge, pelvic pain, and weight-loss. In general, symptoms occur in early stages of the cancer so it is usually diagnosed early. The overall 5 year survival rate is relatively high and is increasing due to medical research.

Most risk factors for endometrial cancer affect a woman’s estrogen (hormone) level. These include estrogen-only hormone replacement therapy and certain hormone therapies for breast cancer (tamoxifen). Conditions affecting ovulation (polycystic ovarian syndrome, diabetes and obesity) may increase a woman’s risk. Other risk factors include beginning your period before age 12, late menopause, never having been pregnant, and a personal history of breast or ovarian cancer. Lynch syndrome, a genetic condition, also increases a woman’s risk.

Diagnosis may include a pelvic exam, a transvaginal ultrasound (uses sound waves to picture the uterus), an exam using a hysteroscope (thin tube to see inside the uterus), and a uterine biopsy (testing a small piece of tissue). To confirm the diagnosis and stage of cancer, a D&C (special procedure in which cells are scraped from the uterine wall) may be performed.

Treatments may include surgery, hormonal therapy, chemotherapy, and radiation therapy. Prevention includes birth control pills containing both progesterone and estrogen, exercise, maintaining a healthy weight and stopping smoking. If you have been diagnosed with endometrial cancer, talk to your doctor about the most current treatment options. Support groups are good sources of information and can connect you living with endometrial cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Endometrial cancer" returned 1415 free, full-text research articles on human participants. First 3 results:

Measuring the biological effect of presurgical metformin treatment in endometrial cancer.
 

Author(s): V N Sivalingam, S Kitson, R McVey, C Roberts, P Pemberton, K Gilmour, S Ali, A G Renehan, H C Kitchener, E J Crosbie

Journal: Br. J. Cancer. 2016 Feb;114(3):281-9.

 

Preclinical studies in endometrial cancer (EC) show that metformin reduces cellular proliferation by PI3K-AKT-mTOR inhibition. We tested the hypothesis that short-term presurgical metformin reduces cellular proliferation in atypical endometrial hyperplasia (AEH) and endometrioid EC, ...

Last Updated: 3 Feb 2016

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Hypoxia-inducible factor-1α, adrenomedullin and Bcl-2 although expected are not related to increased uptake of fluorine-18-fluorodeoxyglucose in endometrial cancer.
 

Author(s): Sevim Sureyya Cerci, Yakup Yalcin, Kemal Kursat Bozkurt, Ebru Erdemoglu, Burak Tatar, Evrim Erdemoglu

Journal: Hell J Nucl Med. ;18(3):228-32.

 

To study the relation between SUVmax, hypoxia inducible factor 1α (HIF-1α), angiogenetic factor adrenomedullin (AM) and antiapoptotic factor Bcl-2 in endometrial cancer.

Last Updated: 5 Dec 2015

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Body Mass Index Genetic Risk Score and Endometrial Cancer Risk.
 

Author(s): Jennifer Prescott, Veronica W Setiawan, Nicolas Wentzensen, Fredrick Schumacher, Herbert Yu, Ryan Delahanty, Leslie Bernstein, Stephen J Chanock, Chu Chen, Linda S Cook, Christine Friedenreich, Monserrat Garcia-Closas, Christopher A Haiman, Loic Le Marchand, Xiaolin Liang, Jolanta Lissowska, Lingeng Lu, Anthony M Magliocco, Sara H Olson, Harvey A Risch, Xiao-Ou Shu, Giske Ursin, Hannah P Yang, Peter Kraft, Immaculata De Vivo

Journal:

 

Genome-wide association studies (GWAS) have identified common variants that predispose individuals to a higher body mass index (BMI), an independent risk factor for endometrial cancer. Composite genotype risk scores (GRS) based on the joint effect of published BMI risk loci were used ...

Last Updated: 26 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Endometrial cancer" returned 139 free, full-text review articles on human participants. First 3 results:

Soy Intake Is Associated With Lower Endometrial Cancer Risk: A Systematic Review and Meta-Analysis of Observational Studies.
 

Author(s): Guo-Qiang Zhang, Jin-Liang Chen, Qin Liu, Yong Zhang, Huan Zeng, Yong Zhao

Journal: Medicine (Baltimore). 2015 Dec;94(50):e2281.

 

Epidemiologic studies reporting the effect of soy intake on endometrial cancer risk conveyed conflicting results. We systematically reviewed the literature to investigate whether there was an inverse relation between dietary soy intake and endometrial cancer risk. PubMed, EMBASE, ...

Last Updated: 19 Dec 2015

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Synchronous double primary gastric and endometrial cancer: a case report and literature review.
 

Author(s): Mingxu Da, Lingzhi Peng, Yongbin Zhang, Jibin Yao, Yaoxing Duan, Yanghui Wen

Journal:

 

Multiple primary malignant neoplasms (MPMN) are two or more malignancies in an individual without any relationship between the tumors. In recent years, increasing number of cases were reported. However, Synchronous double primary gastric and endometrial cancer are relatively rare ...

Last Updated: 4 Sep 2015

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Improving survival after endometrial cancer: the big picture.
 

Author(s): Janice S Kwon

Journal: J Gynecol Oncol. 2015 Jul;26(3):227-31.

 

To improve survival in women with endometrial cancer, we need to look at the "big picture" beyond initial treatment. Although the majority of women will be diagnosed with early stage disease and are cured with surgery alone, there is a subgroup of women with advanced and high-risk ...

Last Updated: 22 Jul 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of LY3023414 for the Treatment of Recurrent or Persistent Endometrial Cancer
 

Status: Recruiting

Condition Summary: Endometrial Cancer; Recurrent Endometrial Cancer

 

Last Updated: 10 Mar 2016

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Enzalutamide in Combination With Carboplatin and Paclitaxel in Endometrial Cancer
 

Status: Not yet recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 2 Jun 2016

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Endometrial Cancer Testing With Vaginal and Endometrial Cell Samples
 

Status: Recruiting

Condition Summary: Endometrial Cancer; Gynecological Cancers

 

Last Updated: 5 Nov 2015

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