Endometrial cancer

Common Name(s)

Endometrial cancer

Endometrial cancer is a type of cancer that begins in cells of the endometrium or lining of the uterus in women. Endometrial cancer is the 6th most common cancer in women worldwide, but is more common in high income countries. Risk increases with age, with most diagnosed after menopause.

Symptoms of endometrial cancer include abnormal vaginal bleeding or discharge, pelvic pain, and weight-loss. In general, symptoms occur in early stages of the cancer so it is usually diagnosed early. The overall 5 year survival rate is relatively high and is increasing due to medical research.

Most risk factors for endometrial cancer affect a woman’s estrogen (hormone) level. These include estrogen-only hormone replacement therapy and certain hormone therapies for breast cancer (tamoxifen). Conditions affecting ovulation (polycystic ovarian syndrome, diabetes and obesity) may increase a woman’s risk. Other risk factors include beginning your period before age 12, late menopause, never having been pregnant, and a personal history of breast or ovarian cancer. Lynch syndrome, a genetic condition, also increases a woman’s risk.

Diagnosis may include a pelvic exam, a transvaginal ultrasound (uses sound waves to picture the uterus), an exam using a hysteroscope (thin tube to see inside the uterus), and a uterine biopsy (testing a small piece of tissue). To confirm the diagnosis and stage of cancer, a D&C (special procedure in which cells are scraped from the uterine wall) may be performed.

Treatments may include surgery, hormonal therapy, chemotherapy, and radiation therapy. Prevention includes birth control pills containing both progesterone and estrogen, exercise, maintaining a healthy weight and stopping smoking. If you have been diagnosed with endometrial cancer, talk to your doctor about the most current treatment options. Support groups are good sources of information and can connect you living with endometrial cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Endometrial cancer" returned 1086 free, full-text research articles on human participants. First 3 results:

[Historical overview and the current practice of intracavitary treatment of cervical and endometrial cancer in the Oncoradiology Center of Budapest].
 

Author(s): Dániel Sinkó, Csaba Nemeskéri, Ágnes Pallinger, Csaba Weisz, Attila Naszály, László Landherr

Journal: Magy Onkol. 2015 Jun;59(2):140-7.

 

The aims of our study were to describe the history and development of intracavitary brachytherapy in the treatment of gynecological tumors, to introduce our current practice for intracavitary brachytherapy treatments based on CT planning. Gynecological intracavitary brachytherapy ...

Last Updated: 3 Jun 2015

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Tea and coffee and risk of endometrial cancer: cohort study and meta-analysis.
 

Author(s): TienYu Owen Yang, Francesca Crowe, Benjamin J Cairns, Gillian K Reeves, Valerie Beral

Journal: Am. J. Clin. Nutr.. 2015 Mar;101(3):570-8.

 

Previous reports, mostly from retrospective studies, suggested possible protective effects of both tea and coffee against endometrial cancer, but recent reports from prospective studies generally showed weaker or null associations.

Last Updated: 3 Mar 2015

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HER2 over-expressing high grade endometrial cancer expresses high levels of p95HER2 variant.
 

Author(s): Whitfield B Growdon, Jolijn Groeneweg, Virginia Byron, Celeste DiGloria, Darrell R Borger, Rosemary Tambouret, Rosemary Foster, Ahmed Chenna, Jeff Sperinde, John Winslow, Bo R Rueda

Journal: Gynecol. Oncol.. 2015 Apr;137(1):160-6.

 

Subsets of high grade endometrial cancer (EnCa) over-express HER2 (ERBB2), yet clinical trials have failed to demonstrate any anti-tumor activity utilizing trastuzumab, an approved platform for HER2 positive breast cancer (BrCa). A truncated p95HER2 variant lacking the trastuzumab ...

Last Updated: 30 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Endometrial cancer" returned 108 free, full-text review articles on human participants. First 3 results:

Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case report with an immunohistochemical study.
 

Author(s): Andrzej Semczuk, Eva Colas, Beata Walczyna, Maciej Joźwik, Andrzej Pyra, Anna Semczuk-Sikora, Tomasz Rechberger

Journal:

 

Coexistence of two or even more independent primary tumors derived from the female genital tract organs is a unique event. The most common combination is the coexistence of synchronous tumors in the ovary and endometrium. In the present case study, we described a coincidence of homologous-type ...

Last Updated: 17 Nov 2014

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Polycystic ovary syndrome and risk of endometrial cancer: a mini-review.
 

Author(s): Aytekin Tokmak, Mahmut Kuntay Kokanali, Ali Irfan Guzel, Aydan Kara, Hasan Onur Topcu, Sabri Cavkaytar

Journal: Asian Pac. J. Cancer Prev.. 2014 ;15(17):7011-4.

 

The polycystic ovary syndrome is the most common endocrinological disorder of reproductive age women with a prevalence of 5 to 8 %. The most common diagnostic criteria used for polycystic ovary syndrome are oligo- or an-ovulation, clinical and/ or biochemical signs of hyperandrogenism ...

Last Updated: 17 Sep 2014

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The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer.
 

Author(s): Peixin Dong, Yosuke Konno, Hidemichi Watari, Masayoshi Hosaka, Masayuki Noguchi, Noriaki Sakuragi

Journal:

 

Activation of the PI3K/AKT pathway, a common mechanism in all subtypes of endometrial cancers (endometrioid and non-endometrioid tumors), has important roles in contributing to epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) features. MicroRNAs (miRNAs) are small ...

Last Updated: 28 Aug 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Endometrial Cancer Testing With Vaginal and Endometrial Cell Samples
 

Status: Recruiting

Condition Summary: Endometrial Cancer; Gynecological Cancers

 

Last Updated: 7 Nov 2014

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Follow-up of Endometrial Cancer Patients
 

Status: Recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 28 Nov 2014

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Investigating the Use of Fluorescence Imaging in Endometrial Cancer Surgery
 

Status: Recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 4 Jun 2015

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