Endometrial cancer

Common Name(s)

Endometrial cancer

Endometrial cancer is a type of cancer that begins in cells of the endometrium or lining of the uterus in women. Endometrial cancer is the 6th most common cancer in women worldwide, but is more common in high income countries. Risk increases with age, with most diagnosed after menopause.

Symptoms of endometrial cancer include abnormal vaginal bleeding or discharge, pelvic pain, and weight-loss. In general, symptoms occur in early stages of the cancer so it is usually diagnosed early. The overall 5 year survival rate is relatively high and is increasing due to medical research.

Most risk factors for endometrial cancer affect a woman’s estrogen (hormone) level. These include estrogen-only hormone replacement therapy and certain hormone therapies for breast cancer (tamoxifen). Conditions affecting ovulation (polycystic ovarian syndrome, diabetes and obesity) may increase a woman’s risk. Other risk factors include beginning your period before age 12, late menopause, never having been pregnant, and a personal history of breast or ovarian cancer. Lynch syndrome, a genetic condition, also increases a woman’s risk.

Diagnosis may include a pelvic exam, a transvaginal ultrasound (uses sound waves to picture the uterus), an exam using a hysteroscope (thin tube to see inside the uterus), and a uterine biopsy (testing a small piece of tissue). To confirm the diagnosis and stage of cancer, a D&C (special procedure in which cells are scraped from the uterine wall) may be performed.

Treatments may include surgery, hormonal therapy, chemotherapy, and radiation therapy. Prevention includes birth control pills containing both progesterone and estrogen, exercise, maintaining a healthy weight and stopping smoking. If you have been diagnosed with endometrial cancer, talk to your doctor about the most current treatment options. Support groups are good sources of information and can connect you living with endometrial cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Endometrial cancer" returned 1485 free, full-text research articles on human participants. First 3 results:

Intraperitoneal Fat through GRP78: A Risk Factor for Endometrial Cancer.
 

Author(s): Răzvan Ciortea, Costin Berceanu, Andrei Mihai Măluţan, Radu Mocan, Cristian Iuhas, Carmen Elena Bucuri, Maria Patricia Rada, Dan Mihu

Journal: Anal Cell Pathol (Amst). 2016 ;2016():3496538.

 

Introduction. The identification of biological markers that indicate an increased risk for the development or recurrence of endometrial cancer (EC) in obese women might be useful for decreasing EC mortality and morbidity. Glucose-regulated protein 78 (GRP78) is a major protein of ...

Last Updated: 8 Nov 2016

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Outcomes of Patients With Surgically and Pathologically Staged IIIA-IVB Pure Endometrioid-type Endometrial Cancer: A Taiwanese Gynecology Oncology Group (TGOG-2005) Retrospective Cohort Study (A STROBE-Compliant Article).
 

Author(s): Jen-Ruei Chen, Ting-Chang Chang, Hung-Chun Fu, Hei-Yu Lau, I-Hui Chen, Yu-Min Ke, Yu-Ling Liang, An-Jen Chiang, Chia-Yen Huang, Yu-Chieh Chen, Mun-Kun Hong, Yu-Chi Wang, Kuo-Feng Huang, Sheng-Mou Hsiao, Peng-Hui Wang

Journal: Medicine (Baltimore). 2016 Apr;95(15):e3330.

 

In the management of patients with advanced-stage pure endometrioid-type endometrial cancer (E-EC), such as positive lymph nodes (stage III) or stage IV, treatment options are severely limited. This article aims to investigate the outcome of women with FIGO III-IV E-EC (based on FIGO ...

Last Updated: 16 Apr 2016

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Treatment of Early Stage Endometrial Cancer by Transumbilical Laparoendoscopic Single-Site Surgery Versus Traditional Laparoscopic Surgery: A Comparison Study.
 

Author(s): Hui-Hua Cai, Mu-Biao Liu, Yuan-Li He

Journal: Medicine (Baltimore). 2016 Apr;95(14):e3211.

 

To compare the outcomes of transumbilical laparoendoscopic single-site surgery (TU-LESS) versus traditional laparoscopic surgery (TLS) for early stage endometrial cancer (EC).We retrospectively reviewed the medical records of patients with early stage EC who were surgically treated ...

Last Updated: 9 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Endometrial cancer" returned 161 free, full-text review articles on human participants. First 3 results:

Treatment of Older Women With Endometrial Cancer: Improving Outcomes With Personalized Care.
 

Author(s): Linda Duska, Armin Shahrokni, Melanie Powell

Journal: Am Soc Clin Oncol Educ Book. 2016 ;35():164-74.

 

Endometrial cancer is the most common gynecologic cancer, and with a median age of 62 at diagnosis, it affects a significant number of older women. With increasing age and obesity rates in the world's population, there is an anticipated concomitant increase in older women with endometrial ...

Last Updated: 2 Jun 2016

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What Is the Best Preoperative Imaging for Endometrial Cancer?
 

Author(s): Ingfrid S Haldorsen, Helga B Salvesen

Journal: Curr Oncol Rep. 2016 Apr;18(4):25.

 

Although endometrial cancer is surgicopathologically staged, preoperative imaging is recommended for diagnostic work-up to tailor surgery and adjuvant treatment. For preoperative staging, imaging by transvaginal ultrasound (TVU) and/or magnetic resonance imaging (MRI) is valuable ...

Last Updated: 29 Feb 2016

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Obesity-related endometrial cancer: an update on survivorship approaches to reducing cardiovascular death.
 

Author(s): R A Laskey, M L McCarroll, V E von Gruenigen

Journal: BJOG. 2016 Jan;123(2):293-8.

 

As the rate of obesity increases worldwide, so will the number of women diagnosed with obesity-related malignancy. The strongest correlation between obesity and cancer is endometrial cancer (EC). Obesity is the most significant modifiable risk factor for development of EC and also ...

Last Updated: 4 Feb 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Follow-up of Endometrial Cancer Patients
 

Status: Recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 13 Oct 2015

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Linking Obesity and Estrogen-responsive Genes in Endometrial Cancer
 

Status: Recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 20 Apr 2015

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Lymph Node Mapping in Patients With Endometrial Cancer
 

Status: Recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 21 Oct 2016

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