Endometrial cancer

Common Name(s)

Endometrial cancer

Endometrial cancer is a type of cancer that begins in cells of the endometrium or lining of the uterus in women. Endometrial cancer is the 6th most common cancer in women worldwide, but is more common in high income countries. Risk increases with age, with most diagnosed after menopause.

Symptoms of endometrial cancer include abnormal vaginal bleeding or discharge, pelvic pain, and weight-loss. In general, symptoms occur in early stages of the cancer so it is usually diagnosed early. The overall 5 year survival rate is relatively high and is increasing due to medical research.

Most risk factors for endometrial cancer affect a woman’s estrogen (hormone) level. These include estrogen-only hormone replacement therapy and certain hormone therapies for breast cancer (tamoxifen). Conditions affecting ovulation (polycystic ovarian syndrome, diabetes and obesity) may increase a woman’s risk. Other risk factors include beginning your period before age 12, late menopause, never having been pregnant, and a personal history of breast or ovarian cancer. Lynch syndrome, a genetic condition, also increases a woman’s risk.

Diagnosis may include a pelvic exam, a transvaginal ultrasound (uses sound waves to picture the uterus), an exam using a hysteroscope (thin tube to see inside the uterus), and a uterine biopsy (testing a small piece of tissue). To confirm the diagnosis and stage of cancer, a D&C (special procedure in which cells are scraped from the uterine wall) may be performed.

Treatments may include surgery, hormonal therapy, chemotherapy, and radiation therapy. Prevention includes birth control pills containing both progesterone and estrogen, exercise, maintaining a healthy weight and stopping smoking. If you have been diagnosed with endometrial cancer, talk to your doctor about the most current treatment options. Support groups are good sources of information and can connect you living with endometrial cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Endometrial cancer" returned 1627 free, full-text research articles on human participants. First 3 results:

Survival benefits of pelvic lymphadenectomy versus pelvic and para-aortic lymphadenectomy in patients with endometrial cancer: A meta-analysis.
 

Author(s): Weina Guo, Jing Cai, Min Li, Hongbo Wang, Yi Shen

Journal: Medicine (Baltimore). 2018 Jan;97(1):e9520.

 

Despite that pelvic and para-aortic lymphadenectomy (PPaLND) is recommended as part of accurate surgical staging by International Federation of Gynecology and Obstetrics (FIGO) in endometrial cancer, the impact of para-aortic lymphadenectomy on survival remains controversial. The ...

Last Updated: 31 Dec 1969

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Antitumor effects of metformin via indirect inhibition of protein phosphatase 2A in patients with endometrial cancer.
 

Author(s): Shinsuke Hanawa, Akira Mitsuhashi, Makio Shozu

Journal:

 

Metformin, an antidiabetic drug, inhibits the endometrial cancer cell growth in vivo by improving the insulin resistance; however, its mechanism of action is not completely understood. Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase associated with insulin resistance ...

Last Updated: 31 Dec 1969

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Tissue microarray is suitable for scientific biomarkers studies in endometrial cancer.
 

Author(s): Nicole C M Visser, Anneke A M van der Wurff, Johanna M A Pijnenborg, Leon F A G Massuger, Johan Bulten, Iris D Nagtegaal

Journal: Virchows Arch.. 2018 Mar;472(3):407-413.

 

The aim of this study was to define the concordance between tissue microarrays (TMAs) of different sizes and whole slide for 15 different antibodies in endometrial cancer and study the use of TMAs in preoperative endometrial samples. Cores of preoperative and hysterectomy specimens ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Endometrial cancer" returned 181 free, full-text review articles on human participants. First 3 results:

Hormone therapy as a management strategy for lung metastasis after 5 years of endometrial cancer: A case report and literature review.
 

Author(s): Huifang Zhao, Yushuang Yao, Hongjuan Yang, Dehua Ma, Aiping Chen

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9223.

 

Endometrial cancer patients with lung metastases are rare, and more rarely with long-term management of progesterone after recurrence.

Last Updated: 31 Dec 1969

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Transvaginal ultrasound versus magnetic resonance imaging for preoperative assessment of myometrial infiltration in patients with endometrial cancer: a systematic review and meta-analysis.
 

Author(s): Juan Luis Alcázar, Begoña Gastón, Beatriz Navarro, Rocío Salas, Juana Aranda, Stefano Guerriero

Journal: J Gynecol Oncol. 2017 Nov;28(6):e86.

 

To compare the diagnostic accuracy of transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI) for detecting myometrial infiltration (MI) in endometrial carcinoma.

Last Updated: 31 Dec 1969

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Comparison of fertility-sparing treatments in patients with early endometrial cancer and atypical complex hyperplasia: A meta-analysis and systematic review.
 

Author(s): Jing Wei, Weiyuan Zhang, Limin Feng, Wanli Gao

Journal: Medicine (Baltimore). 2017 Sep;96(37):e8034.

 

There are some fertility-sparing treatments in patients with early endometrial cancer (EEC) or atypical complex hyperplasia (ACH), and the objective is to compare them by evaluating the oncologic and reproductive outcomes.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Linking Obesity and Estrogen-responsive Genes in Endometrial Cancer
 

Status: Recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 3 Apr 2018

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Study of Avelumab in Patients With MSS, MSI-H and POLE-mutated Recurrent or Persistent Endometrial Cancer
 

Status: Recruiting

Condition Summary: Metastatic Endometrial Cancer

 

Last Updated: 5 Jun 2017

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Sentinel Lymph Node Dissection (SLND) in Patients With Apparent Early Stage Endometrial Cancer
 

Status: Recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 5 Dec 2017

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