Endometrial cancer

Common Name(s)

Endometrial cancer

Endometrial cancer is a type of cancer that begins in cells of the endometrium or lining of the uterus in women. Endometrial cancer is the 6th most common cancer in women worldwide, but is more common in high income countries. Risk increases with age, with most diagnosed after menopause.

Symptoms of endometrial cancer include abnormal vaginal bleeding or discharge, pelvic pain, and weight-loss. In general, symptoms occur in early stages of the cancer so it is usually diagnosed early. The overall 5 year survival rate is relatively high and is increasing due to medical research.

Most risk factors for endometrial cancer affect a woman’s estrogen (hormone) level. These include estrogen-only hormone replacement therapy and certain hormone therapies for breast cancer (tamoxifen). Conditions affecting ovulation (polycystic ovarian syndrome, diabetes and obesity) may increase a woman’s risk. Other risk factors include beginning your period before age 12, late menopause, never having been pregnant, and a personal history of breast or ovarian cancer. Lynch syndrome, a genetic condition, also increases a woman’s risk.

Diagnosis may include a pelvic exam, a transvaginal ultrasound (uses sound waves to picture the uterus), an exam using a hysteroscope (thin tube to see inside the uterus), and a uterine biopsy (testing a small piece of tissue). To confirm the diagnosis and stage of cancer, a D&C (special procedure in which cells are scraped from the uterine wall) may be performed.

Treatments may include surgery, hormonal therapy, chemotherapy, and radiation therapy. Prevention includes birth control pills containing both progesterone and estrogen, exercise, maintaining a healthy weight and stopping smoking. If you have been diagnosed with endometrial cancer, talk to your doctor about the most current treatment options. Support groups are good sources of information and can connect you living with endometrial cancer.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endometrial cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Endometrial cancer" returned 1343 free, full-text research articles on human participants. First 3 results:

Risk of Endometrial Cancer in Women With Pelvic Inflammatory Disease: A Nationwide Population-Based Retrospective Cohort Study.
 

Author(s): Teng-Kai Yang, Chi-Jung Chung, Shiu-Dong Chung, Chih-Hsin Muo, Chao-Hsiang Chang, Chao-Yuan Huang

Journal: Medicine (Baltimore). 2015 Aug;94(34):e1278.

 

To investigate the association between pelvic inflammatory disease (PID) and endometrial cancer (EC).We conducted a nationwide population-based retrospective cohort study, and data were obtained from the National Health Insurance Research Database. We defined 41,065 patients with ...

Last Updated: 28 Aug 2015

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Laparoscopy Versus Laparotomy in the Treatment of High-Risk Endometrial Cancer: A Propensity Score Matching Analysis.
 

Author(s): Huiqiao Gao, Zhenyu Zhang

Journal: Medicine (Baltimore). 2015 Jul;94(30):e1245.

 

The aim of this study was to compare the long-term safety and efficacy of laparoscopic surgery and laparotomy for high-risk endometrial cancer (EC).A retrospective analysis based on our decade of clinical data of patients with high-risk EC who were comprehensively surgically staged ...

Last Updated: 30 Jul 2015

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Female Hormonal Factors and the Risk of Endometrial Cancer in Lynch Syndrome.
 

Author(s): Seyedeh Ghazaleh Dashti, Rowena Chau, Driss Ait Ouakrim, Daniel D Buchanan, Mark Clendenning, Joanne P Young, Ingrid M Winship, Julie Arnold, Dennis J Ahnen, Robert W Haile, Graham Casey, Steven Gallinger, Stephen N Thibodeau, Noralane M Lindor, Loïc Le Marchand, Polly A Newcomb, John D Potter, John A Baron, John L Hopper, Mark A Jenkins, Aung Ko Win

Journal: JAMA. 2015 Jul;314(1):61-71.

 

Apart from hysterectomy, there is no consensus recommendation for reducing endometrial cancer risk for women with a mismatch repair gene mutation (Lynch syndrome).

Last Updated: 8 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Endometrial cancer" returned 130 free, full-text review articles on human participants. First 3 results:

Obesity, diet, physical activity, and health-related quality of life in endometrial cancer survivors.
 

Author(s): Dimitrios A Koutoukidis, M Tish Knobf, Anne Lanceley

Journal: Nutr. Rev.. 2015 Jun;73(6):399-408.

 

Obesity, low-quality diet, and inactivity are all prevalent among survivors of endometrial cancer. The present review was conducted to assess whether these characteristics are associated with health-related quality of life (HRQoL). Electronic databases, conference abstracts, and reference ...

Last Updated: 27 May 2015

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The mutational landscape of endometrial cancer.
 

Author(s): Bo Hong, Matthieu Le Gallo, Daphne W Bell

Journal: Curr. Opin. Genet. Dev.. 2015 Feb;30():25-31.

 

Globally, endometrial carcinoma causes about 74000 deaths annually. Endometrial carcinomas can be classified into several histological subtypes including endometrioid and serous histologies. Over the course of the past two years, a number of studies have decoded the exomes of endometrioid ...

Last Updated: 22 Jun 2015

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Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case report with an immunohistochemical study.
 

Author(s): Andrzej Semczuk, Eva Colas, Beata Walczyna, Maciej Joźwik, Andrzej Pyra, Anna Semczuk-Sikora, Tomasz Rechberger

Journal:

 

Coexistence of two or even more independent primary tumors derived from the female genital tract organs is a unique event. The most common combination is the coexistence of synchronous tumors in the ovary and endometrium. In the present case study, we described a coincidence of homologous-type ...

Last Updated: 17 Nov 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Endometrial Cancer Testing With Vaginal and Endometrial Cell Samples
 

Status: Recruiting

Condition Summary: Endometrial Cancer; Gynecological Cancers

 

Last Updated: 5 Nov 2015

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Follow-up of Endometrial Cancer Patients
 

Status: Recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 13 Oct 2015

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Linking Obesity and Estrogen-responsive Genes in Endometrial Cancer
 

Status: Recruiting

Condition Summary: Endometrial Cancer

 

Last Updated: 20 Apr 2015

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