Diabetes mellitus type 1

Common Name(s)

Diabetes mellitus type 1

Diabetes mellitus type 1 (DM1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. Lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. DM1 can occur at any age, but usually develops by early adulthood, most often in adolescence. Symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. The exact cause of DM1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. A predisposition to develop DM1 runs in families, but no known inheritance pattern exists. Treatment includes blood sugar control and insulin replacement therapy. Improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. If not treated, the condition can be life-threatening. Over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes mellitus type 1" for support, advocacy or research.

Logo
Diabetes Hands Foundation

We work to connect, engage, and empower people touched by diabetes while keeping in mind a vision of a world where people with diabetes and their loved ones do not feel alone, understand and manage a life with diabetes and work together towards a better future.

Last Updated: 6 Mar 2013

View Details
Logo
Taking Control of Your Diabetes

Guided by the belief that every person with diabetes has the right to live a healthy, happy, and productive life, Taking Control of Your Diabetes educates and motivates people with diabetes to take a more active role in their condition and provides innovative and integrative continuing diabetes education to medical professionals caring for people with diabetes.

Last Updated: 28 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes mellitus type 1" for support, advocacy or research.

Logo
Diabetes Hands Foundation

We work to connect, engage, and empower people touched by diabetes while keeping in mind a vision of a world where people with diabetes and their loved ones do not feel alone, understand and manage a life with diabetes and work together towards a better future.

http://www.diabeteshandsfoundation.org

Last Updated: 6 Mar 2013

View Details
Logo
Taking Control of Your Diabetes

Guided by the belief that every person with diabetes has the right to live a healthy, happy, and productive life, Taking Control of Your Diabetes educates and motivates people with diabetes to take a more active role in their condition and provides innovative and integrative continuing diabetes education to medical professionals caring for people with diabetes.

http://www.tcoyd.org

Last Updated: 28 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diabetes mellitus type 1" returned 574 free, full-text research articles on human participants. First 3 results:

[Screening for autoimmune polyglandular syndrome in a cohort of patients with type 1 diabetes mellitus].
 

Author(s): Sofia Gouveia, Leonor Gomes, Cristina Ribeiro, Francisco Carrilho

Journal: Arq Bras Endocrinol Metabol. 2013 Dec;57(9):733-8.

 

To characterize a cohort of patients with type 1 diabetes mellitus (T1DM) on the presence of other autoimmune disorders that could establish the diagnosis of autoimmune polyglandular syndrome (APS).

Last Updated: 9 Jan 2014

Go To URL

Last Updated: 10 Mar 2014

Go To URL
[Epilepsy as the first presentation in a child with type 1 diabetes mellitus].
 

Author(s): Jin Li, Zhe Tao, Ren-Zhe An

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2013 Dec;15(12):1148-9.

 

Last Updated: 17 Dec 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diabetes mellitus type 1" returned 83 free, full-text review articles on human participants. First 3 results:

The role of interferon induced with helicase C domain 1 (IFIH1) in the development of type 1 diabetes mellitus.
 

Author(s): Ana Paula Bouças, Fernanda dos Santos de Oliveira, Luis Henrique Canani, Daisy Crispim

Journal: Arq Bras Endocrinol Metabol. 2013 Dec;57(9):667-76.

 

Type 1 diabetes mellitus (T1DM) is a chronic, progressive, autoimmune disease characterized by metabolic decompensation frequently leading to dehydration and ketoacidosis. Viral pathogens seem to play a major role in triggering the autoimmune destruction that leads to the development ...

Last Updated: 9 Jan 2014

Go To URL
Simultaneous occurrence of type 1 diabetes mellitus and Graves' disease: a report of two cases and a review of the literature.
 

Author(s): Tetsuya Mizokami, Ayumi Yamauchi, Yuichi Sato, Masae Toyonaga, Hirofumi Imoto, Hiroto Kojima, Hiroh Saji, Kiyohide Nunoi

Journal: Intern. Med.. 2013 ;52(22):2537-43.

 

Two unrelated Japanese women, 41 and 27 years of age, were admitted with histories of thirst, weight loss and palpitations of a few weeks' duration. Both were diagnosed to have diabetic ketosis or ketoacidosis with acute-onset type 1 diabetes (T1D) and Graves' disease (GD) (autoimmune ...

Last Updated: 18 Nov 2013

Go To URL
Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: systematic review and meta-analyses of clinical studies.
 

Author(s): S Calanna, M Christensen, J J Holst, B Laferrère, L L Gluud, T Vilsbøll, F K Knop

Journal: Diabetologia. 2013 May;56(5):965-72.

 

We carried out a systematic review of clinical studies investigating glucagon-like peptide-1 (GLP-1) secretion in patients with type 2 diabetes and non-diabetic controls and performed meta-analyses of plasma total GLP-1 concentrations during an OGTT and/or meal test.

Last Updated: 11 Apr 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation of Vildagliptin (Galvus®) as add-on to Insulin in New-onset Type 1 Diabetes Mellitus
 

Status: Recruiting

Condition Summary: Type 1 Diabetes; Insulin Dependent Diabetes; Juvenile Onset Diabetes Mellitus; Autoimmune Diabetes

 

Last Updated: 13 May 2014

Go to URL
Imatinib Treatment in Recent Onset Type 1 Diabetes Mellitus
 

Status: Recruiting

Condition Summary: Diabetes Mellitus, Type I; Diabetes Mellitus, Insulin-Dependent, 1; Type 1 Diabetes Mellitus; Insulin-Dependent Diabetes Mellitus 1; IDDM

 

Last Updated: 14 Jul 2014

Go to URL

Last Updated: 29 Apr 2014

Go to URL