Diabetes mellitus type 1

Common Name(s)

Diabetes mellitus type 1

Diabetes mellitus type 1 (DM1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. Lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. DM1 can occur at any age, but usually develops by early adulthood, most often in adolescence. Symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. The exact cause of DM1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. A predisposition to develop DM1 runs in families, but no known inheritance pattern exists. Treatment includes blood sugar control and insulin replacement therapy. Improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. If not treated, the condition can be life-threatening. Over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes mellitus type 1" for support, advocacy or research.

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Diabetes Hands Foundation

We work to connect, engage, and empower people touched by diabetes while keeping in mind a vision of a world where people with diabetes and their loved ones do not feel alone, understand and manage a life with diabetes and work together towards a better future.

Last Updated: 6 Mar 2013

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Taking Control of Your Diabetes

Guided by the belief that every person with diabetes has the right to live a healthy, happy, and productive life, Taking Control of Your Diabetes educates and motivates people with diabetes to take a more active role in their condition and provides innovative and integrative continuing diabetes education to medical professionals caring for people with diabetes.

Last Updated: 28 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes mellitus type 1" for support, advocacy or research.

Logo
Diabetes Hands Foundation

We work to connect, engage, and empower people touched by diabetes while keeping in mind a vision of a world where people with diabetes and their loved ones do not feel alone, understand and manage a life with diabetes and work together towards a better future.

http://www.diabeteshandsfoundation.org

Last Updated: 6 Mar 2013

View Details
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Taking Control of Your Diabetes

Guided by the belief that every person with diabetes has the right to live a healthy, happy, and productive life, Taking Control of Your Diabetes educates and motivates people with diabetes to take a more active role in their condition and provides innovative and integrative continuing diabetes education to medical professionals caring for people with diabetes.

http://www.tcoyd.org

Last Updated: 28 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diabetes mellitus type 1" returned 783 free, full-text research articles on human participants. First 3 results:

High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1.
 

Author(s): Beata Kowalewska, Katarzyna Zorena, Małgorzata Szmigiero-Kawko, Piotr Wąż, Małgorzata Myśliwiec

Journal: Dis. Markers. 2016 ;2016():4685976.

 

The objective of the research was to investigate serum levels of interleukin-12 (IL12) in relation to percentage of yeast-like fungi colonies residing in the gastrointestinal tract in children and adolescents with type 1 diabetes mellitus (T1DM). The study involved 83 children and ...

Last Updated: 27 Jan 2017

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PECAM-1 Leu125Val (rs688) Polymorphism and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus.
 

Author(s): Matej Završnik, Stojan Kariž, Jana Makuc, Maja Šeruga, Ines Cilenšek, Daniel Petrovič

Journal: Anal Cell Pathol (Amst). 2016 ;2016():3152967.

 

Objectives. Platelet endothelial cell adhesion molecule-1 (PECAM-1) plays a key role in the transendothelial migration of circulating leukocytes during inflammation and in the maintenance of vascular endothelial integrity. We hypothesized that genetic variation in PECAM-1 gene could ...

Last Updated: 24 Jan 2017

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ACE Gene I/D Polymorphism and Obesity in 1,574 Patients with Type 2 Diabetes Mellitus.
 

Author(s): Yan-Hong Pan, Min Wang, Yan-Mei Huang, Ying-Hui Wang, Yin-Ling Chen, Li-Jun Geng, Xiao-Xi Zhang, Hai-Lu Zhao

Journal: Dis. Markers. 2016 ;2016():7420540.

 

Association between ACE gene I/D polymorphism and the risk of overweight/obesity remains controversial. We investigated the possible relationship between ACE gene I/D polymorphism and obesity in Chinese type 2 diabetes mellitus (T2DM) patients. In this study, obesity was defined as ...

Last Updated: 24 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diabetes mellitus type 1" returned 104 free, full-text review articles on human participants. First 3 results:

Effect of Associated Autoimmune Diseases on Type 1 Diabetes Mellitus Incidence and Metabolic Control in Children and Adolescents.
 

Author(s): Aleksandra Krzewska, Iwona Ben-Skowronek

Journal: Biomed Res Int. 2016 ;2016():6219730.

 

Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases developing in childhood. The incidence of the disease in children increases for unknown reasons at a rate from 3 to 5% every year worldwide. The background of T1DM is associated with the autoimmune process ...

Last Updated: 15 Aug 2016

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Different role of zinc transporter 8 between type 1 diabetes mellitus and type 2 diabetes mellitus.
 

Author(s): Bo Yi, Gan Huang, Zhiguang Zhou

Journal: J Diabetes Investig. 2016 Jul;7(4):459-65.

 

Diabetes can be simply classified into type 1 diabetes mellitus and type 2 diabetes mellitus. Zinc transporter 8 (ZnT8), a novel islet autoantigen, is specifically expressed in insulin-containing secretory granules of β-cells. Genetic studies show that the genotypes of SLC30A8 ...

Last Updated: 4 Jul 2016

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Viral infections in type 1 diabetes mellitus--why the β cells?
 

Author(s): Anne Op de Beeck, Decio L Eizirik

Journal: Nat Rev Endocrinol. 2016 05;12(5):263-73.

 

Type 1 diabetes mellitus (T1DM) is caused by progressive autoimmune-mediated loss of pancreatic β-cell mass via apoptosis. The onset of T1DM depends on environmental factors that interact with predisposing genes to induce an autoimmune assault against β cells. Epidemiological, clinical ...

Last Updated: 14 Apr 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Use of Stem Cells in Diabetes Mellitus Type 1
 

Status: Recruiting

Condition Summary: Diabetes Mellitus Type 1

 

Last Updated: 23 Feb 2017

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A Pilot Study of the Therapeutic Potential of Stem Cell Educator Therapy in Type 1 Diabetes
 

Status: Not yet recruiting

Condition Summary: Diabetes Mellitus Type 1

 

Last Updated: 23 May 2016

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Continuous Glucose Monitoring During Intecorse in Young Adults With Type 1 Diabetes
 

Status: Not yet recruiting

Condition Summary: Diabetes Mellitus Type 1

 

Last Updated: 20 Apr 2016

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