Diabetes mellitus type 1

Common Name(s)

Diabetes mellitus type 1

Diabetes mellitus type 1 (DM1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. Lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. DM1 can occur at any age, but usually develops by early adulthood, most often in adolescence. Symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. The exact cause of DM1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. A predisposition to develop DM1 runs in families, but no known inheritance pattern exists. Treatment includes blood sugar control and insulin replacement therapy. Improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. If not treated, the condition can be life-threatening. Over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes mellitus type 1" for support, advocacy or research.

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Diabetes Hands Foundation

We work to connect, engage, and empower people touched by diabetes while keeping in mind a vision of a world where people with diabetes and their loved ones do not feel alone, understand and manage a life with diabetes and work together towards a better future.

Last Updated: 6 Mar 2013

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Taking Control of Your Diabetes

Guided by the belief that every person with diabetes has the right to live a healthy, happy, and productive life, Taking Control of Your Diabetes educates and motivates people with diabetes to take a more active role in their condition and provides innovative and integrative continuing diabetes education to medical professionals caring for people with diabetes.

Last Updated: 28 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes mellitus type 1" for support, advocacy or research.

Logo
Diabetes Hands Foundation

We work to connect, engage, and empower people touched by diabetes while keeping in mind a vision of a world where people with diabetes and their loved ones do not feel alone, understand and manage a life with diabetes and work together towards a better future.

http://www.diabeteshandsfoundation.org

Last Updated: 6 Mar 2013

View Details
Logo
Taking Control of Your Diabetes

Guided by the belief that every person with diabetes has the right to live a healthy, happy, and productive life, Taking Control of Your Diabetes educates and motivates people with diabetes to take a more active role in their condition and provides innovative and integrative continuing diabetes education to medical professionals caring for people with diabetes.

http://www.tcoyd.org

Last Updated: 28 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diabetes mellitus type 1" returned 695 free, full-text research articles on human participants. First 3 results:

A Cross-Sectional Study Demonstrating Increased Serum Amyloid A Related Inflammation in High-Density Lipoproteins from Subjects with Type 1 Diabetes Mellitus and How this Association Was Augmented by Poor Glycaemic Control.
 

Author(s): Jane McEneny, Jane-Ann Daniels, Anne McGowan, Anjuli Gunness, Kevin Moore, Michael Stevenson, Ian S Young, James Gibney

Journal: J Diabetes Res. 2015 ;2015():351601.

 

Inflammatory atherosclerosis is increased in subjects with type 1 diabetes mellitus (T1DM). Normally high-density lipoproteins (HDL) protect against atherosclerosis; however, in the presence of serum amyloid-A- (SAA-) related inflammation this property may be reduced. Fasting blood ...

Last Updated: 11 Nov 2015

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Differences in emotional distress among inpatients with type 1, obese type 2, and non-obese type 2 diabetes mellitus.
 

Author(s): Yoshiko Miyawaki, Hiromi Iwahashi, Yukiyoshi Okauchi, Yoshiko Sudo, Yuko Fujiwara, Yayoko Omote, Akihisa Imagawa, Iichiro Shimomura

Journal: Intern. Med.. 2015 ;54(20):2561-7.

 

Objective The purpose of this study was to determine the differences in emotional distress among three groups of inpatients with type 1, obese type 2, and non-obese type 2 diabetes during hospitalization. Methods The 42 participating inpatients were divided into three groups: type ...

Last Updated: 15 Oct 2015

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Effect of Sancaijiangtang on plasma nitric oxide and endothelin-1 levels in patients with type 2 diabetes mellitus and vascular dementia: a single-blind randomized controlled trial.
 

Author(s): Guo Qiang, Cao Wenzhai, Zhao Huan, Zhu Yuxia, Yang Dongdong, Zhong Sen, Chen Qiu

Journal: J Tradit Chin Med. 2015 Aug;35(4):375-80.

 

To observe the effect of Sancaijiangtang powders on plasma nitric oxide and endothelin-1 levels. We sought to identify the common pathological link and mechanism of action for Traditional Chinese medicine in type 2 diabetes mellitus and vascular dementia, and to explicate the material ...

Last Updated: 2 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diabetes mellitus type 1" returned 94 free, full-text review articles on human participants. First 3 results:

Type 1 Diabetes Mellitus and Pernicious Anemia in an Elderly Japanese Patient: A Case Report and Literature Review.
 

Author(s): Nobumasa Ohara, Masanori Kaneko, Toshio Yano, Naoko Sato, Hiroyuki Usuda, Masashi Miyakoshi, Tatsuo Furukawa, Tadashi Koike, Kenzo Kaneko, Kyuzi Kamoi

Journal: Intern. Med.. 2015 ;54(18):2361-5.

 

We herein report the case of a 66-year-old Japanese man with acute-onset type 1 diabetes mellitus (T1D) accompanied by pernicious anemia. After 2 weeks of polyuria, the patient developed insulin-deficient hyperglycemia with diabetic ketoacidosis in the absence of verifiable islet-related ...

Last Updated: 15 Sep 2015

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Current and Future Clinical Applications of Zinc Transporter-8 in Type 1 Diabetes Mellitus.
 

Author(s): Bo Yi, Gan Huang, Zhi-Guang Zhou

Journal: Chin. Med. J.. 2015 Sep;128(17):2387-94.

 

To evaluate the utility of zinc transporter-8 (ZnT8) in the improvement of type 1 diabetes mellitus (T1DM) diagnosis and prediction, and to explore whether ZnT8 is a potential therapeutic target in T1DM.

Last Updated: 28 Aug 2015

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Efficacy of inhibition of IL-1 in patients with rheumatoid arthritis and type 2 diabetes mellitus: two case reports and review of the literature.
 

Author(s): Piero Ruscitti, Paola Cipriani, Luca Cantarini, Vasiliki Liakouli, Antonio Vitale, Francesco Carubbi, Onorina Berardicurti, Mauro Galeazzi, Marco Valenti, Roberto Giacomelli

Journal:

 

Rheumatoid arthritis is an autoimmune arthritis in which two inflammatory cytokines, tumor necrosis factor-α and interleukin-1β, play a critical role in the induction and progression of the disease. Several reports and data from registries have discussed the association between ...

Last Updated: 6 Jun 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Effect of Melatonin on Early Signs of Hypertension in Teenagers With Diabetes Mellitus Type 1
 

Status: Not yet recruiting

Condition Summary: Diabetes Mellitus, Type 1; Hypertension

 

Last Updated: 30 Dec 2015

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A Pilot Study of the Therapeutic Potential of Stem Cell Educator Therapy in Type 1 Diabetes
 

Status: Not yet recruiting

Condition Summary: Diabetes Mellitus Type 1

 

Last Updated: 4 Dec 2015

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Evaluation of Vildagliptin (Galvus®) as add-on to Insulin in New-onset Type 1 Diabetes Mellitus
 

Status: Recruiting

Condition Summary: Type 1 Diabetes; Insulin Dependent Diabetes; Juvenile Onset Diabetes Mellitus; Autoimmune Diabetes

 

Last Updated: 13 May 2014

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