Diabetes mellitus type 1

Common Name(s)

Diabetes mellitus type 1

Diabetes mellitus type 1 (DM1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. Lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. DM1 can occur at any age, but usually develops by early adulthood, most often in adolescence. Symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. The exact cause of DM1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. A predisposition to develop DM1 runs in families, but no known inheritance pattern exists. Treatment includes blood sugar control and insulin replacement therapy. Improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. If not treated, the condition can be life-threatening. Over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes mellitus type 1" for support, advocacy or research.

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Diabetes Hands Foundation

We work to connect, engage, and empower people touched by diabetes while keeping in mind a vision of a world where people with diabetes and their loved ones do not feel alone, understand and manage a life with diabetes and work together towards a better future.

Last Updated: 6 Mar 2013

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Taking Control of Your Diabetes

Guided by the belief that every person with diabetes has the right to live a healthy, happy, and productive life, Taking Control of Your Diabetes educates and motivates people with diabetes to take a more active role in their condition and provides innovative and integrative continuing diabetes education to medical professionals caring for people with diabetes.

Last Updated: 28 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes mellitus type 1" for support, advocacy or research.

Logo
Diabetes Hands Foundation

We work to connect, engage, and empower people touched by diabetes while keeping in mind a vision of a world where people with diabetes and their loved ones do not feel alone, understand and manage a life with diabetes and work together towards a better future.

http://www.diabeteshandsfoundation.org

Last Updated: 6 Mar 2013

View Details
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Taking Control of Your Diabetes

Guided by the belief that every person with diabetes has the right to live a healthy, happy, and productive life, Taking Control of Your Diabetes educates and motivates people with diabetes to take a more active role in their condition and provides innovative and integrative continuing diabetes education to medical professionals caring for people with diabetes.

http://www.tcoyd.org

Last Updated: 28 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diabetes mellitus type 1" returned 655 free, full-text research articles on human participants. First 3 results:

Effect of Sancaijiangtang on plasma nitric oxide and endothelin-1 levels in patients with type 2 diabetes mellitus and vascular dementia: a single-blind randomized controlled trial.
 

Author(s): Guo Qiang, Cao Wenzhai, Zhao Huan, Zhu Yuxia, Yang Dongdong, Zhong Sen, Chen Qiu

Journal: J Tradit Chin Med. 2015 Aug;35(4):375-80.

 

To observe the effect of Sancaijiangtang powders on plasma nitric oxide and endothelin-1 levels. We sought to identify the common pathological link and mechanism of action for Traditional Chinese medicine in type 2 diabetes mellitus and vascular dementia, and to explicate the material ...

Last Updated: 2 Oct 2015

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A Population-Based Cohort Study of All-Cause and Site-Specific Cancer Incidence Among Patients With Type 1 Diabetes Mellitus in Taiwan.
 

Author(s): Pei-Chun Hsu, Wei-Hung Lin, Te-Hui Kuo, Hui-Mei Lee, Chieh Kuo, Chung-Yi Li

Journal: J Epidemiol. 2015 ;25(9):567-73.

 

The relationship between type 1 diabetes mellitus (T1DM) and cancer incidence remains unclear. We sought to assess the all-cause and site-specific cancer incidence in patients with T1DM.

Last Updated: 8 Sep 2015

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Polymorphisms of the peroxisome proliferator-activated receptor-γ (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus.
 

Author(s): Peter Kruzliak, Andreana P Haley, Jovana Nikolajevic Starcevic, Ludovit Gaspar, Daniel Petrovic

Journal:

 

The aim of this study was to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 (PGC-1α) gene (rs8192673) are associated ...

Last Updated: 24 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diabetes mellitus type 1" returned 89 free, full-text review articles on human participants. First 3 results:

Efficacy of inhibition of IL-1 in patients with rheumatoid arthritis and type 2 diabetes mellitus: two case reports and review of the literature.
 

Author(s): Piero Ruscitti, Paola Cipriani, Luca Cantarini, Vasiliki Liakouli, Antonio Vitale, Francesco Carubbi, Onorina Berardicurti, Mauro Galeazzi, Marco Valenti, Roberto Giacomelli

Journal:

 

Rheumatoid arthritis is an autoimmune arthritis in which two inflammatory cytokines, tumor necrosis factor-α and interleukin-1β, play a critical role in the induction and progression of the disease. Several reports and data from registries have discussed the association between ...

Last Updated: 6 Jun 2015

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Toll-like receptor 3 (TLR3) and the development of type 1 diabetes mellitus.
 

Author(s): Taís Silveira Assmann, Letícia de Almeida Brondani, Ana Paula Bouças, Luís Henrique Canani, Daisy Crispim

Journal: Arch Endocrinol Metab. 2015 Feb;59(1):4-12.

 

Type 1 diabetes mellitus (T1DM) is a chronic, progressive autoimmune disease characterized by metabolic decompensation often leading to dehydration and ketoacidosis. Viral agents seem to play an important role in triggering the autoimmune destruction that leads to the development ...

Last Updated: 30 Apr 2015

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Fulminant type 1 diabetes mellitus and fulminant viral myocarditis. A case report and literature review.
 

Author(s): Nobumasa Ohara, Masanori Kaneko, Hirohiko Kuwano, Katsuya Ebe, Toshio Fujita, Tsuneo Nagai, Tatsuo Furukawa, Yoshifusa Aizawa, Kyuzi Kamoi

Journal: Int Heart J. 2015 ;56(2):239-44.

 

A 35-year-old Japanese woman was admitted with coma following flu-like symptoms. She was diagnosed with diabetic ketoacidosis and fulminant type 1 diabetes (FT1D) and received intravenous infusion of insulin and saline. The next day, the ketoacidosis disappeared, and she recovered ...

Last Updated: 23 Mar 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Effect of Melatonin on Early Signs of Hypertension in Teenagers With Diabetes Mellitus Type 1
 

Status: Not yet recruiting

Condition Summary: Diabetes Mellitus, Type 1; Hypertension

 

Last Updated: 30 Dec 2015

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A Pilot Study of the Therapeutic Potential of Stem Cell Educator Therapy in Type 1 Diabetes
 

Status: Not yet recruiting

Condition Summary: Diabetes Mellitus Type 1

 

Last Updated: 4 Dec 2015

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Evaluation of Vildagliptin (Galvus®) as add-on to Insulin in New-onset Type 1 Diabetes Mellitus
 

Status: Recruiting

Condition Summary: Type 1 Diabetes; Insulin Dependent Diabetes; Juvenile Onset Diabetes Mellitus; Autoimmune Diabetes

 

Last Updated: 13 May 2014

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