Chronic obstructive pulmonary disease

Common Name(s)

Chronic obstructive pulmonary disease, COPD

Chronic obstructive pulmonary disease (COPD) is a progressive disease that makes breathing difficult. COPD is a general term describing several progressive lung diseases including emphysema, chronic bronchitis, refractory (non-reversible) asthma, and some forms of bronchiectasis. COPD is usually symptom free at first; but as the lung damage increases, symptoms begin to appear and then worsen over time. Symptoms of COPD may include coughing that produces large amounts of mucus, wheezing, shortness of breath, and chest tightness. COPD is caused by long-term exposure to lung irritants such as cigarette smoke and pollutants as well as genetic factors, including alpha 1 antitrypsin deficiency.

With COPD, less air flows in and out of the airways because of one or more of the following: the airways and air sacs of the lungs lose their elastic quality, the walls between many of the air sacs are destroyed, the walls of the airways become thick and inflamed, and/or the airways make more mucus than usual, which can clog them. COPD may be diagnosed using a noninvasive breathing test called spirometry. Spirometry can detect COPD before symptoms begin, and your doctor may advise you to be screened regularly for COPD if you have a history of smoking, exposure to toxins, fumes or pollutants or have a genetic predisposition to or family history of COPD. Your physician may order other tests to rule out other lung conditions and to determine the best treatment for your stage of COPD. Treatment includes medications and lung therapy. Surgery is sometimes necessary for those with severe emphysema. Although there is currently no cure for COPD, treatments and lifestyle changes can help patients feel better, stay more active, and slow the progress of the disease. If you or a family member has been diagnosed with COPD, talk with your doctor about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic obstructive pulmonary disease" for support, advocacy or research.

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COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

Last Updated: 25 Mar 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic obstructive pulmonary disease" for support, advocacy or research.

Logo
COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

http://www.copdfoundation.org

Last Updated: 25 Mar 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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General Support Organizations

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General Resources

COPD Research Registry

The COPD Research Registry is a confidential database of individuals diagnosed with COPD or at risk of developing COPD who have consented to be contacted for participation in COPD research studies and clinical trials.

Uploaded By: COPD Foundation

Updated 21 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic obstructive pulmonary disease" returned 3114 free, full-text research articles on human participants. First 3 results:

Diabetes mellitus in patients with chronic obstructive pulmonary disease-The impact on mortality.
 

Author(s): Te-Wei Ho, Chun-Ta Huang, Sheng-Yuan Ruan, Yi-Ju Tsai, Feipei Lai, Chong-Jen Yu

Journal:

 

Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide. There is evidence to support a connection between COPD and diabetes mellitus (DM), another common medical disorder. However, additional research is required to improve our knowledge ...

Last Updated: 14 Apr 2017

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Outcomes of patients with chronic obstructive pulmonary disease diagnosed with or without pulmonary function testing.
 

Author(s): Andrea Gershon, Graham Mecredy, Ruth Croxford, Teresa To, Matthew B Stanbrook, Shawn D Aaron,

Journal: CMAJ. 2017 Apr;189(14):E530-E538.

 

A small number of people with chronic obstructive pulmonary disease (COPD) receive pulmonary function testing around the time of diagnosis. Because omitting testing increases misdiagnosis, we sought to determine whether health outcomes differed between patients whose COPD was diagnosed ...

Last Updated: 11 Apr 2017

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The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease.
 

Author(s): Jingtong Zheng, Yue Shi, Lingxin Xiong, Weijie Zhang, Ying Li, Peter G Gibson, Jodie L Simpson, Chao Zhang, Junying Lu, Jingying Sai, Guoqiang Wang, Fang Wang

Journal: J Immunol Res. 2017 ;2017():8539294.

 

Viral infection is a common trigger for acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The aim of this study is to investigate the expression of cytokines in AECOPD. Patients with AECOPD requiring hospitalization were recruited. Meanwhile healthy volunteers ...

Last Updated: 29 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic obstructive pulmonary disease" returned 625 free, full-text review articles on human participants. First 3 results:

The Role of Mitochondria and Oxidative/Antioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease.
 

Author(s): Adam Jerzy Białas, Przemysław Sitarek, Joanna Miłkowska-Dymanowska, Wojciech Jerzy Piotrowski, Paweł Górski

Journal: Oxid Med Cell Longev. 2016 ;2016():7808576.

 

Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable disease, characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or ...

Last Updated: 20 Jan 2017

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Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis.
 

Author(s): Sang Wook Kang, Su Kang Kim, Joo-Ho Chung, Hee-Jae Jung, Kwan-Il Kim, Jinju Kim, Ju Yeon Ban

Journal: Biomed Res Int. 2016 ;2016():7636123.

 

The relationship between polymorphism of the angiotensin I converting enzyme (ACE) gene and chronic obstructive pulmonary disease (COPD) has been examined in many previous studies. However, their results were controversial. Therefore, we performed a meta-analysis to evaluate the relationship ...

Last Updated: 10 Nov 2016

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Extracellular Vesicles in Chronic Obstructive Pulmonary Disease.
 

Author(s): Tsukasa Kadota, Yu Fujita, Yusuke Yoshioka, Jun Araya, Kazuyoshi Kuwano, Takahiro Ochiya

Journal:

 

Chronic obstructive pulmonary disease (COPD) is characterized by the progression of irreversible airflow limitation and is a leading cause of morbidity and mortality worldwide. Although several crucial mechanisms of COPD pathogenesis have been studied, the precise mechanism remains ...

Last Updated: 1 Nov 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Imaging of Apoptosis in Chronic Obstructive Pulmonary Disease (COPD)
 

Status: Not yet recruiting

Condition Summary: Chronic Obstructive Pulmonary Disease (COPD)

 

Last Updated: 28 Nov 2016

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Cardiovascular Risk and Chronic Obstructive Pulmonary Disease
 

Status: Recruiting

Condition Summary: Chronic Obstructive Pulmonary Disease

 

Last Updated: 11 Jan 2017

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Identification of Volatile Organic Compounds in Exhaled Air During Exacerbation of Chronic Obstructive Pulmonary Disease
 

Status: Recruiting

Condition Summary: Chronic Obstructive Pulmonary Disease

 

Last Updated: 30 Mar 2017

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