Chronic obstructive pulmonary disease

Common Name(s)

Chronic obstructive pulmonary disease, COPD

Chronic obstructive pulmonary disease (COPD) is a progressive disease that makes breathing difficult. COPD is a general term describing several progressive lung diseases including emphysema, chronic bronchitis, refractory (non-reversible) asthma, and some forms of bronchiectasis. COPD is usually symptom free at first; but as the lung damage increases, symptoms begin to appear and then worsen over time. Symptoms of COPD may include coughing that produces large amounts of mucus, wheezing, shortness of breath, and chest tightness. COPD is caused by long-term exposure to lung irritants such as cigarette smoke and pollutants as well as genetic factors, including alpha 1 antitrypsin deficiency.

With COPD, less air flows in and out of the airways because of one or more of the following: the airways and air sacs of the lungs lose their elastic quality, the walls between many of the air sacs are destroyed, the walls of the airways become thick and inflamed, and/or the airways make more mucus than usual, which can clog them. COPD may be diagnosed using a noninvasive breathing test called spirometry. Spirometry can detect COPD before symptoms begin, and your doctor may advise you to be screened regularly for COPD if you have a history of smoking, exposure to toxins, fumes or pollutants or have a genetic predisposition to or family history of COPD. Your physician may order other tests to rule out other lung conditions and to determine the best treatment for your stage of COPD. Treatment includes medications and lung therapy. Surgery is sometimes necessary for those with severe emphysema. Although there is currently no cure for COPD, treatments and lifestyle changes can help patients feel better, stay more active, and slow the progress of the disease. If you or a family member has been diagnosed with COPD, talk with your doctor about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic obstructive pulmonary disease" for support, advocacy or research.

Logo
COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

Last Updated: 25 Mar 2013

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic obstructive pulmonary disease" for support, advocacy or research.

Logo
COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

http://www.copdfoundation.org

Last Updated: 25 Mar 2013

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

COPD Research Registry

The COPD Research Registry is a confidential database of individuals diagnosed with COPD or at risk of developing COPD who have consented to be contacted for participation in COPD research studies and clinical trials.

Uploaded By: COPD Foundation

Updated 21 Mar 2013

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic obstructive pulmonary disease" returned 3146 free, full-text research articles on human participants. First 3 results:

Impact of Chronic Obstructive Pulmonary Disease on Long-Term Outcome in Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Intervention.
 

Author(s): Ming Zhang, Yun-Jiu Cheng, Wei-Ping Zheng, Guang-Hui Liu, Huai-Sheng Chen, Yu Ning, Xin Zhao, Li-Xiao Su, Li-Juan Liu

Journal: Biomed Res Int. 2016 ;2016():8212459.

 

Objective. The aim of this study was to investigate the association between COPD and major adverse cardiovascular and cerebral events (MACCE) in patients undergoing percutaneous coronary intervention (PCI). Methods. 2,362 patients who underwent PCI were included in this study. Subjects ...

Last Updated: 2 Jan 2017

Go To URL
Announcement: National Chronic Obstructive Pulmonary Disease Awareness Month - November 2016.
 

Author(s):

Journal:

 

Approximately 15.7 million U.S. adults have received a diagnosis of chronic obstructive pulmonary disease (COPD), which includes chronic bronchitis and emphysema (1). However, many more adults with symptoms of COPD, including frequent coughing, shortness of breath, excess phlegm or ...

Last Updated: 17 Nov 2016

Go To URL
Chronic obstructive pulmonary disease (COPD) and erectile dysfunction (ED): Results of the BRED observational study.
 

Author(s): Stefano Lauretti, Vittorio Cardaci, Francesco Barrese, Luigino Calzetta

Journal:

 

Most patients with chronic obstructive pulmonary disease (COPD) share many risk factors and similar aetiological agents with erectile dysfunction (ED). Both conditions also cause serious interference with quality of life and sexual relationships. In general, ageing and chronic illness ...

Last Updated: 6 Oct 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic obstructive pulmonary disease" returned 624 free, full-text review articles on human participants. First 3 results:

[Epigenetic and current treatment approaches in chronic obstructive pulmonary disease].
 

Author(s): Serap Duru

Journal: Tuberk Toraks. 2016 Mar;64(1):47-52.

 

Epigenetics mechanisms such as DNA methylation, histone acetylation and non-coding RNAs may play are a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Researchs with regard epigenetic in COPD can shed light on pathogenes and may be relevant in the development ...

Last Updated: 9 Jun 2016

Go To URL
Bronchiectasis as a Comorbidity of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.
 

Author(s): Qingxia Du, Jianmin Jin, Xiaofang Liu, Yongchang Sun

Journal:

 

Bronchiectasis revealed by chest computed tomography in COPD patients and its comorbid effect on prognosis have not been addressed by large-sized studies. Understanding the presence of bronchiectasis in COPD is important for future intervention and preventing disease progression.

Last Updated: 16 Mar 2016

Go To URL
Can roflumilast, a phosphodiesterase-4 inhibitor, improve clinical outcomes in patients with moderate-to-severe chronic obstructive pulmonary disease? A meta-analysis.
 

Author(s): Jian Luo, Ke Wang, Dan Liu, Bin-Miao Liang, Chun-Tao Liu

Journal:

 

Effects of roflumilast on lung function, symptoms, acute exacerbation and adverse events in patients with chronic obstructive pulmonary disease (COPD) are controversial. We aimed to further clarify the efficacy and safety of roflumilast in treatment of moderate-to-severe COPD.

Last Updated: 18 Feb 2016

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Imaging of Apoptosis in Chronic Obstructive Pulmonary Disease (COPD)
 

Status: Not yet recruiting

Condition Summary: Chronic Obstructive Pulmonary Disease (COPD)

 

Last Updated: 28 Nov 2016

Go to URL
Cardiovascular Risk and Chronic Obstructive Pulmonary Disease
 

Status: Recruiting

Condition Summary: Chronic Obstructive Pulmonary Disease

 

Last Updated: 11 Jan 2017

Go to URL
Identification of Volatile Organic Compounds in Exhaled Air During Exacerbation of Chronic Obstructive Pulmonary Disease
 

Status: Recruiting

Condition Summary: Chronic Obstructive Pulmonary Disease

 

Last Updated: 6 Dec 2016

Go to URL