Chronic obstructive pulmonary disease

Common Name(s)

Chronic obstructive pulmonary disease, COPD

Chronic obstructive pulmonary disease (COPD) is a progressive disease that makes breathing difficult. COPD is a general term describing several progressive lung diseases including emphysema, chronic bronchitis, refractory (non-reversible) asthma, and some forms of bronchiectasis. COPD is usually symptom free at first; but as the lung damage increases, symptoms begin to appear and then worsen over time. Symptoms of COPD may include coughing that produces large amounts of mucus, wheezing, shortness of breath, and chest tightness. COPD is caused by long-term exposure to lung irritants such as cigarette smoke and pollutants as well as genetic factors, including alpha 1 antitrypsin deficiency.

With COPD, less air flows in and out of the airways because of one or more of the following: the airways and air sacs of the lungs lose their elastic quality, the walls between many of the air sacs are destroyed, the walls of the airways become thick and inflamed, and/or the airways make more mucus than usual, which can clog them. COPD may be diagnosed using a noninvasive breathing test called spirometry. Spirometry can detect COPD before symptoms begin, and your doctor may advise you to be screened regularly for COPD if you have a history of smoking, exposure to toxins, fumes or pollutants or have a genetic predisposition to or family history of COPD. Your physician may order other tests to rule out other lung conditions and to determine the best treatment for your stage of COPD. Treatment includes medications and lung therapy. Surgery is sometimes necessary for those with severe emphysema. Although there is currently no cure for COPD, treatments and lifestyle changes can help patients feel better, stay more active, and slow the progress of the disease. If you or a family member has been diagnosed with COPD, talk with your doctor about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic obstructive pulmonary disease" for support, advocacy or research.

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COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

Last Updated: 25 Mar 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic obstructive pulmonary disease" for support, advocacy or research.

Logo
COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

http://www.copdfoundation.org

Last Updated: 25 Mar 2013

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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General Support Organizations

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General Resources

COPD Research Registry

The COPD Research Registry is a confidential database of individuals diagnosed with COPD or at risk of developing COPD who have consented to be contacted for participation in COPD research studies and clinical trials.

Uploaded By: COPD Foundation

Updated 21 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic obstructive pulmonary disease" returned 2751 free, full-text research articles on human participants. First 3 results:

The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes from alpha-1 antitrypsin deficient subjects with chronic obstructive pulmonary disease - a pilot study.
 

Author(s): Jennie M Gane, Robert A Stockley, Elizabeth Sapey

Journal:

 

Polymorphisms in the TNF-A gene have been associated with chronic obstructive pulmonary disease (COPD) in some case-control studies. Previous work has shown that COPD/chronic bronchitis subjects with alpha-1 antitrypsin deficiency with the rs361525 TNF-α single nucleotide polymorphism ...

Last Updated: 1 Dec 2015

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Inhaled Corticosteroids Increase the Risk of Pneumonia in Patients With Chronic Obstructive Pulmonary Disease: A Nationwide Cohort Study.
 

Author(s): Ming-Chia Lee, Chih-Hsin Lee, Shu-Chen Chien, Jer-Hwa Chang, Han-Lin She, Jann-Yuan Wang, Ming-Chih Yu

Journal: Medicine (Baltimore). 2015 Oct;94(42):e1723.

 

The association of inhaled corticosteroids (ICS) and pneumonia in patients with chronic obstructive pulmonary disease (COPD) is still controversial.From the National Health Insurance Database of Taiwan, COPD cases with history of acute exacerbation (AE) were identified (COPD cohort). ...

Last Updated: 27 Oct 2015

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Lung-Function Trajectories and Chronic Obstructive Pulmonary Disease.
 

Author(s): Peter Lange, Bartolome Celli, Alvar Agustí

Journal: N. Engl. J. Med.. 2015 Oct;373(16):1575.

 

Last Updated: 15 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic obstructive pulmonary disease" returned 585 free, full-text review articles on human participants. First 3 results:

Clinical, humanistic, and economic burden of chronic obstructive pulmonary disease (COPD) in Canada: a systematic review.
 

Author(s): Tam Dang-Tan, Afisi Ismaila, Shiyuan Zhang, Victoria Zarotsky, Mark Bernauer

Journal:

 

Chronic obstructive pulmonary disease (COPD) is a chronic, irreversible disease and a leading cause of worldwide morbidity and mortality. In Canada, COPD is the fourth leading cause of death. This systematic review was undertaken to update healthcare professionals and decision makers ...

Last Updated: 22 Sep 2015

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A re-evaluation of the role of inhaled corticosteroids in the management of patients with chronic obstructive pulmonary disease.
 

Author(s): Anthony D'Urzo, James F Donohue, Peter Kardos, Marc Miravitlles, David Price

Journal: Expert Opin Pharmacother. 2015 ;16(12):1845-60.

 

Inhaled corticosteroids (ICS) (in fixed combinations with long-acting β2-agonists [LABAs]) are frequently prescribed for patients with chronic obstructive pulmonary disease (COPD), outside their labeled indications and recommended treatment strategies and guidelines, despite having ...

Last Updated: 21 Jul 2015

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Supported self-management for patients with moderate to severe chronic obstructive pulmonary disease (COPD): an evidence synthesis and economic analysis.
 

Author(s): Rachel E Jordan, Saimma Majothi, Nicola R Heneghan, Deirdre B Blissett, Richard D Riley, Alice J Sitch, Malcolm J Price, Elizabeth J Bates, Alice M Turner, Susan Bayliss, David Moore, Sally Singh, Peymane Adab, David A Fitzmaurice, Susan Jowett, Kate Jolly

Journal: Health Technol Assess. 2015 May;19(36):1-516.

 

Self-management (SM) support for patients with chronic obstructive pulmonary disease (COPD) is variable in its coverage, content, method and timing of delivery. There is insufficient evidence for which SM interventions are the most effective and cost-effective.

Last Updated: 18 May 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Mindfulness-based Cognitive Therapy for Chronic Obstructive Pulmonary Disease
 

Status: Recruiting

Condition Summary: Chronic Obstructive Pulmonary Disease (COPD); Chronic Obstructive Lung Disease; Chronic Obstructive Airway Disease; Chronic Bronchitis; Emphysema

 

Last Updated: 3 Jun 2015

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Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study
 

Status: Recruiting

Condition Summary: Chronic Obstructive Pulmonary Disease

 

Last Updated: 11 Jan 2016

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Cognitive Status in Chronic Obstructive Pulmonary Disease's Patients
 

Status: Recruiting

Condition Summary: Chronic Obstructive Pulmonary Disease

 

Last Updated: 17 May 2014

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