Central precocious puberty

Common Name(s)

Central precocious puberty

Early activation of the hypothalamic-pituitary-gonadal axis results in gonadotropin-dependent precocious puberty, also known as central precocious puberty, which is clinically defined by the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Pubertal timing is influenced by complex interactions among genetic, nutritional, environmental, and socioeconomic factors. The timing of puberty is associated with risks of subsequent disease: earlier age of menarche in girls is associated with increased risk of breast cancer, endometrial cancer, obesity, type 2 diabetes, and cardiovascular disease. Central precocious puberty has also been associated with an increased incidence of conduct and behavior disorders during adolescence (summary by {1:Abreu et al., 2013}). Genetic Heterogeneity of Central Precocious Puberty Central precocious puberty-2 (CPPB2; {615346}) is caused by mutation in the MKRN3 gene ({603856}) on chromosome 15q11.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Central precocious puberty" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Central precocious puberty" returned 71 free, full-text research articles on human participants. First 3 results:

The Influence of GnRH Analog Therapy on Growth in Central Precocious Puberty.
 

Author(s): Ewa Głąb, Beata Wikiera, Jolanta Bieniasz, Ewa Barg

Journal: Adv Clin Exp Med. ;25(1):27-32.

 

Children with central precocious puberty (CPP) present various somatic and psychological abnormalities.

Last Updated: 3 Mar 2016

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A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010.
 

Author(s): Shin Hye Kim, Kyoung Huh, Sungho Won, Kuk-Wha Lee, Mi-Jung Park

Journal:

 

Few studies have explored the trends in central precocious puberty (CPP) in Asian populations. This study assessed the prevalence and annual incidence of CPP among Korean children.

Last Updated: 6 Nov 2015

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A case of familial central precocious puberty caused by a novel mutation in the makorin RING finger protein 3 gene.
 

Author(s): Anna Grandone, Grazia Cantelmi, Grazia Cirillo, Pierluigi Marzuillo, Caterina Luongo, Emanuele Miraglia del Giudice, Laura Perrone

Journal:

 

Central precocious puberty (CPP) is often familial but its genetic cause is largely unknown. Very recently, the makorin RING finger protein 3 (MKRN3) gene, located on chromosome 15 in the Prader-Willi syndrome (PWS)-associated region (15q11-q13), has been found mutated in 5 families ...

Last Updated: 27 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Central precocious puberty" returned 4 free, full-text review articles on human participants. First 3 results:

MANAGEMENT OF ENDOCRINE DISEASE: Long-term outcomes of the treatment of central precocious puberty.
 

Author(s): Federica Guaraldi, Guglielmo Beccuti, Davide Gori, Lucia Ghizzoni

Journal: Eur. J. Endocrinol.. 2016 Mar;174(3):R79-87.

 

GnRH analogues (GnRHa) are the treatment of choice for central precocious puberty (CPP), with the main objective to recover the height potential compromised by the premature fusion of growth cartilages. The aim of this review was to analyze long-term effects of GnRHa on height, body ...

Last Updated: 16 Jan 2016

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New causes of central precocious puberty: the role of genetic factors.
 

Author(s): Delanie Bulcao Macedo, Vinicius Nahime Brito, Ana Claudia Latronico

Journal: Neuroendocrinology. 2014 ;100(1):1-8.

 

A pivotal event in the onset of puberty in humans is the reemergence of the pulsatile release of the gonadotropin-releasing hormone (GnRH) from hypothalamic neurons. Pathways governing GnRH ontogeny and physiology have been discovered by studying animal models and humans with reproductive ...

Last Updated: 18 Nov 2014

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[Effects of central precocious puberty on physical and sexual development in children].
 

Author(s): Lan Zhao, Yan Zhong

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 May;16(5):555-9.

 

As abnormal pubertal development, central precocious puberty (CPP) is manifested by the secondary sexual characteristics, skeletal maturation, and physical development in advance. It ultimately affects the adult height of children, even producing some psychological and behavioral ...

Last Updated: 26 May 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Markers of Pubertal Suppression During Therapy for Precocious Puberty
 

Status: Recruiting

Condition Summary: Central Precocious Puberty

 

Last Updated: 3 Sep 2014

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Last Updated: 21 Jun 2016

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Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children
 

Status: Recruiting

Condition Summary: Central Precocious Puberty

 

Last Updated: 21 Feb 2007

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