Central precocious puberty

Common Name(s)

Central precocious puberty

Early activation of the hypothalamic-pituitary-gonadal axis results in gonadotropin-dependent precocious puberty, also known as central precocious puberty, which is clinically defined by the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Pubertal timing is influenced by complex interactions among genetic, nutritional, environmental, and socioeconomic factors. The timing of puberty is associated with risks of subsequent disease: earlier age of menarche in girls is associated with increased risk of breast cancer, endometrial cancer, obesity, type 2 diabetes, and cardiovascular disease. Central precocious puberty has also been associated with an increased incidence of conduct and behavior disorders during adolescence (summary by {1:Abreu et al., 2013}). Genetic Heterogeneity of Central Precocious Puberty Central precocious puberty-2 (CPPB2; {615346}) is caused by mutation in the MKRN3 gene ({603856}) on chromosome 15q11.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Central precocious puberty" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Central precocious puberty" returned 55 free, full-text research articles on human participants. First 3 results:

[Effects of gonadotropin releasing hormone analog and growth hormone on height in girls with idiopathic central precocious puberty].
 

Author(s): Chun-Lin Wang, Li Liang, Pei-Ning Liu, Xian-Jiang Jin, Lin-Qi Chen, Fang Yang, Qun Lian, Rui-Min Chen

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Jan;16(1):25-30.

 

To determine the effect of gonadotropin releasing hormone agonist (GnRHa), by itself alone or in combination with recombinant human growth hormone (rhGH), on height in young girls (bone age≥10 years) with idiopathic central precocious puberty (ICPP).

Last Updated: 27 Jan 2014

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Presentation of 493 consecutive girls with idiopathic central precocious puberty: a single-center study.
 

Author(s): Eloïse Giabicani, Slimane Allali, Adélaïde Durand, Julie Sommet, Ana-Claudia Couto-Silva, Raja Brauner

Journal:

 

Despite the number of reported data concerning idiopathic central precocious puberty (CPP) in girls, major questions remain including its diagnosis, factors, and indications of gonadotropin releasing hormone (GnRH) analog treatment.

Last Updated: 12 Aug 2013

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A single histrelin implant is effective for 2 years for treatment of central precocious puberty.
 

Author(s): Katherine A Lewis, Andrea K Goldyn, Karen W West, Erica A Eugster

Journal: J. Pediatr.. 2013 Oct;163(4):1214-6.

 

We investigated whether a "yearly" histrelin implant would provide pubertal suppression when left in place for 2 years. Equivalent suppression was observed when comparing 12 and 24 months in 33 children with central precocious puberty. A single implant for 2 years reduces cost and ...

Last Updated: 27 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Central precocious puberty" returned 2 free, full-text review articles on human participants. First 3 results:

Treatment of central precocious puberty by GnRH analogs: long-term outcome in men.
 

Author(s): Silvano Bertelloni, Dick Mul

Journal: Asian J. Androl.. 2008 Jul;10(4):525-34.

 

In boys, central precocious puberty (CPP) is the appearance of secondary sex characteristics driven by pituitary gonadotropin secretion before the age of 9 years. In the last years, relevant improvements in the treatment of CPP have been achieved. Because CPP is rare in boys, the ...

Last Updated: 14 May 2008

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Combined therapy with luteinizing hormone releasing hormone agonist (LHRHa) and growth hormone (GH) in central precocious puberty.
 

Author(s): Cecilia Volta, Carla Regazzi, Juliette Ndaka, Rosa Vitale, Sergio Bernasconi

Journal: Acta Biomed. 2005 Sep;76(2):73-8.

 

Luteinizing Hormone Releasing Hormone analogues (LHRHa) are considered the treatment of choice in central precocious puberty (CPP). Final height after therapy is usually higher than the predicted one before treatment, but about 60% of patients do not reach their genetic target. The ...

Last Updated: 14 Dec 2005

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Markers of Pubertal Suppression During Therapy for Precocious Puberty
 

Status: Not yet recruiting

Condition Summary: Central Precocious Puberty

 

Last Updated: 4 Dec 2013

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Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children
 

Status: Recruiting

Condition Summary: Central Precocious Puberty

 

Last Updated: 21 Feb 2007

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