Central precocious puberty

Common Name(s)

Central precocious puberty

Early activation of the hypothalamic-pituitary-gonadal axis results in gonadotropin-dependent precocious puberty, also known as central precocious puberty, which is clinically defined by the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Pubertal timing is influenced by complex interactions among genetic, nutritional, environmental, and socioeconomic factors. The timing of puberty is associated with risks of subsequent disease: earlier age of menarche in girls is associated with increased risk of breast cancer, endometrial cancer, obesity, type 2 diabetes, and cardiovascular disease. Central precocious puberty has also been associated with an increased incidence of conduct and behavior disorders during adolescence (summary by {1:Abreu et al., 2013}). Genetic Heterogeneity of Central Precocious Puberty Central precocious puberty-2 (CPPB2; {615346}) is caused by mutation in the MKRN3 gene ({603856}) on chromosome 15q11.
 

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Condition Specific Organizations

Following organizations serve the condition "Central precocious puberty" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Central precocious puberty" returned 76 free, full-text research articles on human participants. First 3 results:

Herbal medicine for idiopathic central precocious puberty: A protocol for a systematic review of controlled trials.
 

Author(s): Hye Lim Lee, Yoo Been Lee, Jun-Yong Choi, Ju Ah Lee

Journal: Medicine (Baltimore). 2018 Mar;97(13):e0267.

 

Herbal medicine is widely used in East Asia to treat idiopathic central precocious puberty (ICPP). Most of the available clinical trials that investigated herbal medicine for ICPP have been included in this review. This systematic review will assess the efficacy and safety of herbal ...

Last Updated: 31 Dec 1969

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Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty.
 

Author(s): Andrew Dauber, Marina Cunha-Silva, Delanie B Macedo, Vinicius N Brito, Ana Paula Abreu, Stephanie A Roberts, Luciana R Montenegro, Melissa Andrew, Andrew Kirby, Matthew T Weirauch, Guillaume Labilloy, Danielle S Bessa, Rona S Carroll, Dakota C Jacobs, Patrick E Chappell, Berenice B Mendonca, David Haig, Ursula B Kaiser, Ana Claudia Latronico

Journal: J. Clin. Endocrinol. Metab.. 2017 05;102(5):1557-1567.

 

Central precocious puberty (CPP) results from premature activation of the hypothalamic-pituitary-gonadal axis. Few genetic causes of CPP have been identified, with the most common being mutations in the paternally expressed imprinted gene MKRN3.

Last Updated: 31 Dec 1969

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Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche.
 

Author(s): Mesut Parlak, Doğa Türkkahraman, Hamit Yaşar Ellidağ, Gamze Çelmeli, Ayşe Eda Parlak, Necat Yılmaz

Journal: J Clin Res Pediatr Endocrinol. 2017 Jun;9(2):101-105.

 

To find out the diagnostic role of kisspeptin and neurokinin B in idiopathic central precocious puberty (ICPP) and premature thelarche (PT).

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Central precocious puberty" returned 4 free, full-text review articles on human participants. First 3 results:

Central precocious puberty: revisiting the diagnosis and therapeutic management.
 

Author(s): Vinícius Nahime Brito, Angela Maria Spinola-Castro, Cristiane Kochi, Cristiane Kopacek, Paulo César Alves da Silva, Gil Guerra-Júnior

Journal: Arch Endocrinol Metab. 2016 Apr;60(2):163-72.

 

Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain challenging due to lack of standardization. The aim of this revision was to address the diagnostic and therapeutic features of CPP in Brazil based on relevant international literature and availability ...

Last Updated: 31 Dec 1969

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MANAGEMENT OF ENDOCRINE DISEASE: Long-term outcomes of the treatment of central precocious puberty.
 

Author(s): Federica Guaraldi, Guglielmo Beccuti, Davide Gori, Lucia Ghizzoni

Journal: Eur. J. Endocrinol.. 2016 Mar;174(3):R79-87.

 

GnRH analogues (GnRHa) are the treatment of choice for central precocious puberty (CPP), with the main objective to recover the height potential compromised by the premature fusion of growth cartilages. The aim of this review was to analyze long-term effects of GnRHa on height, body ...

Last Updated: 31 Dec 1969

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New causes of central precocious puberty: the role of genetic factors.
 

Author(s): Delanie Bulcao Macedo, Vinicius Nahime Brito, Ana Claudia Latronico

Journal: Neuroendocrinology. 2014 ;100(1):1-8.

 

A pivotal event in the onset of puberty in humans is the reemergence of the pulsatile release of the gonadotropin-releasing hormone (GnRH) from hypothalamic neurons. Pathways governing GnRH ontogeny and physiology have been discovered by studying animal models and humans with reproductive ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Leuprorelin Acetate DPS (Leuplin DPS) Treatment Quarterly in Patients With Central Precocious Puberty
 

Status: Recruiting

Condition Summary: Central Precocious Puberty

 

Last Updated: 17 Oct 2017

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Analysis of Body Mass Index in Central Precocious Puberty Patients Treated With Leuprolide Acetate
 

Status: Recruiting

Condition Summary: Precocious Puberty, Central

 

Last Updated: 22 Nov 2016

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Last Updated: 26 Feb 2018

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