Central precocious puberty

Common Name(s)

Central precocious puberty

Early activation of the hypothalamic-pituitary-gonadal axis results in gonadotropin-dependent precocious puberty, also known as central precocious puberty, which is clinically defined by the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Pubertal timing is influenced by complex interactions among genetic, nutritional, environmental, and socioeconomic factors. The timing of puberty is associated with risks of subsequent disease: earlier age of menarche in girls is associated with increased risk of breast cancer, endometrial cancer, obesity, type 2 diabetes, and cardiovascular disease. Central precocious puberty has also been associated with an increased incidence of conduct and behavior disorders during adolescence (summary by {1:Abreu et al., 2013}). Genetic Heterogeneity of Central Precocious Puberty Central precocious puberty-2 (CPPB2; {615346}) is caused by mutation in the MKRN3 gene ({603856}) on chromosome 15q11.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Central precocious puberty" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Central precocious puberty" returned 61 free, full-text research articles on human participants. First 3 results:

[Effects of HPGA suppression on predicted adult height in girls with central precocious puberty].
 

Author(s): Yue-Hong Tao, Bi-He Zeng, Nazir Sharif

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Oct;17(10):1093-7.

 

To study the relationship between the suppression of the hypothalamic-pituitary-gonadal axis (HPGA) and the predicted adult height (PAH) in girls with central precocious puberty (CPP) during the treatment with gonadotropin-releasing hormone analogue (GnRHa), in order to provide guidance ...

Last Updated: 20 Oct 2015

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[Effects of obesity on peak level of luteinizing hormone in gonadotropin-releasing hormone agonist test and obesity-related hormones in girls with central precocious puberty].
 

Author(s): Xue-Lian Zhou, Jun-Fen Fu, Ju-Hua Jin, Guan-Ping Dong, You-Jun Jiang, Ke Huang, Xue-Feng Chen, Wei Wu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Aug;17(8):763-8.

 

To explore the effects of obesity on the peak level of luteinizing hormone (LH) in the gonadotropin-releasing hormone (GnRH) agonist test and obesity-related hormones in girls with central precocious puberty (CPP).

Last Updated: 20 Aug 2015

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Long-Term Continuous Suppression With Once-Yearly Histrelin Subcutaneous Implants for the Treatment of Central Precocious Puberty: A Final Report of a Phase 3 Multicenter Trial.
 

Author(s): Lawrence A Silverman, E Kirk Neely, Gad B Kletter, Katherine Lewis, Surya Chitra, Oksana Terleckyj, Erica A Eugster

Journal: J. Clin. Endocrinol. Metab.. 2015 Jun;100(6):2354-63.

 

The histrelin implant has proven to be an effective method of delivering GnRH analog (GnRHa) therapy to children with central precocious puberty (CPP), yet there are limited data available regarding hormonal suppression and auxological changes during an extended course of therapy.

Last Updated: 6 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Central precocious puberty" returned 3 free, full-text review articles on human participants. First 3 results:

New causes of central precocious puberty: the role of genetic factors.
 

Author(s): Delanie Bulcao Macedo, Vinicius Nahime Brito, Ana Claudia Latronico

Journal: Neuroendocrinology. 2014 ;100(1):1-8.

 

A pivotal event in the onset of puberty in humans is the reemergence of the pulsatile release of the gonadotropin-releasing hormone (GnRH) from hypothalamic neurons. Pathways governing GnRH ontogeny and physiology have been discovered by studying animal models and humans with reproductive ...

Last Updated: 18 Nov 2014

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[Effects of central precocious puberty on physical and sexual development in children].
 

Author(s): Lan Zhao, Yan Zhong

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 May;16(5):555-9.

 

As abnormal pubertal development, central precocious puberty (CPP) is manifested by the secondary sexual characteristics, skeletal maturation, and physical development in advance. It ultimately affects the adult height of children, even producing some psychological and behavioral ...

Last Updated: 26 May 2014

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Treatment of central precocious puberty by GnRH analogs: long-term outcome in men.
 

Author(s): Silvano Bertelloni, Dick Mul

Journal: Asian J. Androl.. 2008 Jul;10(4):525-34.

 

In boys, central precocious puberty (CPP) is the appearance of secondary sex characteristics driven by pituitary gonadotropin secretion before the age of 9 years. In the last years, relevant improvements in the treatment of CPP have been achieved. Because CPP is rare in boys, the ...

Last Updated: 14 May 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Markers of Pubertal Suppression During Therapy for Precocious Puberty
 

Status: Recruiting

Condition Summary: Central Precocious Puberty

 

Last Updated: 3 Sep 2014

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Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children
 

Status: Recruiting

Condition Summary: Central Precocious Puberty

 

Last Updated: 21 Feb 2007

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A Study to Assess the Safety and Efficacy of Leuprorelin in Central Precocious Puberty in Chinese Patients
 

Status: Not yet recruiting

Condition Summary: Puberty, Precocious

 

Last Updated: 23 Apr 2015

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