Bronchiectasis

Common Name(s)

Bronchiectasis

Bronchiectasis is a condition in which the tubes that carry air to the lungs slowly lose their ability to clear out mucus due to widening and scarring. As the mucus builds up, bacteria have the opportunity to grow. This bacterial growth leads to repeated, serious lung infections, causing damage to the airways. Over time, the airways can't move enough air in and out of the lungs, which may lead to the body’s vital organs not receiving enough oxygen.

Symptoms of this condition may include long-term (chronic) coughing, coughing up large amounts of mucus, wheezing, chest pain, shortness of breath, clubbing (where the skin beneath the nails becomes thicker), weight loss, and fatigue.

Bronchiectasis has two forms: congenital, which results from a problem with the lung development in a fetus, or acquired, which results from a viral or bacterial infection of the lungs. Lung (pulmonary) conditions including cystic fibrosis, pneumonia, tuberculosis, and COPD have also been known to cause bronchiectasis.

This condition is typically diagnosed when an affected individual expresses their symptoms to the doctor. Using a physical exam, a chest X-ray, and other pulmonary function exams, the doctor can make an official diagnosis. Although there is no cure at this time, there are many treatment options available. The use of antibiotics and mucus-thinning medications can be used to treat infections and help lessen the amount of mucus in the lungs. Bronchodilators, oxygen therapy, and physical therapy have been useful to increase airflow to the lungs. In more serious cases, there are also surgical options available.

Although bronchiectasis is manageable, leaving the condition untreated could result in further lung damage. If you or someone you know is experiencing the symptoms of bronchiectasis, it is important to contact your doctor as soon as possible to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bronchiectasis" for support, advocacy or research.

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COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

Last Updated: 25 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bronchiectasis" for support, advocacy or research.

Logo
COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

http://www.copdfoundation.org

Last Updated: 25 Mar 2013

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General Resources

Bronchiectasis Research Registry

The Bronchiectasis Research Registry is a consolidated database of non-cystic fibrosis (non-CF) bronchiectasis patients and Nontuberculous Mycobacteria (NTM) patients from multiple clinical institutions.

Uploaded By: COPD Foundation

Updated 21 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bronchiectasis" returned 466 free, full-text research articles on human participants. First 3 results:

HLA class I deficiency as an additional cause of bronchiectasis - Reply.
 

Author(s): Wei-Jie Guan, Yong-Hua Gao, Rong-Chang Chen, Nan-Shan Zhong

Journal: Respirology. 2015 Oct;20(7):1145-6.

 

Last Updated: 14 Sep 2015

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HLA class I deficiency as an additional cause of bronchiectasis.
 

Author(s): Jacques Zimmer, Markus Ollert

Journal: Respirology. 2015 Oct;20(7):1145.

 

Last Updated: 14 Sep 2015

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Observational study of sleep, respiratory mechanics and quality of life in patients with non-cystic fibrosis bronchiectasis: a protocol study.
 

Author(s): Newton Santos Faria Júnior, Luis Vicente Franco Oliveira, Eduardo Araújo Perez, Ezequiel Fernandes de Oliveira, Nadua Apostolico, Nixon Alves Pereira, Israel dos Reis dos Santos, Jessica Julioti Urbano, Ismael Dias Souza, Igor Bastos Polonio, José Gustavo Barian Romaldini, Déborah Madeu Pereira, Vera Lúcia dos Santos Alves, Ângela Honda Souza, Oliver Augusto Nascimento, José Roberto Jardim, Roberto Stirbulov

Journal:

 

Bronchiectasis is a chronic disorder characterised by permanent and irreversible abnormal dilation of the bronchi and bronchioles, primarily caused by repeated cycles of pulmonary infections and inflammation, which lead to reduced mucociliary clearance and to the excessive production ...

Last Updated: 14 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bronchiectasis" returned 32 free, full-text review articles on human participants. First 3 results:

Clinical characteristics of patients with chronic obstructive pulmonary disease with comorbid bronchiectasis: a systemic review and meta-analysis.
 

Author(s): Yingmeng Ni, Guochao Shi, Youchao Yu, Jimin Hao, Tiantian Chen, Huihui Song

Journal:

 

In the 2014 Global initiative for chronic Obstructive Lung Disease guidelines, bronchiectasis was for the first time defined as a comorbidity of chronic obstructive pulmonary disease (COPD), and this change has been retained in the 2015 update, which emphasizes the influence of bronchiectasis ...

Last Updated: 7 Aug 2015

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Nontuberculous Mycobacteria in Noncystic Fibrosis Bronchiectasis.
 

Author(s): Giulia Bonaiti, Alberto Pesci, Almerico Marruchella, Giuseppe Lapadula, Andrea Gori, Stefano Aliberti

Journal: Biomed Res Int. 2015 ;2015():197950.

 

During the past decades, a growing interest has been raised in evaluating nontuberculous mycobacteria (NTM) in patients with noncystic fibrosis bronchiectasis (NCFBE). This paper reviews several aspects of the correlations between NTM and NCFBE, including pathogenesis, radiological ...

Last Updated: 24 Jun 2015

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Year in review 2014: Interstitial lung disease, physiology, sleep and ventilation, acute respiratory distress syndrome, cystic fibrosis, bronchiectasis and rare lung disease.
 

Author(s): Toby M Maher, Amanda Piper, Yuanlin Song, Marcos I Restrepo, Neil D Eves

Journal: Respirology. 2015 Jul;20(5):834-45.

 

Last Updated: 15 Jun 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Natural History of Bronchiectasis
 

Status: Recruiting

Condition Summary: Bronchiectasis; Cystic Fibrosis; Autoimmune Disease; Common Variable Immunodeficiency

 

Last Updated: 15 Dec 2015

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Exercise Capacity in Bronchiectasis Resection
 

Status: Recruiting

Condition Summary: Bronchiectasis

 

Last Updated: 29 Dec 2010

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Prevention of Bronchiectasis in Infants With Cystic Fibrosis
 

Status: Recruiting

Condition Summary: Cystic Fibrosis; Bronchiectasis

 

Last Updated: 28 Apr 2016

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