Bronchiectasis

Common Name(s)

Bronchiectasis

Bronchiectasis is a condition in which the tubes that carry air to the lungs slowly lose their ability to clear out mucus due to widening and scarring. As the mucus builds up, bacteria have the opportunity to grow. This bacterial growth leads to repeated, serious lung infections, causing damage to the airways. Over time, the airways can't move enough air in and out of the lungs, which may lead to the body’s vital organs not receiving enough oxygen.

Symptoms of this condition may include long-term (chronic) coughing, coughing up large amounts of mucus, wheezing, chest pain, shortness of breath, clubbing (where the skin beneath the nails becomes thicker), weight loss, and fatigue.

Bronchiectasis has two forms: congenital, which results from a problem with the lung development in a fetus, or acquired, which results from a viral or bacterial infection of the lungs. Lung (pulmonary) conditions including cystic fibrosis, pneumonia, tuberculosis, and COPD have also been known to cause bronchiectasis.

This condition is typically diagnosed when an affected individual expresses their symptoms to the doctor. Using a physical exam, a chest X-ray, and other pulmonary function exams, the doctor can make an official diagnosis. Although there is no cure at this time, there are many treatment options available. The use of antibiotics and mucus-thinning medications can be used to treat infections and help lessen the amount of mucus in the lungs. Bronchodilators, oxygen therapy, and physical therapy have been useful to increase airflow to the lungs. In more serious cases, there are also surgical options available.

Although bronchiectasis is manageable, leaving the condition untreated could result in further lung damage. If you or someone you know is experiencing the symptoms of bronchiectasis, it is important to contact your doctor as soon as possible to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bronchiectasis" for support, advocacy or research.

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COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

Last Updated: 25 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bronchiectasis" for support, advocacy or research.

Logo
COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

http://www.copdfoundation.org

Last Updated: 25 Mar 2013

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General Resources

Bronchiectasis Research Registry

The Bronchiectasis Research Registry is a consolidated database of non-cystic fibrosis (non-CF) bronchiectasis patients and Nontuberculous Mycobacteria (NTM) patients from multiple clinical institutions.

Uploaded By: COPD Foundation

Updated 21 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bronchiectasis" returned 363 free, full-text research articles on human participants. First 3 results:

Capsaicin cough sensitivity and the association with clinical parameters in bronchiectasis.
 

Author(s): Wei-jie Guan, Yong-hua Gao, Gang Xu, Zhi-ya Lin, Yan Tang, Hui-min Li, Zhi-min Lin, Jin-ping Zheng, Rong-chang Chen, Nan-shan Zhong

Journal:

 

Cough hypersensitivity has been common among respiratory diseases.

Last Updated: 21 Nov 2014

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Impact of traffic related air pollution indicators on non-cystic fibrosis bronchiectasis mortality: a cohort analysis.
 

Author(s): Pieter C Goeminne, Esmee Bijnens, Ben Nemery, Tim S Nawrot, Lieven J Dupont

Journal:

 

Mortality in non-cystic fibrosis bronchiectasis (NCFB) is known to be influenced by a number of factors such as gender, age, smoking history and Pseudomonas aeruginosa, but the impact of traffic related air pollution indicators on NCFB mortality is unknown.

Last Updated: 8 Sep 2014

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Treatment adherence and health outcomes in patients with bronchiectasis.
 

Author(s): Amanda R McCullough, Michael M Tunney, Alexandra L Quittner, J Stuart Elborn, Judy M Bradley, Carmel M Hughes

Journal:

 

We aimed to determine adherence to inhaled antibiotics, other respiratory medicines and airway clearance and to determine the association between adherence to these treatments and health outcomes (pulmonary exacerbations, lung function and Quality of Life Questionnaire-Bronchiectasis ...

Last Updated: 11 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bronchiectasis" returned 25 free, full-text review articles on human participants. First 3 results:

Aerosolized antibiotics for non-cystic fibrosis bronchiectasis.
 

Author(s): Bruce K Rubin, Ronald W Williams

Journal: Respiration. 2014 ;88(3):177-84.

 

Patients with non-cystic fibrosis bronchiectasis (NCFB) share many of the respiratory symptoms and the disease progression of cystic fibrosis (CF). As there are no approved therapies for the management of NCFB, an approach has been to use therapies similar to those used to treat CF. ...

Last Updated: 17 Sep 2014

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Macrolide therapy in adults and children with non-cystic fibrosis bronchiectasis: a systematic review and meta-analysis.
 

Author(s): Yong-Hua Gao, Wei-Jie Guan, Gang Xu, Yan Tang, Yang Gao, Zhi-Ya Lin, Zhi-Min Lin, Nan-Shan Zhong, Rong-Chang Chen

Journal:

 

A systematic review and meta-analysis was conducted to evaluate the efficacy and safety of macrolide therapy in adults and children with bronchiectasis.

Last Updated: 7 Mar 2014

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Long-term macrolides for non-cystic fibrosis bronchiectasis: a systematic review and meta-analysis.
 

Author(s): Qibiao Wu, Weixing Shen, Haibo Cheng, Xiqiao Zhou

Journal: Respirology. 2014 Apr;19(3):321-9.

 

Long-term macrolides are increasingly being prescribed for stable bronchiectasis. This meta-analysis assessed the clinical effect of this treatment in bronchiectasis. A systematic review and meta-analysis were carried out. All randomized, controlled trials (RCT) comparing long-term ...

Last Updated: 13 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Natural History of Bronchiectasis
 

Status: Recruiting

Condition Summary: Bronchiectasis; Cystic Fibrosis; Autoimmune Disease; Common Variable Immunodeficiency

 

Last Updated: 24 Feb 2015

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Exercise Capacity in Bronchiectasis Resection
 

Status: Recruiting

Condition Summary: Bronchiectasis

 

Last Updated: 29 Dec 2010

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ELTGOL and Bronchiectasis. Respiratory Therapy
 

Status: Recruiting

Condition Summary: Respiratory; Complications, Therapy; Bronchiectasis

 

Last Updated: 16 Apr 2012

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