Bronchiectasis

Common Name(s)

Bronchiectasis

Bronchiectasis is a condition in which the tubes that carry air to the lungs slowly lose their ability to clear out mucus due to widening and scarring. As the mucus builds up, bacteria have the opportunity to grow. This bacterial growth leads to repeated, serious lung infections, causing damage to the airways. Over time, the airways can't move enough air in and out of the lungs, which may lead to the body’s vital organs not receiving enough oxygen.

Symptoms of this condition may include long-term (chronic) coughing, coughing up large amounts of mucus, wheezing, chest pain, shortness of breath, clubbing (where the skin beneath the nails becomes thicker), weight loss, and fatigue.

Bronchiectasis has two forms: congenital, which results from a problem with the lung development in a fetus, or acquired, which results from a viral or bacterial infection of the lungs. Lung (pulmonary) conditions including cystic fibrosis, pneumonia, tuberculosis, and COPD have also been known to cause bronchiectasis.

This condition is typically diagnosed when an affected individual expresses their symptoms to the doctor. Using a physical exam, a chest X-ray, and other pulmonary function exams, the doctor can make an official diagnosis. Although there is no cure at this time, there are many treatment options available. The use of antibiotics and mucus-thinning medications can be used to treat infections and help lessen the amount of mucus in the lungs. Bronchodilators, oxygen therapy, and physical therapy have been useful to increase airflow to the lungs. In more serious cases, there are also surgical options available.

Although bronchiectasis is manageable, leaving the condition untreated could result in further lung damage. If you or someone you know is experiencing the symptoms of bronchiectasis, it is important to contact your doctor as soon as possible to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bronchiectasis" for support, advocacy or research.

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COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

Last Updated: 25 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bronchiectasis" for support, advocacy or research.

Logo
COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

http://www.copdfoundation.org

Last Updated: 25 Mar 2013

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General Resources

Bronchiectasis Research Registry

The Bronchiectasis Research Registry is a consolidated database of non-cystic fibrosis (non-CF) bronchiectasis patients and Nontuberculous Mycobacteria (NTM) patients from multiple clinical institutions.

Uploaded By: COPD Foundation

Updated 21 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bronchiectasis" returned 442 free, full-text research articles on human participants. First 3 results:

High prevalence of bronchiectasis is linked to HTLV-1-associated inflammatory disease.
 

Author(s): Shohreh Honarbakhsh, Graham P Taylor

Journal:

 

Human T-lymphotropic virus type 1 (HTLV-1), a retrovirus, is the causative agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia/lymphoma (ATLL). The reported association with pulmonary disease such as bronchiectasis is less certain.

Last Updated: 7 Jul 2015

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Identification of a novel SERPINA-1 mutation causing alpha-1 antitrypsin deficiency in a patient with severe bronchiectasis and pulmonary embolism.
 

Author(s): Katrin Milger, Lesca Miriam Holdt, Daniel Teupser, Rudolf Maria Huber, Jürgen Behr, Nikolaus Kneidinger

Journal:

 

Deficiency in the serine protease inhibitor, alpha-1 antitrypsin (AAT), is known to cause emphysema and liver disease. Other manifestations, including airway disease or skin disorders, have also been described. A 44-year-old woman presented to our emergency department with dyspnea ...

Last Updated: 25 May 2015

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The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease.
 

Author(s): Yeon Wook Kim, Kwang-Nam Jin, Eun Young Heo, Sung Soo Park, Hee Soon Chung, Deog Kyeom Kim

Journal:

 

Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD), a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representative ...

Last Updated: 25 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bronchiectasis" returned 28 free, full-text review articles on human participants. First 3 results:

Year in review 2014: Interstitial lung disease, physiology, sleep and ventilation, acute respiratory distress syndrome, cystic fibrosis, bronchiectasis and rare lung disease.
 

Author(s): Toby M Maher, Amanda Piper, Yuanlin Song, Marcos I Restrepo, Neil D Eves

Journal: Respirology. 2015 Jul;20(5):834-45.

 

Last Updated: 15 Jun 2015

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The etiologies of non-CF bronchiectasis in childhood: a systematic review of 989 subjects.
 

Author(s): Kelly S Brower, Michael T Del Vecchio, Stephen C Aronoff

Journal:

 

While cystic fibrosis (CF) is the most common cause of bronchiectasis in childhood, non-CF bronchiectasis is associated with a wide variety of disorders. The objective of this study was to determine the relative prevalence and specific etiologies on non-CF bronchiectasis in childhood.

Last Updated: 27 Apr 2015

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Aerosolized antibiotics for non-cystic fibrosis bronchiectasis.
 

Author(s): Bruce K Rubin, Ronald W Williams

Journal: Respiration. 2014 ;88(3):177-84.

 

Patients with non-cystic fibrosis bronchiectasis (NCFB) share many of the respiratory symptoms and the disease progression of cystic fibrosis (CF). As there are no approved therapies for the management of NCFB, an approach has been to use therapies similar to those used to treat CF. ...

Last Updated: 17 Sep 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Natural History of Bronchiectasis
 

Status: Recruiting

Condition Summary: Bronchiectasis; Cystic Fibrosis; Autoimmune Disease; Common Variable Immunodeficiency

 

Last Updated: 15 Dec 2015

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Exercise Capacity in Bronchiectasis Resection
 

Status: Recruiting

Condition Summary: Bronchiectasis

 

Last Updated: 29 Dec 2010

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Prevention of Bronchiectasis in Infants With Cystic Fibrosis
 

Status: Recruiting

Condition Summary: Cystic Fibrosis; Bronchiectasis

 

Last Updated: 22 Oct 2014

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