Bronchiectasis

Common Name(s)

Bronchiectasis

Bronchiectasis is a condition in which the tubes that carry air to the lungs slowly lose their ability to clear out mucus due to widening and scarring. As the mucus builds up, bacteria have the opportunity to grow. This bacterial growth leads to repeated, serious lung infections, causing damage to the airways. Over time, the airways can't move enough air in and out of the lungs, which may lead to the body’s vital organs not receiving enough oxygen.

Symptoms of this condition may include long-term (chronic) coughing, coughing up large amounts of mucus, wheezing, chest pain, shortness of breath, clubbing (where the skin beneath the nails becomes thicker), weight loss, and fatigue.

Bronchiectasis has two forms: congenital, which results from a problem with the lung development in a fetus, or acquired, which results from a viral or bacterial infection of the lungs. Lung (pulmonary) conditions including cystic fibrosis, pneumonia, tuberculosis, and COPD have also been known to cause bronchiectasis.

This condition is typically diagnosed when an affected individual expresses their symptoms to the doctor. Using a physical exam, a chest X-ray, and other pulmonary function exams, the doctor can make an official diagnosis. Although there is no cure at this time, there are many treatment options available. The use of antibiotics and mucus-thinning medications can be used to treat infections and help lessen the amount of mucus in the lungs. Bronchodilators, oxygen therapy, and physical therapy have been useful to increase airflow to the lungs. In more serious cases, there are also surgical options available.

Although bronchiectasis is manageable, leaving the condition untreated could result in further lung damage. If you or someone you know is experiencing the symptoms of bronchiectasis, it is important to contact your doctor as soon as possible to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bronchiectasis" for support, advocacy or research.

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COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

Last Updated: 25 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Bronchiectasis" for support, advocacy or research.

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COPD Foundation

The mission of the COPD Foundation is to develop and support programs which improve the quality of life through research, education, early diagnosis, and enhanced therapy for persons whose lives are impacted by Chronic Obstructive Pulmonary Disease.

http://www.copdfoundation.org

Last Updated: 25 Mar 2013

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General Resources

Bronchiectasis Research Registry

The Bronchiectasis Research Registry is a consolidated database of non-cystic fibrosis (non-CF) bronchiectasis patients and Nontuberculous Mycobacteria (NTM) patients from multiple clinical institutions.

Uploaded By: COPD Foundation

Updated 21 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Bronchiectasis" returned 500 free, full-text research articles on human participants. First 3 results:

[Pachyonychia congenita associated with renal artery stenosis and bronchiectasis].
 

Author(s): El Alaoui Ismaili Fatiha, Chemlal Abdeljalil, Karimi Ilham, Benabdellah Nawal, Bentata Yassamine, Zizi Nada, Benajiba Nafissa, Haddiya Intissar

Journal:

 

Pachyonychia congenita (PC) is a rare hereditary disease, mainly characterized by a painful palmoplantar keratoderma, thickened nails, cysts and white lesions of the oral mucosa. Its clinical manifestations are very variable, it may appear from birth to adulthood. This study report ...

Last Updated: 31 Oct 2016

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Combined inhaled corticosteroid and long-acting β2-adrenergic agonist therapy for noncystic fibrosis bronchiectasis with airflow limitation: An observational study.
 

Author(s): Ping Wei, Jia-Wei Yang, Hai-Wen Lu, Bei Mao, Wen-Lan Yang, Jin-Fu Xu

Journal: Medicine (Baltimore). 2016 Oct;95(42):e5116.

 

There is presently no clear evidence on the effect of combined treatment for non-cystic fibrosis (non-CF) bronchiectasis with inhaled corticosteroid (ICS) and long-acting β2-adrenergic agonist (LABA). The objective of this study is to assess the efficacy and safety of salmeterol-fluticasone ...

Last Updated: 19 Oct 2016

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Factors associated with bronchiectasis in patients with moderate-severe chronic obstructive pulmonary disease.
 

Author(s): Jianmin Jin, Wenling Yu, Shuling Li, Lijin Lu, Xiaofang Liu, Yongchang Sun

Journal: Medicine (Baltimore). 2016 Jul;95(29):e4219.

 

A high prevalence of bronchiectasis was found by chest computed tomography (CT) in patients with moderate-severe chronic obstructive pulmonary disease (COPD), and it was shown to be associated with more severe symptoms, higher frequency of exacerbations and mortality. The risk factors ...

Last Updated: 22 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Bronchiectasis" returned 38 free, full-text review articles on human participants. First 3 results:

Bronchiectasis as a Comorbidity of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.
 

Author(s): Qingxia Du, Jianmin Jin, Xiaofang Liu, Yongchang Sun

Journal:

 

Bronchiectasis revealed by chest computed tomography in COPD patients and its comorbid effect on prognosis have not been addressed by large-sized studies. Understanding the presence of bronchiectasis in COPD is important for future intervention and preventing disease progression.

Last Updated: 16 Mar 2016

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Efficiency and safety of surgical intervention to patients with Non-Cystic Fibrosis bronchiectasis: a meta-analysis.
 

Author(s): Li-Chao Fan, Shuo Liang, Hai-Wen Lu, Ke Fei, Jin-Fu Xu

Journal:

 

No quantitative systematic review was found to report the efficiency and safety of surgical resection in the management of non-cystic fibrosis (non-CF) bronchiectasis. We therefore conducted a meta-analysis to assess the effects of operative intervention to patients with non-CF bronchiectasis. ...

Last Updated: 2 Dec 2015

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Distribution of Major Pathogens from Sputum and Bronchoalveolar Lavage Fluid in Patients with Noncystic Fibrosis Bronchiectasis: A Systematic Review.
 

Author(s): Xia-Yi Miao, Xiao-Bin Ji, Hai-Wen Lu, Jia-Wei Yang, Jin-Fu Xu

Journal: Chin. Med. J.. 2015 Oct;128(20):2792-7.

 

Noncystic fibrosis (non-CF) bronchiectasis remains as a common health problem in Asia. Pathogens' distribution in airways of patients with non-CF bronchiectasis is important for doctors to make right decision.

Last Updated: 20 Oct 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Role of Innate Immunity in Non-Cystic Fibrosis Bronchiectasis
 

Status: Recruiting

Condition Summary: Bronchiectasis

 

Last Updated: 7 Sep 2016

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Last Updated: 15 Aug 2016

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Bacteriology and Inflammation in Bronchiectasis
 

Status: Recruiting

Condition Summary: Bronchiectasis

 

Last Updated: 8 Aug 2016

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