Behcet's disease

Common Name(s)

Behcet's disease, Behcet disease

Behçet’s disease is a rare condition that causes inflammation in blood vessels throughout the body. Inflammation is characterized by redness, swelling and pain and is part of our normal immune response when injured or fighting infection. However, sometimes inflammation may be long term and cause problems. The inflammation caused by Behçet’s disease may lead to numerous symptoms that may seem unrelated. These signs and symptoms may include mouth sores, eye inflammation, skin rashes and lesions, joint swelling, enlarged veins and arteries, inflammation in the brain and genital sores. The symptoms vary from person to person and may disappear and recur. The cause of Behçet’s disease is unknown. It may be an autoimmune disorder, which means the body’s immune system may be mistakenly attacking its own healthy cells.

Risk factors include age, location, sex, and genes. Individuals in their 20’s and 30’s are most likely to develop Behçet’s disease. The disease occurs worldwide, but is more common in the Middle East and Far East. The condition occurs in both men and women, but is usually more severe in men. It is believed that certain genes are associated with a higher risk of developing Behçet’s.

There is no treatment to cure Behçet’s disease. Doctors usually treat signs and symptoms to reduce the risk of complications, such as blindness. There is no definitive diagnostic test for Behçet’s disease; therefore, your doctor may conduct a physical exam and blood tests to rule out other conditions. Talk with your doctor about the most current treatment options if you or a family member has been diagnosed with Behçet’s disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Behcet's disease" for support, advocacy or research.

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American Behcet's Disease Association (ABDA)

The American Behçet's Disease Association's mission is to provide support and information to people with Behçet's Disease and their families and to educate the medical community about Behçet's Disease. Through education, support, research and fundraising, the American Behçet's Disease Association is working to find a cure and to promote awareness and understanding of Behçet's Disease

Last Updated: 11 Feb 2013

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Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

Last Updated: 24 Jul 2015

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Deutsches Register Morbus Adamantiades-Behçet eV

The purpose of the association is the promotion of science and research in the field of Adamantiades-Behçet disease. This aim will be achieved by raising funds for the promotion of research projects in the field of Adamantiades-Behçet disease by other entities. Purpose of the association is the formation of doctors, patients and laypersons. Purpose of the association is also raising funds for the promotion of public health in the field of Adamantiades-Behçet disease by other entities.

Last Updated: 1 Apr 2013

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Behcet's disease" for support, advocacy or research.

Logo
American Behcet's Disease Association (ABDA)

The American Behçet's Disease Association's mission is to provide support and information to people with Behçet's Disease and their families and to educate the medical community about Behçet's Disease. Through education, support, research and fundraising, the American Behçet's Disease Association is working to find a cure and to promote awareness and understanding of Behçet's Disease

https://www.behcets.com

Last Updated: 11 Feb 2013

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Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

http://www.autoinflammatory.org

Last Updated: 24 Jul 2015

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Deutsches Register Morbus Adamantiades-Behçet eV

The purpose of the association is the promotion of science and research in the field of Adamantiades-Behçet disease. This aim will be achieved by raising funds for the promotion of research projects in the field of Adamantiades-Behçet disease by other entities. Purpose of the association is the formation of doctors, patients and laypersons. Purpose of the association is also raising funds for the promotion of public health in the field of Adamantiades-Behçet disease by other entities.

http://www.behcet.de

Last Updated: 1 Apr 2013

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

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General Resources

Healthier Ever After (injection tips book & program)

This child-friendly book is for patients and their families to learn how to manage their injectable medications, and has a program to help children to discuss and make a plan of care, and goals with rewards to chart on a reusable white board page.

Updated 6 May 2015

Open Doc
 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Behcet's disease" returned 829 free, full-text research articles on human participants. First 3 results:

Efficacy and Safety of Intravenous Immunoglobulin Treatment in Refractory Behcet's Disease with Different Organ Involvement: A Case Series.
 

Author(s): Luca Cantarini, Maria L Stromillo, Antonio Vitale, Giuseppe Lopalco, Giacomo Emmi, Elena Silvestri, Antonio Federico, Mauro Galeazzi, Florenzo Iannone, Nicola De Stefano

Journal: Isr. Med. Assoc. J.. ;18(3-4):238-42.

 

Behçet's disease (BD) is a multi-systemic disorder of unknown etiology characterized by relapsing oral-genital ulcers, uveitis, and involvement of the articular, gastrointestinal, neurologic, and vascular systems. The choice of treatment is based on the severity of systemic involvement, ...

Last Updated: 27 May 2016

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Behçet's: A Disease or a Syndrome? Answer from an Expression Profiling Study.
 

Author(s): Ali Kemal Oğuz, Seda Taşır Yılmaz, Çağdaş Şahap Oygür, Tuba Çandar, Irmak Sayın, Sibel Serin Kılıçoğlu, İhsan Ergün, Aşkın Ateş, Hilal Özdağ, Nejat Akar

Journal:

 

Behçet's disease (BD) is a chronic, relapsing, multisystemic inflammatory disorder with unanswered questions regarding its etiology/pathogenesis and classification. Distinct manifestation based subsets, pronounced geographical variations in expression, and discrepant immunological ...

Last Updated: 19 Feb 2016

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Genetic Variation in the REL Gene Increases Risk of Behcet's Disease in a Chinese Han Population but That of PRKCQ Does Not.
 

Author(s): Feilan Chen, Lei Xu, Tingting Zhao, Xiang Xiao, Yongquan Pan, Shengping Hou

Journal:

 

Genome-wide association studies (GWAS) and candidate gene studies have identified the REL and PRKCQ genes as risk loci for various autoimmune diseases. The purpose of the present study was to investigate the association of the REL and PRKCQ genes with Behcet's disease (BD) in a Chinese ...

Last Updated: 20 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Behcet's disease" returned 83 free, full-text review articles on human participants. First 3 results:

Interleukin-1 Inhibition in Behçet's disease.
 

Author(s): Antonio Vitale, Donato Rigante, Giuseppe Lopalco, Carlo Selmi, Mauro Galeazzi, Florenzo Iannone, Luca Cantarini

Journal: Isr. Med. Assoc. J.. ;18(3-4):171-6.

 

Behçet's disease (BD) is a systemic inflammatory disorder characterized by a protean clinical spectrum and an enigmatic pathogenesis. After being classified as an autoimmune disorder, spondyloarthritis and vasculitis, today BD is considered at the crossroad between autoimmune and ...

Last Updated: 27 May 2016

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Intestinal Behçet's Disease: A True Inflammatory Bowel Disease or Merely an Intestinal Complication of Systemic Vasculitis?
 

Author(s): Duk Hwan Kim, Jae Hee Cheon

Journal: Yonsei Med. J.. 2016 Jan;57(1):22-32.

 

Behçet's disease (BD) is a multi-systemic inflammatory disorder of an unknown etiology and shows a chronic recurrent clinical course. When the disease involves the alimentary tract, it is called intestinal BD because of its clinical importance. Intestinal BD is more frequently reported ...

Last Updated: 3 Dec 2015

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A Clinical Picture of the Visual Outcome in Adamantiades-Behçet's Disease.
 

Author(s): Michele Figus, Chiara Posarelli, Timothy G Albert, Rosaria Talarico, Marco Nardi

Journal: Biomed Res Int. 2015 ;2015():120519.

 

Adamantiades-Behçet's disease is a multisystemic vasculitis with multiorgan involvement. Ocular disorders occur often in this syndrome typically in the form of a relapsing-remitting panuveitis and vasculitis and can lead to blindness as one of its most disabling complications if ...

Last Updated: 11 Nov 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Immunogenetic Mechanisms in Behcet's Disease
 

Status: Recruiting

Condition Summary: Behcet's Disease; Uveitis

 

Last Updated: 12 Aug 2016

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Last Updated: 11 Jul 2016

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