Behcet's disease

Common Name(s)

Behcet's disease, Behcet disease

Behçet’s disease is a rare condition that causes inflammation in blood vessels throughout the body. Inflammation is characterized by redness, swelling and pain and is part of our normal immune response when injured or fighting infection. However, sometimes inflammation may be long term and cause problems. The inflammation caused by Behçet’s disease may lead to numerous symptoms that may seem unrelated. These signs and symptoms may include mouth sores, eye inflammation, skin rashes and lesions, joint swelling, enlarged veins and arteries, inflammation in the brain and genital sores. The symptoms vary from person to person and may disappear and recur. The cause of Behçet’s disease is unknown. It may be an autoimmune disorder, which means the body’s immune system may be mistakenly attacking its own healthy cells.

Risk factors include age, location, sex, and genes. Individuals in their 20’s and 30’s are most likely to develop Behçet’s disease. The disease occurs worldwide, but is more common in the Middle East and Far East. The condition occurs in both men and women, but is usually more severe in men. It is believed that certain genes are associated with a higher risk of developing Behçet’s.

There is no treatment to cure Behçet’s disease. Doctors usually treat signs and symptoms to reduce the risk of complications, such as blindness. There is no definitive diagnostic test for Behçet’s disease; therefore, your doctor may conduct a physical exam and blood tests to rule out other conditions. Talk with your doctor about the most current treatment options if you or a family member has been diagnosed with Behçet’s disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Behcet's disease" for support, advocacy or research.

Logo
American Behcet's Disease Association (ABDA)

The American Behçet's Disease Association's mission is to provide support and information to people with Behçet's Disease and their families and to educate the medical community about Behçet's Disease. Through education, support, research and fundraising, the American Behçet's Disease Association is working to find a cure and to promote awareness and understanding of Behçet's Disease

Last Updated: 11 Feb 2013

View Details
Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

Last Updated: 24 Jul 2015

View Details
Deutsches Register Morbus Adamantiades-Behçet eV

The purpose of the association is the promotion of science and research in the field of Adamantiades-Behçet disease. This aim will be achieved by raising funds for the promotion of research projects in the field of Adamantiades-Behçet disease by other entities. Purpose of the association is the formation of doctors, patients and laypersons. Purpose of the association is also raising funds for the promotion of public health in the field of Adamantiades-Behçet disease by other entities.

Last Updated: 1 Apr 2013

View Details
stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Behcet's disease" for support, advocacy or research.

Logo
American Behcet's Disease Association (ABDA)

The American Behçet's Disease Association's mission is to provide support and information to people with Behçet's Disease and their families and to educate the medical community about Behçet's Disease. Through education, support, research and fundraising, the American Behçet's Disease Association is working to find a cure and to promote awareness and understanding of Behçet's Disease

https://www.behcets.com

Last Updated: 11 Feb 2013

View Details
Autoinflammatory Alliance

The Autoinflammatory Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases. We started in 2006 under the name, The NOMID Alliance with the same basic goal: to help patients with CAPS and other autoinflammatory diseases. We have a IRS approval as tax-exempt under both names.

http://www.autoinflammatory.org

Last Updated: 24 Jul 2015

View Details
Deutsches Register Morbus Adamantiades-Behçet eV

The purpose of the association is the promotion of science and research in the field of Adamantiades-Behçet disease. This aim will be achieved by raising funds for the promotion of research projects in the field of Adamantiades-Behçet disease by other entities. Purpose of the association is the formation of doctors, patients and laypersons. Purpose of the association is also raising funds for the promotion of public health in the field of Adamantiades-Behçet disease by other entities.

http://www.behcet.de

Last Updated: 1 Apr 2013

View Details
stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

Healthier Ever After (injection tips book & program)

This child-friendly book is for patients and their families to learn how to manage their injectable medications, and has a program to help children to discuss and make a plan of care, and goals with rewards to chart on a reusable white board page.

Updated 6 May 2015

Open Doc
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Behcet's disease" returned 813 free, full-text research articles on human participants. First 3 results:

Reconstitution of disrupted photoreceptor layer in uveitis associated with Behçet's disease by infliximab treatment.
 

Author(s): Masaru Takeuchi, Kozo Harimoto, Manzo Taguchi, Yutaka Sakurai

Journal:

 

Behçet's disease (BD)-associated uveitis causes retinal damage leading to severe visual disturbance. The early morphological changes in the retina are revealed by disappearance or disruption of the external limiting membrane (ELM), inner segment ellipsoid zone (EZ) and cone interdigitation ...

Last Updated: 15 Dec 2015

Go To URL
Putative Role of Serum Amyloid-A and Proinflammatory Cytokines as Biomarkers for Behcet's Disease.
 

Author(s): Giuseppe Lopalco, Orso Maria Lucherini, Antonio Vitale, Rosaria Talarico, Antonio Lopalco, Mauro Galeazzi, Giovanni Lapadula, Luca Cantarini, Florenzo Iannone

Journal: Medicine (Baltimore). 2015 Oct;94(42):e1858.

 

Behcet's disease (BD) is a multisystemic disorder of unknown etiology characterized by relapsing oral-genital ulcers, uveitis, and involvement of vascular, gastrointestinal, neurological, and musculoskeletal system. Although disease pathogenesis is still unclear, both innate and adaptive ...

Last Updated: 27 Oct 2015

Go To URL
[Multiple small bowel perforations due to Behcet's disease].
 

Author(s): Tevfik Eker, Aydan Eroğlu

Journal: Ulus Travma Acil Cerrahi Derg. 2015 Jul;21(4):300-2.

 

Behcet's disease is a chronic, relapsing, multisystemic, idiopathic, and inflammatory disease. A common gastrointestinal site other than the mouth is the ileocecal region. Intestinal ulcers, due to Behcet's disease, can cause perforation. A 19-year-old male patient was admitted to ...

Last Updated: 16 Sep 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Behcet's disease" returned 75 free, full-text review articles on human participants. First 3 results:

Successful Treatment with Infliximab for Refractory Uveitis in a Hemodialysis Patient with Behçet's Disease and a Review of the Literature for Infliximab Use in Patients on Hemodialysis.
 

Author(s): Izumi Kurata, Hiroto Tsuboi, Hidenori Takahashi, Saori Abe, Hiroshi Ebe, Shinya Hagiwara, Naoto Umeda, Yuya Kondo, Hiroshi Ogishima, Takeshi Suzuki, Isao Matsumoto, Sujin Hoshi, Tetsuro Oshika, Takayuki Sumida

Journal: Intern. Med.. 2015 ;54(12):1553-7.

 

A 36-year-old man with a 16-year history of refractory Behçet's disease (BD)-associated uveitis and chronic renal failure requiring hemodialysis suffered from frequent ocular attacks despite treatment with systemic corticosteroids and cyclosporine A. Following infliximab administration, ...

Last Updated: 15 Jun 2015

Go To URL
Gastrointestinal Behçet's disease: a review.
 

Author(s): Wasseem Skef, Matthew J Hamilton, Thurayya Arayssi

Journal: World J. Gastroenterol.. 2015 Apr;21(13):3801-12.

 

Behçet's disease (BD) is an idiopathic, chronic, relapsing, multi-systemic vasculitis characterized by recurrent oral and genital aphthous ulcers, ocular disease and skin lesions. Prevalence of BD is highest in countries along the ancient silk road from the Mediterranean basin to ...

Last Updated: 8 Apr 2015

Go To URL
[Case of Behcet's disease diagnosed by bilateral epididymitis].
 

Author(s): Sayaka Horii, Shingo Takada, Takanori Kinjo, Daichi Nonomura, Yoshiyuki Yamamoto, Suguru Yoneda, Hironori Nomura, Norihide Tei, Kiyomi Matsumiya, Yoshimi Shiroyama

Journal: Hinyokika Kiyo. 2014 Nov;60(11):593-6.

 

A 24-year-old man visited our emergency room with testicular pain and left shoulder pain, and was admitted to our hospital for diagnosis of bilateral epididymitis. Antibiotics and anti-inflammatory medication were started, but the symptoms did not improve. During hospitalization, ...

Last Updated: 16 Dec 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Immunogenetic Mechanisms in Behcet's Disease
 

Status: Recruiting

Condition Summary: Behcet's Disease; Uveitis

 

Last Updated: 20 May 2016

Go to URL
Special Investigation in Patients With Intestinal Behcet's Disease (All Case Investigation)
 

Status: Recruiting

Condition Summary: Behcet's Disease

 

Last Updated: 16 May 2016

Go to URL
1 Year Canakinumab Treatment in Behcet's Disease Patients With Neurologic or Vascular Involvement
 

Status: Not yet recruiting

Condition Summary: Behcet Disease

 

Last Updated: 26 Apr 2016

Go to URL