Behcet's Disease

Common Name(s)

Behcet's Disease, Behcet Disease

Behcet's disease is a chronic multisystem inflammatory disorder characterized by ulcers affecting the mouth and genitals, various skin lesions, and abnormalities affecting the eyes.  Although it can happen at any age, symptoms generally begin when individuals are in their 20s or 30s. The disease is common in Japan, Turkey and Israel, and less common in the United States. The exact cause of Behcet's disease is unknown.   Treatment is symptomatic and supportive.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Behcet's Disease" for support, advocacy or research.

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American Behcet's Disease Association (ABDA)

The American Behçet's Disease Association's mission is to provide support and information to people with Behçet's Disease and their families and to educate the medical community about Behçet's Disease. Through education, support, research and fundraising, the American Behçet's Disease Association is working to find a cure and to promote awareness and understanding of Behçet's Disease

Last Updated: 11 Feb 2013

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Deutsches Register Morbus Adamantiades-Behçet eV

The purpose of the association is the promotion of science and research in the field of Adamantiades-Behçet disease. This aim will be achieved by raising funds for the promotion of research projects in the field of Adamantiades-Behçet disease by other entities. Purpose of the association is the formation of doctors, patients and laypersons. Purpose of the association is also raising funds for the promotion of public health in the field of Adamantiades-Behçet disease by other entities.

Last Updated: 1 Apr 2013

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

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The NOMID Alliance

The NOMID Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases.

Last Updated: 16 Aug 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Behcet's Disease" for support, advocacy or research.

Logo
American Behcet's Disease Association (ABDA)

The American Behçet's Disease Association's mission is to provide support and information to people with Behçet's Disease and their families and to educate the medical community about Behçet's Disease. Through education, support, research and fundraising, the American Behçet's Disease Association is working to find a cure and to promote awareness and understanding of Behçet's Disease

https://www.behcets.com

Last Updated: 11 Feb 2013

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Deutsches Register Morbus Adamantiades-Behçet eV

The purpose of the association is the promotion of science and research in the field of Adamantiades-Behçet disease. This aim will be achieved by raising funds for the promotion of research projects in the field of Adamantiades-Behçet disease by other entities. Purpose of the association is the formation of doctors, patients and laypersons. Purpose of the association is also raising funds for the promotion of public health in the field of Adamantiades-Behçet disease by other entities.

http://www.behcet.de

Last Updated: 1 Apr 2013

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stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

View Details
The NOMID Alliance

The NOMID Alliance is a 501 (c)(3) non-profit public charity dedicated to promoting awareness, proper diagnosis and treatment, and improved care for people with autoinflammatory diseases.

http://www.nomidalliance.org

Last Updated: 16 Aug 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Behcet's Disease" returned 687 free, full-text research articles on human participants. First 3 results:

Decreased expression of the aryl hydrocarbon receptor in ocular Behcet's disease.
 

Author(s): Chaokui Wang, Zi Ye, Aize Kijlstra, Yan Zhou, Peizeng Yang

Journal: Mediators Inflamm.. 2014 ;2014():195094.

 

Recent studies show that the aryl hydrocarbon receptor (AhR) is involved in immune responses. AhR is activated following interaction with its ligands, such as 6-formylindolo[3,2-b]carbazole (FICZ) and 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE). In this ...

Last Updated: 21 Jul 2014

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Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease.
 

Author(s): Marina Mesquida, Blanca Molins, Victor Llorenç, Maite Sainz de la Maza, María Victoria Hernandez, Gerard Espinosa, Alfredo Adán

Journal: Mediators Inflamm.. 2014 ;2014():396204.

 

The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behçet's disease (BD) and to compare them with those obtained from healthy control subjects. We determined the ...

Last Updated: 4 Jul 2014

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The role of CTLA-4 exon-1 49 A/G polymorphism and soluble CTLA-4 protein level in egyptian patients with Behçet's disease.
 

Author(s): Sahar M Abdel Galil, Hoda A Hagrass

Journal: Biomed Res Int. 2014 ;2014():513915.

 

This study analyzed the association of the A/G SNP at position +49 of exon-1 in the CTLA-4 gene to the susceptibility and clinical manifestations of Behcet's disease (BD). It was performed on 60 Egyptian BD patients and 95 age- and sex-matched healthy controls. The genotypes for the ...

Last Updated: 3 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Behcet's Disease" returned 70 free, full-text review articles on human participants. First 3 results:

Immunopathogenesis of ocular Behçet's disease.
 

Author(s): Un Chul Park, Tae Wan Kim, Hyeong Gon Yu

Journal: J Immunol Res. 2014 ;2014():653539.

 

Behçet's disease (BD) is a chronic recurrent systemic inflammatory disorder of unknown etiology characterized by oral and genital ulcerations, skin lesions, and uveitis. The ocular involvement of BD, or Behçet's uveitis (BU), is characterized by panuveitis or posterior uveitis with ...

Last Updated: 25 Jul 2014

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Biological treatments in Behçet's disease: beyond anti-TNF therapy.
 

Author(s): Francesco Caso, Luisa Costa, Donato Rigante, Orso Maria Lucherini, Paolo Caso, Vittoria Bascherini, Bruno Frediani, Rolando Cimaz, Edoardo Marrani, Laura Nieves-Martín, Mariangela Atteno, Carmela G L Raffaele, Giusyda Tarantino, Mauro Galeazzi, Leonardo Punzi, Luca Cantarini

Journal: Mediators Inflamm.. 2014 ;2014():107421.

 

Behçet's disease (BD) is universally recognized as a multisystemic inflammatory disease of unknown etiology with chronic course and unpredictable exacerbations: its clinical spectrum varies from pure vasculitic manifestations with thrombotic complications to protean inflammatory ...

Last Updated: 25 Jul 2014

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Behçet's disease-like symptoms associated with myelodysplastic syndrome with trisomy 8: a case report and review of the literature.
 

Author(s): Hanako Koguchi-Yoshioka, Daisuke Inokuma, Masatoshi Kanda, Makoto Kondo, Kazuhiro Kikuchi, Satoko Shimizu

Journal: Acta Derm. Venereol.. 2014 May;94(3):355-6.

 

Last Updated: 7 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Immunogenetic Mechanisms in Behcet's Disease
 

Status: Recruiting

Condition Summary: Behcet's Disease; Uveitis

 

Last Updated: 21 Jan 2015

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Efficacy and Safety Study of Gevokizumab to Treat Behcet's Disease Uveitis
 

Status: Recruiting

Condition Summary: Behcet's Disease Uveitis

 

Last Updated: 21 Nov 2014

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Special Investigation in Patients With Intestinal Behcet's Disease (All Case Investigation)
 

Status: Recruiting

Condition Summary: Behcet's Disease

 

Last Updated: 16 Feb 2015

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