Becker muscular dystrophy

Common Name(s)

Becker muscular dystrophy

Becker muscular dystrophy (BMD) is a genetic disorder that causes progressive muscle weakness and decreased muscle tissue (atrophy). BMD is a milder form of Duchenne muscular dystrophy. It is seen mostly in males with symptoms typically beginning in the teenage years or later. Symptoms of the condition begin with muscle weakness in the lower body, usually in the legs and pelvis area. This weakness progresses, causing difficulty with walking, running, and jumping. Individuals with BMD may lose the ability to walk, but typically much later than individuals with Duchenne muscular dystrophy. Another symptom of BMD is weakness of the heart muscle (cardiomyopathy), which may cause shortness of breath, abnormal heartbeat (arrhythmia), and extreme tiredness (fatigue).

BMD, which is caused by mutations in the DMD gene, is inherited in an X-linked recessive pattern. Males have one copy of the DMD gene while females have two copies. Males who have a mutation in their only copy of the gene have the condition, while females with a mutation in one of their two copies typically do not.

In order to diagnose this condition, your child’s doctor will take a detailed medical history, perform a physical exam, and likely perform one of many possible tests, which can include collecting and examining a small piece of muscle tissue (muscle biopsy), measuring electrical activity in muscles (electromyography), measuring the amount of CK enzyme in blood, as well as monitoring the heart and lungs. DMD gene testing is typically needed to confirm the diagnosis. Treatment of BMD is geared towards managing symptoms in order to maximize quality of life. Medications may be prescribed to help with pain. Physical activity can help maintain strength. Physical therapy and orthopedic devices such as braces and wheelchairs may be helpful for self-care and independent movement. Talk with a doctor about the right treatment for you or your child.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Becker muscular dystrophy" for support, advocacy or research.

LGMD-diagnosis.org

LGMD-diagnosis.org is sponsored by a consortium of family foundations that each focus on a separate form of LGMD. By coming together and pooling resources, the consortium foundations are rapidly and efficiently diagnosing many patients. The consortium includes the Cecil B Day Family, Inc (LGMD2B), Coalition to Cure Calpain 3 (LGMD2A), Jain Foundation (LGMD2B), Kurt + Peter Foundation (LGMD2C), LGMD2D Foundation, LGMD2I Fund, and McColl-Lockwood Laboratory (LGMD2I).

Last Updated: 22 May 2015

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Neuromuscular Disease Association of China

There are over 40 different types of Muscular Dystrophy and related Neuromuscular conditions.These conditions are characterised by loss of muscular strength,as progressive muscle wasting or nerve

Last Updated: 21 May 2010

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Parent Project Muscular Dystrophy

Parent Project Muscular Dystrophy’s mission is to end Duchenne. We accelerate research, raise our voices in Washington, demand optimal care for all young men, and educate the global community.

Last Updated: 15 Nov 2012

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Thisbe and Noah Scott Foundation, Inc.

It is the mission of the Thisbe and Noah Scott Foundation, Inc. to save lives by promoting research, awareness and support for children and families affected by pediatric neuromuscular diseases.

Last Updated: 19 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Becker muscular dystrophy" for support, advocacy or research.

LGMD-diagnosis.org

LGMD-diagnosis.org is sponsored by a consortium of family foundations that each focus on a separate form of LGMD. By coming together and pooling resources, the consortium foundations are rapidly and efficiently diagnosing many patients. The consortium includes the Cecil B Day Family, Inc (LGMD2B), Coalition to Cure Calpain 3 (LGMD2A), Jain Foundation (LGMD2B), Kurt + Peter Foundation (LGMD2C), LGMD2D Foundation, LGMD2I Fund, and McColl-Lockwood Laboratory (LGMD2I).

https://www.lgmd-diagnosis.org

Last Updated: 22 May 2015

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Neuromuscular Disease Association of China

There are over 40 different types of Muscular Dystrophy and related Neuromuscular conditions.These conditions are characterised by loss of muscular strength,as progressive muscle wasting or nerve

http://www.mdachina.org

Last Updated: 21 May 2010

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Parent Project Muscular Dystrophy

Parent Project Muscular Dystrophy’s mission is to end Duchenne. We accelerate research, raise our voices in Washington, demand optimal care for all young men, and educate the global community.

http://www.parentprojectmd.org

Last Updated: 15 Nov 2012

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Thisbe and Noah Scott Foundation, Inc.

It is the mission of the Thisbe and Noah Scott Foundation, Inc. to save lives by promoting research, awareness and support for children and families affected by pediatric neuromuscular diseases.

http://www.thisbeandnoah.org/

Last Updated: 19 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Becker muscular dystrophy" returned 126 free, full-text research articles on human participants. First 3 results:

Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.
 

Author(s): Narinder Janghra, Jennifer E Morgan, Caroline A Sewry, Francis X Wilson, Kay E Davies, Francesco Muntoni, Jonathon Tinsley

Journal:

 

Duchenne muscular dystrophy is a severe and currently incurable progressive neuromuscular condition, caused by mutations in the DMD gene that result in the inability to produce dystrophin. Lack of dystrophin leads to loss of muscle fibres and a reduction in muscle mass and function. ...

Last Updated: 15 Mar 2016

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Life-threatening Arrhythmias in a Becker Muscular Dystrophy Family due to the Duplication of Exons 3-4 of the Dystrophin Gene.
 

Author(s): Masatoshi Ishizaki, Akiko Fujimoto, Hidetsugu Ueyama, Yasuto Nishida, Shigehiro Imamura, Makoto Uchino, Yukio Ando

Journal: Intern. Med.. 2015 ;54(23):3075-8.

 

We herein present a report of three patients with Becker muscular dystrophy in the same family who developed complete atrioventricular block or ventricular tachycardia with severe cardiomyopathy. Our cases became unable to walk in their teens, and were introduced to mechanical ventilation ...

Last Updated: 3 Dec 2015

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TNF-α-Induced microRNAs Control Dystrophin Expression in Becker Muscular Dystrophy.
 

Author(s): Alyson A Fiorillo, Christopher R Heier, James S Novak, Christopher B Tully, Kristy J Brown, Kitipong Uaesoontrachoon, Maria C Vila, Peter P Ngheim, Luca Bello, Joe N Kornegay, Corrado Angelini, Terence A Partridge, Kanneboyina Nagaraju, Eric P Hoffman

Journal: Cell Rep. 2015 Sep;12(10):1678-90.

 

The amount and distribution of dystrophin protein in myofibers and muscle is highly variable in Becker muscular dystrophy and in exon-skipping trials for Duchenne muscular dystrophy. Here, we investigate a molecular basis for this variability. In muscle from Becker patients sharing ...

Last Updated: 10 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Becker muscular dystrophy" returned 7 free, full-text review articles on human participants. First 3 results:

[Advance in therapy for Duchenne/Becker muscular dystrophy].
 

Author(s): Tian-Tian Xu, Dan Lan

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Mar;17(3):294-8.

 

Duchenne/Becker muscular dystrophy (DMD/BMD) is the most common X-linked recessive inherited neuromuscular disease, characterized by progressive muscle weakness. Mutations in the dystrophin gene are responsible for this disease. Treatment for this disease has always been a topic of ...

Last Updated: 30 Mar 2015

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Read-through strategies for suppression of nonsense mutations in Duchenne/ Becker muscular dystrophy: aminoglycosides and ataluren (PTC124).
 

Author(s): Richard S Finkel

Journal: J. Child Neurol.. 2010 Sep;25(9):1158-64.

 

Nucleotide changes within an exon can alter the trinucleotide normally encoding a particular amino acid, such that a new ''stop'' signal is transcribed into the mRNA open reading frame. This causes the ribosome to prematurely terminate its reading of the mRNA, leading to nonsense-mediated ...

Last Updated: 6 Sep 2010

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Current understanding and management of dilated cardiomyopathy in Duchenne and Becker muscular dystrophy.
 

Author(s): Rita Wen Kaspar, Hugh D Allen, Federica Montanaro

Journal: J Am Acad Nurse Pract. 2009 May;21(5):241-9.

 

To review the current understanding of the pathophysiology of dilated cardiomyopathy (DCM) in patients with Duchenne and Becker muscular dystrophies, assessment of cardiac dysfunction for these patients, and the recommended pharmacological treatment options and ongoing research directions.

Last Updated: 12 May 2009

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study)
 

Status: Recruiting

Condition Summary: Becker Muscular Dystrophy

 

Last Updated: 23 Aug 2013

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Muscle MRI in Becker Muscular Dystrophy and in Limb-girdle Muscular Dystrophy Type 2I
 

Status: Recruiting

Condition Summary: Becker Muscular Dystrophy; Limb-Girdle Muscular Dystrophy Type 2I

 

Last Updated: 16 Jun 2014

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Ramipril Versus Carvedilol in Duchenne and Becker Patients
 

Status: Recruiting

Condition Summary: Duchenne Muscular Dystrophy; Becker Muscular Dystrophy

 

Last Updated: 27 Jan 2016

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