Alcohol dependence

Common Name(s)

Alcohol dependence, Alcoholism, Alcohol addiction

Alcoholism means a person is physically or mentally dependent on alcohol. It is a serious medical condition. People with alcoholism often struggle to live normal lives. They may try to hide their problem. Yet drinking too much alcohol can lead to poor life choices such as drinking and driving. Alcohol can cause serious health consequences. Symptoms of alcoholism may include not being able to stop drinking or having a hard time controlling how much you drink, needing more alcohol to feel good, spending a lot of time drinking and recovering from drinking, giving up other activities so you can drink, and withdrawal symptoms if you stop drinking or wait too long between drinks. Withdrawal symptoms may include feeling sick to your stomach, sweating, shakiness and anxiety. Alcoholism may interfere with your relationships and your ability to perform your job.

Alcoholism may be caused by a variety of factors. Genetic, psychological, social and environmental factors may all be part of the cause. Risk factors include steady drinking over time or binge drinking on a regular basis, starting to drink alcohol at a young age, a family history of alcoholism, and suffering from depression, bipolar disorder or anxiety. Alcoholism increases your risk for developing liver damage (cirrhosis), digestive problems, heart problems, sexual dysfunction, birth defects, bone loss, neurological complications and complications with diabetes. Alcoholism can weaken your immune system and increase your risk of certain cancers. Talk to your doctor if you or a family member may have an alcohol addiction. They may ask you a series of questions to determine if you are addicted to alcohol and to rule out other conditions. There are a variety of treatments to help you stop drinking including both inpatient and outpatient programs and private and group counseling. Your doctor can help you decide the best treatment plan for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alcohol dependence" for support, advocacy or research.

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National Council on Alcoholism and Drug Dependence, Inc. (NCADD)

The National Council on Alcoholism and Drug Dependence, Inc. (NCADD) and its Affiliate Network is a voluntary health organization dedicated to fighting the Nation's #1 health problem -- alcoholism, drug addiction and the devastating consequences of alcohol and other drugs on individuals, families and communities.

Last Updated: 8 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alcohol dependence" for support, advocacy or research.

Logo
National Council on Alcoholism and Drug Dependence, Inc. (NCADD)

The National Council on Alcoholism and Drug Dependence, Inc. (NCADD) and its Affiliate Network is a voluntary health organization dedicated to fighting the Nation's #1 health problem -- alcoholism, drug addiction and the devastating consequences of alcohol and other drugs on individuals, families and communities.

https://ncadd.org/

Last Updated: 8 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Alcohol dependence" returned 718 free, full-text research articles on human participants. First 3 results:

Incongruent reduction of dopamine transporter availability in different subgroups of alcohol dependence.
 

Author(s): Che-Hung Yen, Mei-Chen Shih, Cheng-Yi Cheng, Kuo-Hsing Ma, Ru-Band Lu, San-Yuan Huang

Journal: Medicine (Baltimore). 2016 Aug;95(33):e4048.

 

The dopamine transporter (DAT) plays a crucial role in the pathogenesis of alcohol dependence (AD) and major depression (MD), and males have more risk factors for the development of AD. However, imaging studies on brain DAT availability in males with AD comorbid with MD (AD/MD) are ...

Last Updated: 19 Aug 2016

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[μ-Opioid Receptor Gene (OPRM1) Polymorphisms A118G and C17T in Alcohol Dependence: A Turkish Sample].
 

Author(s): Şeref Can Gürel, Yavuz Ayhan, Çağatay Karaaslan, Hayriye Akel, Ragıp Özgür Karaca, Melih Önder Babaoğlu, Ümit Yaşar, Atilla Bozkurt, Nesrin Dilbaz, Berna Diclenur Uluğ, Başaran Demir

Journal: Turk Psikiyatri Derg. 2016 ;27(2):0.

 

Previous investigations on opioid system genetics have identified polymorphisms of the OPRM1 gene expressing μ-opioid receptors to be significantly associated with some features of alcohol dependence (AD). In the present study, we evaluated the relationship between single nucleotide ...

Last Updated: 2 Jul 2016

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Women with alcohol dependence: A randomized trial of couple versus individual plus couple therapy.
 

Author(s): Barbara S McCrady, Elizabeth E Epstein, Kevin A Hallgren, Sharon Cook, Noelle K Jensen

Journal: Psychol Addict Behav. 2016 05;30(3):287-99.

 

Couple therapy for women with alcohol use disorders (AUDs) yields positive drinking outcomes, but many women prefer individual to conjoint treatment. The present study compared conjoint cognitive-behavioral therapy (CBT) for women with AUDs to a blend of individual and conjoint therapy. ...

Last Updated: 24 May 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Alcohol dependence" returned 89 free, full-text review articles on human participants. First 3 results:

Risks and Benefits of Nalmefene in the Treatment of Adult Alcohol Dependence: A Systematic Literature Review and Meta-Analysis of Published and Unpublished Double-Blind Randomized Controlled Trials.
 

Author(s): Clément Palpacuer, Bruno Laviolle, Rémy Boussageon, Jean Michel Reymann, Eric Bellissant, Florian Naudet

Journal:

 

Nalmefene is a recent option in alcohol dependence treatment. Its approval was controversial. We conducted a systematic review and meta-analysis of the aggregated data (registered as PROSPERO 2014:CRD42014014853) to compare the harm/benefit of nalmefene versus placebo or active comparator ...

Last Updated: 23 Dec 2015

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Should naltrexone be the first-line medicine to treat alcohol dependence in Aboriginal and Torres Strait Islander populations? An Australian perspective.
 

Author(s): Jonathan Brett, Rowena Ivers, Michael Doyle, Leanne Lawrence, Kate Conigrave

Journal: Aust Fam Physician. 2015 ;44(11):815-9.

 

There is a pressing need to improve alcohol treatment services for Aboriginal and Torre Strait Islander peoples with alcohol dependence. One component of treatment is the use of medicines including naltrexone and acamprosate. Access to these medicines among the general drinking population ...

Last Updated: 23 Nov 2015

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How Imaging Glutamate, γ-Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal.
 

Author(s): Ansel T Hillmer, Graeme F Mason, Lisa M Fucito, Stephanie S O'Malley, Kelly P Cosgrove

Journal: Alcohol. Clin. Exp. Res.. 2015 Dec;39(12):2268-82.

 

Neuroimaging studies have dramatically advanced our understanding of the neurochemical basis of alcohol dependence, a major public health issue. In this paper, we review the research generated from neurochemical specific imaging modalities including magnetic resonance spectroscopy, ...

Last Updated: 13 Jan 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment for Alcohol Dependence With Gabapentin
 

Status: Recruiting

Condition Summary: Alcohol Dependence

 

Last Updated: 9 Jun 2016

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Study of Familiarity in Alcohol Dependence
 

Status: Recruiting

Condition Summary: Alcohol Dependence

 

Last Updated: 1 Feb 2017

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Neurofeedback & Alcohol Dependence
 

Status: Recruiting

Condition Summary: Alcohol Dependence

 

Last Updated: 26 Jul 2016

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