Alcohol dependence

Common Name(s)

Alcohol dependence, Alcoholism, Alcohol addiction

Alcoholism means a person is physically or mentally dependent on alcohol. It is a serious medical condition. People with alcoholism often struggle to live normal lives. They may try to hide their problem. Yet drinking too much alcohol can lead to poor life choices such as drinking and driving. Alcohol can cause serious health consequences. Symptoms of alcoholism may include not being able to stop drinking or having a hard time controlling how much you drink, needing more alcohol to feel good, spending a lot of time drinking and recovering from drinking, giving up other activities so you can drink, and withdrawal symptoms if you stop drinking or wait too long between drinks. Withdrawal symptoms may include feeling sick to your stomach, sweating, shakiness and anxiety. Alcoholism may interfere with your relationships and your ability to perform your job.

Alcoholism may be caused by a variety of factors. Genetic, psychological, social and environmental factors may all be part of the cause. Risk factors include steady drinking over time or binge drinking on a regular basis, starting to drink alcohol at a young age, a family history of alcoholism, and suffering from depression, bipolar disorder or anxiety. Alcoholism increases your risk for developing liver damage (cirrhosis), digestive problems, heart problems, sexual dysfunction, birth defects, bone loss, neurological complications and complications with diabetes. Alcoholism can weaken your immune system and increase your risk of certain cancers. Talk to your doctor if you or a family member may have an alcohol addiction. They may ask you a series of questions to determine if you are addicted to alcohol and to rule out other conditions. There are a variety of treatments to help you stop drinking including both inpatient and outpatient programs and private and group counseling. Your doctor can help you decide the best treatment plan for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alcohol dependence" for support, advocacy or research.

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National Council on Alcoholism and Drug Dependence, Inc. (NCADD)

The National Council on Alcoholism and Drug Dependence, Inc. (NCADD) and its Affiliate Network is a voluntary health organization dedicated to fighting the Nation's #1 health problem -- alcoholism, drug addiction and the devastating consequences of alcohol and other drugs on individuals, families and communities.

Last Updated: 8 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Alcohol dependence" for support, advocacy or research.

Logo
National Council on Alcoholism and Drug Dependence, Inc. (NCADD)

The National Council on Alcoholism and Drug Dependence, Inc. (NCADD) and its Affiliate Network is a voluntary health organization dedicated to fighting the Nation's #1 health problem -- alcoholism, drug addiction and the devastating consequences of alcohol and other drugs on individuals, families and communities.

https://ncadd.org/

Last Updated: 8 Jul 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Alcohol dependence" returned 759 free, full-text research articles on human participants. First 3 results:

Differential spontaneous recovery across cognitive abilities during detoxification period in alcohol-dependence.
 

Author(s): Géraldine Petit, Olivier Luminet, Mariana Cordovil de Sousa Uva, Alexis Zorbas, Pierre Maurage, Philippe de Timary

Journal:

 

There is a lack of consensus regarding the extent to which cognitive dysfunctions may recover upon cessation of alcohol intake by alcohol-dependents (AD), and the divergent findings are most likely due to methodological differences between the various studies. The present study was ...

Last Updated: 2 Aug 2017

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Genetic variants in ALDH1B1 and alcohol dependence risk in a British and Irish population: A bioinformatic and genetic study.
 

Author(s): Michael J Way, M Adam Ali, Andrew McQuillin, Marsha Y Morgan

Journal:

 

Alcohol is metabolized in the liver via the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Polymorphisms in the genes encoding these enzymes, which are common in East Asian populations, can alter enzyme kinetics and hence the risk of alcohol dependence and ...

Last Updated: 8 Jun 2017

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From the neurobiological basis of comorbid alcohol dependence and depression to psychological treatment strategies: study protocol of a randomized controlled trial.
 

Author(s): Alena Becker, Anna M Ehret, Peter Kirsch

Journal:

 

Alcohol use disorder and depression occur commonly in the community. Even though this high-prevalence comorbidity is associated with poorer posttreatment outcomes and greater utilization of costly treatment services, existing treatment trials often exclude patients with comorbid depressive ...

Last Updated: 29 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Alcohol dependence" returned 94 free, full-text review articles on human participants. First 3 results:

Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies.
 

Author(s): Xiangyi Kong, Hao Deng, Shun Gong, Theodore Alston, Yanguo Kong, Jingping Wang

Journal:

 

Studies have sought associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol-dependence, but findings are inconsistent. We summarize the information as to associations of rs1799971 (A > G) and the alcohol-dependence.

Last Updated: 26 Oct 2017

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[Neurobiology of Alcohol Dependence and Implications on Treatment].
 

Author(s): Ertuğrul Eşel, Köksal Dinç

Journal: Turk Psikiyatri Derg. 2017 ;28(1):51-60.

 

The process of alcohol dependence has been conceptualized as a progress from controlled alcohol intake to compulsive alcohol consumption or a shift from alcohol intake for pleasure to compulsory alcohol seeking behavior. Hereditary and physical factors and the interaction of individuals ...

Last Updated: 14 Mar 2017

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Reprogramming of mPFC transcriptome and function in alcohol dependence.
 

Author(s): M Heilig, E Barbier, A L Johnstone, J Tapocik, M W Meinhardt, S Pfarr, C Wahlestedt, W H Sommer

Journal: Genes Brain Behav.. 2017 Jan;16(1):86-100.

 

Despite its limited immediate reinforcement value, alcohol has a potent ability to induce neuroadaptations that promote its incentive salience, escalation of voluntary alcohol intake and aversion-resistant alcohol seeking. A constellation of these traits, collectively called 'post-dependent', ...

Last Updated: 22 Sep 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment for Alcohol Dependence With Gabapentin
 

Status: Recruiting

Condition Summary: Alcohol Dependence

 

Last Updated: 9 Jun 2016

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Study of Familiarity in Alcohol Dependence
 

Status: Recruiting

Condition Summary: Alcohol Dependence

 

Last Updated: 22 Aug 2017

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Biomarkers to Measure Treatment Response for Alcohol Dependence
 

Status: Recruiting

Condition Summary: Alcohol Dependence

 

Last Updated: 15 Aug 2017

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