Age-related macular degeneration 3

Common Name(s)

Age-related macular degeneration 3

Hereditary neuropathy with or without age-related macular degeneration is a complex autosomal dominant syndrome characterized by a variable peripheral neuropathy resembling demyelinating Charcot-Marie-Tooth disease (see, e.g., CMT1A, {118220}) and/or axonal CMT (see, e.g., CMT2A1, {118210}) with sensorimotor impairment mainly of the distal lower extremities, or spinal CMT, also known as distal hereditary motor neuropathy (see, e.g., HMN1; {182960}) with intact sensation. Age-related macular degeneration, if present, shows very late onset in the seventies or eighties. In addition, some patients may show hyperelasticity of the skin or joints. The age at onset of neuropathy and severity of the disorder is highly variable, even within families (summary by {1:Auer-Grumbach et al., 2011}). For a phenotypic description and a discussion of genetic heterogeneity of age-related macular degeneration, see {603075}.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Age-related macular degeneration 3" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Age-related macular degeneration 3" returned 22 free, full-text research articles on human participants. First 3 results:

Visual Function in Older Eyes in Normal Macular Health: Association with Incident Early Age-Related Macular Degeneration 3 Years Later.
 

Author(s): Cynthia Owsley, Mark E Clark, Carrie E Huisingh, Christine A Curcio, Gerald McGwin

Journal: Invest. Ophthalmol. Vis. Sci.. 2016 Apr;57(4):1782-9.

 

In older eyes in normal macular health, we examined associations between impaired photopic acuity, mesopic acuity, spatial contrast sensitivity, light sensitivity, and the presence of low luminance deficit (difference between photopic and mesopic acuity) at baseline and incident AMD ...

Last Updated: 14 Apr 2016

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Associations of 6p21.3 Region with Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy.
 

Author(s): Zimeng Ye, Ping Shuai, Yaru Zhai, Fang Li, Lingxi Jiang, Fang Lu, Feng Wen, Lulin Huang, Dingding Zhang, Xiaoqi Liu, Ying Lin, Huaichao Luo, Houbin Zhang, Xianjun Zhu, Zhengzheng Wu, Zhenglin Yang, Bo Gong, Yi Shi

Journal:

 

Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are leading causes of blindness in aging populations. This study was conducted to investigate the associations of chromosome 6p21.3 region, including CFB-SKIV2L-TNXB-FKBPL-NOTCH4 genes, ...

Last Updated: 10 Feb 2016

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Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
 

Author(s): Aya Aoki, Maiko Inoue, Elizabeth Nguyen, Ryo Obata, Kazuaki Kadonosono, Shoji Shinkai, Hideki Hashimoto, Satoshi Sasaki, Yasuo Yanagi

Journal:

 

This case-control study reports the association between nutrient intake and neovascular age-related macular degeneration (AMD) in Japan. The nutrient intake of 161 neovascular AMD cases from two university hospitals and 369 population-based control subjects from a cohort study was ...

Last Updated: 5 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Age-related macular degeneration 3" returned 2 free, full-text review articles on human participants. First 3 results:

Association of toll-like receptor 3 polymorphism rs3775291 with age-related macular degeneration: a systematic review and meta-analysis.
 

Author(s): Li Ma, Fang Yao Tang, Wai Kit Chu, Alvin L Young, Marten E Brelen, Chi Pui Pang, Li Jia Chen

Journal:

 

Association of a polymorphism rs3775291 in the toll-like receptor 3 (TLR3) gene with age-related macular degeneration (AMD) had been investigated intensively, with variable results across studies. Here we conducted a meta-analysis to verify the effect of rs3775291 on AMD. We searched ...

Last Updated: 22 Jan 2016

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Omega-3 Fatty Acids and Age-Related Macular Degeneration.
 

Author(s): Eric H Souied, Tariq Aslam, Alfredo Garcia-Layana, Frank G Holz, Anita Leys, Rufino Silva, Cécile Delcourt

Journal: Ophthalmic Res.. 2015 ;55(2):62-9.

 

Against a background of considerable epidemiological and other evidence implicating omega-3 fatty acids in the prevention of age-related macular degeneration (AMD), the negative results of the Age-Related Disease Study 2 (AREDS2) were unexpected. The possibility that the design, setting, ...

Last Updated: 15 Dec 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Microperimetry and Eye Progressing From Stage 3 to Stage 4 Age-related Macular Degeneration (AMD)
 

Status: Recruiting

Condition Summary: Stage 3 Age Related Macular Degeneration (AREDS Classification)

 

Last Updated: 4 Oct 2016

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Intravitreal tPA and C3F8 for the Treatment of Submacular Haemorrhage as a Complication of Neovascular Age-related Macular Degeneration
 

Status: Recruiting

Condition Summary: Exudative Macular Degeneration; Retinal Hemorrhage

 

Last Updated: 22 Jan 2016

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