Zollinger-Ellison syndrome

Common Name(s)

Zollinger-Ellison syndrome

Zollinger-Ellison syndrome (ZES) is a condition in which tumors called gastrinomas in the pancreas and duodenum (part of the small intestine) cause high levels of the hormone gastrin in the blood. High levels of gastrin then cause production of too much stomach acid. Signs and symptoms may include abdominal pain, peptic ulcers, vomiting blood, and diarrhea. The tumors are sometimes cancerous and may spread to other areas of the body. In most cases, the cause of ZES is unknown. However, about 25-30% of gastrinomas are caused by an inherited condition called multiple endocrine neoplasia type 1 (MEN1). Treatment for ZES may include medication to reduce the production of stomach acid, and surgery for peptic ulcers or to remove tumors.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Zollinger-Ellison syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Zollinger-Ellison syndrome" returned 119 free, full-text research articles on human participants. First 3 results:

Zollinger-Ellison syndrome: an unusual case of chronic diarrhoea in a child.
 

Author(s): R Goyal, U Debi, P Dey, K K Prasad, B R Thapa

Journal: Malays J Pathol. 2016 Dec;38(3):321-325.

 

Most cases of Zollinger-Ellison syndrome (ZES) are described in adults. It is a rare disorder in childhood. Most cases present with abdominal pain due to peptic ulceration and chronic diarrhoea not responding to general measures. The symptom complex is initially confused with other ...

Last Updated: 28 Dec 2016

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Weight Gain in Zollinger-Ellison Syndrome After Acid Suppression.
 

Author(s): Brian P Riff, David A Leiman, Bonita Bennett, Douglas L Fraker, David C Metz

Journal: Pancreas. 2016 Feb;45(2):193-7.

 

Zollinger-Ellison syndrome (ZES) is characterized by hypergastrinemia and gastric acid hypersecretion resulting in peptic ulcer disease, diarrhea, and weight loss. Acid secretion can be controlled with medication, and biochemical cure is possible with surgery. Data on how these interventions ...

Last Updated: 12 Jan 2016

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From hypomagnesaemia to Zollinger-Ellison syndrome: an adverse effect of a proton pump inhibitor.
 

Author(s): Allon Eyal, Alain Sueissa, Eyal Braun, Mohammad Ebrahim Naffaa

Journal:

 

We describe the case of a 53-year-old man who presented with abdominal pain, diarrhoea and hypomagnesaemia. The hypomagnesaemia proved to be due to gastrointestinal loss as urinary fractional excretion was very low, suggesting non-renal loss. Common causes were discarded and the hypomagnesaemia ...

Last Updated: 2 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Zollinger-Ellison syndrome" returned 15 free, full-text review articles on human participants. First 3 results:

Zollinger-Ellison Syndrome Associated with von Recklinghausen Disease: Case Report and Literature Review.
 

Author(s): Mohamad J Alshikho, Salem I Noureldine, Joud M Talas, Antoine Nasimian, Safi Zazou, Bashir Mobaed, Mahmoud Nasser

Journal:

 

Pancreatic endocrine tumors (PETs) are rare and can occur as part of neurofibromatosis type 1 (NF1). Gastrinomas are functional PETs that are rarely associated with NF1. Only two cases of their occurrence have been reported in the literature.

Last Updated: 13 Jun 2016

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Zollinger-Ellison syndrome: classical considerations and current controversies.
 

Author(s): Irene Epelboym, Haggi Mazeh

Journal: Oncologist. 2014 Jan;19(1):44-50.

 

Zollinger-Ellison syndrome (ZES) is an endocrinopathy characterized by gastrin-secreting tumors, responsible for causing the formation of multiple, refractory, and recurrent peptic ulcers in the distal duodenum and proximal jejunum. Two main variants have been described, sporadic ...

Last Updated: 20 Jan 2014

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Zollinger-Ellison syndrome: recent advances and controversies.
 

Author(s): Tetsuhide Ito, Hisato Igarashi, Robert T Jensen

Journal: Curr. Opin. Gastroenterol.. 2013 Nov;29(6):650-61.

 

To review the recent advances and current controversies in patients with Zollinger-Ellison syndrome (ZES).

Last Updated: 9 Oct 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor
 

Status: Not yet recruiting

Condition Summary: Functional Pancreatic Neuroendocrine Tumor; Malignant Somatostatinoma; Merkel Cell Carcinoma; Metastatic Adrenal Gland Pheochromocytoma; Metastatic Carcinoid Tumor; Multiple Endocrine Neoplasia Type 1; Multiple Endocrine Neoplasia Type 2A; Multiple Endocrine Neoplasia Type 2B; Neuroendocrine Neoplasm; Non-Functional Pancreatic Neuroendocrine Tumor; Pancreatic Glucagonoma; Pancreatic Insulinoma; Recurrent Adrenal Cortex Carcinoma; Recurrent Adrenal Gland Pheochromocytoma; Recurrent Merkel Cell Carcinoma; Somatostatin-Producing Neuroendocrine Tumor; Stage III Adrenal Cortex Carcinoma; Stage III Thyroid Gland Medullary Carcinoma; Stage IIIA Merkel Cell Carcinoma; Stage IIIB Merkel Cell Carcinoma; Stage IV Adrenal Cortex Carcinoma; Stage IV Merkel Cell Carcinoma; Stage IVA Thyroid Gland Medullary Carcinoma; Stage IVB Thyroid Gland Medullary Carcinoma; Stage IVC Thyroid Gland Medullary Carcinoma; Thymic Carcinoid Tumor; VIP-Producing Neuroendocrine Tumor; Well Differentiated Adrenal Cortex Carcinoma; Zollinger Ellison Syndrome

 

Last Updated: 14 Jul 2017

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Regorafenib in Treating Patients With Advanced or Metastatic Neuroendocrine Tumors
 

Status: Recruiting

Condition Summary: Gastrinoma; Glucagonoma; Insulinoma; Metastatic Gastrointestinal Carcinoid Tumor; Pancreatic Polypeptide Tumor; Pulmonary Carcinoid Tumor; Recurrent Gastrointestinal Carcinoid Tumor; Recurrent Islet Cell Carcinoma; Somatostatinoma

 

Last Updated: 18 Apr 2017

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Laser Tissue Welding - Distal Pancreatectomy Sealing Study
 

Status: Recruiting

Condition Summary: Pancreatic Tumor, Benign; Pancreatic Neoplasms; Pancreatic Adenocarcinoma; Pancreatic Pseudocyst; Pancreatic Neuroendocrine Tumor; Pancreas; Insulinoma; Pancreatic Cyst; Pancreatic Teratoma; Pancreatic Polypeptide Tumor; Pancreatic Vipoma; Pancreatic Cystadenoma; Pancreas Injury; Pancreatic Gastrinoma; Pancreatic Glucagonoma

 

Last Updated: 9 May 2017

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