Yaws

Common Name(s)

Yaws

Yaws is a tropical disease caused by a form of bacteria known as treponemes that affects the skin, bone, and cartilage. This disease mainly affects children under the age of 15, and is found primarily in poor communities in warm, humid, and tropical forest areas of Africa, Asia, Latin America, and the Pacific. Yaws is transmitted from person to person through direct non-sexual contact with the fluids from the lesion of an infected person. Signs and symptoms include an early infectious stage and a late non-infectious stage. During the early infectious stage, an initial clear, circular swelling of the skin will develop at the site of entry. Other signs in the early stage are thinkening and darkening of the palms of the hands and soles of the feet. Bone pain and bone lesions may also appear in the early stage. Late Yaws symptoms appear five years after the initial infection and include disfigurement of the nose and bones and thickening of the palms of the hand and the soles of the feet. Humans are the only reservoir of Yaws.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Yaws" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Yaws" returned 108 free, full-text research articles on human participants. First 3 results:

Mass Treatment with Single-Dose Azithromycin for Yaws.
 

Author(s): Oriol Mitjà, Sheila Lukehart, Quique Bassat

Journal: N. Engl. J. Med.. 2016 Sep;375(11):1094.

 

Last Updated: 15 Sep 2016

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Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws.
 

Author(s): Michael Marks, Ventis Vahi, Oliver Sokana, Kai-Hua Chi, Elliot Puiahi, Georgina Kilua, Allan Pillay, Tenneth Dalipanda, Christian Bottomley, Anthony W Solomon, David C Mabey

Journal:

 

Community mass treatment with 30 mg/kg azithromycin is central to the new WHO strategy for eradicating yaws. Both yaws and trachoma--which is earmarked for elimination by 2020 using a strategy that includes mass treatment with 20 mg/kg azithromycin--are endemic in the Pacific, raising ...

Last Updated: 5 Aug 2015

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Macrolide Resistance in the Syphilis Spirochete, Treponema pallidum ssp. pallidum: Can We Also Expect Macrolide-Resistant Yaws Strains?
 

Author(s): David Šmajs, Lenka Paštěková, Linda Grillová

Journal: Am. J. Trop. Med. Hyg.. 2015 Oct;93(4):678-83.

 

Treponema pallidum ssp. pallidum (TPA) causes over 10 million new cases of syphilis worldwide whereas T. pallidum ssp. pertenue (TPE), the causative agent of yaws, affects about 2.5 million people. Although penicillin remains the drug of choice in the treatment of syphilis, in penicillin-allergic ...

Last Updated: 8 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Yaws" returned 9 free, full-text review articles on human participants. First 3 results:

Trachoma and Yaws: Common Ground?
 

Author(s): Anthony W Solomon, Michael Marks, Diana L Martin, Alexei Mikhailov, Rebecca M Flueckiger, Oriol Mitjà, Kingsley Asiedu, Jean Jannin, Dirk Engels, David C W Mabey

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Last Updated: 4 Dec 2015

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Challenges and key research questions for yaws eradication.
 

Author(s): Michael Marks, Oriol Mitjà, Lasse S Vestergaard, Allan Pillay, Sascha Knauf, Cheng-Yen Chen, Quique Bassat, Diana L Martin, David Fegan, Fasihah Taleo, Jacob Kool, Sheila Lukehart, Paul M Emerson, Anthony W Solomon, Tun Ye, Ronald C Ballard, David C W Mabey, Kingsley B Asiedu

Journal: Lancet Infect Dis. 2015 Oct;15(10):1220-5.

 

Yaws is endemic in west Africa, southeast Asia, and the Pacific region. To eradicate yaws by 2020, WHO has launched a campaign of mass treatment with azithromycin. Progress has been made towards achievement of this ambitious goal, including the validation of point-of-care and molecular ...

Last Updated: 14 Oct 2015

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Global epidemiology of yaws: a systematic review.
 

Author(s): Oriol Mitjà, Michael Marks, Diby J P Konan, Gilbert Ayelo, Camila Gonzalez-Beiras, Bernard Boua, Wendy Houinei, Yiragnima Kobara, Earnest N Tabah, Agana Nsiire, Damas Obvala, Fasiah Taleo, Rita Djupuri, Zhang Zaixing, Jürg Utzinger, Lase S Vestergaard, Quique Bassat, Kingsley Asiedu

Journal: Lancet Glob Health. 2015 Jun;3(6):e324-31.

 

To achieve yaws eradication, the use of the new WHO strategy of initial mass treatment with azithromycin and surveillance twice a year needs to be extended everywhere the disease occurs. However, the geographic scope of the disease is unknown. We aimed to synthesise published and ...

Last Updated: 24 May 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Transcutaneous Electrical Acupoint Stimulation for Non-small Cell Lung Cancer Patients
 

Status: Recruiting

Condition Summary: Non-Small Cell Lung Cancer; Lung Cancer

 

Last Updated: 21 Jan 2016

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