Wilms' tumor

Common Name(s)

Wilms' tumor, Nephroblastoma

A Wilms’ tumor, also known as a nephroblastoma, is a rare, cancerous, kidney tumor that affects children. The tumor can be found in one or both kidneys and tends to be found in children between the ages of 3 and 4. The risk for a Wilms’ tumor decreases after the age of 5. Although some children who have a Wilms’ tumor appear healthy, some symptoms may include a lump in the abdomen (abdominal mass), pain or swelling, blood in the urine, nausea, constipation, loss of appetite, and fever.

All tumors are the result of an overgrowth of tissue that is caused by errors in the DNA of a cell. A Wilms’ tumor is the result of this happening in the kidney. There are multiple risk factors for a child having a Wilms’ tumor, including being African American, having a family history of Wilms’ tumors, being born with an abnormality in the colored portion of the eye (aniridia), having one part of the body that is larger than the other (hemihypertrophy), having undescended testicles (cryptorchidism), or having the urinary opening on the underside of the penis (hypospadias). Wilms’ tumors are also seen as part of a few different genetic conditions, including WAGR syndrome, Denys-Drash Syndrome, and Beckwith-Wiedemann syndrome.

A diagnosis is usually made using a physical exam, blood and urine tests, and imaging tests (CT or MRI). Once a diagnosis is made, the options for treatment include surgery to remove the tumor, chemotherapy, or radiation. Recent improvements for detection and treatment of a Wilms’ tumor has improved the outlook for many children. If your child has been diagnosed with a Wilms’ tumor, talk with their doctor about all treatment options. Support groups can provide additional information and connect you with other affected families.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wilms' tumor" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

Last Updated: 24 Jul 2015

View Details
International WAGR Syndrome Association

Our mission is to promote international knowledge and awareness of WAGR syndrome and its complications and treatments, to stimulate research and to reach out to those affected by WAGR syndrome in an effort to improve their lives.

Last Updated: 12 Dec 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wilms' tumor" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

http://www.trisomy18.org

Last Updated: 24 Jul 2015

View Details
International WAGR Syndrome Association

Our mission is to promote international knowledge and awareness of WAGR syndrome and its complications and treatments, to stimulate research and to reach out to those affected by WAGR syndrome in an effort to improve their lives.

http://www.wagr.org

Last Updated: 12 Dec 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Wilms' tumor" returned 387 free, full-text research articles on human participants. First 3 results:

Role of Cyclooxygenase-2 Pathway in Creating an Immunosuppressive Microenvironment and in Initiation and Progression of Wilms' Tumor.
 

Author(s): Paramahamsa Maturu, Devin Jones, E Cristy Ruteshouser, Qianghua Hu, Joseph M Reynolds, John Hicks, Nagireddy Putluri, Suhendan Ekmekcioglu, Elizabeth A Grimm, Chen Dong, Willem W Overwijk

Journal: Neoplasia. 2017 Mar;19(3):237-249.

 

Wilms' tumors (WT), which accountfor 6% of all childhood cancers, arise from dysregulated differentiation of nephrogenic progenitor cells from embryonic kidneys. Though there is an improvement in the prognosis of WT, still 10% of patients with WT die due to recurrence. Thus more effective ...

Last Updated: 3 Mar 2017

Go To URL
Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation.
 

Author(s): Adriana Carol Eleonora Graziano, Venera Cardile, Rosanna Avola, Nunzio Vicario, Carmela Parenti, Lucia Salvatorelli, Gaetano Magro, Rosalba Parenti

Journal: Oncotarget. 2017 Feb;8(8):13917-13931.

 

Wilms' tumor gene 1 (WT1) plays complex roles in tumorigenesis, acting as tumor suppressor gene or an oncogene depending on the cellular context. A high WT1 expression level was described in various types of human bone and soft-tissue sarcomas, including osteosarcoma (OS), but its ...

Last Updated: 20 Jan 2017

Go To URL
The Simultaneous Elevation of Oxidative Stress Markers and Wilms' Tumor 1 Gene during the Progression of Myelodysplastic Syndrome.
 

Author(s): Naomi Shimizu, Hidekazu Hasunuma, Yasuhiro Watanabe, Yasuo Matsuzawa, Youichi Iwashita, Ichiro Tatsuno, Hiromitsu Yokota

Journal: Intern. Med.. ;55(24):3661-3664.

 

Oxidative stress is closely related to iron overload in myelodysplastic syndrome (MDS) and induces DNA damage. We evaluated the oxidative stress markers derivatives of reactive oxidative metabolites (dROM) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) during azacitidine treatment in an ...

Last Updated: 16 Dec 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Wilms' tumor" returned 27 free, full-text review articles on human participants. First 3 results:

Genetic variation frequencies in Wilms' tumor: A meta-analysis and systematic review.
 

Author(s): Changkai Deng, Rong Dai, Xuliang Li, Feng Liu

Journal: Cancer Sci.. 2016 May;107(5):690-9.

 

Over the last few decades, numerous biomarkers in Wilms' tumor have been confirmed and shown variations in prevalence. Most of these studies were based on small sample sizes. We carried out a meta-analysis of the research published from 1992 to 2015 to obtain more precise and comprehensive ...

Last Updated: 13 May 2016

Go To URL
Adult Wilms' tumor: A case report with review of literature.
 

Author(s): Amit V Varma, Kamal Malukani, Preeti Rihal, Shirish S Nandedkar

Journal: J Cancer Res Ther. ;11(4):934-6.

 

Wilms' tumor presents a diagnostic problem due to its rare occurrence in adults. Most of the cases of adult Wilms' tumor are diagnosed unexpectedly following nephrectomy for renal cell carcinoma. We are reporting herein a rare case of Adult Wilms' tumor of kidney with triphasic histology ...

Last Updated: 17 Feb 2016

Go To URL
Wilms' tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis.
 

Author(s): Xiao-wei Qi, Fan Zhang, Hong Wu, Jun-lan Liu, Bei-ge Zong, Chuan Xu, Jun Jiang

Journal:

 

Though proposed as a promising target antigen for cancer immunotherapy, the prognostic value of Wilms' tumor 1 (WT1) in solid tumors remains inconclusive. Here, we report a systematic review and meta-analysis of the association between WT1 expression and prognosis in solid tumors. ...

Last Updated: 9 Mar 2015

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Collaborative Wilms Tumour Africa Project
 

Status: Recruiting

Condition Summary: Wilms Tumour

 

Last Updated: 14 Nov 2016

Go to URL

Last Updated: 12 Jul 2017

Go to URL
Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma, Rhabdomyosarcoma, and Wilms Tumors
 

Status: Recruiting

Condition Summary: Ewing Sarcoma; Rhabdomyosarcoma; Wilms Tumor

 

Last Updated: 3 Aug 2016

Go to URL