Wilms' tumor

Common Name(s)

Wilms' tumor, Nephroblastoma

A Wilms’ tumor, also known as a nephroblastoma, is a rare, cancerous, kidney tumor that affects children. The tumor can be found in one or both kidneys and tends to be found in children between the ages of 3 and 4. The risk for a Wilms’ tumor decreases after the age of 5. Although some children who have a Wilms’ tumor appear healthy, some symptoms may include a lump in the abdomen (abdominal mass), pain or swelling, blood in the urine, nausea, constipation, loss of appetite, and fever.

All tumors are the result of an overgrowth of tissue that is caused by errors in the DNA of a cell. A Wilms’ tumor is the result of this happening in the kidney. There are multiple risk factors for a child having a Wilms’ tumor, including being African American, having a family history of Wilms’ tumors, being born with an abnormality in the colored portion of the eye (aniridia), having one part of the body that is larger than the other (hemihypertrophy), having undescended testicles (cryptorchidism), or having the urinary opening on the underside of the penis (hypospadias). Wilms’ tumors are also seen as part of a few different genetic conditions, including WAGR syndrome, Denys-Drash Syndrome, and Beckwith-Wiedemann syndrome.

A diagnosis is usually made using a physical exam, blood and urine tests, and imaging tests (CT or MRI). Once a diagnosis is made, the options for treatment include surgery to remove the tumor, chemotherapy, or radiation. Recent improvements for detection and treatment of a Wilms’ tumor has improved the outlook for many children. If your child has been diagnosed with a Wilms’ tumor, talk with their doctor about all treatment options. Support groups can provide additional information and connect you with other affected families.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wilms' tumor" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

Last Updated: 24 Jul 2015

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International WAGR Syndrome Association

Our mission is to promote international knowledge and awareness of WAGR syndrome and its complications and treatments, to stimulate research and to reach out to those affected by WAGR syndrome in an effort to improve their lives.

Last Updated: 12 Dec 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wilms' tumor" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

http://www.trisomy18.org

Last Updated: 24 Jul 2015

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International WAGR Syndrome Association

Our mission is to promote international knowledge and awareness of WAGR syndrome and its complications and treatments, to stimulate research and to reach out to those affected by WAGR syndrome in an effort to improve their lives.

http://www.wagr.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Wilms' tumor" returned 403 free, full-text research articles on human participants. First 3 results:

Evaluation of Renal Function in Pediatric Patients After Treatment for Wilms' Tumor.
 

Author(s): Małgorzata Janeczko, Ewa Niedzielska, Wojciech Pietras

Journal: Adv Clin Exp Med. ;24(3):497-504.

 

Wilms' tumor is the most common kidney cancer in children. Treatment consists of pre- and post-operative chemotherapy, surgery and in some cases radiotherapy. The treatment of nephroblastomas is very effective. Hence, the population of adult patients cured of this cancer in their ...

Last Updated: 15 Oct 2015

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Prognostic Factors of Wilms' Tumor Complicated with Nephroblastomatosis.
 

Author(s): Hong-Chuan Niu, Wei-Ping Zhang, Ning Sun, Le-Jian He, Yun Peng

Journal: Chin. Med. J.. 2015 Sep;128(18):2539-41.

 

Last Updated: 14 Sep 2015

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RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms' Tumor in Chinese Children.
 

Author(s): Yang Yu, Yuanjun Hu, Kaisheng Li, Zhihong Chen, Hongmei Zhang, Lei Zhang

Journal:

 

Wilms' tumor (WT) is the most common malignant renal tumor in children. Previous studies suggested the reversion-inducing, cysteine-rich protein with Kazal motifs (RECK) down-regulation might have a role in numerous human cancers. The current study was done to investigate the associations ...

Last Updated: 4 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Wilms' tumor" returned 27 free, full-text review articles on human participants. First 3 results:

Wilms' tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis.
 

Author(s): Xiao-wei Qi, Fan Zhang, Hong Wu, Jun-lan Liu, Bei-ge Zong, Chuan Xu, Jun Jiang

Journal:

 

Though proposed as a promising target antigen for cancer immunotherapy, the prognostic value of Wilms' tumor 1 (WT1) in solid tumors remains inconclusive. Here, we report a systematic review and meta-analysis of the association between WT1 expression and prognosis in solid tumors. ...

Last Updated: 9 Mar 2015

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Botryoid Wilms' tumor: a case report and review of the literature.
 

Author(s): Guofeng Xu, Jimeng Hu, Yeming Wu, Yongtao Xiao, Maosheng Xu

Journal:

 

Here, we report a new case of botryoid Wilms' tumor, a 4-year-old boy, who was referred to us with a chief complaint of dysuria and gross hematuria. The computed tomography and radical nephroureterectomy showed that a botryoid sarcoma-like appearance occupied the right renal pelvis ...

Last Updated: 23 May 2013

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Active specific immunotherapy targeting the Wilms' tumor protein 1 (WT1) for patients with hematological malignancies and solid tumors: lessons from early clinical trials.
 

Author(s): Ann Van Driessche, Zwi N Berneman, Viggo F I Van Tendeloo

Journal: Oncologist. 2012 ;17(2):250-9.

 

There is a growing body of evidence that Wilms' tumor protein 1 (WT1) is a promising tumor antigen for the development of a novel class of universal cancer vaccines. Recently, in a National Cancer Institute prioritization project, WT1 was ranked first in a list of 75 cancer antigens. ...

Last Updated: 27 Feb 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Collaborative Wilms Tumour Africa Project
 

Status: Recruiting

Condition Summary: Wilms Tumour

 

Last Updated: 9 Dec 2014

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Last Updated: 17 May 2016

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Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma, Rhabdomyosarcoma, and Wilms Tumors
 

Status: Not yet recruiting

Condition Summary: Ewing Sarcoma; Rhabdomyosarcoma; Wilms Tumor

 

Last Updated: 19 Oct 2015

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