Wilms' tumor

Common Name(s)

Wilms' tumor, Nephroblastoma

A Wilms’ tumor, also known as a nephroblastoma, is a rare, cancerous, kidney tumor that affects children. The tumor can be found in one or both kidneys and tends to be found in children between the ages of 3 and 4. The risk for a Wilms’ tumor decreases after the age of 5. Although some children who have a Wilms’ tumor appear healthy, some symptoms may include a lump in the abdomen (abdominal mass), pain or swelling, blood in the urine, nausea, constipation, loss of appetite, and fever.

All tumors are the result of an overgrowth of tissue that is caused by errors in the DNA of a cell. A Wilms’ tumor is the result of this happening in the kidney. There are multiple risk factors for a child having a Wilms’ tumor, including being African American, having a family history of Wilms’ tumors, being born with an abnormality in the colored portion of the eye (aniridia), having one part of the body that is larger than the other (hemihypertrophy), having undescended testicles (cryptorchidism), or having the urinary opening on the underside of the penis (hypospadias). Wilms’ tumors are also seen as part of a few different genetic conditions, including WAGR syndrome, Denys-Drash Syndrome, and Beckwith-Wiedemann syndrome.

A diagnosis is usually made using a physical exam, blood and urine tests, and imaging tests (CT or MRI). Once a diagnosis is made, the options for treatment include surgery to remove the tumor, chemotherapy, or radiation. Recent improvements for detection and treatment of a Wilms’ tumor has improved the outlook for many children. If your child has been diagnosed with a Wilms’ tumor, talk with their doctor about all treatment options. Support groups can provide additional information and connect you with other affected families.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wilms' tumor" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

Last Updated: 24 Jul 2015

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International WAGR Syndrome Association

Our mission is to promote international knowledge and awareness of WAGR syndrome and its complications and treatments, to stimulate research and to reach out to those affected by WAGR syndrome in an effort to improve their lives.

Last Updated: 12 Dec 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wilms' tumor" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

http://www.trisomy18.org

Last Updated: 24 Jul 2015

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International WAGR Syndrome Association

Our mission is to promote international knowledge and awareness of WAGR syndrome and its complications and treatments, to stimulate research and to reach out to those affected by WAGR syndrome in an effort to improve their lives.

http://www.wagr.org

Last Updated: 12 Dec 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Wilms' tumor" returned 392 free, full-text research articles on human participants. First 3 results:

Comparative study of quality of life of adult survivors of childhood acute lymphocytic leukemia and Wilms' tumor.
 

Author(s): Clélia Marta Casellato de Souza, Lilian Maria Cristofani, Ana Lucia Beltrati Cornacchioni, Vicente Odone Filho, Evelyn Kuczynski

Journal: Einstein (Sao Paulo). ;13(4):492-9.

 

To analyze and compare the health-related quality of life of adult survivors of acute lymphocytic leukemia and Wilms' tumor amongst themselves and in relation to healthy participants.

Last Updated: 14 Jan 2016

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Assessment of Relationship between Wilms' Tumor Gene (WT1) Expression in Peripheral Blood of Acute Leukemia Patients and Serum IL-12 and C3 Levels.
 

Author(s): Omran Rezai, Ali Khodadadi, Yuji Heike, Ali Mostafai, Nader Dashti Gerdabi, Mohammad Rashno, Zahra Abdoli

Journal: Asian Pac. J. Cancer Prev.. 2015 ;16(16):7303-7.

 

Leukemia is a common cancer among children and adolescents. Wilms' tumor gene (WT1) is highly expressed in patients with acute leukemia. It is found as a tumor associated antigen (TAA) in various types of hematopoietic malignancies and can be employed as a useful marker for targeted ...

Last Updated: 30 Oct 2015

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Evaluation of Renal Function in Pediatric Patients After Treatment for Wilms' Tumor.
 

Author(s): Małgorzata Janeczko, Ewa Niedzielska, Wojciech Pietras

Journal: Adv Clin Exp Med. ;24(3):497-504.

 

Wilms' tumor is the most common kidney cancer in children. Treatment consists of pre- and post-operative chemotherapy, surgery and in some cases radiotherapy. The treatment of nephroblastomas is very effective. Hence, the population of adult patients cured of this cancer in their ...

Last Updated: 15 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Wilms' tumor" returned 28 free, full-text review articles on human participants. First 3 results:

Adult Wilms' tumor: A case report with review of literature.
 

Author(s): Amit V Varma, Kamal Malukani, Preeti Rihal, Shirish S Nandedkar

Journal: J Cancer Res Ther. ;11(4):934-6.

 

Wilms' tumor presents a diagnostic problem due to its rare occurrence in adults. Most of the cases of adult Wilms' tumor are diagnosed unexpectedly following nephrectomy for renal cell carcinoma. We are reporting herein a rare case of Adult Wilms' tumor of kidney with triphasic histology ...

Last Updated: 17 Feb 2016

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Wilms' tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis.
 

Author(s): Xiao-wei Qi, Fan Zhang, Hong Wu, Jun-lan Liu, Bei-ge Zong, Chuan Xu, Jun Jiang

Journal:

 

Though proposed as a promising target antigen for cancer immunotherapy, the prognostic value of Wilms' tumor 1 (WT1) in solid tumors remains inconclusive. Here, we report a systematic review and meta-analysis of the association between WT1 expression and prognosis in solid tumors. ...

Last Updated: 9 Mar 2015

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Botryoid Wilms' tumor: a case report and review of the literature.
 

Author(s): Guofeng Xu, Jimeng Hu, Yeming Wu, Yongtao Xiao, Maosheng Xu

Journal:

 

Here, we report a new case of botryoid Wilms' tumor, a 4-year-old boy, who was referred to us with a chief complaint of dysuria and gross hematuria. The computed tomography and radical nephroureterectomy showed that a botryoid sarcoma-like appearance occupied the right renal pelvis ...

Last Updated: 23 May 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Collaborative Wilms Tumour Africa Project
 

Status: Recruiting

Condition Summary: Wilms Tumour

 

Last Updated: 14 Nov 2016

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Last Updated: 10 Aug 2016

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Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma, Rhabdomyosarcoma, and Wilms Tumors
 

Status: Recruiting

Condition Summary: Ewing Sarcoma; Rhabdomyosarcoma; Wilms Tumor

 

Last Updated: 3 Aug 2016

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