Whipple disease

Common Name(s)

Whipple disease

Whipple disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats. The disorder usually occurs in the gastrointestinal system, but may affect any part of the body including the heart, lungs, brain, joints, and eyes. In the gastrointestinal system it interferes with the body's ability to absorb certain nutrients. This leads to a condition known as malabsorption.  Whipple disease causes weight loss, incomplete breakdown of carbohydrates or fats, and malfunctions of the immune system.  It is caused by infection from bacteria called Tropheryma whippelii. When recognized and treated, Whipple disease can usually be cured. Untreated, the disease may be fatal.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Whipple disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Whipple disease" returned 21 free, full-text research articles on human participants. First 3 results:

[Whipple´s disease].
 

Author(s): Ángel Cosme, Luis Bujanda

Journal: Rev Esp Enferm Dig. 2012 May;104(5):276.

 

Last Updated: 5 Jun 2012

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Whipple disease research accelerates.
 

Author(s): Kenneth H Wilson

Journal: J. Infect. Dis.. 2011 Jul;204(1):4-5.

 

Last Updated: 1 Jun 2011

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MR imaging of central nervous system Whipple disease: a 15-year review.
 

Author(s): D F Black, A J Aksamit, J M Morris

Journal: AJNR Am J Neuroradiol. 2010 Sep;31(8):1493-7.

 

CNS WD is fatal if antibiotics are not begun early, but knowledge regarding the variety of presentations on MR imaging is limited. In order to more effectively recognize this entity on MR imaging, the Mayo Clinic medical records were reviewed for subjects diagnosed with CNS WD from ...

Last Updated: 13 Sep 2010

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Whipple disease" returned 4 free, full-text review articles on human participants. First 3 results:

Whipple disease diagnosed with PCR using formalin-fixed paraffin-embedded specimens of the intestinal mucosa.
 

Author(s): Nobuhisa Yajima, Ryuichi Wada, Sotai Kimura, Yutaka Matsuzaki, Daisuke Chiba, Yoshihito Ebina, Kiyofumi Ohkusu, Soroku Yagihashi

Journal: Intern. Med.. 2013 ;52(2):219-22.

 

We herein present the case of a 54-year-old Japanese woman with Whipple disease diagnosed with polymerase chain reaction (PCR) using formalin-fixed paraffin-embedded (FFPE) specimens. The patient complained of weight loss, diarrhea and arthralgia. An endoscopic examination revealed ...

Last Updated: 15 Jan 2013

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[Whipple disease and central nervous system].
 

Author(s): Pedro Abreu, Elsa Azevedo, Luís Lobo, Conceição Souto Moura, Celso Pontes

Journal: Acta Med Port. ;18(3):199-208.

 

Whipple disease (WD) is a rare systemic infection caused by the bacteria Tropheryma whipplei. Slowly progressive dementia, supranuclear ophthalmoplegia, headache, myoclonus, hypothalamic dysfunction, oculomasticatory-skeletal myorythmia are characteristic manifestations when WD involves ...

Last Updated: 6 Oct 2005

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Whipple disease associated with giardiasis.
 

Author(s): Florence Fenollar, Hubert Lepidi, René Gérolami, Michel Drancourt, Didier Raoult

Journal: J. Infect. Dis.. 2003 Sep;188(6):828-34.

 

We tested 53 fixed duodenal biopsy samples from 25 patients with Whipple disease for the presence Giardia and 6 fresh duodenal biopsy samples for Giardia duodenalis DNA by polymerase chain reaction (PCR). We also used histological examination and PCR assay to determine the prevalence ...

Last Updated: 9 Sep 2003

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Use of Wound Protector in Whipple's Procedure With Intrabiliary Stent
 

Status: Recruiting

Condition Summary: Surgical Wound Infection; Pancreatic Neoplasms

 

Last Updated: 1 Dec 2014

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Whipple Procedure: Standard of Care vs. Thunderbeat
 

Status: Recruiting

Condition Summary: Pancreatic Neoplasms; Bile Duct Carcinoma

 

Last Updated: 28 Jul 2014

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Pancreatic Resection, Malnutrition and Readmission
 

Status: Recruiting

Condition Summary: Pancreatic Cancer; Malnutrition

 

Last Updated: 21 Oct 2014

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