WHIMS

Common Name(s)

WHIMS, Warts, hypogammaglobulinemia, infections, and myelokathexis

WHIM syndrome is an acronym for a rare immunodeficiency disorder with each letter representing a predominant feature of the condition: (W) = warts; (H) = hypogammaglobulinemia; (I) = infections; and (M) = myelokathexis (retention of neutrophils in the bone marrow). Symptoms usually begin in early childhood with recurrent bacterial infections such as respiratory infections and cellulitis. In later childhood, individuals develop widespread warts that often become persistent despite treatments that are normally effective. Warts that involve the genital area may eventually cause cancer. It is caused by mutations in the CXCR4 gene and is inherited in an autosomal dominant manner. Treatment may include medications that replace antibodies (intravenous immunoglobulin) or increase the number of neutrophils; vaccinations; and prophylactic antibiotics to reduce the risk of infections.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "WHIMS" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "WHIMS" returned 6 free, full-text research articles on human participants. First 3 results:

The rationale, design, and baseline characteristics of the Women's Health Initiative Memory Study of Younger Women (WHIMS-Y).
 

Author(s): Leslie Vaughan, Mark A Espeland, Beverly Snively, Sally A Shumaker, Stephen R Rapp, Jill Shupe, Jennifer G Robinson, Gloria E Sarto, Susan M Resnick,

Journal: Brain Res.. 2013 Jun;1514():3-11.

 

The Women's Health Initiative Memory Study-Younger (WHIMS-Y) was designed to assess the effect of prior random assignment to hormone therapy (HT) (conjugated equine estrogen (CEE) alone or CEE plus medroxyprogesterone acetate (MPA)) on global cognitive function in younger middle-aged ...

Last Updated: 3 Jun 2013

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Relationship of hypertension, blood pressure, and blood pressure control with white matter abnormalities in the Women's Health Initiative Memory Study (WHIMS)-MRI trial.
 

Author(s): Lewis H Kuller, Karen L Margolis, Sarah A Gaussoin, Nick R Bryan, Diana Kerwin, Marian Limacher, Sylvia Wassertheil-Smoller, Jeff Williamson, Jennifer G Robinson,

Journal: J Clin Hypertens (Greenwich). 2010 Mar;12(3):203-12.

 

This paper evaluates the relationship of blood pressure (BP) levels at Women's Health Initiative (WHI) baseline, treatment of hypertension, and white matter abnormalities among women in conjugated equine estrogen (CEE) and medroxyprogesterone acetate and CEE-alone arms. The WHI Memory ...

Last Updated: 3 May 2010

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Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI Study.
 

Author(s): S M Resnick, M A Espeland, S A Jaramillo, C Hirsch, M L Stefanick, A M Murray, J Ockene, C Davatzikos

Journal: Neurology. 2009 Jan;72(2):135-42.

 

To determine whether menopausal hormone therapy (HT) affects regional brain volumes, including hippocampal and frontal regions.

Last Updated: 13 Jan 2009

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "WHIMS" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
 

Status: Recruiting

Condition Summary: WHIMS; Neutrophil Disorder; Myelokathexis; Hypogammaglobulinemia

 

Last Updated: 25 Mar 2014

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Plerixafor Versus G-CSF in the Treatment of People With WHIM Syndrome
 

Status: Not yet recruiting

Condition Summary: Myelokathexis; WHIMS; Neutropenia; Warts

 

Last Updated: 4 Sep 2014

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