West nile encephalitis

Common Name(s)

West nile encephalitis

West Nile encephalitis (WNE) is a disease which is caused by the West Nile virus (WNV). The West Nile virus is passed by mosquitoes. The virus is most common in the Middle East, Africa, and Asia, but has now spread worldwide. It first came to the United States in 2002 and was passed from person to person through bites from infected mosquitos. Most people with the viral infection do not develop symptoms. However, those who do may develop a fever, headache, bodyaches, fatigue, and back pain. Signs and symptoms only last a few days. In some rare cases, West Nile encephalitis can progress from a WNV infection. Encephalitis describes an inflamation or swelling of the brain, which can cause neurological problems. Symptoms of West Nile encephalitis may include high fever, severe headache, stupor or coma, tremors or muscle jerking, partial paralysis or muscle weakness, loss of coordination, and pain. These symptoms may last for weeks and may become permanent. Medical treatment is critical to a good outcome, so seek medical attention if you or a loved one has any of the symptoms listed above.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "West nile encephalitis" for support, advocacy or research.

Encephalitis Global Inc.

Encephalitis Global (E Global) is a U.S.A. 501(c)(3) public charity formed in 2005 as an alliance connecting encephalitis survivors and caregivers around the world. E Global strives to raise awareness, aiming to promote swift diagnosis, to alleviate unnecessary suffering and to prevent untimely death.

Last Updated: 19 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "West nile encephalitis" for support, advocacy or research.

Encephalitis Global Inc.

Encephalitis Global (E Global) is a U.S.A. 501(c)(3) public charity formed in 2005 as an alliance connecting encephalitis survivors and caregivers around the world. E Global strives to raise awareness, aiming to promote swift diagnosis, to alleviate unnecessary suffering and to prevent untimely death.

http://www.encephalitisglobal.org

Last Updated: 19 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "West nile encephalitis" returned 60 free, full-text research articles on human participants. First 3 results:

IL-1R1 is required for dendritic cell-mediated T cell reactivation within the CNS during West Nile virus encephalitis.
 

Author(s): Douglas M Durrant, Michelle L Robinette, Robyn S Klein

Journal: J. Exp. Med.. 2013 Mar;210(3):503-16.

 

Infections of the central nervous system (CNS) with cytopathic viruses require efficient T cell responses to promote viral clearance, limit immunopathology, and enhance survival. We found that IL-1R1 is critical for effector T cell reactivation and limits inflammation within the CNS ...

Last Updated: 12 Mar 2013

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IL-22 signaling contributes to West Nile encephalitis pathogenesis.
 

Author(s): Penghua Wang, Fengwei Bai, Lauren A Zenewicz, Jianfeng Dai, David Gate, Gong Cheng, Long Yang, Feng Qian, Xiaoling Yuan, Ruth R Montgomery, Richard A Flavell, Terrence Town, Erol Fikrig

Journal: PLoS ONE. 2012 ;7(8):e44153.

 

The Th17 cytokine, IL-22, regulates host immune responses to extracellular pathogens. Whether IL-22 plays a role in viral infection, however, is poorly understood. We report here that Il22(-/-) mice were more resistant to lethal West Nile virus (WNV) encephalitis, but had similar ...

Last Updated: 6 Sep 2012

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Characterization of Rabensburg virus, a flavivirus closely related to West Nile virus of the Japanese encephalitis antigenic group.
 

Author(s): Matthew T Aliota, Susan A Jones, Alan P Dupuis, Alexander T Ciota, Zdenek Hubalek, Laura D Kramer

Journal: PLoS ONE. 2012 ;7(6):e39387.

 

Rabensburg virus (RABV), a Flavivirus with ∼76% nucleotide and 90% amino acid identity with representative members of lineage one and two West Nile virus (WNV), previously was isolated from Culex pipiens and Aedes rossicus mosquitoes in the Czech Republic, and phylogenetic and serologic ...

Last Updated: 22 Jun 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "West nile encephalitis" returned 8 free, full-text review articles on human participants. First 3 results:

Role of γδ T cells in West Nile virus-induced encephalitis: friend or foe?
 

Author(s): Tian Wang

Journal: J. Neuroimmunol.. 2011 Dec;240-241():22-7.

 

West Nile virus (WNV)-induced encephalitis has been a public health concern in North America over the past decade. No therapeutics or vaccines are available for human use. Studies in animal models have provided important information for investigations of WNV pathogenesis and the host ...

Last Updated: 5 Dec 2011

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West nile virus (Kunjin subtype) disease in the northern territory of Australia--a case of encephalitis and review of all reported cases.
 

Author(s): Timothy J Gray, James N Burrow, Peter G Markey, Peter I Whelan, Justin Jackson, David W Smith, Bart J Currie

Journal: Am. J. Trop. Med. Hyg.. 2011 Nov;85(5):952-6.

 

West Nile virus Kunjin subtype (WNV/KUNV) is enzootic across the tropical north of Australia, with epizootic spread into other jurisdictions. The clinical spectrum of illness in humans is poorly described. We report a clinical case of WNV/KUNV encephalitis and performed a retrospective ...

Last Updated: 3 Nov 2011

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[West Nile fever/encephalitis].
 

Author(s): Tomohiko Takasaki

Journal: Uirusu. 2007 Dec;57(2):199-205.

 

West Nile virus (WNV), a member of the family Flaviviridae (genus Flavivirus), is a mosquito-borne virus first isolated in 1937 in the West Nile district of Uganda. The disease in humans is characterized by a dengue-like illness with fever, and a more severe form is characterized ...

Last Updated: 24 Mar 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.