Werner syndrome

Common Name(s)

Werner syndrome, Werner's syndrome

Werner syndrome is a rare genetic condition that causes accelerated aging. Affected individuals usually display normal growth and development during childhood but then lack a normal growth spurt at puberty. As a result, they are typically short in height. Those with the condition also typically have unique facial features that include a beaked nose and prominent eyes.

Individuals with Werner syndrome usually notice the first signs of rapid aging during their twenties. These first symptoms may include graying or loss of hair, a hoarse voice, and the development of thinner, rougher skin. In the individual’s thirties, more advanced signs of aging will likely begin. These include cloudy eye lenses (cataracts), sores or open wounds on the skin (ulcers), type II diabetes, thinning of bones (osteoporosis), various types of cancer, and a decrease or loss of fertility and other genital functioning (hypogonadism). Most affected individuals pass away in their late forties to early fifties from conditions such as cancer and atherosclerosis (hardening of the arteries).

There is a specific gene, called "WRN," that is associated with this condition. A functional WRN gene instructs the body to produce a protein that is responsible for protecting a person’s DNA from damage and keeping the DNA in its proper shape. If the WRN gene is changed (mutated), the individual’s DNA becomes more prone to damage and leads to the various physical signs of Werner syndrome. This condition is inherited in an autosomal recessive pattern, which means a person must have a mutation in both copies of their WRN gene in order to develop the condition. Contacting a genetic counselor or specialist may be helpful to further explain the genetics and inheritance pattern of this condition.

Unfortunately there is no cure for Werner syndrome at this time. If you or a loved one has been diagnosed with Werner syndrome, contact your doctor to discuss current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Werner syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Werner syndrome" returned 182 free, full-text research articles on human participants. First 3 results:

Do you know this syndrome? Werner syndrome.
 

Author(s): Özlem Bilgiç

Journal: An Bras Dermatol. ;92(2):271-272.

 

Werner syndrome is a rare autosomal recessive disorder, caused by mutations in the WRN gene. Clinical findings include: senile appearance, short stature, grey hair, alopecia, bird-like face, scleroderma-like skin changes, skin ulcers, voice abnormalities, cataracts, osteoporosis, ...

Last Updated: 24 May 2017

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The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation.
 

Author(s): Baomin Li, Sita Reddy, Lucio Comai

Journal:

 

The Werner syndrome protein (WRN) suppresses the loss of telomeres replicated by lagging-strand synthesis by a yet to be defined mechanism. Here, we show that whereas either WRN or the Bloom syndrome helicase (BLM) stimulates DNA polymerase δ progression across telomeric G-rich repeats, ...

Last Updated: 16 Nov 2016

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Pelvic cystic mass and ipsilateral renal agenesis detected by ultrasound in a young girl: early onset of Herlyn-Werner-Wunderlich Syndrome.
 

Author(s): María Fernández-Ibieta, Esperanza Banu Hernández-Anselmi, María Soledad Fernández-Córdoba

Journal: Med Ultrason. 2016 Sep;18(3):405-6.

 

Last Updated: 14 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Werner syndrome" returned 10 free, full-text review articles on human participants. First 3 results:

Scoliosis in Herlyn-Werner-Wunderlich syndrome: a case report and literature review.
 

Author(s): Zheng Li, Xin Yu, Jianxiong Shen, Jinqian Liang

Journal: Medicine (Baltimore). 2014 Dec;93(28):e185.

 

Herlyn-Werner-Wunderlich syndrome (HWWS) is a congenital Müllerian duct anomaly characterized by uterine didelphys, obstructed hemivagina, and ipsilateral renal agenesis. Little is reported about spinal deformity associated with this syndrome. This study presents a case of scoliosis ...

Last Updated: 20 Dec 2014

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Search and insights into novel genetic alterations leading to classical and atypical Werner syndrome.
 

Author(s): Junko Oshima, Fuki M Hisama

Journal: Gerontology. 2014 ;60(3):239-46.

 

Segmental progeroid syndromes are a group of disorders with multiple features resembling accelerated aging. Adult-onset Werner syndrome (WS) and childhood-onset Hutchinson-Gilford progeria syndrome are the best known examples. The discovery of genes responsible for such syndromes ...

Last Updated: 22 Apr 2014

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Spectrum and risk of neoplasia in Werner syndrome: a systematic review.
 

Author(s): Julia M Lauper, Alison Krause, Thomas L Vaughan, Raymond J Monnat

Journal: PLoS ONE. 2013 ;8(4):e59709.

 

Werner syndrome (WS) is an autosomal recessive genetic instability and progeroid ('premature aging') syndrome which is associated with an elevated risk of cancer.

Last Updated: 10 Apr 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.