Wells syndrome

Common Name(s)

Wells syndrome

Wells syndrome is a rare eosinophilic disorder characterized by itchy, burning, red, and inflamed areas on the skin often on the lower arm or leg. The lesions may be single or multiple. They are usually red at first (looking like cellulitis) then change to brown red, to blue gray, then greenish gray. The lesions are usually painful and are sometimes associated with a fever. They typically heal without scarring within weeks to months; however they often recur. The cause of Wells syndrome is unknown; but some researchers think that Wells syndrome is an autoimmune reaction.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wells syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Wells syndrome" returned 45 free, full-text research articles on human participants. First 3 results:

Early detection of sensorineural hearing loss in Muckle-Wells-syndrome.
 

Author(s): Jasmin B Kuemmerle-Deschner, Assen Koitschev, Pascal N Tyrrell, Stefan K Plontke, Norbert Deschner, Sandra Hansmann, Katharina Ummenhofer, Peter Lohse, Christiane Koitschev, Susanne M Benseler

Journal:

 

Muckle-Wells-syndrome (MWS) is an autoinflammatory disease characterized by systemic and organ-specific inflammation due to excessive interleukin (IL)-1 release. Inner ear inflammation results in irreversible sensorineural hearing loss, if untreated. Early recognition and therapy ...

Last Updated: 4 Nov 2015

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Wells syndrome associated with chronic lymphocytic leukemia.
 

Author(s): Petra Maria de Oliveira Duarte Stuhr, Everton Carlos Siviero do Vale

Journal: An Bras Dermatol. ;90(4):571-4.

 

Eosinophilic cellulitis or Wells syndrome is an uncommon skin condition of unknown etiology that can occur alone or associated with other conditions. Typically, it presents with recurrent pruritic, erythematous and edematous plaques, but it can also show clinical polymorphism. Besides ...

Last Updated: 17 Sep 2015

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Idiopathic Hypereosinophilic Syndrome With Cutaneous Manifestations and Flame Figures: A Spectrum of Eosinophilic Dermatoses Whose Features Overlap With Wells' Syndrome.
 

Author(s): Sabrina M Smith, Elizabeth A Kiracofe, Lindsey N Clark, Alejandro A Gru

Journal: Am J Dermatopathol. 2015 Dec;37(12):910-4.

 

Wells syndrome (WS) (eosinophilic cellulitis) is an uncommon eosinophilic dermatitis that has been rarely described in association with, but distinct from, hypereosinophilic syndrome (HES).

Last Updated: 21 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Wells syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

IgG4-related disease of the paratestis in a patient with Wells syndrome: a case report.
 

Author(s): Takashi Karashima, Yoshinori Taniguchi, Tsutomu Shimamoto, Tomoya Nao, Hiroshi Nishikawa, Satoshi Fukata, Masayuki Kamada, Keiji Inoue, Kentaro Oko, Hideki Nakajima, Shigetoshi Sano, Manabu Matsumoto, Naoto Kuroda, Yoshihiro Kamei, Taro Shuin

Journal:

 

We report a case of a 33-year-old man who presented with immunoglobulin (Ig)G4-related disease (IgG4-RD) forming a pseudotumor in the left paratesticular region during oral administration of corticosteroid for Wells syndrome, which involves cellulitis with eosinophilia.

Last Updated: 27 Apr 2015

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[Biological and clinical aspects of Muckle-Wells syndrome].
 

Author(s): Tetsuo Kubota, Ryuji Koike

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2007 Apr;30(2):114-22.

 

Muckle-Wells syndrome (MWS), as well as familial cold autoinflammatory syndrome (FCAS) and chronic infantile neurological cutaneous and articular syndrome (CINCA), arises from a missense mutation in the CIAS1 gene. Current progress of biology revealed that NALP3, a protein coded by ...

Last Updated: 2 May 2007

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Eosinophilic cellulitis (Wells' syndrome) as a cutaneous reaction to the administration of adalimumab.
 

Author(s): P Boura, A Sarantopoulos, I Lefaki, P Skendros, P Papadopoulos

Journal: Ann. Rheum. Dis.. 2006 Jun;65(6):839-40.

 

Last Updated: 15 May 2006

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

HL2351 CAPS Phase II Study
 

Status: Recruiting

Condition Summary: Cryopyrin‑Associated Periodic Syndromes (CAPS)

 

Last Updated: 28 Jul 2016

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Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor
 

Status: Not yet recruiting

Condition Summary: Functional Pancreatic Neuroendocrine Tumor; Malignant Somatostatinoma; Merkel Cell Carcinoma; Metastatic Adrenal Gland Pheochromocytoma; Metastatic Carcinoid Tumor; Multiple Endocrine Neoplasia Type 1; Multiple Endocrine Neoplasia Type 2A; Multiple Endocrine Neoplasia Type 2B; Neuroendocrine Neoplasm; Non-Functional Pancreatic Neuroendocrine Tumor; Pancreatic Glucagonoma; Pancreatic Insulinoma; Recurrent Adrenal Cortex Carcinoma; Recurrent Adrenal Gland Pheochromocytoma; Recurrent Merkel Cell Carcinoma; Somatostatin-Producing Neuroendocrine Tumor; Stage III Adrenal Cortex Carcinoma; Stage III Thyroid Gland Medullary Carcinoma; Stage IIIA Merkel Cell Carcinoma; Stage IIIB Merkel Cell Carcinoma; Stage IV Adrenal Cortex Carcinoma; Stage IV Merkel Cell Carcinoma; Stage IVA Thyroid Gland Medullary Carcinoma; Stage IVB Thyroid Gland Medullary Carcinoma; Stage IVC Thyroid Gland Medullary Carcinoma; Thymic Carcinoid Tumor; VIP-Producing Neuroendocrine Tumor; Well Differentiated Adrenal Cortex Carcinoma; Zollinger Ellison Syndrome

 

Last Updated: 10 Jul 2016

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Immunotherapy and Paraneoplastic Neurological Syndromes
 

Status: Recruiting

Condition Summary: Paraneoplastic Neurological Syndromes

 

Last Updated: 9 May 2016

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