Wegener's granulomatosis

Common Name(s)

Wegener's granulomatosis

Wegener's granulomatosis is a type of vasculitis, or inflammation of the blood vessels. This limits the flow of blood to important organs, causing damage. It can affect any organ, but it mainly affects the sinuses, nose, trachea (windpipe), lungs and kidneys. Symptoms can vary in nature and severity, and may include sinus pain; discolored or bloody fluid from the nose; nasal ulcers; constant runny nose (rhinorrhea); joint pain; weakness; tiredness; and/or skin lesions. The cause of Wegener's granulomatosis is unknown. Early treatment is important. Most people improve with medicines to slow or stop the inflammation.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wegener's granulomatosis" for support, advocacy or research.

stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

Last Updated: 5 Mar 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Wegener's granulomatosis" for support, advocacy or research.

stopcaidnow.org

Our mission is simple-Educate, Provide Awareness, and Fund Researchers who are committed to finding a cure. StopCAIDnow(501c3) is focused on providing tools to better educate Doctor’s and the community on AutoInflammatory diseases. There is a need for an understanding of these diseases so proper diagnosis can be made, and treatment can be started. This will help alleviate the inflammation process, 7 the pain that comes with it. Proper diagnosis is urgent for the prognosis of these diseases. If left untreated damage to the tissues, organs & vision(for some) will not only be irreversible but devastating

http://www.stopcaidnow.org

Last Updated: 5 Mar 2013

View Details

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Wegener's granulomatosis" returned 549 free, full-text research articles on human participants. First 3 results:

Cytoplasmic-anti-neutrophil cytoplasmic antibodies targeting myeloperoxidase in Wegener's granulomatosis: a rare phenomenon.
 

Author(s): Bhavana M Venkatesh, Sangeeta Joshi, Ranjeeta Adhikary

Journal: Indian J Pathol Microbiol. ;57(3):470-2.

 

Wegener's granulomatosis (WG) patients can rarely have antineutrophil cytoplasmic antibodies (ANCAs) directed against myeloperoxidase (MPO), producing a cytoplasmic pattern on indirect immunofluorescence (IIF). This has important implications in the diagnosis and pathophysiology of ...

Last Updated: 14 Aug 2014

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A case of Wegener's granulomatosis mimicking recurrent hemophagocytic lymphohistiocytosis.
 

Author(s): Sung Min Jung, Yun Hwa Jung, Hyun Jin Noh, In Sook Woo, Chi Wha Han

Journal: Korean J. Intern. Med.. 2014 May;29(3):393-7.

 

Last Updated: 22 May 2014

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Wegener's granulomatosis with an atypical presentation as acute tonsillitis.
 

Author(s): Selçuk Arslan, Abdülcemal Ümit Işik, Sevdegül Mungan, Ahmet Ural, Refik Ali Sari

Journal: ORL J. Otorhinolaryngol. Relat. Spec.. 2014 ;76(1):57-61.

 

Wegener's granulomatosis (WG) is a rare necrotizing granulomatous vasculitis of unknown etiology commonly involving vessels, the upper and lower respiratory system and the kidneys. There are various symptoms and signs of WG due to a wide spectrum of involvement sites. The initial ...

Last Updated: 27 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Wegener's granulomatosis" returned 34 free, full-text review articles on human participants. First 3 results:

Panhypopituitarism due to Wegener's granulomatosis.
 

Author(s): Silvina G Santoro, Alberto H Guida, Alejandra E Furioso, Patricia Glikman, Amelia S Rogozinski

Journal: Arq Bras Endocrinol Metabol. 2011 Oct;55(7):481-5.

 

Wegener's granulomatosis (WG) is a multi-system necrotizing granulomatous vasculitis which classically affects the upper respiratory tract, lungs and kidneys. Pituitary participation has been described in 24 patients in the literature to date. The aim of this article is to report ...

Last Updated: 7 Dec 2011

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Cyclophosphamide as induction therapy for Wegener's granulomatosis and microscopic polyangiitis.
 

Author(s): C A Langford

Journal: Clin. Exp. Immunol.. 2011 May;164 Suppl 1():31-4.

 

The introduction of cyclophosphamide (CyP) as a treatment for Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) has been among the most significant contributions in vasculitis. Prior to the introduction of CyP, WG was a uniformly fatal disease, with mortality occurring ...

Last Updated: 30 Mar 2011

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Nomenclature and classification of vasculitis: lessons learned from granulomatosis with polyangiitis (Wegener's granulomatosis).
 

Author(s): J C Jennette

Journal: Clin. Exp. Immunol.. 2011 May;164 Suppl 1():7-10.

 

Names influence how something is perceived. Diagnostic terms (diagnoses) are the names of diseases that are usually derived either from some distinctive characteristic of the disease or include an eponym recognizing someone who elucidated the disease. No matter how logical and appropriate ...

Last Updated: 30 Mar 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Abatacept for the Treatment of Relapsing, Non-Severe, Granulomatosis With Polyangiitis (Wegener's)
 

Status: Not yet recruiting

Condition Summary: Granulomatosis With Polyangiitis (Wegener's); Granulomatosis With Polyangiitis; Wegener's Granulomatosis; ANCA-Associated Vasculitis

 

Last Updated: 2 Dec 2014

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Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)
 

Status: Recruiting

Condition Summary: Granulomatosis With Polyangiitis

 

Last Updated: 22 May 2013

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Last Updated: 23 Mar 2015

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