Waldenstrom macroglobulinemia

Common Name(s)

Waldenstrom macroglobulinemia

Waldenstrom macroglobulinemia is a chronic, slow-growing lymphoproliferative disorder. It usually affects older adults and is primarily found in the bone marrow, although lymph nodes and the spleen may be involved. Affected individuals have a high level of an antibody called immunoglobulin M (IgM) in their blood, which can cause thickening of the blood (hyperviscosity). Although some individuals initially do not have symptoms and are diagnosed from routine blood work, common symptoms may include weakness, appetite loss and weight loss. Other symptoms may include peripheral neuropathy, fever, Raynaud's phenomenon, and mental status changes. Hyperviscosity of the blood may cause nosebleeds, headaches, dizziness, and blurring or loss of vision. The cause of the condition is not known but environmental, genetic, and viral factors have been suggested. There have been some reports of familial cases suggesting a genetic predisposition. Treatment is often reserved for those with symptoms and may include various medications including corticosteroids, alkylating agents, biologic response modifiers and purine analogues.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Waldenstrom macroglobulinemia" for support, advocacy or research.

International Waldenstrom's Macroglobulinemia Foundation

To offer mutual support and encouragement to the Waldenstrom's macroglobulinemia community and others with an interest in the disease. To provide information and educational programs that address patients' concerns. To promote and support research leading to better treatments and ultimately a cure.

Last Updated: 16 Jul 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Waldenstrom macroglobulinemia" for support, advocacy or research.

International Waldenstrom's Macroglobulinemia Foundation

To offer mutual support and encouragement to the Waldenstrom's macroglobulinemia community and others with an interest in the disease. To provide information and educational programs that address patients' concerns. To promote and support research leading to better treatments and ultimately a cure.

http://www.iwmf.com

Last Updated: 16 Jul 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Waldenstrom macroglobulinemia" returned 98 free, full-text research articles on human participants. First 3 results:

A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia.
 

Author(s): Guang Yang, Yangsheng Zhou, Xia Liu, Lian Xu, Yang Cao, Robert J Manning, Christopher J Patterson, Sara J Buhrlage, Nathanael Gray, Yu-Tzu Tai, Kenneth C Anderson, Zachary R Hunter, Steven P Treon

Journal: Blood. 2013 Aug;122(7):1222-32.

 

Myeloid differentiation factor 88 (MYD88) L265P somatic mutation is highly prevalent in Waldenström macroglobulinemia (WM) and supports malignant growth through nuclear factor κB (NF-κB). The signaling cascade(s) by which MYD88 L265P promotes NF-κB activation in WM remain unclear. ...

Last Updated: 16 Aug 2013

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Simultaneous presentation of Waldenström macroglobulinemia and multiple myeloma: multidisciplinary diagnosis, treatment and 30-month follow-up.
 

Author(s): Giovanni Carulli, Eugenio M Ciancia, Antonio Azzarà, Virginia Ottaviano, Susanna Grassi, Elena Ciabatti, Maria I Ferreri, Melania Rocco, Alessandra Marini, Mario Petrini

Journal: J Clin Exp Hematop. 2013 ;53(1):29-36.

 

Waldenström macroglobulinemia and multiple myeloma are mature B-cell neoplasms deriving from post-germinal cells at different stages of differentiation. The simultaneous presentation of Waldenström macroglobulinemia and multiple myeloma in the same patient is a very rare phenomenon ...

Last Updated: 26 Jun 2013

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A new era for Waldenstrom macroglobulinemia: MYD88 L265P.
 

Author(s): Steven P Treon, Zachary R Hunter

Journal: Blood. 2013 May;121(22):4434-6.

 

In this issue of Blood, Poulain et al demonstrate the high prevalence of the MYD88 L265P somatic mutation in patients with Waldenstrom macroglobulinemia (WM) and provide insight into its biological relevance in the growth and survival of WM.

Last Updated: 31 May 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Waldenstrom macroglobulinemia" returned 12 free, full-text review articles on human participants. First 3 results:

The bone marrow microenvironment in Waldenström macroglobulinemia.
 

Author(s): Amit Agarwal, Irene M Ghobrial

Journal: Clin Lymphoma Myeloma Leuk. 2013 Apr;13(2):218-21.

 

Waldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma characterized by widespread involvement of the bone marrow (BM). The BM microenvironment serves as not only a site for disease involvement, but it also appears that the interaction of WM cells with the BM is essential ...

Last Updated: 13 May 2013

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Immunoglobulin m monoclonal gammopathy of undetermined significance and smoldering Waldenström macroglobulinemia.
 

Author(s): Robert A Kyle, Terry M Therneau, Angela Dispenzieri, Shaji Kumar, Joanne T Benson, Dirk R Larson, L Joseph Melton, S Vincent Rajkumar

Journal: Clin Lymphoma Myeloma Leuk. 2013 Apr;13(2):184-6.

 

Monoclonal gammopathy of undetermined significance of the immunoglobulin M class was diagnosed in 213 patients at the Mayo Clinic, 29 (14%) of whom developed lymphoma, Waldenström macroglobulinemia, or a related disorder over 1567 person-years of follow-up. The cumulative probability ...

Last Updated: 13 May 2013

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Waldenstrom macroglobulinemia presenting with pancreatic mass: a case report and review of literature.
 

Author(s): Hemanta Kumar Nayak, Premashish Kar, Avishek Bagchi, Neha Kapoor, Siddarth Kapahtia, Ujjwal Sonika, Naresh Kumar, Suresh Kumar

Journal:

 

Waldenstrom macroglobulinemia is a rare lymphoplasmacytic lymphoma characterized by a wide range of clinical presentations related to direct tumor infiltration and the production of IgM. Most commonly it presents with cytopenia, hepatosplenomegaly, lymphadenopathy, constitutional ...

Last Updated: 11 Jan 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Trial Comparing Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia
 

Status: Recruiting

Condition Summary: Waldenström Macroglobulinemia; Lymphoplasmacytic Lymphoma; Splenic Marginal Zone Lymphoma

 

Last Updated: 30 Nov 2007

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Randomised Trial in Waldenstrom's Macroglobulinaemia
 

Status: Recruiting

Condition Summary: Waldenstrom's Macroglobulinaemia

 

Last Updated: 26 Mar 2013

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An Open-label, Phase 1b Study of ACP 196 in Subjects With Waldenström Macroglobulinemia
 

Status: Recruiting

Condition Summary: Waldenström Macroglobulinemia (WM)

 

Last Updated: 19 Sep 2014

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