Barrett's Esophagus

Common Name(s)

Barrett's Esophagus, Barrett syndrome

Barrett syndrome, also known as Barrett esophagus, is a disorder in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestine. This process is called intestinal metaplasia.  The exact cause of Barrett syndrome is not known, but gastroesophageal reflux disease (GERD) is a risk factor for the condition.  While Barrett syndrome itself does not cause symptoms, the acid reflux associated with GERD often leads to symptoms of heartburn.   Less than 1% of people with Barrett syndrome develop a rare type of cancer called esophageal adenocarcinoma. Treatment of GERD should improve symptoms, and may keep Barrett syndrome from getting worse. Endoscopic or surgical treatments can be used to treat Barrett syndrome with severe dysplasia or cancer.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Barrett's Esophagus" returned 416 free, full-text research articles on human participants. First 3 results:

The prevalence of Barrett's-esophagus-associated dysplasia in Puerto Rico.
 

Author(s): Priscilla Magno, Lorena González, Marcia Cruz-Correa, Erick Suárez

Journal: P R Health Sci J. 2014 Dec;33(4):184-9.

 

Barrett's esophagus (BE) is the strongest risk factor of esophageal adenocarcinoma (EAC). A previous study found a lower incidence of EAC in Puerto Rico (PR) as compared to other racial/ethnic groups in the United States (US). Notwithstanding, BE epidemiology in PR is unknown. Study ...

Last Updated: 7 Jan 2015

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Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.
 

Author(s): Claire Palles, Laura Chegwidden, Xinzhong Li, John M Findlay, Garry Farnham, Francesc Castro Giner, Maikel P Peppelenbosch, Michal Kovac, Claire L Adams, Hans Prenen, Sarah Briggs, Rebecca Harrison, Scott Sanders, David MacDonald, Chris Haigh, Art Tucker, Sharon Love, Manoj Nanji, John deCaestecker, David Ferry, Barrie Rathbone, Julie Hapeshi, Hugh Barr, Paul Moayyedi, Peter Watson, Barbara Zietek, Neera Maroo, Laura Gay, Tim Underwood, Lisa Boulter, Hugh McMurtry, David Monk, Praful Patel, Krish Ragunath, David Al Dulaimi, Iain Murray, Konrad Koss, Andrew Veitch, Nigel Trudgill, Chuka Nwokolo, Bjorn Rembacken, Paul Atherfold, Elaine Green, Yeng Ang, Ernst J Kuipers, Wu Chow, Stuart Paterson, Sudarshan Kadri, Ian Beales, Charles Grimley, Paul Mullins, Conrad Beckett, Mark Farrant, Andrew Dixon, Sean Kelly, Matthew Johnson, Shahjehan Wajed, Anjan Dhar, Elinor Sawyer, Rebecca Roylance, Lynn Onstad, Marilie D Gammon, Douglas A Corley, Nicholas J Shaheen, Nigel C Bird, Laura J Hardie, Brian J Reid, Weimin Ye, Geoffrey Liu, Yvonne Romero, Leslie Bernstein, Anna H Wu, Alan G Casson, Rebecca Fitzgerald, David C Whiteman, Harvey A Risch, David M Levine, Tom L Vaughan, Auke P Verhaar, Jan van den Brande, Eelke L Toxopeus, Manon C Spaander, Bas P L Wijnhoven, Luc J W van der Laan, Kausilia Krishnadath, Cisca Wijmenga, Gosia Trynka, Ross McManus, John V Reynolds, Jacintha O'Sullivan, Padraic MacMathuna, Sarah A McGarrigle, Dermot Kelleher, Severine Vermeire, Isabelle Cleynen, Raf Bisschops, Ian Tomlinson, Janusz Jankowski

Journal: Gastroenterology. 2015 Feb;148(2):367-78.

 

Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subsequently, ...

Last Updated: 24 Jan 2015

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Lifetime risk of esophageal adenocarcinoma in patients with Barrett's esophagus.
 

Author(s): Piers Gatenby, Christine Caygill, Christine Wall, Santanu Bhatacharjee, James Ramus, Anthony Watson, Marc Winslet

Journal: World J. Gastroenterol.. 2014 Jul;20(28):9611-7.

 

To investigate the lifetime risk of development of esophageal adenocarcinoma and/or high-grade dysplasia in patients diagnosed with Barrett's esophagus.

Last Updated: 29 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Barrett's Esophagus" returned 80 free, full-text review articles on human participants. First 3 results:

Barrett's esophagus and cancer risk: how research advances can impact clinical practice.
 

Author(s): Massimiliano di Pietro, Durayd Alzoubaidi, Rebecca C Fitzgerald

Journal: Gut Liver. 2014 Jul;8(4):356-70.

 

Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), whose incidence has increased sharply in the last 4 decades. The annual conversion rate of BE to cancer is significant, but small. The identification of patients at a higher risk of cancer therefore ...

Last Updated: 29 Jul 2014

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Advances in understanding the pathogenesis of Barrett's esophagus.
 

Author(s): Nicholas J Clemons, Shze Yung Koh, Wayne A Phillips

Journal: Discov Med. 2014 Jan;17(91):7-14.

 

Barrett's esophagus (BE) is an intestinal-like columnar metaplasia that replaces the normal stratified squamous epithelium in the distal esophagus. Clinically, BE is an important entity as it is the only established precursor to esophageal adenocarcinoma (EAC), a disease with an extremely ...

Last Updated: 13 Jan 2014

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Meta-analysis of Barrett's esophagus in China.
 

Author(s): Ying Dong, Bing Qi, Xiao-Ying Feng, Chun-Meng Jiang

Journal: World J. Gastroenterol.. 2013 Dec;19(46):8770-9.

 

To investigate the epidemiology and characteristics of Barrett's esophagus (BE) in China and compare with cases in the west.

Last Updated: 31 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Vitamin D Supplementation on 15-Prostaglandin Dehydrogenase Expression in Barrett's Esophagus
 

Status: Recruiting

Condition Summary: Short Segment Barrett's Esophagus; Long Segment Barrett's Esophagus

 

Last Updated: 1 Dec 2014

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Familial Barrett's Esophagus
 

Status: Recruiting

Condition Summary: Barrett's Esophagus; Esophageal Neoplasm

 

Last Updated: 15 Jan 2013

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Barrett's Esophagus Related Neoplasia (BERN) Project
 

Status: Recruiting

Condition Summary: Barrett's Esophagus; Neoplasms; Gastroesophageal Reflux

 

Last Updated: 14 Apr 2015

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