Barrett's Esophagus

Common Name(s)

Barrett's Esophagus, Barrett syndrome

Barrett syndrome, also known as Barrett esophagus, is a disorder in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestine. This process is called intestinal metaplasia.  The exact cause of Barrett syndrome is not known, but gastroesophageal reflux disease (GERD) is a risk factor for the condition.  While Barrett syndrome itself does not cause symptoms, the acid reflux associated with GERD often leads to symptoms of heartburn.   Less than 1% of people with Barrett syndrome develop a rare type of cancer called esophageal adenocarcinoma. Treatment of GERD should improve symptoms, and may keep Barrett syndrome from getting worse. Endoscopic or surgical treatments can be used to treat Barrett syndrome with severe dysplasia or cancer.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Barrett's Esophagus" returned 541 free, full-text research articles on human participants. First 3 results:

Gastric Polyp Growth during Endoscopic Surveillance for Esophageal Varices or Barrett's Esophagus.
 

Author(s): Dan M Livovsky, Orit Pappo, Galina Skarzhinsky, Asaf Peretz, Elliot Turvall, Zvi Ackerman

Journal: Isr. Med. Assoc. J.. 2016 May;18(5):267-71.

 

We recently observed patients with chronic liver disease (CLD) or chronic reflux symptoms (CRS) who developed gastric polyps (GPs) while undergoing surveillance gastroscopies for the detection of esophageal varices or Barrett's esophagus, respectively.

Last Updated: 19 Jul 2016

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Increasing diagnostic accuracy to grade dysplasia in Barrett's esophagus using an immunohistochemical panel for CDX2, p120ctn, c-Myc and Jagged1.
 

Author(s): Dipti M Karamchandani, Heather L Lehman, Sara E Ohanessian, Julie Massé, Patricia A Welsh, Robert D Odze, John R Goldblum, Arthur S Berg, Douglas B Stairs

Journal:

 

Patients with non-dysplastic Barrett's esophagus (ND-BE) and low-grade dysplasia (LGD) are typically monitored by periodic endoscopic surveillance, while those with high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) are usually treated by more aggressive interventions ...

Last Updated: 1 Mar 2016

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Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus.
 

Author(s): Ming Yu, Rachele M O'Leary, Andrew M Kaz, Shelli M Morris, Kelly T Carter, Amitabh Chak, Apoorva Chandar, Joseph E Willis, Helen R Moinova, Sanford D Markowitz, Dean E Brenner, Sharmila Anandabapasathy, Maria Westerhoff, Chao-Jen Wong, Nicholas J Shaheen, Yanwen Chen, Jill S Barnholtz-Sloan, William M Grady

Journal: Cancer Epidemiol. Biomarkers Prev.. 2015 Dec;24(12):1890-7.

 

Barrett's esophagus (BE) is a preneoplastic condition in which normal esophageal squamous epithelium (SQ) is replaced by specialized intestinal metaplasia. It is the presumed precursor for esophageal adenocarcinoma (EAC) as well as the strongest risk factor for this cancer. Unfortunately, ...

Last Updated: 4 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Barrett's Esophagus" returned 100 free, full-text review articles on human participants. First 3 results:

Magnitude of Missed Esophageal Adenocarcinoma After Barrett's Esophagus Diagnosis: A Systematic Review and Meta-analysis.
 

Author(s): Kavel Visrodia, Siddharth Singh, Rajesh Krishnamoorthi, David A Ahlquist, Kenneth K Wang, Prasad G Iyer, David A Katzka

Journal: Gastroenterology. 2016 Mar;150(3):599-607.e7; quiz e14-5.

 

A proportion of patients with Barrett's esophagus (BE) are diagnosed with esophageal adenocarcinoma (EAC) within 1 year of an endoscopic examination that produced negative findings. These cases of missed cancers have not been well studied, despite current surveillance strategies for ...

Last Updated: 23 Feb 2016

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Genetic Biomarkers of Barrett's Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis.
 

Author(s): John M Findlay, Mark R Middleton, Ian Tomlinson

Journal: Dig. Dis. Sci.. 2016 Jan;61(1):25-38.

 

Barrett's esophagus (BE) is a common and important precursor lesion of esophageal adenocarcinoma (EAC). A third of patients with BE are asymptomatic, and our ability to predict the risk of progression of metaplasia to dysplasia and EAC (and therefore guide management) is limited. ...

Last Updated: 5 Jan 2016

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Prevalence of Barrett's Esophagus in Asian Countries: A Systematic Review and Meta-analysis.
 

Author(s): Seiji Shiota, Siddharth Singh, Ashraf Anshasi, Hashem B El-Serag

Journal: Clin. Gastroenterol. Hepatol.. 2015 Nov;13(11):1907-18.

 

The prevalence and risk factors of Barrett's esophagus (BE) in Asian countries are unclear. Studies report a wide range of BE prevalence in Asian countries. We conducted a systematic review and meta-analysis to examine the prevalence of BE and its temporal changes and risk factors ...

Last Updated: 19 Oct 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

BETERNet Notch Signaling and Novel Biomarkers for Barretts Esophagus
 

Status: Recruiting

Condition Summary: Barrett's Esophagus

 

Last Updated: 11 Apr 2016

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"Acetic Acid Chromoendoscopy in Barrett's Esophagus Surveillance
 

Status: Not yet recruiting

Condition Summary: Barrett's Esophagus

 

Last Updated: 2 Aug 2016

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Trial of a Gastrin Receptor Antagonist in Barrett's Esophagus
 

Status: Recruiting

Condition Summary: Barrett's Esophagus

 

Last Updated: 25 Jul 2016

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