Barrett's Esophagus

Common Name(s)

Barrett's Esophagus, Barrett syndrome

Barrett syndrome, also known as Barrett esophagus, is a disorder in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestine. This process is called intestinal metaplasia.  The exact cause of Barrett syndrome is not known, but gastroesophageal reflux disease (GERD) is a risk factor for the condition.  While Barrett syndrome itself does not cause symptoms, the acid reflux associated with GERD often leads to symptoms of heartburn.   Less than 1% of people with Barrett syndrome develop a rare type of cancer called esophageal adenocarcinoma. Treatment of GERD should improve symptoms, and may keep Barrett syndrome from getting worse. Endoscopic or surgical treatments can be used to treat Barrett syndrome with severe dysplasia or cancer.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Barrett's Esophagus" returned 478 free, full-text research articles on human participants. First 3 results:

Cost-Effectiveness Analysis on Endoscopic Surveillance Among Western Patients With Barrett's Esophagus for Esophageal Adenocarcinoma Screening.
 

Author(s): Yu Yang, Hai-Ning Chen, Rui Wang, Yun-Jing Tang, Xin-Zu Chen

Journal: Medicine (Baltimore). 2015 Sep;94(39):e1105.

 

Incidence of esophageal adenocarcinoma (EAC) has risen rapidly over the past decades in Western countries. As a premalignant lesion, Barrett's esophagus (BE) is an established risk factor of EAC. This study estimated the impact of surveillance endoscopy for BE on population's survival ...

Last Updated: 2 Oct 2015

Go To URL
Association Between Alcohol Consumption and the Risk of Barrett's Esophagus: A Meta-Analysis of Observational Studies.
 

Author(s): Qin Xu, Wei Guo, Xingang Shi, Wei Zhang, Tianyi Zhang, Cheng Wu, Jian Lu, Rui Wang, Yanfang Zhao, Xiuqiang Ma, Jia He

Journal: Medicine (Baltimore). 2015 Aug;94(32):e1244.

 

The association between alcohol consumption and Barrett's esophagus (BE) remained uncertain and controversial in the previous studies. We performed a meta-analysis of observational studies to clarify the association.We searched PubMed, Web of Science, and Embase for studies on alcohol ...

Last Updated: 13 Aug 2015

Go To URL
The Presence of Genetic Mutations at Key Loci Predicts Progression to Esophageal Adenocarcinoma in Barrett's Esophagus.
 

Author(s): Swathi Eluri, William R Brugge, Ebubekir S Daglilar, Sara A Jackson, Mindi A Styn, Keith M Callenberg, Derek C Welch, Todd M Barr, Lucas C Duits, Jacques J Bergman, Nicholas J Shaheen

Journal: Am. J. Gastroenterol.. 2015 Jun;110(6):828-34.

 

Risk stratification in Barrett's esophagus (BE) is challenging. We evaluated the ability of a panel of genetic markers to predict progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC).

Last Updated: 9 Jun 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Barrett's Esophagus" returned 86 free, full-text review articles on human participants. First 3 results:

Screening for Barrett's Esophagus.
 

Author(s): Massimiliano di Pietro, Daniel Chan, Rebecca C Fitzgerald, Kenneth K Wang

Journal: Gastroenterology. 2015 May;148(5):912-23.

 

The large increase in the incidence of esophageal adenocarcinoma in the West during the past 30 years has stimulated interest in screening for Barrett's esophagus (BE), a precursor to esophageal cancer. Effective endoscopic treatments for dysplasia and intramucosal cancer, coupled ...

Last Updated: 24 Apr 2015

Go To URL
Current issues in Barrett's esophagus and Barrett's-related dysplasia.
 

Author(s): John R Goldblum

Journal: Mod. Pathol.. 2015 Jan;28 Suppl 1():S1-6.

 

Surgical pathologists frequently encounter biopsies in patients with Barrett's esophagus (BE), defined as replacement of the normal stratified squamous epithelium of the distal esophagus by metaplastic columnar epithelium containing goblet cells. Thus, one of the primary roles of ...

Last Updated: 6 Jan 2015

Go To URL
Barrett's esophagus and cancer risk: how research advances can impact clinical practice.
 

Author(s): Massimiliano di Pietro, Durayd Alzoubaidi, Rebecca C Fitzgerald

Journal: Gut Liver. 2014 Jul;8(4):356-70.

 

Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), whose incidence has increased sharply in the last 4 decades. The annual conversion rate of BE to cancer is significant, but small. The identification of patients at a higher risk of cancer therefore ...

Last Updated: 29 Jul 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Acetylsalicylic Acid in Preventing Disease Recurrence in Patients With Barrett's Esophagus After Successful Elimination by Radiofrequency Ablation
 

Status: Recruiting

Condition Summary: Barrett Esophagus; Barrett Esophagus-Negative for Dysplasia; Dysplasia in Barrett Esophagus

 

Last Updated: 4 Feb 2016

Go to URL
Familial Barrett's Esophagus
 

Status: Recruiting

Condition Summary: Barrett's Esophagus; Esophageal Neoplasm

 

Last Updated: 15 Jan 2013

Go to URL
Barrett's Esophagus Related Neoplasia (BERN) Project
 

Status: Recruiting

Condition Summary: Barrett's Esophagus; Neoplasms; Gastroesophageal Reflux

 

Last Updated: 19 Oct 2015

Go to URL