Barrett's Esophagus

Common Name(s)

Barrett's Esophagus, Barrett syndrome

Barrett syndrome, also known as Barrett esophagus, is a disorder in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestine. This process is called intestinal metaplasia.  The exact cause of Barrett syndrome is not known, but gastroesophageal reflux disease (GERD) is a risk factor for the condition.  While Barrett syndrome itself does not cause symptoms, the acid reflux associated with GERD often leads to symptoms of heartburn.   Less than 1% of people with Barrett syndrome develop a rare type of cancer called esophageal adenocarcinoma. Treatment of GERD should improve symptoms, and may keep Barrett syndrome from getting worse. Endoscopic or surgical treatments can be used to treat Barrett syndrome with severe dysplasia or cancer.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Barrett's Esophagus" returned 537 free, full-text research articles on human participants. First 3 results:

Pathway Cross-Talk Analysis in Detecting Significant Pathways in Barrett's Esophagus Patients.
 

Author(s): Zhengyuan Xu, Yan Yan, Jian He, Xinfang Shan, Weiguo Wu

Journal:

 

BACKGROUND The pathological mechanism of Barrett's esophagus (BE) is still unclear. In the present study, pathway cross-talks were analyzed to identify hub pathways for BE, with the purpose of finding an efficient and cost-effective detection method to discover BE at its early stage ...

Last Updated: 6 Mar 2017

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Health-related quality of life in patients with Barrett's esophagus.
 

Author(s): Chi-Yang Chang, Lukas Jyuhn-Hsiarn Lee, Jung-Der Wang, Ching-Tai Lee, Chi-Ming Tai, Tao-Qian Tang, Jaw-Town Lin

Journal:

 

Gastroesophageal reflux disease (GERD) has become a major health problem globally, affecting patients' health-related quality of life (HRQOL). Barrett's esophagus (BE) is a precancerous lesion associated with GERD. BE patients might not only suffer from HRQOL losses by GERD but also ...

Last Updated: 15 Nov 2016

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Feasibility of volumetric laser endomicroscopy in Barrett's esophagus with dysplasia and in post-ablation surveillance.
 

Author(s): Tanmayee Benjamin, Sampurna Shakya, Prashanthi Nagavenkata Thota

Journal: J Gastrointestin Liver Dis. 2016 Sep;25(3):407-8.

 

Last Updated: 30 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Barrett's Esophagus" returned 103 free, full-text review articles on human participants. First 3 results:

Turning Skyscrapers into Town Houses: Insights into Barrett's Esophagus.
 

Author(s): Theresa D Ahrens, Lisa Lutz, Silke Lassmann, Martin Werner

Journal: Pathobiology. 2017 ;84(2):87-98.

 

Barrett's esophagus (BE) is defined as metaplasia of the esophageal squamous epithelium with multiple cell layers into a single layer of intestinal columnar epithelial cells - or, in other words, skyscrapers are turned into town houses. The underlying pathomechanism(s) and the cell ...

Last Updated: 22 Sep 2016

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Acetic acid chromoendoscopy: Improving neoplasia detection in Barrett's esophagus.
 

Author(s): Fergus J Q Chedgy, Sharmila Subramaniam, Kesavan Kandiah, Sreedhari Thayalasekaran, Pradeep Bhandari

Journal: World J. Gastroenterol.. 2016 Jul;22(25):5753-60.

 

Barrett's esophagus (BE) is an important condition given its significant premalignant potential and dismal five-year survival outcomes of advanced esophageal adenocarcinoma. It is therefore suggested that patients with a diagnosis of BE undergo regular surveillance in order to pick ...

Last Updated: 19 Jul 2016

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Post-ablation surveillance in Barrett's esophagus: A review of the literature.
 

Author(s): Matthew W Stier, Vani J Konda, John Hart, Irving Waxman

Journal: World J. Gastroenterol.. 2016 May;22(17):4297-306.

 

Barrett's esophagus (BE) is a pre-malignant condition affecting up to 15% of patients with gastroesophageal reflux disease. Neoplastic Barrett's mucosa is defined as harboring high grade dysplasia or intra-mucosal cancer, and carries a high risk of progression to esophageal adenocarcinoma. ...

Last Updated: 9 May 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

BETERNet Notch Signaling and Novel Biomarkers for Barretts Esophagus
 

Status: Recruiting

Condition Summary: Barrett's Esophagus

 

Last Updated: 24 Jan 2017

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"Acetic Acid Chromoendoscopy in Barrett's Esophagus Surveillance
 

Status: Recruiting

Condition Summary: Barrett's Esophagus

 

Last Updated: 10 Mar 2017

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Trial of a Gastrin Receptor Antagonist in Barrett's Esophagus
 

Status: Recruiting

Condition Summary: Barrett's Esophagus

 

Last Updated: 25 Jul 2016

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