Barrett's Esophagus

Common Name(s)

Barrett's Esophagus, Barrett syndrome

Barrett syndrome, also known as Barrett esophagus, is a disorder in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestine. This process is called intestinal metaplasia.  The exact cause of Barrett syndrome is not known, but gastroesophageal reflux disease (GERD) is a risk factor for the condition.  While Barrett syndrome itself does not cause symptoms, the acid reflux associated with GERD often leads to symptoms of heartburn.   Less than 1% of people with Barrett syndrome develop a rare type of cancer called esophageal adenocarcinoma. Treatment of GERD should improve symptoms, and may keep Barrett syndrome from getting worse. Endoscopic or surgical treatments can be used to treat Barrett syndrome with severe dysplasia or cancer.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Barrett's Esophagus" returned 379 free, full-text research articles on human participants. First 3 results:

Body mass index, smoking, and alcohol and risks of Barrett's esophagus and esophageal adenocarcinoma: a UK prospective cohort study.
 

Author(s): Max Yates, Edward Cheong, Robert Luben, Laszlo Igali, Rebecca Fitzgerald, Kay-Tee Khaw, Andrew Hart

Journal: Dig. Dis. Sci.. 2014 Jul;59(7):1552-9.

 

The timing of the risk factors cigarette smoking, alcohol and obesity in the development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) is unclear.

Last Updated: 24 Jun 2014

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Association between Helicobacter pylori and Barrett's esophagus: a case-control study.
 

Author(s): Lori A Fischbach, David Y Graham, Jennifer R Kramer, Massimo Rugge, Gordana Verstovsek, Paola Parente, Abeer Alsarraj, Stephanie Fitzgerald, Yasser Shaib, Neena S Abraham, Anna Kolpachi, Swapna Gupta, Marcelo F Vela, Maria Velez, Rhonda Cole, Bhupinderjit Anand, Hashem B El Serag

Journal: Am. J. Gastroenterol.. 2014 Mar;109(3):357-68.

 

The estimated association between Helicobacter pylori and Barrett's esophagus (BE) has been heterogenous across previous studies. In this study, we aimed to examine the association between H. pylori and BE and to identify factors that may explain or modify this association.

Last Updated: 5 Mar 2014

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Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett's esophagus: a pilot ex-vivo study.
 

Author(s): Yutaka Tomizawa, Prasad G Iyer, Louis M Wongkeesong, Navtej S Buttar, Lori S Lutzke, Tsung-Teh Wu, Kenneth K Wang

Journal: World J. Gastroenterol.. 2013 Dec;19(46):8652-8.

 

To investigate a classification of endocytoscopy (ECS) images in Barrett's esophagus (BE) and evaluate its diagnostic performance and interobserver variability.

Last Updated: 31 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Barrett's Esophagus" returned 81 free, full-text review articles on human participants. First 3 results:

Advances in understanding the pathogenesis of Barrett's esophagus.
 

Author(s): Nicholas J Clemons, Shze Yung Koh, Wayne A Phillips

Journal: Discov Med. 2014 Jan;17(91):7-14.

 

Barrett's esophagus (BE) is an intestinal-like columnar metaplasia that replaces the normal stratified squamous epithelium in the distal esophagus. Clinically, BE is an important entity as it is the only established precursor to esophageal adenocarcinoma (EAC), a disease with an extremely ...

Last Updated: 13 Jan 2014

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Meta-analysis of Barrett's esophagus in China.
 

Author(s): Ying Dong, Bing Qi, Xiao-Ying Feng, Chun-Meng Jiang

Journal: World J. Gastroenterol.. 2013 Dec;19(46):8770-9.

 

To investigate the epidemiology and characteristics of Barrett's esophagus (BE) in China and compare with cases in the west.

Last Updated: 31 Dec 2013

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Efficacy and durability of radiofrequency ablation for Barrett's Esophagus: systematic review and meta-analysis.
 

Author(s): Eric S Orman, Nan Li, Nicholas J Shaheen

Journal: Clin. Gastroenterol. Hepatol.. 2013 Oct;11(10):1245-55.

 

In patients with Barrett's esophagus (BE), radiofrequency ablation (RFA) safely and effectively eradicates dysplasia and intestinal metaplasia. We aimed to determine the efficacy and durability of RFA for patients with dysplastic and nondysplastic BE.

Last Updated: 23 Sep 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Vitamin D Supplementation on 15-Prostaglandin Dehydrogenase Expression in Barrett's Esophagus
 

Status: Recruiting

Condition Summary: Short Segment Barrett's Esophagus; Long Segment Barrett's Esophagus

 

Last Updated: 28 May 2014

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Familial Barrett's Esophagus
 

Status: Recruiting

Condition Summary: Barrett's Esophagus; Esophageal Neoplasm

 

Last Updated: 15 Jan 2013

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Barrett's Esophagus Related Neoplasia (BERN) Project
 

Status: Recruiting

Condition Summary: Barrett's Esophagus; Neoplasms; Gastroesophageal Reflux

 

Last Updated: 28 Mar 2014

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