Barrett's Esophagus

Common Name(s)

Barrett's Esophagus, Barrett syndrome

Barrett syndrome, also known as Barrett esophagus, is a disorder in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestine. This process is called intestinal metaplasia.  The exact cause of Barrett syndrome is not known, but gastroesophageal reflux disease (GERD) is a risk factor for the condition.  While Barrett syndrome itself does not cause symptoms, the acid reflux associated with GERD often leads to symptoms of heartburn.   Less than 1% of people with Barrett syndrome develop a rare type of cancer called esophageal adenocarcinoma. Treatment of GERD should improve symptoms, and may keep Barrett syndrome from getting worse. Endoscopic or surgical treatments can be used to treat Barrett syndrome with severe dysplasia or cancer.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Barrett's Esophagus" returned 523 free, full-text research articles on human participants. First 3 results:

Gastric Polyp Growth during Endoscopic Surveillance for Esophageal Varices or Barrett's Esophagus.
 

Author(s): Dan M Livovsky, Orit Pappo, Galina Skarzhinsky, Asaf Peretz, Elliot Turvall, Zvi Ackerman

Journal: Isr. Med. Assoc. J.. 2016 May;18(5):267-71.

 

We recently observed patients with chronic liver disease (CLD) or chronic reflux symptoms (CRS) who developed gastric polyps (GPs) while undergoing surveillance gastroscopies for the detection of esophageal varices or Barrett's esophagus, respectively.

Last Updated: 19 Jul 2016

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Cost-Effectiveness Analysis on Endoscopic Surveillance Among Western Patients With Barrett's Esophagus for Esophageal Adenocarcinoma Screening.
 

Author(s): Yu Yang, Hai-Ning Chen, Rui Wang, Yun-Jing Tang, Xin-Zu Chen

Journal: Medicine (Baltimore). 2015 Sep;94(39):e1105.

 

Incidence of esophageal adenocarcinoma (EAC) has risen rapidly over the past decades in Western countries. As a premalignant lesion, Barrett's esophagus (BE) is an established risk factor of EAC. This study estimated the impact of surveillance endoscopy for BE on population's survival ...

Last Updated: 2 Oct 2015

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Wnt/β-Catenin Signaling Activation beyond Robust Nuclear β-Catenin Accumulation in Nondysplastic Barrett's Esophagus: Regulation via Dickkopf-1.
 

Author(s): Orestis Lyros, Parvaneh Rafiee, Linghui Nie, Rituparna Medda, Nebojsa Jovanovic, Mary F Otterson, Behnaz Behmaram, Ines Gockel, Alexander Mackinnon, Reza Shaker

Journal: Neoplasia. 2015 Jul;17(7):598-611.

 

Wnt/β-catenin signaling activation has been reported only during the late steps of Barrett's esophagus (BE) neoplastic progression, but not in BE metaplasia, based on the absence of nuclear β-catenin. However, β-catenin transcriptional activity has been recorded in absence of robust ...

Last Updated: 22 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Barrett's Esophagus" returned 94 free, full-text review articles on human participants. First 3 results:

Genetic Biomarkers of Barrett's Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis.
 

Author(s): John M Findlay, Mark R Middleton, Ian Tomlinson

Journal: Dig. Dis. Sci.. 2016 Jan;61(1):25-38.

 

Barrett's esophagus (BE) is a common and important precursor lesion of esophageal adenocarcinoma (EAC). A third of patients with BE are asymptomatic, and our ability to predict the risk of progression of metaplasia to dysplasia and EAC (and therefore guide management) is limited. ...

Last Updated: 5 Jan 2016

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Recent developments in pathogenesis, diagnosis and therapy of Barrett's esophagus.
 

Author(s): Magnus Halland, David Katzka, Prasad G Iyer

Journal: World J. Gastroenterol.. 2015 Jun;21(21):6479-90.

 

The burden of illness from esophageal adenocarcinoma continues to rise in the Western world, and overall prognosis is poor. Given that Barrett's esophagus (BE), a metaplastic change in the esophageal lining is a known cancer precursor, an opportunity to decrease disease development ...

Last Updated: 15 Jun 2015

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Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma.
 

Author(s): Andrew M Kaz, William M Grady, Matthew D Stachler, Adam J Bass

Journal: Gastroenterol. Clin. North Am.. 2015 Jun;44(2):473-89.

 

Esophageal adenocarcinoma (EAC) develops from Barrett's esophagus (BE), wherein normal squamous epithelia is replaced by specialized intestinal metaplasia in response to chronic gastroesophageal acid reflux. BE can progress to low- and high-grade dysplasia, intramucosal, and invasive ...

Last Updated: 29 May 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation
 

Status: Recruiting

Condition Summary: Barrett Esophagus; Barrett Esophagus-Negative for Dysplasia; Dysplasia in Barrett Esophagus

 

Last Updated: 18 Aug 2016

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Familial Barrett's Esophagus
 

Status: Recruiting

Condition Summary: Barrett's Esophagus; Esophageal Neoplasm

 

Last Updated: 15 Jan 2013

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Barrett's Esophagus Related Neoplasia (BERN) Project
 

Status: Recruiting

Condition Summary: Barrett's Esophagus; Neoplasms; Gastroesophageal Reflux

 

Last Updated: 19 Oct 2015

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