Barrett's Esophagus

Common Name(s)

Barrett's Esophagus, Barrett syndrome

Barrett syndrome, also known as Barrett esophagus, is a disorder in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestine. This process is called intestinal metaplasia.  The exact cause of Barrett syndrome is not known, but gastroesophageal reflux disease (GERD) is a risk factor for the condition.  While Barrett syndrome itself does not cause symptoms, the acid reflux associated with GERD often leads to symptoms of heartburn.   Less than 1% of people with Barrett syndrome develop a rare type of cancer called esophageal adenocarcinoma. Treatment of GERD should improve symptoms, and may keep Barrett syndrome from getting worse. Endoscopic or surgical treatments can be used to treat Barrett syndrome with severe dysplasia or cancer.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Barrett's Esophagus" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Barrett's Esophagus" returned 370 free, full-text research articles on human participants. First 3 results:

Association between Helicobacter pylori and Barrett's esophagus: a case-control study.
 

Author(s): Lori A Fischbach, David Y Graham, Jennifer R Kramer, Massimo Rugge, Gordana Verstovsek, Paola Parente, Abeer Alsarraj, Stephanie Fitzgerald, Yasser Shaib, Neena S Abraham, Anna Kolpachi, Swapna Gupta, Marcelo F Vela, Maria Velez, Rhonda Cole, Bhupinderjit Anand, Hashem B El Serag

Journal: Am. J. Gastroenterol.. 2014 Mar;109(3):357-68.

 

The estimated association between Helicobacter pylori and Barrett's esophagus (BE) has been heterogenous across previous studies. In this study, we aimed to examine the association between H. pylori and BE and to identify factors that may explain or modify this association.

Last Updated: 5 Mar 2014

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Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett's esophagus: a pilot ex-vivo study.
 

Author(s): Yutaka Tomizawa, Prasad G Iyer, Louis M Wongkeesong, Navtej S Buttar, Lori S Lutzke, Tsung-Teh Wu, Kenneth K Wang

Journal: World J. Gastroenterol.. 2013 Dec;19(46):8652-8.

 

To investigate a classification of endocytoscopy (ECS) images in Barrett's esophagus (BE) and evaluate its diagnostic performance and interobserver variability.

Last Updated: 31 Dec 2013

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Barrett's esophagus suspected at endoscopy but no specialized intestinal metaplasia on biopsy, what's next?
 

Author(s): Hashim E Khandwalla, David Y Graham, Jennifer R Kramer, David J Ramsey, Ngoc Duong, Linda K Green, Hashem B El-Serag

Journal: Am. J. Gastroenterol.. 2014 Feb;109(2):178-82.

 

There are no guidelines regarding the best practice for when Barrett's esophagus (BE) is suspected but not confirmed by histology. The aim of this study was to examine the value of endoscopic follow-up for individuals with endoscopic only BE at index endoscopy.

Last Updated: 5 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Barrett's Esophagus" returned 76 free, full-text review articles on human participants. First 3 results:

Meta-analysis of Barrett's esophagus in China.
 

Author(s): Ying Dong, Bing Qi, Xiao-Ying Feng, Chun-Meng Jiang

Journal: World J. Gastroenterol.. 2013 Dec;19(46):8770-9.

 

To investigate the epidemiology and characteristics of Barrett's esophagus (BE) in China and compare with cases in the west.

Last Updated: 31 Dec 2013

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Role of interleukin-6 in Barrett's esophagus pathogenesis.
 

Author(s): Katerina Dvorak, Bohuslav Dvorak

Journal: World J. Gastroenterol.. 2013 Apr;19(15):2307-12.

 

Barrett's esophagus (BE) is a metaplastic lesion of the distal esophagus arising as a consequence of chronic gastroesophageal reflux disease. Multiple studies show that BE is associated with increased risk of esophageal adenocarcinoma (EAC). Epidemiological studies and animal models ...

Last Updated: 24 Apr 2013

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Barrett's esophagus in 2012: updates in pathogenesis, treatment, and surveillance.
 

Author(s): Subhash Chandra, Emmanuel C Gorospe, Cadman L Leggett, Kenneth K Wang

Journal: Curr Gastroenterol Rep. 2013 May;15(5):322.

 

Barrett's esophagus (BE) is the only established precursor lesion in the development of esophageal adenocarcinoma (EAC) and it increases the risk of cancer by 11-fold. It is regarded as a complication of gastroesophageal reflux disease. There is an ever-increasing body of knowledge ...

Last Updated: 22 Apr 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Vitamin D Supplementation on 15-Prostaglandin Dehydrogenase Expression in Barrett's Esophagus
 

Status: Recruiting

Condition Summary: Short Segment Barrett's Esophagus; Long Segment Barrett's Esophagus

 

Last Updated: 28 May 2014

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Betrnet Stem Cells and the Origins of Barrett's Esophagus Project 3 RF Ablation
 

Status: Recruiting

Condition Summary: Barrett's Esophagus

 

Last Updated: 17 Jan 2014

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Aceto-whitening in the Assessment of Gastrointestinal Neoplasia
 

Status: Recruiting

Condition Summary: Barrett Esophagus; Barrett Metaplasia; Barrett Oesophagitis With Dysplasia; Barrett Adenocarcinoma

 

Last Updated: 13 Jun 2012

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