Von Willebrand Disease

Common Name(s)

Von Willebrand Disease

Von Willebrand disease is a bleeding disorder that slows the blood clotting process. People with this condition often experience bruising, nosebleeds, and prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases, heavy bleeding occurs after minor trauma or even in the absence of injury. Milder forms of Von Willebrand disease do not involve spontaneous bleeding, and the condition may become apparent only when abnormal bleeding occurs following surgery or a serious injury. Symptoms may change over time. Increased age, pregnancy, exercise, and stress may make bleeding symptoms may become less frequent. This condition is caused by mutations in the VWF gene and can have different inheritance patterns.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Von Willebrand Disease" for support, advocacy or research.

Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

Last Updated: 25 Sep 2013

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Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

Last Updated: 26 Nov 2012

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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

Last Updated: 3 Apr 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Von Willebrand Disease" for support, advocacy or research.

Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

http://www.bdai.org

Last Updated: 25 Sep 2013

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Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

http://www.hemophiliafed.org

Last Updated: 26 Nov 2012

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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

http://www.haemophilia.org.uk/

Last Updated: 3 Apr 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Von Willebrand Disease" returned 257 free, full-text research articles on human participants. First 3 results:

Thrombocytopathy and type 2B von Willebrand disease.
 

Author(s): Jerry Ware

Journal: J. Clin. Invest.. 2013 Dec;123(12):5004-6.

 

The knowledge gained from "experiments of nature" has always been paramount in identifying key players in pathophysiologic pathways. This is well characterized by naturally occurring bleeding and thrombotic disorders. In most cases, it is the absence of a particular protein that leads ...

Last Updated: 2 Dec 2013

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Management of von Willebrand disease type 3 during pregnancy - 2 cases reports.
 

Author(s): G InocĂȘncio, A Braga, S Azevedo, G Buchner

Journal: Eur Rev Med Pharmacol Sci. 2013 Nov;17(21):2857-9.

 

von Willebrand disease type 3, is an extremely rare condition. It can be severe and potentially life-threatening, particularly in pregnant women during labor and subsequently during early puerperium. Due to its rarity, there is no optimal treatment/management during pregnancy.

Last Updated: 22 Nov 2013

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Spontaneous intramural duodenal hematoma in type 2B von Willebrand disease.
 

Author(s): Derrick D Eichele, Meredith Ross, Patrick Tang, Grant F Hutchins, Mark Mailliard

Journal: World J. Gastroenterol.. 2013 Nov;19(41):7205-8.

 

Intramural duodenal hematoma is a rare cause of a proximal gastrointestinal tract obstruction. Presentation of intramural duodenal hematoma most often occurs following blunt abdominal trauma in children, but spontaneous non-traumatic cases have been linked to anticoagulant therapy, ...

Last Updated: 13 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Von Willebrand Disease" returned 19 free, full-text review articles on human participants. First 3 results:

Principles of care for the diagnosis and treatment of von Willebrand disease.
 

Author(s): Giancarlo Castaman, Anne Goodeve, Jeroen Eikenboom,

Journal: Haematologica. 2013 May;98(5):667-74.

 

Von Willebrand disease is a common autosomal inherited bleeding disorder caused by quantitative or qualitative defects of von Willebrand factor, a multi-adhesive protein that binds platelets to exposed subendothelium and carries factor VIII in circulation. As a result of von Willebrand ...

Last Updated: 1 May 2013

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Percutaneous coronary intervention and the management of acute coronary syndromes in patients with von Willebrand disease.
 

Author(s): Sulaiman Rathore, Dexter Deleon, Hafsa Akram, David Sane, Timothy Ball

Journal: J Invasive Cardiol. 2013 Apr;25(4):E81-6.

 

Von Willebrand disease (vWD) results from quantitative or qualitative deficiency of von Willebrand factor (vWF). The occurrence of myocardial infarction is very rare in patients with vWD. A few case reports of acute coronary syndrome (ACS) in vWD patients are present in the literature, ...

Last Updated: 3 Apr 2013

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The molecular characterization of von Willebrand disease: good in parts.
 

Author(s): P D James, D Lillicrap

Journal: Br. J. Haematol.. 2013 Apr;161(2):166-76.

 

Since the cloning of the gene that encodes von Willebrand factor (VWF), 27 years ago, significant progress has been made in our understanding of the molecular basis of the most common inherited bleeding disorder, von Willebrand disease (VWD). The molecular pathology of this condition ...

Last Updated: 4 Apr 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Surveillance of Safety and Efficacy of Wilate in Patients With Von Willebrand Disease
 

Status: Recruiting

Condition Summary: Von Willebrand Disease

 

Last Updated: 28 Jul 2014

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Efficacy of Alphanate FVIII/VWF Concentrate in Type 3 Von Willebrand Patients
 

Status: Recruiting

Condition Summary: Von Willebrand Disease

 

Last Updated: 17 Feb 2014

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Global Hemostatic Methods in Hemophilia and Von Willebrand's Disease
 

Status: Recruiting

Condition Summary: Hemophilia A; Hemophilia B; Von Willebrand's Disease

 

Last Updated: 11 Feb 2014

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