Von Willebrand Disease

Common Name(s)

Von Willebrand Disease

Von Willebrand disease is a bleeding disorder that slows the blood clotting process. People with this disoder often experience bruising, nosebleeds, and prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases, heavy bleeding occurs after minor trauma or even in the absence of injury. Milder forms of Von Willebrand disease do not involve spontaneous bleeding, and the condition may become apparent only when abnormal bleeding occurs following surgery or a serious injury. Symptoms may change over time. Increased age, pregnancy, exercise, and stress may make bleeding symptoms become less frequent. This disorder is caused by mutations in the VWF gene and can have different inheritance patterns.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Von Willebrand Disease" for support, advocacy or research.

Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

Last Updated: 25 Sep 2013

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Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

Last Updated: 6 Jul 2015

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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

Last Updated: 3 Apr 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Von Willebrand Disease" for support, advocacy or research.

Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

http://www.bdai.org

Last Updated: 25 Sep 2013

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Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

http://www.hemophiliafed.org

Last Updated: 6 Jul 2015

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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

http://www.haemophilia.org.uk/

Last Updated: 3 Apr 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Von Willebrand Disease" returned 270 free, full-text research articles on human participants. First 3 results:

Low paraoxonase 1 arylesterase activity and high von Willebrand factor levels are associated with severe coronary atherosclerosis in patients with non-diabetic stable coronary artery disease.
 

Author(s): Jieying Ding, Qizhi Chen, Xing Zhuang, Zhilei Feng, Lili Xu, Fuxiang Chen

Journal:

 

Paraoxonase 1 (PON1) activity and von Willebrand factor (VWF) release are associated with lesion initiation in atherosclerosis. Diabetes can complicate coronary artery disease (CAD) due to the production of advanced glycation end products. This study evaluated PON1 activity and VWF ...

Last Updated: 25 Nov 2014

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Isolated spontaneous celiac artery dissection in a 47-year-old man with von Willebrand disease.
 

Author(s): Aziz Ur Rehman, Abdelkader Almanfi, Srikanth Nadella, Umair Sohail

Journal:

 

Isolated spontaneous dissection of the celiac artery is rare, and its occurrence without aortic dissection is even rarer. The typical symptom of this dissection is acute-onset abdominal pain. Complications of the condition include aneurysm formation, rupture, and abdominal-organ ischemia ...

Last Updated: 23 Jun 2014

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Von Willebrand factor regulation in patients with acute and chronic cerebrovascular disease: a pilot, case-control study.
 

Author(s): Peter Kraft, Christiane Drechsler, Ignaz Gunreben, Bernhard Nieswandt, Guido Stoll, Peter Ulrich Heuschmann, Christoph Kleinschnitz

Journal:

 

In animal models, von Willebrand factor (VWF) is involved in thrombus formation and propagation of ischemic stroke. However, the pathophysiological relevance of this molecule in humans, and its potential use as a biomarker for the risk and severity of ischemic stroke remains unclear. ...

Last Updated: 18 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Von Willebrand Disease" returned 25 free, full-text review articles on human participants. First 3 results:

Up to date concepts about Von Willebrand disease and the diagnose of this hemostatic disorder.
 

Author(s): I Buga-Corbu, C Arion

Journal: J Med Life. 2014 Sep;7(3):327-34.

 

The authors review the current data in literature regarding the recent knowledge about hemostase, coagulation and clinical and laboratory diagnostic algorithms of hemostatic disorders. They also present the pathological classification of bleeding disorders - the basis to clinical ...

Last Updated: 21 Nov 2014

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Current therapy in children and adolescents with von Willebrand disease.
 

Author(s): I Buga-Corbu, C Arion

Journal: J Med Life. 2014 Jun;7(2):264-9.

 

The article represents a review of recent data about the therapy of von Willebrand disease in children and adolescents (hereditary as well as acquired forms of the disease). The treatment of bleeding events in these patients, the indications in different subtypes, and the future lines ...

Last Updated: 21 Nov 2014

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Laboratory aspects of von Willebrand disease: test repertoire and options for activity assays and genetic analysis.
 

Author(s): G Castaman, A Hillarp, A Goodeve

Journal: Haemophilia. 2014 May;20 Suppl 4():65-70.

 

The deficiency or abnormal function of von Willebrand factor (VWF) causes von Willebrand disease (VWD), the most frequent inherited bleeding disorder. The laboratory diagnosis of VWD can be difficult as the disease is heterogeneous and an array of assays is required to describe the ...

Last Updated: 25 Apr 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Global Hemostatic Methods in Hemophilia and Von Willebrand's Disease
 

Status: Recruiting

Condition Summary: Hemophilia A; Hemophilia B; Von Willebrand's Disease

 

Last Updated: 11 Feb 2014

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Last Updated: 8 Jun 2015

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Surveillance of Safety and Efficacy of Wilate in Patients With Von Willebrand Disease
 

Status: Recruiting

Condition Summary: Von Willebrand Disease

 

Last Updated: 20 Apr 2015

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