Von Willebrand Disease

Common Name(s)

Von Willebrand Disease

Von Willebrand disease is a bleeding disorder that slows the blood clotting process. People with this disoder often experience bruising, nosebleeds, and prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases, heavy bleeding occurs after minor trauma or even in the absence of injury. Milder forms of Von Willebrand disease do not involve spontaneous bleeding, and the condition may become apparent only when abnormal bleeding occurs following surgery or a serious injury. Symptoms may change over time. Increased age, pregnancy, exercise, and stress may make bleeding symptoms become less frequent. This disorder is caused by mutations in the VWF gene and can have different inheritance patterns.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Von Willebrand Disease" for support, advocacy or research.

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Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

Last Updated: 11 Jul 2016

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Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

Last Updated: 25 Sep 2013

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Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

Last Updated: 6 Jul 2015

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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

Last Updated: 3 Apr 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Von Willebrand Disease" for support, advocacy or research.

Logo
Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

http://www.bensfriends.org

Last Updated: 11 Jul 2016

View Details
Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

http://www.bdai.org

Last Updated: 25 Sep 2013

View Details
Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

http://www.hemophiliafed.org

Last Updated: 6 Jul 2015

View Details
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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

http://www.haemophilia.org.uk/

Last Updated: 3 Apr 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Von Willebrand Disease" returned 431 free, full-text research articles on human participants. First 3 results:

Impact of von Willebrand factor on coronary plaque burden in coronary artery disease patients treated with statins.
 

Author(s): Yuta Kato, Atsushi Iwata, Makito Futami, Motoki Yamashita, Satoshi Imaizumi, Takashi Kuwano, Amane Ike, Makoto Sugihara, Hiroaki Nishikawa, Bo Zhang, Shin'ichiro Yasunaga, Keijiro Saku, Shin-Ichiro Miura

Journal: Medicine (Baltimore). 2018 Apr;97(17):e0589.

 

High von Willebrand factor (VWF) levels have been reported to be associated with an increased risk of cardiovascular events. However, the relationship between VWF levels and coronary atherosclerosis in patients with coronary artery disease (CAD) who have already received stain treatment ...

Last Updated: 31 Dec 1969

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Genetic variation in the C-type lectin receptor CLEC4M in type 1 von Willebrand Disease patients.
 

Author(s): Eric Manderstedt, Christina Lind-Halldén, Stefan Lethagen, Christer Halldén

Journal:

 

von Willebrand factor (VWF) levels in healthy individuals and in patients with type 1 von Willebrand disease (VWD) are influenced by genetic variation in several genes, e.g. VWF, ABO, STXBP5 and CLEC4M. This study aims to screen comprehensively for CLEC4M variants and investigate ...

Last Updated: 31 Dec 1969

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Is gingival bleeding a symptom of type 2 and 3 von Willebrand disease?
 

Author(s): Lisa Epping, Wolfgang Miesbach, Katrin Nickles, Peter Eickholz

Journal:

 

Von Willebrand disease (VWD) is the most common inherent bleeding disorder. Gingival bleeding is a frequently reported symptom of VWD. However, gingival bleeding is also a leading symptom of plaque-induced gingivitis and untreated periodontal disease. In type 1 VWD gingival bleeding ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Von Willebrand Disease" returned 43 free, full-text review articles on human participants. First 3 results:

What have we learned from large population studies of von Willebrand disease?
 

Author(s): Robert R Montgomery, Veronica H Flood

Journal: Hematology Am Soc Hematol Educ Program. 2016 Dec;2016(1):670-677.

 

Von Willebrand factor (VWF) is a critical regulator of hemostatic processes, including collagen binding, platelet adhesion, and platelet aggregation. It also serves as a carrier protein to normalize plasma factor VIII synthesis, release, and survival. While VWF protein measurements ...

Last Updated: 31 Dec 1969

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Utility of the von Willebrand factor collagen binding assay in the diagnosis of von Willebrand disease.
 

Author(s): Emmanuel J Favaloro

Journal: Am. J. Hematol.. 2017 Jan;92(1):114-118.

 

von Willebrand Disease (VWD) is the most common inherited bleeding disorder and also arises as an acquired defect (AVWS). VWD and AVWS are due to quantitative deficiencies and/or qualitative defects in von Willebrand factor (VWF), an adhesive plasma protein with multiple activities. ...

Last Updated: 31 Dec 1969

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Towards personalised therapy for von Willebrand disease: a future role for recombinant products.
 

Author(s): Emmanuel J Favaloro

Journal: Blood Transfus. 2016 05;14(2):262-76.

 

von Willebrand disease (VWD) is reportedly the most common bleeding disorder and is caused by deficiencies and/or defects in the adhesive plasma protein von Willebrand factor (VWF). Functionally, normal VWF prevents bleeding by promoting both primary and secondary haemostasis. In ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Von Willebrand Disease in the Netherlands
 

Status: Not yet recruiting

Condition Summary: Von Willebrand Disease

 

Last Updated: 22 May 2018

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Molecular and Clinical Profile of Von Willebrand Disease in Spain
 

Status: Recruiting

Condition Summary: Von Willebrand Disease

 

Last Updated: 3 Oct 2017

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