Von Willebrand Disease

Common Name(s)

Von Willebrand Disease

Von Willebrand disease is a bleeding disorder that slows the blood clotting process. People with this condition often experience bruising, nosebleeds, and prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases, heavy bleeding occurs after minor trauma or even in the absence of injury. Milder forms of Von Willebrand disease do not involve spontaneous bleeding, and the condition may become apparent only when abnormal bleeding occurs following surgery or a serious injury. Symptoms may change over time. Increased age, pregnancy, exercise, and stress may make bleeding symptoms may become less frequent. This condition is caused by mutations in the VWF gene and can have different inheritance patterns.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Von Willebrand Disease" for support, advocacy or research.

Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

Last Updated: 25 Sep 2013

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Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

Last Updated: 26 Nov 2012

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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

Last Updated: 3 Apr 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Von Willebrand Disease" for support, advocacy or research.

Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

http://www.bdai.org

Last Updated: 25 Sep 2013

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Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

http://www.hemophiliafed.org

Last Updated: 26 Nov 2012

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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

http://www.haemophilia.org.uk/

Last Updated: 3 Apr 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Von Willebrand Disease" returned 265 free, full-text research articles on human participants. First 3 results:

Isolated spontaneous celiac artery dissection in a 47-year-old man with von Willebrand disease.
 

Author(s): Aziz Ur Rehman, Abdelkader Almanfi, Srikanth Nadella, Umair Sohail

Journal:

 

Isolated spontaneous dissection of the celiac artery is rare, and its occurrence without aortic dissection is even rarer. The typical symptom of this dissection is acute-onset abdominal pain. Complications of the condition include aneurysm formation, rupture, and abdominal-organ ischemia ...

Last Updated: 23 Jun 2014

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Von Willebrand factor regulation in patients with acute and chronic cerebrovascular disease: a pilot, case-control study.
 

Author(s): Peter Kraft, Christiane Drechsler, Ignaz Gunreben, Bernhard Nieswandt, Guido Stoll, Peter Ulrich Heuschmann, Christoph Kleinschnitz

Journal:

 

In animal models, von Willebrand factor (VWF) is involved in thrombus formation and propagation of ischemic stroke. However, the pathophysiological relevance of this molecule in humans, and its potential use as a biomarker for the risk and severity of ischemic stroke remains unclear. ...

Last Updated: 18 Jun 2014

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[Clinical studies of 162 patients with von Willebrand disease].
 

Author(s): Wanyan Ouyang, Ziqiang Yu, Jie Yin, Xiaojuan Zhao, Zhaoyue Wang, Wei Zhang, Zhenni Ma, Jian Su, Xia Bai, Changgeng Ruan

Journal: Zhonghua Xue Ye Xue Za Zhi. 2014 Feb;35(2):152-6.

 

To analyse the epidemiological feature, clinical characters and therapeutic regimens for von Willebrand disease(VWD).

Last Updated: 10 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Von Willebrand Disease" returned 22 free, full-text review articles on human participants. First 3 results:

Perils, problems, and progress in laboratory diagnosis of von Willebrand disease.
 

Author(s): Veronica H Flood

Journal: Semin. Thromb. Hemost.. 2014 Feb;40(1):41-8.

 

Diagnosis of von Willebrand disease (VWD) merits consideration of personal and family history of bleeding symptoms along with confirmatory laboratory testing. As the latter yields quantifiable results, overreliance on a laboratory diagnosis may occur. However, existing tests for VWD ...

Last Updated: 28 Jan 2014

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von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy.
 

Author(s): David Lillicrap

Journal: Hematology Am Soc Hematol Educ Program. 2013 ;2013():254-60.

 

von Willebrand disease (VWD) is the most common autosomally inherited bleeding disorder. The disease represents a range of quantitative and qualitative pathologies of the adhesive glycoprotein von Willebrand factor (VWF). The pathogenic mechanisms responsible for the type 2 qualitative ...

Last Updated: 9 Dec 2013

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von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy.
 

Author(s): David Lillicrap

Journal: Blood. 2013 Nov;122(23):3735-40.

 

von Willebrand disease (VWD) is the most common autosomally inherited bleeding disorder. The disease represents a range of quantitative and qualitative pathologies of the adhesive glycoprotein von Willebrand factor (VWF). The pathogenic mechanisms responsible for the type 2 qualitative ...

Last Updated: 29 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Global Hemostatic Methods in Hemophilia and Von Willebrand's Disease
 

Status: Recruiting

Condition Summary: Hemophilia A; Hemophilia B; Von Willebrand's Disease

 

Last Updated: 11 Feb 2014

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Surveillance of Safety and Efficacy of Wilate in Patients With Von Willebrand Disease
 

Status: Recruiting

Condition Summary: Von Willebrand Disease

 

Last Updated: 20 Apr 2015

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Recombinant Von Willebrand Factor in Subjects With Severe Von Willebrand Disease Undergoing Surgery
 

Status: Recruiting

Condition Summary: Von Willebrand Disease

 

Last Updated: 23 Apr 2015

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