Von Willebrand Disease

Common Name(s)

Von Willebrand Disease

Von Willebrand disease is a bleeding disorder that slows the blood clotting process. People with this disoder often experience bruising, nosebleeds, and prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases, heavy bleeding occurs after minor trauma or even in the absence of injury. Milder forms of Von Willebrand disease do not involve spontaneous bleeding, and the condition may become apparent only when abnormal bleeding occurs following surgery or a serious injury. Symptoms may change over time. Increased age, pregnancy, exercise, and stress may make bleeding symptoms become less frequent. This disorder is caused by mutations in the VWF gene and can have different inheritance patterns.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Von Willebrand Disease" for support, advocacy or research.

Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

Last Updated: 25 Sep 2013

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Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

Last Updated: 6 Jul 2015

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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

Last Updated: 3 Apr 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Von Willebrand Disease" for support, advocacy or research.

Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

http://www.bdai.org

Last Updated: 25 Sep 2013

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Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

http://www.hemophiliafed.org

Last Updated: 6 Jul 2015

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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

http://www.haemophilia.org.uk/

Last Updated: 3 Apr 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Von Willebrand Disease" returned 385 free, full-text research articles on human participants. First 3 results:

[Diagnostic algorithm for von Willebrand Disease (vWD) in a Mexican population].
 

Author(s): Jesús Hernández-Juárez, Manuel Moreno-Hernández, Abraham Majluf-Cruz

Journal: Gac Med Mex. ;151(6):828-9.

 

Last Updated: 20 Nov 2015

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Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease.
 

Author(s): Joan C Gill, Giancarlo Castaman, Jerzy Windyga, Peter Kouides, Margaret Ragni, Frank W G Leebeek, Ortrun Obermann-Slupetzky, Miranda Chapman, Sandor Fritsch, Borislava G Pavlova, Isabella Presch, Bruce Ewenstein

Journal: Blood. 2015 Oct;126(17):2038-46.

 

This phase 3 trial evaluated the safety and hemostatic efficacy of a recombinant von Willebrand factor (rVWF) for treatment of bleeds in severe von Willebrand disease (VWD). rVWF was initially administered together with recombinant factor VIII (rFVIII) and subsequently alone, as long ...

Last Updated: 23 Oct 2015

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[Diagnostic algorithm for von Willebrand Disease (vWD) in a Mexican population].
 

Author(s): María Guadalupe Zavelia Padilla-Romo, Ana Rebeca Jaloma-Cruz

Journal: Gac Med Mex. ;151(3):399-402.

 

The diagnosis of von Willebrand disease (vWD) is complex and requires several screening and confirmation tests, such as the analysis of vWF multimers, which is considered the gold standard for vWD subtyping; however, it only discriminates 2A subtype while the 2B, 2M, and 2N subtypes ...

Last Updated: 19 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Von Willebrand Disease" returned 36 free, full-text review articles on human participants. First 3 results:

Diagnostic approach to von Willebrand disease.
 

Author(s): Christopher Ng, David G Motto, Jorge Di Paola

Journal: Blood. 2015 Mar;125(13):2029-37.

 

Last Updated: 27 Mar 2015

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Up to date concepts about Von Willebrand disease and the diagnose of this hemostatic disorder.
 

Author(s): I Buga-Corbu, C Arion

Journal: J Med Life. 2014 Sep;7(3):327-34.

 

The authors review the current data in literature regarding the recent knowledge about hemostase, coagulation and clinical and laboratory diagnostic algorithms of hemostatic disorders. They also present the pathological classification of bleeding disorders - the basis to clinical ...

Last Updated: 21 Nov 2014

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Current therapy in children and adolescents with von Willebrand disease.
 

Author(s): I Buga-Corbu, C Arion

Journal: J Med Life. 2014 Jun;7(2):264-9.

 

The article represents a review of recent data about the therapy of von Willebrand disease in children and adolescents (hereditary as well as acquired forms of the disease). The treatment of bleeding events in these patients, the indications in different subtypes, and the future lines ...

Last Updated: 21 Nov 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Global Hemostatic Methods in Hemophilia and Von Willebrand's Disease
 

Status: Recruiting

Condition Summary: Hemophilia A; Hemophilia B; Von Willebrand's Disease

 

Last Updated: 31 Aug 2015

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Minimize Menorrhagia in Women With Type 1 Von Willebrand Disease
 

Status: Not yet recruiting

Condition Summary: Type 1 Von Willebrand Disease

 

Last Updated: 16 May 2016

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