Von Willebrand Disease

Common Name(s)

Von Willebrand Disease

Von Willebrand disease is a bleeding disorder that slows the blood clotting process. People with this disoder often experience bruising, nosebleeds, and prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases, heavy bleeding occurs after minor trauma or even in the absence of injury. Milder forms of Von Willebrand disease do not involve spontaneous bleeding, and the condition may become apparent only when abnormal bleeding occurs following surgery or a serious injury. Symptoms may change over time. Increased age, pregnancy, exercise, and stress may make bleeding symptoms become less frequent. This disorder is caused by mutations in the VWF gene and can have different inheritance patterns.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Von Willebrand Disease" for support, advocacy or research.

Logo
Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

Last Updated: 11 Jul 2016

View Details
Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

Last Updated: 25 Sep 2013

View Details
Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

Last Updated: 6 Jul 2015

View Details
Logo
The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

Last Updated: 3 Apr 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Von Willebrand Disease" for support, advocacy or research.

Logo
Ben's Friends

Our mission is to ensure that everyone in the world with a rare disease has a safe place to go and connect with others like them.

http://www.bensfriends.org

Last Updated: 11 Jul 2016

View Details
Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

http://www.bdai.org

Last Updated: 25 Sep 2013

View Details
Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

http://www.hemophiliafed.org

Last Updated: 6 Jul 2015

View Details
Logo
The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

http://www.haemophilia.org.uk/

Last Updated: 3 Apr 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Von Willebrand Disease" returned 404 free, full-text research articles on human participants. First 3 results:

Spontaneous recurrent hematuria and hematospermia: Unique manifestations of von Willebrand disease type I. Case report.
 

Author(s): Daniele Minardi, Anna Rita Scortechini, Giulio Milanese, Pietro Leoni, Giovanni Muzzonigro

Journal:

 

In this report we describe the case of a patient with unrecognized von Willebrand disease (vWD), in whom the only presenting symptoms were spontaneous and recurrent hematuria with bladder tamponade, associated with recurrent hematospermia. The diagnosis was made only after several ...

Last Updated: 13 Apr 2016

Go To URL
A Laboratory Phenotype/Genotype Correlation of 1167 French Patients From 670 Families With von Willebrand Disease: A New Epidemiologic Picture.
 

Author(s): Agnès Veyradier, Pierre Boisseau, Edith Fressinaud, Claudine Caron, Catherine Ternisien, Mathilde Giraud, Christophe Zawadzki, Marc Trossaert, Nathalie Itzhar-Baïkian, Marie Dreyfus, Roseline d'Oiron, Annie Borel-Derlon, Sophie Susen, Stéphane Bezieau, Cécile V Denis, Jenny Goudemand,

Journal: Medicine (Baltimore). 2016 Mar;95(11):e3038.

 

von Willebrand disease (VWD) is a genetic bleeding disease due to a defect of von Willebrand factor (VWF), a glycoprotein crucial for platelet adhesion to the subendothelium after vascular injury. VWD include quantitative defects of VWF, either partial (type 1 with VWF levels <50 ...

Last Updated: 18 Mar 2016

Go To URL
A rare case of chronic myeloid leukemia with acquired von Willebrand disease presenting as subdural hematoma.
 

Author(s): Ankur Jain

Journal: J Cancer Res Ther. ;11(4):1022.

 

We report a case of a 32-year-old lady with chronic myeloid leukemia (CML) on Imatinib for the past four years and in complete clinical, hematological and molecular remission who presented to us with sudden onset of headache, vomiting and diplopia following self discontinuation of ...

Last Updated: 17 Feb 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Von Willebrand Disease" returned 36 free, full-text review articles on human participants. First 3 results:

Diagnostic approach to von Willebrand disease.
 

Author(s): Christopher Ng, David G Motto, Jorge Di Paola

Journal: Blood. 2015 Mar;125(13):2029-37.

 

Last Updated: 27 Mar 2015

Go To URL
Up to date concepts about Von Willebrand disease and the diagnose of this hemostatic disorder.
 

Author(s): I Buga-Corbu, C Arion

Journal: J Med Life. 2014 Sep;7(3):327-34.

 

The authors review the current data in literature regarding the recent knowledge about hemostase, coagulation and clinical and laboratory diagnostic algorithms of hemostatic disorders. They also present the pathological classification of bleeding disorders - the basis to clinical ...

Last Updated: 21 Nov 2014

Go To URL
Current therapy in children and adolescents with von Willebrand disease.
 

Author(s): I Buga-Corbu, C Arion

Journal: J Med Life. 2014 Jun;7(2):264-9.

 

The article represents a review of recent data about the therapy of von Willebrand disease in children and adolescents (hereditary as well as acquired forms of the disease). The treatment of bleeding events in these patients, the indications in different subtypes, and the future lines ...

Last Updated: 21 Nov 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Molecular and Clinical Profile of Von Willebrand Disease in Spain
 

Status: Not yet recruiting

Condition Summary: Von Willebrand Disease

 

Last Updated: 11 Aug 2016

Go to URL
Surveillance of Safety and Efficacy of Wilate in Patients With Von Willebrand Disease
 

Status: Recruiting

Condition Summary: Von Willebrand Disease

 

Last Updated: 19 Oct 2016

Go to URL